MALCOLM NOLAN BLUMENTHAL
Affiliation: University of Minnesota
- Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammationM N Blumenthal
Department of Medicine, The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Clin Exp Allergy 40:859-66. 2010..Leukolysin is a novel matrix metalloproteinase (MMP-25/MT-6) released mainly by granulocytic cells, primarily neutrophils, which are implicated in chronic airways inflammation...
- A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of AsthmaMalcolm N Blumenthal
Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
Hum Genet 114:157-64. 2004..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
- The role of genetics in the development of asthma and atopyMalcolm N Blumenthal
Medicine, Pediatrics, and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Allergy Clin Immunol 5:141-5. 2005..This article will present an overview of the current status of genetic studies of asthma and atopy using genome screens and association studies that have occurred in the literature since January 2003...
- Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype"Duaine R Jackola
The Asthma and Allergy Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
Hum Immunol 68:839-43. 2007..004), but QTL-specific heritabilities only in the range of 30%-35%. Allergen-specific IgG1 is a suitable "endophenotype" to be used in searches for genes associated with atopy-associated humoral immune responses to common aeroallergens...
- Asthma, atopy, and lung function among racially diverse, poor inner-urban Minneapolis schoolchildrenIan A Greaves
Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street S E, Minneapolis, MN 55455, USA
Environ Res 103:257-66. 2007..A history of physician-diagnosed asthma was not associated with decreased lung function. Factors other than poverty, inner-urban living, and IgE levels (atopy) need to be considered in the development of childhood asthma...
- CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responsesDuaine R Jackola
The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Int Arch Allergy Immunol 139:217-24. 2006..We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses...
- Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infantsDuaine R Jackola
The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
Mol Immunol 42:19-30. 2005..A theoretical model is proposed to account for this relationship...
- Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early lifeDuaine R Jackola
Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Int Arch Allergy Immunol 132:364-72. 2003..Genetic studies of atopy rely upon evidence of abnormal IgE production, usually elevated total IgE or skin prick test (SPT) reactions. However, these measures may change with subject age...
- Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgEDuaine R Jackola
Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Hum Immunol 65:20-30. 2004..Elevated serum IgE is a consequence, not a predisposing cause, of allergen sensitization...
- Robustness into advanced age of atopy-specific mechanisms in atopy-prone familiesDuaine R Jackola
The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis 55455, USA
J Gerontol A Biol Sci Med Sci 58:99-107. 2003..In addition, established atopic responses may be focused in an immune system compartment either independent of or minimally influenced by T-cell activity...
- Variable binding affinities for allergen suggest a 'selective competition' among immunoglobulins in atopic and non-atopic humansDuaine R Jackola
The Asthma and Allergy Program, University of Minnesota Medical School, MMC 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
Mol Immunol 39:367-77. 2002..These results suggest that there may be a "selective competition" among isotypes for allergens that is driven by the ability to produce high affinity, allergen-specific immunoglobulins...
- Definition of an allergen (immunobiology)Malcolm N Blumenthal
University of Minnesota, Minneapolis, Minnesota, USA
Clin Allergy Immunol 18:37-50. 2004
- A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivityMalcolm N Blumenthal
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
J Allergy Clin Immunol 117:79-85. 2006..Asthma and atopy represent complex traits for which genetic predisposition has been demonstrated. Pollen sensitivity, whether seasonal or chronic, appears to be a major contributor to the asthmatic phenotype...
- Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathwaysSven K Wust
Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Transl Res 148:157-63. 2006..In conclusion, the results suggest that, in asthmatic patients, complement activation does not exhibit an abnormal sensitivity to activation by any of the known activation pathways...
- Genetics of asthmaJacob Bryan Blumenthal
Division of Geriatric Medicine and Gerontology, Department of Medicine, John Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
Med Clin North Am 86:937-50. 2002..A deeper [figure: see text] understanding of these genetic bases and the roles that environmental factors play in the development and manifestations of these conditions will provide better methods of diagnosis and treatment...
- Investigation of the Genetics of AsthmaMalcolm Blumenthal; Fiscal Year: 2006..This will be the first step in the identification of genes that can be used for predictive genetic analyses and development of drug targets for this common medical problem. ..