Yuri A Blednov


Affiliation: University of Texas
Country: USA


  1. request reprint
    Blednov Y, Stoffel M, Cooper R, Wallace D, Mane N, Harris R. Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels. Psychopharmacology (Berl). 2002;159:370-8 pubmed
    ..Activation of the dopamine D(1)receptor in a stressful environment may be stronger in GIRK2 deficient mice, and this modified function of D(1) receptors may cause the transient hyperactive behavioral phenotype of these mice. ..
  2. Blednov Y, Bergeson S, Walker D, Ferreira V, Kuziel W, Harris R. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res. 2005;165:110-25 pubmed
    ..9 and 72.0 cM, respectively) null mutant mice. These data show that disruption of the chemokine network interferes with motivational effects of alcohol. ..
  3. Blednov Y, Walker D, Martinez M, Harris R. Reduced alcohol consumption in mice lacking preprodynorphin. Alcohol. 2006;40:73-86 pubmed
    ..These results indicate that deletion of preprodynorphin leads to substantial reduction of alcohol intake in female mice, and suggest that this is caused by decreased orosensory reward of alcohol (sweet taste and/or palatability). ..
  4. Blednov Y, Harris R. Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. Int J Neuropsychopharmacol. 2008;11:775-93 pubmed publisher
    ..These data show the importance of mGluR5 for several actions of alcohol and support the hypothesis that some effects of acamprosate require mGluR5 signalling. ..
  5. Blednov Y, Borghese C, McCracken M, Benavidez J, Geil C, Osterndorff Kahanek E, et al. Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive ?2-containing GABA(A) receptors. J Pharmacol Exp Ther. 2011;336:145-54 pubmed publisher
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    Blednov Y, Stoffel M, Chang S, Harris R. Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J Pharmacol Exp Ther. 2001;298:521-30 pubmed
    ..These results provide evidence that GIRK2 channels mediate specific behaviors, including anxiety and convulsions, and may influence effects of ethanol on these behaviors. ..
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    Blednov Y, Stoffel M, Chang S, Harris R. GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety. Physiol Behav. 2001;74:109-17 pubmed
    ..Taken together, this data demonstrates that GIRK2 null mutant mice have reduced anxiety with signs of hyperactivity. We suggest that the functional block of dopamine D3 receptors may be a reason for this phenotype. ..
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    Blednov Y, Walker D, Osterndorf Kahanek E, Harris R. Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanol. Alcohol. 2004;34:251-9 pubmed
    ..Consistent with findings of other studies, these results confirm the lack of correlation between ethanol-induced motor stimulation and consumption of ethanol measured in a self-administration paradigm in mice. ..
  9. Blednov Y, Ponomarev I, Geil C, Bergeson S, Koob G, Harris R. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol. 2012;17:108-20 pubmed publisher
    ..Specifically, they suggest a novel role for neuroimmune signaling in regulation of alcohol consumption. ..

More Information


  1. request reprint
    Blednov Y, Jung S, Alva H, Wallace D, Rosahl T, Whiting P, et al. Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J Pharmacol Exp Ther. 2003;304:30-6 pubmed
    ..Overall, these data confirm the crucial role of the GABAA receptor in mechanisms mediating sedative/hypnotic effects. ..
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    Blednov Y, Cravatt B, Boehm S, Walker D, Harris R. Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology. 2007;32:1570-82 pubmed
    ..These data suggest that increased endocannabinoid signaling increased ethanol consumption owing to decreased acute ethanol intoxication. ..
  3. Blednov Y, Walker D, Martinez M, Levine M, Damak S, Margolskee R. Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes Brain Behav. 2008;7:1-13 pubmed
    ..Thus, deletion of any one of three different genes involved in detection of sweet taste leads to a substantial reduction of alcohol intake without any changes in pharmacological actions of ethanol. ..
  4. Blednov Y, Harris R. Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. Neuropharmacology. 2009;56:814-20 pubmed
    ..The studies provide the first evidence that TRPV1 is important for specific behavioral actions of ethanol. ..
  5. Blednov Y, Walker D, Iyer S, Homanics G, Harris A. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol. 2010;15:45-61 pubmed publisher
    ..These results are consistent with earlier proposals that deletion of Gad2 (on 129N2 background) reduces synaptic GABA but also suggest changes in extrasynaptic receptor function. ..