Kenneth Blumenthal

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi Voltage-gated sodium channel toxins: poisons, probes, and future promise
    Kenneth M Blumenthal
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Cell Biochem Biophys 38:215-38. 2003
  2. ncbi Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 280:11127-33. 2005
  3. ncbi Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression
    Donald E Coling
    Center for Hearing and Deafness, 137 Cary Hall, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 226:140-56. 2007
  4. ncbi Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 282:12687-97. 2007
  5. ncbi Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity
    Anna L Seibert
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Biochemistry 42:14515-21. 2003
  6. ncbi Persistent regional downregulation in mitochondrial enzymes and upregulation of stress proteins in swine with chronic hibernating myocardium
    Brian Page
    VA WNY Health Care System, University at Buffalo, Buffalo, NY, USA
    Circ Res 102:103-12. 2008
  7. ncbi Site-3 sea anemone toxins: molecular probes of gating mechanisms in voltage-dependent sodium channels
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, 3435 Main St Buffalo, NY 14214, USA
    Toxicon 49:159-70. 2007
  8. ncbi Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3
    Anna L Seibert
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 43:7082-9. 2004
  9. ncbi ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels
    Birgit T Priest
    Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Toxicon 49:194-201. 2007
  10. ncbi Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel
    Ossama B Kashlan
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:30455-62. 2006

Research Grants

  1. Fluorescence 2D Difference Gel Electrophoresis
    Kenneth Blumenthal; Fiscal Year: 2003
  2. TOXIN: NA-CHANNEL INTERACTIONS AND DRUG DESIGN
    Kenneth Blumenthal; Fiscal Year: 2003

Collaborators

Detail Information

Publications11

  1. ncbi Voltage-gated sodium channel toxins: poisons, probes, and future promise
    Kenneth M Blumenthal
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Cell Biochem Biophys 38:215-38. 2003
    ..In addition, we explore recent advances in the use of these toxins as molecular scaffolding agents, drugs, and insecticides...
  2. ncbi Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 280:11127-33. 2005
    ..This inherent difference suggests that the conformation of domain II more closely resembles that of the K(V)AP channel than does the conformation of domain IV...
  3. ncbi Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression
    Donald E Coling
    Center for Hearing and Deafness, 137 Cary Hall, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 226:140-56. 2007
    ..Changes in cisplatin-induced protein expression are discussed with respect to known or hypothesized functions of the identified proteins...
  4. ncbi Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 282:12687-97. 2007
    ....
  5. ncbi Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity
    Anna L Seibert
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Biochemistry 42:14515-21. 2003
    ....
  6. ncbi Persistent regional downregulation in mitochondrial enzymes and upregulation of stress proteins in swine with chronic hibernating myocardium
    Brian Page
    VA WNY Health Care System, University at Buffalo, Buffalo, NY, USA
    Circ Res 102:103-12. 2008
    ..These proteomic changes may limit oxidative injury and apoptosis and impact functional recovery after revascularization...
  7. ncbi Site-3 sea anemone toxins: molecular probes of gating mechanisms in voltage-dependent sodium channels
    Jaime J Smith
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, 3435 Main St Buffalo, NY 14214, USA
    Toxicon 49:159-70. 2007
    ..Because of their ability to discriminate among channel isoforms, and their high degree of structural conservation, these toxins could serve as important lead compounds for future pharmaceutical design...
  8. ncbi Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3
    Anna L Seibert
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 43:7082-9. 2004
    ..These data represent the first indication of the presence of such residues or regions within Na(V) site 3...
  9. ncbi ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels
    Birgit T Priest
    Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Toxicon 49:194-201. 2007
    ....
  10. ncbi Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel
    Ossama B Kashlan
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:30455-62. 2006
    ..Together, our data suggest that alphaM1 is divided into two distinct regions...
  11. ncbi Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5
    Gabrielle B Edgerton
    Committee on Neurobiology, University of Chicago, 5841 South Maryland Avenue, MC6094, Chicago, IL 60637, USA
    Toxicon 52:489-500. 2008
    ..Some, but not all aspects of ProTxII modification were sensitive to the presence of Ba2+ indicating the contribution of an electrostatic, surface charge-like mechanism and supporting the idea of a multi-faceted toxin-channel interaction...

Research Grants5

  1. Fluorescence 2D Difference Gel Electrophoresis
    Kenneth Blumenthal; Fiscal Year: 2003
    ..abstract_text> ..
  2. TOXIN: NA-CHANNEL INTERACTIONS AND DRUG DESIGN
    Kenneth Blumenthal; Fiscal Year: 2003
    ....