Research Topics
Species | Gladys BlockSummaryAffiliation: University of California Country: USA Publications
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Publications
Intraindividual variability of plasma antioxidants, markers of oxidative stress, C-reactive protein, cotinine, and other biomarkersGladys Block
School of Public Health, University of California, Berkeley, California 94720, USA
Epidemiology 17:404-12. 2006..Within-person variability in biomarkers results in random error that can attenuate estimates of association. Little information on such variability is available for a number of nutrition-related biomarkers...
A randomized trial of the Little by Little CD-ROM: demonstrated effectiveness in increasing fruit and vegetable intake in a low-income populationGladys Block
Public Health Nutrition Program, School of Public Health, University of California, Berkeley 94720, USA
Prev Chronic Dis 1:A08. 2004..We tested the ability of a single brief interactive experience of the Little by Little CD-ROM to increase fruit and vegetable intake in low-income women...- Demonstration of an E-mailed worksite nutrition intervention programGladys Block
Public Health Nutrition Program, School of Public Health, University of California, Berkeley, 94720, USA
Prev Chronic Dis 1:A06. 2004..S. population intake does not meet recommendations. Interventions are needed that incorporate effective behavior-change principles and that can be delivered inexpensively to large segments of the population... - Validation of a food frequency questionnaire for HispanicsGladys Block
University of California, Berkeley, School of Public Health, Division of Community Health and Human Development, 140 Warren Hall, Berkeley, CA 94720, USA
Prev Chronic Dis 3:A77. 2006..S. population by 2050. Compared with non-Hispanic whites, Hispanics have disproportionately higher rates of obesity, diabetes, and other diet-related conditions. Valid methods for studying the dietary intake of this group are needed... - Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementationGladys Block
Division of Community Health and Human Development, School of Public Health, University of California, Berkeley, California 94720, USA
J Am Coll Nutr 23:141-7. 2004..The objective was to determine whether antioxidant supplementation reduces plasma CRP in active and passive smokers... - Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional studyGladys Block
School of Public Health, 50 University Hall, University of California, Berkeley, CA, 94720, USA
Nutr J 6:30. 2007..This study describes the dietary supplement usage patterns, health, and nutritional status of long-term multiple dietary supplement users, and where possible makes comparisons to non-users and multivitamin/mineral supplement users... 
Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1Gladys Block
School of Public Health, University of California at Berkeley, 94720 7360, USA
Am J Clin Nutr 94:929-37. 2011..Glutathione S-transferases (GSTs) detoxify environmental chemicals and are involved in oxidative stress pathways. Deletion polymorphisms affect enzyme activities and have been associated with risk of disease...- Vitamin C treatment reduces elevated C-reactive proteinGladys Block
University of California, Berkeley, 94720, USA
Free Radic Biol Med 46:70-7. 2009..But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers... - Development of Alive! (A Lifestyle Intervention Via Email), and its effect on health-related quality of life, presenteeism, and other behavioral outcomes: randomized controlled trialGladys Block
NutritionQuest, 15 Shattuck Square, Suite 288, Berkeley, CA 94704, USA
J Med Internet Res 10:e43. 2008..It was shown to improve these behaviors in a large randomized controlled trial... - The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline levelGladys Block
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Free Radic Biol Med 45:377-84. 2008..Further studies are needed to establish whether treatment with vitamins C or E in persons with concentrations above that cut point could slow the development of cardiovascular disease... - Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White womenGladys Block
School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720, USA
Nutr J 7:35. 2008..Extensive biological and biochemical data suggest that plasma ascorbic acid may be such a factor. In this study we examined the association between plasma ascorbic acid concentration and blood pressure (BP) in young-adult women... - Relations of glycemic index and glycemic load with plasma oxidative stress markersYouqing Hu
Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA
Am J Clin Nutr 84:70-6; quiz 266-7. 2006..5 than for those with a BMI > or = 26.5. CONCLUSIONS: Chronic consumption of high-GI foods may lead to chronically high oxidative stress. A low-GI diet, not a low-carbohydrate diet, appears to be beneficial in reducing oxidative stress... - Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smokeMarion Dietrich
School of Public Health, University of California Berkeley, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Nutr Cancer 45:176-84. 2003..Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers. This finding might be of importance for the prevention of ETS-associated adverse health effects in nonsmokers... - Factors associated with oxidative stress in human populationsGladys Block
Division of Health Policy and Management, School of Public Health, University of California, Berkeley, CA 94720, USA
Am J Epidemiol 156:274-85. 2002..These data would permit a better understanding of the role that oxidants and antioxidants play in the health of human populations... - Dietary glycemic load, glycemic index, and associated factors in a multiethnic cohort of midlife womenYouqing Hu
Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA
J Am Coll Nutr 28:636-47. 2009..However, current knowledge about the distribution, correlates, and major contributors of these measures in human populations is limited... - Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakesMarion Dietrich
School of Public Health, University of California, Berkeley 94720 7360, USA
Am J Clin Nutr 77:160-6. 2003..Free radicals in cigarette smoke may cause oxidative damage to macromolecules, contributing to cardiovascular diseases and cancer. Decreased plasma antioxidant concentrations may indicate cigarette smoke-related oxidative stress... - Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokersMarion Dietrich
Department of Nutritional Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 11:7-13. 2002..The intake of antioxidants may help prevent smoking-related diseases. Smoking cessation should still be considered the most effective way to prevent smoking-related diseases... - The association of time in the US and diet during pregnancy in low-income women of Mexican descentKim Harley
School of Public Health, University of California, Berkeley, CA 94720-7390, USA
Paediatr Perinat Epidemiol 19:125-34. 2005..A large percentage of women had inadequate intake of vitamin E (58%), folate (61%), iron (77%) and zinc (47%) from their diets during pregnancy and these rates were higher in US-born women than Mexico-born women... - Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humansMarion Dietrich
School of Public Health, University of California, Berkeley, California, USA
Lipids 40:329-34. 2005..0056). High-cholesterol subjects that are epsilon4 carriers have significantly higher levels of lipid peroxidation as assessed by circulating F2-isoprostane levels... - Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking menElana W Silver
School of Public Health, University of California, Berkeley, California 94720-7380, USA
J Androl 26:550-6. 2005..The results of this study do not preclude possible beneficial effects of high antioxidant intake on sperm chromatin integrity for men with fertility problems... - The work and home activities questionnaire: energy expenditure estimates and association with percent body fatGladys Block
School of Public Health, University of California, Berkeley, CA, USA
J Phys Act Health 6:S61-9. 2009..Understanding and increasing physical activity requires assessment of occupational, home, leisure and sedentary activities... - Variation in nutrient intakes by ethnicity: results from the Study of Women's Health Across the Nation (SWAN)Mei Hua Huang
Division of Geriatrics, School of Medicine, University of California, Los Angeles, Los Angeles 90095 1687, California, USA
Menopause 9:309-19. 2002..To use food frequency questionnaires to summarize the macro- and micronutrient intakes of women of diverse ethnicity in the Study of Women's Health Across the Nation... - Food consumption by children and the risk of childhood acute leukemiaMarilyn L Kwan
Division of Public Health Biology and Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
Am J Epidemiol 160:1098-107. 2004..These results suggest that fruits or fruit juices that contain vitamin C and/or potassium may reduce the risk of childhood leukemia, especially if they are consumed on a regular basis during the first 2 years of life... - The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United StatesMarion Dietrich
School of Public Health, University of California Berkeley, Berkeley, CA, USA
J Am Coll Nutr 24:266-74. 2005..S. population following folic acid fortification of enriched cereal-grain products and to explore accompanying changes in food sources and dietary total folate intake... - Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaireKamyar Kalantar-Zadeh
University of California Los Angeles School of Medicine, Los Angeles, CA, USA
J Ren Nutr 12:17-31. 2002..We hypothesize that FFQ is a useful tool to assess the food intake differences between patients receiving dialysis and patients not receiving dialysis... - On food frequency questionnaires: the contribution of open-ended questions and questions on ethnic foodsGladys Block
School of Public Health, University of California, Berkeley, CA 94720, USA
Epidemiology 15:216-21. 2004..Epidemiologic studies of diet must balance the goal of comprehensiveness with that of minimizing subject and study burden. Information on the impact of certain additional questionnaire elements may aid in such decisions... - Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States)Christopher D Jensen
School of Public Health, 419 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Causes Control 15:559-70. 2004..Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL... - A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumorsMarion Dietrich
School of Public Health, University of California Berkeley, Berkeley, CA 94720 7360, USA
Cancer Causes Control 16:619-35. 2005..This approach may be helpful in determining the essential information that must be collected in future epidemiological studies on CBT... - Erythrocyte folate and its response to folic acid supplementation is assay dependent in womenAndrew J Clifford
Department of Nutrition, University of California, Davis, CA 95616, USA
J Nutr 135:137-43. 2005..RBC folate correlated with total folate intake using a folate-targeted food/supplement screener... - Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage?Lyndsay Ammon Avalos
School of Public Health, University of California, Berkeley, Berkeley, CA, USA
Am J Obstet Gynecol 201:563.e1-9. 2009..To determine whether multivitamin supplements modify the relationship between alcohol consumption during pregnancy and the risk of miscarriage... - Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failureKamyar Kalantar-Zadeh
Harbor-UCLA Medical Center, Torrance, CA, USA
J Am Coll Cardiol 43:1439-44. 2004..Reverse epidemiology of conventional cardiovascular risk factors is observed in CHF and may have a bearing on the management of these patients; thus, it deserves further investigation... 
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemiaCatherine Metayer
School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, Berkeley, CA 94704 7392, USA
Cancer Causes Control 22:1243-58. 2011..We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk...- Ascorbic acid, blood pressure, and the American dietGladys Block
School of Public Health, University of California, Berkeley, California 94720, USA
Ann N Y Acad Sci 959:180-7. 2002..African Americans tend to have low blood levels of vitamin C as well as the highest risk of hypertension. Low intake of antioxidant-rich fruits and vegetables may be one of the causes of hypertension... - Long-term effects of nutrient intervention on markers of bone remodeling and calciotropic hormones in late-postmenopausal womenChristopher Jensen
University of California, Berkeley, School of Public Health, Department of Epidemiology, USA
Am J Clin Nutr 75:1114-20. 2002.... - Hemochromatosis gene status as a risk factor for Barrett's esophagusDouglas A Corley
Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA, 94612, USA
Dig Dis Sci 53:3095-102. 2008..As expected, gene defects were associated with increased iron stores. We can conclude from our findings that Barrett's esophagus was not associated with hemochromatosis gene defects, although we cannot exclude small effects... - A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities. Clinical trial of nutritional supplements and age-related cataract report no. 3Giovanni Maraini
Ophthalmology 115:599-607.e1. 2008.... - Dietary antioxidants, fruits, and vegetables and the risk of Barrett's esophagusAi Kubo
Division of Research, Kaiser Permanente, Oakland, California 94612, USA
Am J Gastroenterol 103:1614-23; quiz 1624. 2008..The present study evaluated the associations among antioxidants, fruit and vegetable intake, and the risk of Barrett's esophagus (BE), a potential precursor to esophageal adenocarcinoma... - Dietary patterns and the risk of Barrett's esophagusAi Kubo
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Am J Epidemiol 167:839-46. 2008..Results suggest strong associations between a diet rich in fruits and vegetables and the risk of Barrett's esophagus... - The effect of breakfast type on total daily energy intake and body mass index: results from the Third National Health and Nutrition Examination Survey (NHANES III)Sungsoo Cho
Kellogg-USA, Battle Creek, Michigan, USA
J Am Coll Nutr 22:296-302. 2003..Eating cereal (ready-to-eat or cooked cereal) or quick breads for breakfast is associated with significantly lower body mass index compared to skipping breakfast or eating meats and/or eggs for breakfast... - Final results of the Maryland WIC Food for Life ProgramStephen Havas
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 660 W Redwood Street, Baltimore, MD 21201, USA
Prev Med 37:406-16. 2003.... - Abdominal obesity and body mass index as risk factors for Barrett's esophagusDouglas A Corley
Division of Research, Kaiser Permanente, Oakland, California 94612, USA
Gastroenterology 133:34-41; quiz 311. 2007..Barrett's esophagus is a strong risk factor for esophageal adenocarcinoma, but little is known about its associations with body mass index (BMI) or abdominal obesity... - Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, IndiaSoma R Mitra
Institute of Post Graduate Medical Education and Research, Calcutta, India
Environ Health Perspect 112:1104-9. 2004..However, in light of the small magnitude of increased risks related to these dietary deficiencies, prevention should focus on reducing exposure to arsenic... - Lifestyle and demographic factors in relation to vasomotor symptoms: baseline results from the Study of Women's Health Across the NationEllen B Gold
Department of Epidemiology and Preventive Medicine, University of California School of Medicine, Davis, CA 95616 8648, USA
Am J Epidemiol 159:1189-99. 2004..No dietary nutrients were significantly associated with vasomotor symptoms. These cross-sectional findings require further longitudinal exploration to identify lifestyle changes for women that may help prevent vasomotor symptoms... - The nutritional status of astronauts is altered after long-term space flight aboard the International Space StationScott M Smith
Human Adaptation and Countermeasures Office, NASA Lyndon B Johnson Space Center, Houston, TX 77058, USA
J Nutr 135:437-43. 2005..These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers... - Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian womenBeatrice Boucher
Division of Preventive Onoclogy, Cancer Care Ontario, Toronto, Ontario, Canada
Public Health Nutr 9:84-93. 2006..To assess the validity and reliability of the most recent adaptation of Block's full-diet food-frequency questionnaire (FFQ) among a sample of Canadian women... - Understanding the increased risk of neural tube defect-affected pregnancies among Mexico-born women in California: immigration and anthropometric factorsEllen M Velie
Department of Epidemiology, Michigan State University, East Lansing 48824, USA
Paediatr Perinat Epidemiol 20:219-30. 2006..Findings indicate that recent Mexican immigrants have a sevenfold increased risk for NTDs. Maternal BMI and height contributed very little, and inadequate weight gain contributed modestly to the NTD risk disparity for Mexican immigrants... - Relationship between dietary antioxidants and childhood asthma: more epidemiological studies are neededKamyar Kalantar-Zadeh
Department of Pharmacy, UCLA School of Medicine Harbor UCLA Medical Center, Harbor Mailbox 406, C1 Annex 1000 West Carson Street, Torrance, CA 90509, USA
Med Hypotheses 62:280-90. 2004..Risk set sampling may enable us to explore possible associations between the type and quantity of dietary antioxidants and the development and severity of asthma in such an epidemiological study... - Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A reviewMarion Dietrich
Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Nutritional Epidemiology, Boston, MA 02111, USA
J Am Coll Nutr 25:292-9. 2006..In this article, we review publications on dietary gamma-tocopherol intake, plasma gamma-tocopherol levels, cardiovascular disease and cancer risk in humans... - Diet and lifestyle factors associated with premenstrual symptoms in a racially diverse community sample: Study of Women's Health Across the Nation (SWAN)Ellen B Gold
Department of Public Health Sciences, University of California Davis School of Medicine, Davis, California 95616, USA
J Womens Health (Larchmt) 16:641-56. 2007.... - Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 19:1507-19. 2004..However, it is not clear which one is a more sensitive and stronger predictor of outcome... - Development and reliability of brief dietary assessment tools for HispanicsPatricia Wakimoto
National Center for Minority Health and Health Disparities, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Prev Chronic Dis 3:A95. 2006..To address this issue and promote a healthy diet for disease prevention, we developed screening tools to assess the fruit, vegetable, and fat intake of Mexican Americans... - Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Clin Nutr 83:202-10. 2006..In maintenance hemodialysis (MHD) patients, a larger body size is associated with better survival but a worse self-reported quality of life (QoL). It is not clear whether muscle mass or body fat confers the survival advantage... - Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor University of California, Los Angeles Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Am J Clin Nutr 80:299-307. 2004..Malnutrition-inflammation complex syndrome, an outcome predictor in maintenance hemodialysis (MHD) patients, may be related to anorexia...
Research Grants
- Obesity, Inflammation, and Oxidative StressGladys Block; Fiscal Year: 2010..Targeting the inflammatory component of obesity may help slow its progression towards insulin resistance and cardiovascular disease. ..
- Oxidative Damage in Smokers and Passive SmokersGladys Block; Fiscal Year: 2003..smokers 6) To determine the level of vitamin C required by smokers to attain the plasma vitamin C levels of non-smokers 7) To study the effect of supplemental vitamin C or antioxidant cocktail on other plasma antioxidants ..
- Gender Obesity C-Reactive Protein and Oxidative StressGladys Block; Fiscal Year: 2007..2a. In women, to determine whether postmenopausal status is associated with higher baseline CRP or lipid peroxidation, after control of covariates. ..