Michael S Bobola

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery and Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Cancer Res 11:2747-55. 2005
  2. ncbi Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98105, USA
    Clin Cancer Res 13:612-20. 2007
  3. ncbi Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Mol Cancer Ther 9:1208-18. 2010
  4. ncbi Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Clin Cancer Res 11:7405-14. 2005
  5. ncbi Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Int J Cancer 129:2370-9. 2011
  6. ncbi Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N.E Pacific Street, Seattle, WA 98195-6470, USA
    Clin Cancer Res 10:7875-83. 2004
  7. ncbi The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3008-18. 2002
  8. ncbi O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis
    Michael S Bobola
    Department of Neurological Surgery, Box 356470, University of Washington, Seattle, WA 98195 6470, USA
    DNA Repair (Amst) 6:1127-33. 2007
  9. ncbi The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function
    A Blank
    Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA
    DNA Repair (Amst) 3:629-38. 2004
  10. ncbi O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1826:71-82. 2012

Collaborators

Detail Information

Publications10

  1. ncbi O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery and Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Cancer Res 11:2747-55. 2005
    ..Few such data for pediatric glioma lines, particularly those from low-grade tumors, are currently available...
  2. ncbi Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98105, USA
    Clin Cancer Res 13:612-20. 2007
    ..Our purpose is to characterize the sensitivity of human glioma cells to methyl-lexitropsin (Me-lex), a sequence-specific alkylator that produces 3-methyladenine (3-meA) as the predominant (>90%) DNA lesion...
  3. ncbi Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Mol Cancer Ther 9:1208-18. 2010
    ..These results provide novel information on which to base further mechanistic study of radiosensitization by temozolomide in human GBM cells and to develop strategies to improve the outcome of concurrent temozolomide radiotherapy...
  4. ncbi Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Clin Cancer Res 11:7405-14. 2005
    ....
  5. ncbi Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Int J Cancer 129:2370-9. 2011
    ..Our findings support the use of inhibitors of Ap endo activity to overcome resistance...
  6. ncbi Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N.E Pacific Street, Seattle, WA 98195-6470, USA
    Clin Cancer Res 10:7875-83. 2004
    ..CONCLUSIONS: Our data suggest that Ap endo activity mediates resistance to alkylating agents and radiation and may be a useful predictor of progression after adjuvant therapy in a subset of gliomas...
  7. ncbi The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3008-18. 2002
    ..Our results may also be relevant to the design of therapeutic regimens using concurrent ionizing radiation (a generator of ROS) and alkylating agent-based chemotherapy...
  8. ncbi O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis
    Michael S Bobola
    Department of Neurological Surgery, Box 356470, University of Washington, Seattle, WA 98195 6470, USA
    DNA Repair (Amst) 6:1127-33. 2007
    ..Our findings provide possible mechanistic insight into epidemiologic data associating maternal alkylating agent exposure with brain tumor incidence...
  9. ncbi The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function
    A Blank
    Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA
    DNA Repair (Amst) 3:629-38. 2004
    ....
  10. ncbi O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1826:71-82. 2012
    ..We conclude by considering approaches that may improve the utility of MGMT methylation status in planning optimal therapies tailored to individual patients...