Mordecai P Blaustein

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint Ouabain-digoxin antagonism in rat arteries and neurones
    Hong Song
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA or
    J Physiol 592:941-69. 2014
  2. pmc Livin' with NCX and lovin' it: a 45 year romance
    Mordecai P Blaustein
    Department of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, MD 210201, USA
    Adv Exp Med Biol 961:3-15. 2013
  3. pmc How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension
    Mordecai P Blaustein
    Dept of Physiology, Univ of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD, 21201, USA
    Am J Physiol Heart Circ Physiol 302:H1031-49. 2012
  4. pmc Getting a grip on calcium regulation
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 104:18349-50. 2007
  5. pmc Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, USA
    Biochim Biophys Acta 1802:1219-29. 2010
  6. ncbi request reprint How does salt retention raise blood pressure?
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, Maryland 21201, USA
    Am J Physiol Regul Integr Comp Physiol 290:R514-23. 2006
  7. pmc Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H1472-83. 2010
  8. pmc Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 297:H1140-50. 2009
  9. pmc Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats
    Cristina I Linde
    Dept of Physiology, Univ of Maryland School of Medicine, 685 W Baltimore St HSF1, Rm 565, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 302:H611-20. 2012
  10. pmc Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats
    Maria V Pulina
    Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H263-74. 2010

Collaborators

Detail Information

Publications35

  1. doi request reprint Ouabain-digoxin antagonism in rat arteries and neurones
    Hong Song
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA or
    J Physiol 592:941-69. 2014
    ..The interactions between these common CTSs may be of considerable therapeutic relevance. ..
  2. pmc Livin' with NCX and lovin' it: a 45 year romance
    Mordecai P Blaustein
    Department of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, MD 210201, USA
    Adv Exp Med Biol 961:3-15. 2013
    ..Indeed, that is what is so fascinating and romantic about scientific research. I will describe the discovery of NCX, but will begin by explaining how I got there, and will then discuss how the discovery influenced my career path...
  3. pmc How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension
    Mordecai P Blaustein
    Dept of Physiology, Univ of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD, 21201, USA
    Am J Physiol Heart Circ Physiol 302:H1031-49. 2012
    ..These several central and peripheral mechanisms are coordinated, in part by EO, to effect and maintain the salt-induced elevation of BP...
  4. pmc Getting a grip on calcium regulation
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 104:18349-50. 2007
  5. pmc Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, USA
    Biochim Biophys Acta 1802:1219-29. 2010
    ..In sum, the reports reviewed here provide novel insight into the molecular mechanisms by which salt retention leads to hypertension...
  6. ncbi request reprint How does salt retention raise blood pressure?
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, Maryland 21201, USA
    Am J Physiol Regul Integr Comp Physiol 290:R514-23. 2006
    ..Thus, endogenous ouabain, and vascular alpha2 Na+ pumps and NCX1, are critical links between salt and hypertension. New pharmacological agents that act on these molecular links have potential in the clinical management of hypertension...
  7. pmc Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H1472-83. 2010
    ..In NCX1(SM-/-) mouse artery myocytes, the reduced Ca(2+) entry via NCX1 may lower cytosolic Ca(2+) concentration and thereby reduce MT and BP. The reduced LVGC activity may be the consequence of a low cytosolic Ca(2+) concentration...
  8. pmc Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 297:H1140-50. 2009
    ..66 nM should raise resistance by approximately 35%. We conclude that dynamic constriction in response to circulating nanomolar ouabain in small arteries likely makes a major contribution to the increased vascular tone and BP in OH rats...
  9. pmc Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats
    Cristina I Linde
    Dept of Physiology, Univ of Maryland School of Medicine, 685 W Baltimore St HSF1, Rm 565, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 302:H611-20. 2012
    ..These molecular and functional changes provide a mechanism for the increased peripheral vascular resistance (whole body autoregulation) that underlies the sustained hypertension...
  10. pmc Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats
    Maria V Pulina
    Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H263-74. 2010
    ..This may explain the augmented myogenic responses and enhanced phenylephrine-induced vasoconstriction in OH arteries (83) as well as the high blood pressure in OH rats...
  11. pmc Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?
    Cristina I Linde
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 303:H784-94. 2012
    ..These ouabain/endogenous ouabain-modulated mechanisms underlie the whole body autoregulation associated with increased vascular resistance and elevation of BP in human, salt-sensitive hypertension...
  12. pmc Cross talk between plasma membrane Na(+)/Ca (2+) exchanger-1 and TRPC/Orai-containing channels: key players in arterial hypertension
    Maria V Pulina
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Adv Exp Med Biol 961:365-74. 2013
    ..Enhanced expression and function of ASM NCX1 and TRPC/Orai1-containing channels in hypertension implies that these proteins are potential targets for pharmacological intervention...
  13. pmc Local subplasma membrane Ca2+ signals detected by a tethered Ca2+ sensor
    Moo Yeol Lee
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Proc Natl Acad Sci U S A 103:13232-7. 2006
    ..Similar methods may be useful for studying localized Ca(2+) signals in other subPM microdomains and signals associated with other organelles...
  14. ncbi request reprint Role of Cav1.2 L-type Ca2+ channels in vascular tone: effects of nifedipine and Mg2+
    Jin Zhang
    Dept of Physiology, Univ of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 292:H415-25. 2007
    ..The results indicate that Mg(2+) relaxes MT by inhibiting Ca(2+) influx through LVGCs. These data provide new information about the central role of Ca(v)1.2 LVGCs in generating and maintaining MT in mouse mesenteric small arteries...
  15. pmc Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice
    Chongyu Ren
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H1484-91. 2010
    ..We conclude that in NCX1(SM-/-) myocytes, reduced Ca(2+) entry via NCX1 lowers cytosolic [Ca(2+)], thereby reducing PKC activation that lowers LVGC activation...
  16. ncbi request reprint An N-terminal sequence targets and tethers Na+ pump alpha2 subunits to specialized plasma membrane microdomains
    Hong Song
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 281:12929-40. 2006
    ..Amino acid substitutions in the 1-120 alpha1 and alpha2 constructs, and in full-length alpha1, revealed that Leu-27 and Ala-35 are essential for targeting/tethering the constructs to PM-S/ER junctions...
  17. pmc Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Physiol 569:243-56. 2005
    ..Accordingly, in salt-dependent hypertension, EOLC probably increases vascular resistance and blood pressure by reducing alpha2 Na(+) pump activity and promoting Ca(2)(+) entry via NCX in myocytes...
  18. ncbi request reprint On the mechanism of myogenic tone in small arteries
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Muscle Res Cell Motil 25:615. 2004
  19. pmc Nanomolar ouabain augments Ca2+ signalling in rat hippocampal neurones and glia
    Hong Song
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Physiol 591:1671-89. 2013
    ..The significance of these effects is heightened by the evidence that ouabain is endogenous in mammals...
  20. pmc Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat
    Chunhua Cao
    Department of Medicine, UMMS, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 296:F98-F106. 2009
    ..Chronic exposure to ouabain, in vivo, leads to hypertension and DVR endothelial dysfunction, manifested as reduced [Ca(2+)](CYT) responses to both ouabain- and endothelium-dependent vasodilators...
  21. pmc In vivo assessment of artery smooth muscle [Ca2+]i and MLCK activation in FRET-based biosensor mice
    Jin Zhang
    Dept of Physiology, Univ of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 299:H946-56. 2010
    ..Based on the observed variance of the FRET data, this method should enable the detection of a difference in basal [Ca(2+)](i) of 29 nM between two groups of 12 mice with a significance of P < 0.05...
  22. pmc Salt sensitivity, endogenous ouabain and hypertension
    John M Hamlyn
    Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 22:51-8. 2013
    ..Here we discuss recent observations on mechanisms of salt sensitivity that involve endogenous ouabain and novel pathways in the brain and discuss their possible relationship to arterial and renal function in hypertension...
  23. ncbi request reprint Mg2+ blocks myogenic tone but not K+-induced constriction: role for SOCs in small arteries
    Jin Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Physiol Heart Circ Physiol 283:H2692-705. 2002
    ..The data suggest that Ca(2+) entry through SOCs helps maintain both myogenic tone and alpha(1)-adrenoceptor-induced tonic vasoconstriction...
  24. ncbi request reprint Na+ pump alpha 2-subunit expression modulates Ca2+ signaling
    Vera A Golovina
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 284:C475-86. 2003
    ..This, in turn, augments adjacent ER Ca(2+) stores and thereby amplifies Ca(2+) signaling without elevating bulk [Na(+)](cyt)...
  25. ncbi request reprint Molecular mechanisms linking sodium to hypertension: report of a symposium
    Bruce P Hamilton
    Department of Medicine, Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Investig Med 54:86-94. 2006
    ..These include agents that compete with EO for binding to the Na+ pump and inhibitors of NCX1...
  26. ncbi request reprint Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes
    Lubomira Lencesova
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:2885-93. 2004
    ..These PM and ER components appear to be linked through the cytoskeletal spectrin network, to which they are probably tethered by Ank 2...
  27. ncbi request reprint Sex, digitalis, and the sodium pump
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Interv 3:68-72, 50. 2003
    ..Blaustein and colleagues delve into the report and discuss possible explanations for these findings, suggest alternative ones, and advocate for enrolling greater numbers of women in clinical studies...
  28. ncbi request reprint Organization of Ca2+ stores in vascular smooth muscle: functional implications
    Mordecai P Blaustein
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Novartis Found Symp 246:125-37; discussion 137-41, 221-7. 2002
    ..As a result of this organization, low-dose ouabain can selectively modulate Na+ and Ca2+ concentrations in the PLasmERosomes and jSR Ca2+ stores, and can thereby regulate Ca2+ signalling...
  29. ncbi request reprint TTX-sensitive voltage-gated Na+ channels are expressed in mesenteric artery smooth muscle cells
    Roberto Berra-Romani
    Dept of Physiology, Univ of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 289:H137-45. 2005
    ..The presence of these channels in freshly isolated SMC depends critically on the enzymatic dissociation conditions. This could resolve controversy about the presence of Na+ channels in arterial smooth muscle...
  30. ncbi request reprint Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies
    Vera A Golovina
    Department of Physiology, University of Maryland School of Medicine, 685 West Baltimore St, HSF1, Room 571, Baltimore, Maryland 21201, USA
    Nat Protoc 1:2681-7. 2006
    ..Fluorescent dyes can also be introduced to visualize a variety of activities, some of which may be specific to vascular smooth muscle cells. This protocol requires about 3 h on each of 2 consecutive days to complete...
  31. ncbi request reprint Local sodium, global reach: filling the gap between salt and hypertension
    Mordecai P Blaustein
    Circ Res 101:959-61. 2007
  32. ncbi request reprint Sodium pumps: ouabain, ion transport, and signaling in hypertension
    Mordecai P Blaustein
    Am J Physiol Renal Physiol 293:F438; author reply F439. 2007
  33. ncbi request reprint Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle
    Takahiro Iwamoto
    Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Nat Med 10:1193-9. 2004
    ..3 mutants. These findings indicate that salt-sensitive hypertension is triggered by Ca(2+) entry through NCX1 in arterial smooth muscle and suggest that NCX1 inhibitors might be useful therapeutically...
  34. ncbi request reprint Na+/Ca2+ exchange inhibitors: a new class of calcium regulators
    Takahiro Iwamoto
    Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Cardiovasc Hematol Disord Drug Targets 7:188-98. 2007
    ..This article presents the characteristics of selective and non-selective NCX inhibitors and their therapeutic potential as a new calcium regulator...
  35. ncbi request reprint Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle
    Guangju Ji
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Biol Chem 279:21461-8. 2004
    ..Ca2+ signaling mice should provide significant advantages in the study of processive biological signaling...