Yuri A Blednov

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas A4800, 2500 Speedway, MBB 1 124, Austin, TX 78712 1095, USA
    Psychopharmacology (Berl) 159:370-8. 2002
  2. ncbi request reprint Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traits
    I Ponomarev
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA
    Genes Brain Behav 3:360-8. 2004
  3. pmc Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas A 4800, 1 University Station, 2500 Speedway MBB 1 124, Austin, TX 78712 1095, USA
    Behav Brain Res 165:110-25. 2005
  4. pmc Reduced alcohol consumption in mice lacking preprodynorphin
    Yuri A Blednov
    University of Texas, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Alcohol 40:73-86. 2006
  5. pmc Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway MBB 1 124, Austin, TX 78712 0159, USA
    Brain Behav Immun 25:S92-S105. 2011
  6. ncbi request reprint Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Texas 78712 1095, USA
    J Pharmacol Exp Ther 298:521-30. 2001
  7. ncbi request reprint Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 28:1683-92. 2004
  8. ncbi request reprint Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanol
    Yuri A Blednov
    University of Texas, Waggoner Center for Alcohol and Addiction Research, I University Station A4800, Austin, TX 78712 0159, USA
    Alcohol 34:251-9. 2004
  9. pmc Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA
    Int J Neuropsychopharmacol 11:775-93. 2008
  10. pmc Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addictions Research, University of Texas, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 29:1949-58. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas A4800, 2500 Speedway, MBB 1 124, Austin, TX 78712 1095, USA
    Psychopharmacology (Berl) 159:370-8. 2002
    ..Co-localization of GIRK2 channels and dopamine receptors in the mesolimbic system suggests a role in regulation of motor activity...
  2. ncbi request reprint Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traits
    I Ponomarev
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA
    Genes Brain Behav 3:360-8. 2004
    ..Our results point to the increasing potential of the convergent approach and biological databases to investigate genetic mechanisms of complex traits...
  3. pmc Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas A 4800, 1 University Station, 2500 Speedway MBB 1 124, Austin, TX 78712 1095, USA
    Behav Brain Res 165:110-25. 2005
    ..9 and 72.0 cM, respectively) null mutant mice. These data show that disruption of the chemokine network interferes with motivational effects of alcohol...
  4. pmc Reduced alcohol consumption in mice lacking preprodynorphin
    Yuri A Blednov
    University of Texas, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Alcohol 40:73-86. 2006
    ..These results indicate that deletion of preprodynorphin leads to substantial reduction of alcohol intake in female mice, and suggest that this is caused by decreased orosensory reward of alcohol (sweet taste and/or palatability)...
  5. pmc Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway MBB 1 124, Austin, TX 78712 0159, USA
    Brain Behav Immun 25:S92-S105. 2011
    ..These results suggest that activation of immune signaling promotes alcohol consumption and alters certain aspects of alcohol reward/aversion...
  6. ncbi request reprint Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Texas 78712 1095, USA
    J Pharmacol Exp Ther 298:521-30. 2001
    ..These results provide evidence that GIRK2 channels mediate specific behaviors, including anxiety and convulsions, and may influence effects of ethanol on these behaviors...
  7. ncbi request reprint Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 28:1683-92. 2004
    ..We addressed the role of leptin in alcohol-related behaviors by studying ethanol consumption in two strains of spontaneously mutant mice that lack leptin (ob/ob) or the leptin receptor (db/db)...
  8. ncbi request reprint Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanol
    Yuri A Blednov
    University of Texas, Waggoner Center for Alcohol and Addiction Research, I University Station A4800, Austin, TX 78712 0159, USA
    Alcohol 34:251-9. 2004
    ..Consistent with findings of other studies, these results confirm the lack of correlation between ethanol-induced motor stimulation and consumption of ethanol measured in a self-administration paradigm in mice...
  9. pmc Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA
    Int J Neuropsychopharmacol 11:775-93. 2008
    ..These data show the importance of mGluR5 for several actions of alcohol and support the hypothesis that some effects of acamprosate require mGluR5 signalling...
  10. pmc Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addictions Research, University of Texas, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 29:1949-58. 2005
    ..No strain has been found to consume more ethanol than B6. In one of our laboratories (Texas), we noted a markedly greater intake of ethanol in an F1 hybrid of B6 and FVB/NJ (FVB) mice...
  11. pmc Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station, Austin, TX 78712 0159, USA
    Addict Biol 15:45-61. 2010
    ..These results are consistent with earlier proposals that deletion of Gad2 (on 129N2 background) reduces synaptic GABA but also suggest changes in extrasynaptic receptor function...
  12. pmc Hybrid mice as genetic models of high alcohol consumption
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway MBB 1 124, Austin, TX 78712, USA
    Behav Genet 40:93-110. 2010
    ..These new genetic models offer some advantages over inbred strains because they provide high, sustained, alcohol intake, and should allow mapping of loci important for the genetic architecture of these traits...
  13. pmc Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
    Neuropharmacology 56:814-20. 2009
    ..The studies provide the first evidence that TRPV1 is important for specific behavioral actions of ethanol...
  14. ncbi request reprint Perception of sweet taste is important for voluntary alcohol consumption in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Genes Brain Behav 7:1-13. 2008
    ..Thus, deletion of any one of three different genes involved in detection of sweet taste leads to a substantial reduction of alcohol intake without any changes in pharmacological actions of ethanol...
  15. pmc Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station, Austin, TX 78712, USA
    J Pharmacol Exp Ther 336:145-54. 2011
    ....
  16. ncbi request reprint Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase
    Yuri A Blednov
    Department of Neurobiology, Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712 0159, USA
    Neuropsychopharmacology 32:1570-82. 2007
    ..These data suggest that increased endocannabinoid signaling increased ethanol consumption owing to decreased acute ethanol intoxication...
  17. ncbi request reprint GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanol
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas, Austin, TX 78712 1095, USA
    J Pharmacol Exp Ther 305:854-63. 2003
    ..The unique effects of deletion of these two GABAA receptor subunits on ethanol responses are discussed in terms of the distinct changes in different populations of GABAA receptors...
  18. pmc Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology and Department Pharmacology Toxicology, University of Texas, Austin, USA
    Addict Biol 17:108-20. 2012
    ..Specifically, they suggest a novel role for neuroimmune signaling in regulation of alcohol consumption...
  19. ncbi request reprint Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712 0159, USA
    J Pharmacol Exp Ther 304:30-6. 2003
    ..Overall, these data confirm the crucial role of the GABAA receptor in mechanisms mediating sedative/hypnotic effects...
  20. ncbi request reprint GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, A4800, 2500 Speedway, MBB 1 124, Austin, TX 78712 1095, USA
    Physiol Behav 74:109-17. 2001
    ..Taken together, this data demonstrates that GIRK2 null mutant mice have reduced anxiety with signs of hyperactivity. We suggest that the functional block of dopamine D3 receptors may be a reason for this phenotype...
  21. pmc Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo
    Lindsay M McCracken
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA
    J Pharmacol Exp Ther 344:489-500. 2013
    ....
  22. pmc Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols
    Cecilia M Borghese
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 340:304-16. 2012
    ..The behavioral characterization of these knockin mice is presented in a companion article (J Pharmacol Exp Ther 340:317-329, 2012)...
  23. pmc Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 340:317-29. 2012
    ..Thus, in addition to reducing ethanol action on the GlyRs, these mutations reduced glycinergic inhibition, which may also alter sensitivity to GABAergic drugs...
  24. pmc Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns
    ANGELA R OZBURN
    Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    BMC Neurosci 13:130. 2012
    ..In the present study, we tested the hypothesis that these phenotypes are represented by differential production of the inducible transcription factor, ΔFosB, in reward, aversion, and stress related brain regions...
  25. ncbi request reprint Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice
    Stephen L Boehm
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway, MBB 1 124, Austin, TX 78712, USA
    Neurosci Lett 372:6-11. 2004
    ....
  26. ncbi request reprint gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions
    Stephen L Boehm
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
    Biochem Pharmacol 68:1581-602. 2004
    ..However, three-way validation is hampered by the incomplete behavioral characterization of many of the mutant mice, and additional subunits are likely to be linked to alcohol actions as behavioral testing progresses...
  27. ncbi request reprint Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant
    Geoffrey S Findlay
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 23:8051-9. 2003
    ....
  28. ncbi request reprint Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits
    Stephen L Boehm
    University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin TX, 78712 0159, USA
    J Pharmacol Exp Ther 309:1154-9. 2004
    ..These data suggest that fyn-kinase may alter the function of GABA(A) receptors, perhaps via actions on beta2 and/or beta3 receptor subunits...
  29. pmc Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation
    Elizabeth Osterndorff-Kahanek
    Waggoner Center for Alcohol and Addiction Research, Colleges of Natural Science and Pharmacy, University of Texas at Austin, Austin, Texas, United States of America
    PLoS ONE 8:e59870. 2013
    ..We demonstrate common consequences of chronic alcohol consumption and immune activation in both liver and brain and show distinct genomic consequences of different types of alcohol consumption...
  30. pmc Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice
    Angela Renee Ozburn
    Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, United States
    Pharmacol Biochem Behav 104:33-9. 2013
    ..The development of tolerance supports the validity of using this model of high alcohol consumption in genetic studies of alcoholism...
  31. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  32. pmc Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake
    A R Ozburn
    Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, 1 University Station, Austin, TX 78712 0159, USA
    Behav Genet 40:551-63. 2010
    ..Results obtained offer insights about factors that determine SAP and RAP in these new genetic models of alcohol consumption...
  33. pmc Wheel running, voluntary ethanol consumption, and hedonic substitution
    Angela Renee Ozburn
    Waggoner Center for Alcohol and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Alcohol 42:417-24. 2008
    ..Collectively, the results support theories of hedonic substitution and suggest that female C57BL/6J mice express ethanol seeking and craving under these specific conditions...
  34. pmc Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors
    Igor Ponomarev
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    J Neurosci 26:5673-83. 2006
    ....
  35. pmc A pervasive mechanism for analgesia: activation of GIRK2 channels
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas, Austin 78712, USA
    Proc Natl Acad Sci U S A 100:277-82. 2003
    ..Furthermore, this pathway accounts for essentially all of the antinociceptive effects in males, although females appear to recruit additional signal transduction mechanisms for some analgesic drugs...
  36. ncbi request reprint Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol
    Stephen L Boehm
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Texas 78712 0159, USA
    Alcohol Clin Exp Res 27:1033-40. 2003
    ..However, in vivo acute tolerance to ethanol was not examined directly...
  37. ncbi request reprint An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice
    C M Borghese
    Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, University of Texas at Austin, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 319:208-18. 2006
    ..This knockin mouse line should be useful in determining which behavioral actions of volatile anesthetics and ethanol are mediated by the GABA(A)Rs containing the alpha(1) subunit...
  38. ncbi request reprint Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice
    G S Findlay
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas at Austin, 78712, USA
    J Pharmacol Exp Ther 300:526-34. 2002
    ..These results support the idea that glycine receptors contribute to some behavioral actions of ethanol and that ethanol sensitivity can be changed in vivo by transgenic expression of a single receptor subunit...
  39. doi request reprint Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains
    M K Mulligan
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA
    Genes Brain Behav 7:677-89. 2008
    ..H2afz, Psen1, Wdfy1 and Clu were also identified as candidate genes that may be involved in influencing alcohol consumption...
  40. doi request reprint GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of America
    PLoS ONE 9:e85525. 2014
    ..These data indicate that ethanol action on GABAA receptors containing ρ1/ρ2 subunits may be important for specific effects of ethanol in vivo. ..
  41. doi request reprint Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence
    Yury O Nunez
    The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA
    BMC Genomics 14:725. 2013
    ....
  42. ncbi request reprint Male transgenic glycine receptor alpha1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responses
    G S Findlay
    Waggoner Center for Alcohol and Addiction Research A4800, Section of Neurobiology, University of Texas at Austin, Austin, TX 78712, USA
    Pharmacol Biochem Behav 82:215-22. 2005
    ....
  43. ncbi request reprint delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol
    Stephen L Boehm
    Department of Psychology, State University of New York at Binghamton, 13902, USA
    Eur J Pharmacol 541:158-62. 2006
    ....
  44. ncbi request reprint Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice
    Katherine G Hill
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 169:108-14. 2003
    ..Under some conditions, GIRK2 knockout mice consume more ethanol than wild types, but it is unclear whether they do so because they are more sensitive to ethanol's rewarding effects or less sensitive to its aversive effects...
  45. ncbi request reprint Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol
    David F Werner
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 319:219-27. 2006
    ..Overall, these studies demonstrate that the postsynaptic effects of ethanol at GABAergic synapses containing the alpha1 subunit are important for specific ethanol-induced behavioral effects...

Research Grants2

  1. Biochemical and Genetic Determinants of Differences in Alcohol Consumption
    YURI BLEDNOV; Fiscal Year: 2007
    ..Alcantara - Austin, Texas; S. Bergeson - Austin, Texas; R. D. Mayfield - Austin, Texas; R. Davis - Houston, Texas; A. Ryabinin - Portland, Oregon; B. Tabakoff - Aurora, Colorado). ..