MALCOLM NOLAN BLUMENTHAL

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation
    M N Blumenthal
    Department of Medicine, The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Exp Allergy 40:859-66. 2010
  2. ncbi request reprint A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
  3. ncbi request reprint The role of genetics in the development of asthma and atopy
    Malcolm N Blumenthal
    Medicine, Pediatrics, and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Allergy Clin Immunol 5:141-5. 2005
  4. pmc Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype"
    Duaine R Jackola
    The Asthma and Allergy Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Hum Immunol 68:839-43. 2007
  5. ncbi request reprint Asthma, atopy, and lung function among racially diverse, poor inner-urban Minneapolis schoolchildren
    Ian A Greaves
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Environ Res 103:257-66. 2007
  6. ncbi request reprint CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
  7. ncbi request reprint Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 42:19-30. 2005
  8. ncbi request reprint Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life
    Duaine R Jackola
    Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 132:364-72. 2003
  9. ncbi request reprint Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE
    Duaine R Jackola
    Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Immunol 65:20-30. 2004
  10. ncbi request reprint Robustness into advanced age of atopy-specific mechanisms in atopy-prone families
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis 55455, USA
    J Gerontol A Biol Sci Med Sci 58:99-107. 2003

Research Grants

  1. Investigation of the Genetics of Asthma
    Malcolm Blumenthal; Fiscal Year: 2003
  2. Investigation of the Genetics of Asthma
    Malcolm Blumenthal; Fiscal Year: 2006

Detail Information

Publications15

  1. ncbi request reprint Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation
    M N Blumenthal
    Department of Medicine, The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Exp Allergy 40:859-66. 2010
    ..Leukolysin is a novel matrix metalloproteinase (MMP-25/MT-6) released mainly by granulocytic cells, primarily neutrophils, which are implicated in chronic airways inflammation...
  2. ncbi request reprint A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
    ..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
  3. ncbi request reprint The role of genetics in the development of asthma and atopy
    Malcolm N Blumenthal
    Medicine, Pediatrics, and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Allergy Clin Immunol 5:141-5. 2005
    ..This article will present an overview of the current status of genetic studies of asthma and atopy using genome screens and association studies that have occurred in the literature since January 2003...
  4. pmc Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype"
    Duaine R Jackola
    The Asthma and Allergy Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Hum Immunol 68:839-43. 2007
    ..004), but QTL-specific heritabilities only in the range of 30%-35%. Allergen-specific IgG1 is a suitable "endophenotype" to be used in searches for genes associated with atopy-associated humoral immune responses to common aeroallergens...
  5. ncbi request reprint Asthma, atopy, and lung function among racially diverse, poor inner-urban Minneapolis schoolchildren
    Ian A Greaves
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Environ Res 103:257-66. 2007
    ..A history of physician-diagnosed asthma was not associated with decreased lung function. Factors other than poverty, inner-urban living, and IgE levels (atopy) need to be considered in the development of childhood asthma...
  6. ncbi request reprint CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
    ..We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses...
  7. ncbi request reprint Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 42:19-30. 2005
    ..A theoretical model is proposed to account for this relationship...
  8. ncbi request reprint Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life
    Duaine R Jackola
    Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 132:364-72. 2003
    ..Genetic studies of atopy rely upon evidence of abnormal IgE production, usually elevated total IgE or skin prick test (SPT) reactions. However, these measures may change with subject age...
  9. ncbi request reprint Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE
    Duaine R Jackola
    Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Immunol 65:20-30. 2004
    ..Elevated serum IgE is a consequence, not a predisposing cause, of allergen sensitization...
  10. ncbi request reprint Robustness into advanced age of atopy-specific mechanisms in atopy-prone families
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis 55455, USA
    J Gerontol A Biol Sci Med Sci 58:99-107. 2003
    ..In addition, established atopic responses may be focused in an immune system compartment either independent of or minimally influenced by T-cell activity...
  11. ncbi request reprint Variable binding affinities for allergen suggest a 'selective competition' among immunoglobulins in atopic and non-atopic humans
    Duaine R Jackola
    The Asthma and Allergy Program, University of Minnesota Medical School, MMC 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 39:367-77. 2002
    ..These results suggest that there may be a "selective competition" among isotypes for allergens that is driven by the ability to produce high affinity, allergen-specific immunoglobulins...
  12. ncbi request reprint Definition of an allergen (immunobiology)
    Malcolm N Blumenthal
    University of Minnesota, Minneapolis, Minnesota, USA
    Clin Allergy Immunol 18:37-50. 2004
  13. ncbi request reprint A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Allergy Clin Immunol 117:79-85. 2006
    ..Asthma and atopy represent complex traits for which genetic predisposition has been demonstrated. Pollen sensitivity, whether seasonal or chronic, appears to be a major contributor to the asthmatic phenotype...
  14. ncbi request reprint Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways
    Sven K Wust
    Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Transl Res 148:157-63. 2006
    ..In conclusion, the results suggest that, in asthmatic patients, complement activation does not exhibit an abnormal sensitivity to activation by any of the known activation pathways...
  15. ncbi request reprint Genetics of asthma
    Jacob Bryan Blumenthal
    Division of Geriatric Medicine and Gerontology, Department of Medicine, John Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Med Clin North Am 86:937-50. 2002
    ..A deeper [figure: see text] understanding of these genetic bases and the roles that environmental factors play in the development and manifestations of these conditions will provide better methods of diagnosis and treatment...

Research Grants4

  1. Investigation of the Genetics of Asthma
    Malcolm Blumenthal; Fiscal Year: 2003
    ..This will be the first step in the identification of genes that can be used for predictive genetic analyses and development of drug targets for this common medical problem. ..
  2. Investigation of the Genetics of Asthma
    Malcolm Blumenthal; Fiscal Year: 2006
    ..This will be the first step in the identification of genes that can be used for predictive genetic analyses and development of drug targets for this common medical problem. ..