Michael S Bobola

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery and Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Cancer Res 11:2747-55. 2005
  2. ncbi request reprint Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98105, USA
    Clin Cancer Res 13:612-20. 2007
  3. pmc Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Mol Cancer Ther 9:1208-18. 2010
  4. ncbi request reprint Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Clin Cancer Res 11:7405-14. 2005
  5. pmc Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Int J Cancer 129:2370-9. 2011
  6. ncbi request reprint Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6470, USA
    Clin Cancer Res 10:7875-83. 2004
  7. ncbi request reprint The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3008-18. 2002
  8. pmc O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1826:71-82. 2012
  9. pmc O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis
    Michael S Bobola
    Department of Neurological Surgery, Box 356470, University of Washington, Seattle, WA 98195 6470, USA
    DNA Repair (Amst) 6:1127-33. 2007
  10. ncbi request reprint The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function
    A Blank
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    DNA Repair (Amst) 3:629-38. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery and Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Cancer Res 11:2747-55. 2005
    ..Few such data for pediatric glioma lines, particularly those from low-grade tumors, are currently available...
  2. ncbi request reprint Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98105, USA
    Clin Cancer Res 13:612-20. 2007
    ..Our purpose is to characterize the sensitivity of human glioma cells to methyl-lexitropsin (Me-lex), a sequence-specific alkylator that produces 3-methyladenine (3-meA) as the predominant (>90%) DNA lesion...
  3. pmc Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Mol Cancer Ther 9:1208-18. 2010
    ..These results provide novel information on which to base further mechanistic study of radiosensitization by temozolomide in human GBM cells and to develop strategies to improve the outcome of concurrent temozolomide radiotherapy...
  4. ncbi request reprint Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Clin Cancer Res 11:7405-14. 2005
    ....
  5. pmc Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195 6470, USA
    Int J Cancer 129:2370-9. 2011
    ..Our findings support the use of inhibitors of Ap endo activity to overcome resistance...
  6. ncbi request reprint Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6470, USA
    Clin Cancer Res 10:7875-83. 2004
    ..Clin Cancer Res 2002;8:3008.). Here we examine the association of glioma Ap endo activity with clinical response after alkylating agent-based chemotherapy or after radiotherapy...
  7. ncbi request reprint The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3008-18. 2002
    ..Our results may also be relevant to the design of therapeutic regimens using concurrent ionizing radiation (a generator of ROS) and alkylating agent-based chemotherapy...
  8. pmc O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
    John R Silber
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1826:71-82. 2012
    ..We conclude by considering approaches that may improve the utility of MGMT methylation status in planning optimal therapies tailored to individual patients...
  9. pmc O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis
    Michael S Bobola
    Department of Neurological Surgery, Box 356470, University of Washington, Seattle, WA 98195 6470, USA
    DNA Repair (Amst) 6:1127-33. 2007
    ..Our findings provide possible mechanistic insight into epidemiologic data associating maternal alkylating agent exposure with brain tumor incidence...
  10. ncbi request reprint The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function
    A Blank
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    DNA Repair (Amst) 3:629-38. 2004
    ....