JULIE ANN BLENDY

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint The role of CREB in depression and antidepressant treatment
    Julie A Blendy
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 59:1144-50. 2006
  2. ncbi request reprint Reduced nicotine reward in obesity: cross-comparison in human and mouse
    Julie A Blendy
    Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Psychopharmacology (Berl) 180:306-15. 2005
  3. pmc Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:41-6. 2011
  4. ncbi request reprint Mu-opioid receptor and CREB activation are required for nicotine reward
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 46:933-43. 2005
  5. ncbi request reprint Differential distribution of CREB in the mesolimbic dopamine reward pathway
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    J Neurochem 87:1237-44. 2003
  6. ncbi request reprint Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Brain Res 1032:193-9. 2005
  7. pmc Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Pharmacol Exp Ther 334:665-72. 2010
  8. doi request reprint Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB
    Arati S Kreibich
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Neuropsychopharmacology 34:2609-17. 2009
  9. pmc Sex differences in response to nicotine in C57Bl/6:129SvEv mice
    Carolina Isiegas
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nicotine Tob Res 11:851-8. 2009
  10. doi request reprint Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice
    Jessica N Cleck
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 201:15-28. 2008

Research Grants

  1. GENETIC ANALYSIS OF DRUG ADDICTION
    Julie Blendy; Fiscal Year: 2004
  2. Molecular genetic analysis of drug addiction
    Julie Blendy; Fiscal Year: 2007
  3. Molecular genetic analysis of drug addiction
    JULIE ANN BLENDY; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The role of CREB in depression and antidepressant treatment
    Julie A Blendy
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 59:1144-50. 2006
    ..Human postmortem and genetic studies that implicate CREB in depression and antidepressant efficacy are also discussed...
  2. ncbi request reprint Reduced nicotine reward in obesity: cross-comparison in human and mouse
    Julie A Blendy
    Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Psychopharmacology (Berl) 180:306-15. 2005
    ..Tobacco use and obesity lead to significant morbidity and mortality...
  3. pmc Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:41-6. 2011
    ..Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine receptors (nAChR) maybe involved in the etiology of withdrawal symptoms...
  4. ncbi request reprint Mu-opioid receptor and CREB activation are required for nicotine reward
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 46:933-43. 2005
    ..Together, pharmacologic and genetic manipulations indicate that phosphorylation of CREB and upregulation of functional MORs are required for nicotine-conditioned reward...
  5. ncbi request reprint Differential distribution of CREB in the mesolimbic dopamine reward pathway
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    J Neurochem 87:1237-44. 2003
    ..Consequently, the 90% reduction of CREB in CREBalphaDelta mutant mice differentially affects CREB phosphorylation and induction of downstream targets of CREB in the NAc and VTA...
  6. ncbi request reprint Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice
    Carrie L Walters
    Department of Pharmacology, University of Pennsylvania, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Brain Res 1032:193-9. 2005
    ..Together, these results indicate that the role of CREB in dose-dependent changes in behaviors induced by morphine is different depending on the brain regions involved in mediating the behavior...
  7. pmc Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior
    Jill R Turner
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Pharmacol Exp Ther 334:665-72. 2010
    ..These results suggest that the partial agonists varenicline and sazetidine-A may have diverse therapeutic benefits in affective disorders...
  8. doi request reprint Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB
    Arati S Kreibich
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Neuropsychopharmacology 34:2609-17. 2009
    ..Taken together, these studies suggest that both CREB and CRF(R1) activation are necessary for stress-induced potentiation of drug reward...
  9. pmc Sex differences in response to nicotine in C57Bl/6:129SvEv mice
    Carolina Isiegas
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nicotine Tob Res 11:851-8. 2009
    ..Investigation of these parameters in mice may also reveal sex differences...
  10. doi request reprint Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice
    Jessica N Cleck
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 201:15-28. 2008
    ..Stress can reinstate previous cocaine-seeking long after drug is no longer present. However, little is known regarding the effect of chronic drug exposure and subsequent drug abstinence on responsivity to stress...
  11. ncbi request reprint cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response
    Tamar L Gur
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:7860-8. 2007
    ..Together, these data show that increased hippocampal neurogenesis allows for an antidepressant phenotype as well as a rapid onset of behavioral responses to AD treatment...
  12. ncbi request reprint Regulation of antidepressant activity by cAMP response element binding proteins
    Alana C Conti
    Departments of Pharmacology and Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Neurobiol 30:143-55. 2004
    ..This article discusses the transcription factor cAMP response element binding protein and a related protein, cyclic AMP response element modulator, and their roles as molecular mediators of antidepressant action...
  13. ncbi request reprint cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs
    Alana C Conti
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 22:3262-8. 2002
    ....
  14. ncbi request reprint Antidepressant action: to the nucleus and beyond
    Jessica E Malberg
    Neuroscience Discovery, Wyeth Research, Princeton, NJ 08543, USA
    Trends Pharmacol Sci 26:631-8. 2005
    ....

Research Grants9

  1. GENETIC ANALYSIS OF DRUG ADDICTION
    Julie Blendy; Fiscal Year: 2004
    ..The complete understanding of these neurobiological mechanisms would open new perspectives for the future development of a more rational therapy for drug addiction. ..
  2. Molecular genetic analysis of drug addiction
    Julie Blendy; Fiscal Year: 2007
    ..These studies may give rise to novel potential therapeutics that can ultimately be translated to the clinic for relapse prevention in humans ..
  3. Molecular genetic analysis of drug addiction
    JULIE ANN BLENDY; Fiscal Year: 2010
    ..These studies may give rise to novel potential therapeutics that can ultimately be translated to the clinic for relapse prevention in humans. ..