Affiliation: University of Pennsylvania
- Daf-2 signaling modifies mutant SOD1 toxicity in C. elegansMarco Boccitto
Department of Pediatrics, Division of Neurology, Children s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e33494. 2012..These results suggest that manipulation of the DAF-2 Insulin/IGF-1 signaling pathway may have therapeutic potential for the treatment of ALS...
- Regulation of Foxo-dependent transcription by post-translational modificationsMarco Boccitto
Department of Pediatrics, Division of Neurology, Abramson Research Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Curr Drug Targets 12:1303-10. 2011....
- Stress and aging induce distinct polyQ protein aggregation statesLorenza E Moronetti Mazzeo
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 109:10587-92. 2012..Our findings show that in vivo, the same protein can adopt distinct aggregation states depending on the initiating stressor and that stress and aging impact the proteome in related but distinct ways...
- Signaling events in axons and/or dendrites render motor neurons vulnerable to mutant superoxide dismutase toxicityGoo Bo Jeong
Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 31:295-9. 2011..BDNF action depends upon endocytosis of the BDNF-TrkB complex and de novo protein synthesis. These results highlight the importance of signaling events occurring in axons/dendrites in mutant SOD toxicity...