Affiliation: University of North Carolina
- Drug repurposing in pediatrics and pediatric hematology oncologyJulie Blatt
Department of Pediatrics and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
Drug Discov Today 18:4-10. 2013..The observant clinician, pharmacologist and translational bioinformatician, as well as structural targeting, will have a role in discovering new repurposing opportunities...
- β-blockers for infantile hemangiomas: a single-institution experienceJulie Blatt
University of North Carolina School of Medicine and the University of North Carolina School of Medicine Vascular Anomalies Clinic, Chapel Hill, NC, USA
Clin Pediatr (Phila) 50:757-63. 2011..They suggest daily home monitoring of patients for the first 2 weeks of initiating or increasing doses. Frequent feeding of infants and young children on this drug is recommended...
- Treatment of childhood kaposiform hemangioendothelioma with sirolimusJulie Blatt
Division of Pediatric Hematology Oncology, Vascular Lesions Clinic, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Pediatr Blood Cancer 55:1396-8. 2010..1 mg/kg/day). This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions...
- Isolated central nervous system relapse in an adolescent with acute myelomonocytic leukemia, Charcot Marie Tooth syndrome, and paraneoplastic autoantibodyJulie Blatt
Division of Pediatric Hematology Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Pediatr Hematol Oncol 32:571-3. 2010..Titres to VGKC, a paraneoplastic autoantibody, were elevated, suggesting an additional mechanism for the polyneuropathy. This case extends the clinical spectrum of cancer with CMT, and of paraneoplastic disorders...
- Autism in children and adolescents with cancerJulie Blatt
Division of Pediatric Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7236, USA
Pediatr Blood Cancer 54:144-7. 2010..We explore possible associations between AD and childhood cancer...
- Wilms tumor associated with hirschsprung diseaseJulie Blatt
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Pediatr Hematol Oncol 29:858-9. 2007..Although this limited evaluation failed to show abnormalities, we speculate that comprehensive analysis of the RET gene may identify mutations to account for the development of WT in this and other children with WT...
- Pregnancy outcome in long-term survivors of childhood cancerJ Blatt
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill 27599 7220, USA
Med Pediatr Oncol 33:29-33. 1999..By the year 2010, 1/250 young adults will be long-term survivors of childhood cancer. One of the major concerns is whether they will be able to have healthy children...
- Childhood non-Hodgkin lymphoma presenting as hemophagocytic syndromeJulie Blatt
Division of Pediatric Hematolotv Oncology, University of North Carolina, Chapel Hill 27599, USA
Pediatr Hematol Oncol 19:45-9. 2002..In children with systenic hemophagocytosis, a diagnosis of NHL should be aggressively pursued...
- Ovarian carcinoma in an adolescent with transgenerational exposure to diethylstilbestrolJulie Blatt
Department of Pediatrics, The University of North Carolina School of Medicine at Chapel Hill, North Carolina 27599 7220, USA
J Pediatr Hematol Oncol 25:635-6. 2003..This case, while anecdotal, suggests that a transgenerational history of DES exposure should be noted, and that granddaughters with persistent abdominal pain even during childhood may need evaluation for genital tract abnormalities...
- Posterior fossa neoplasm and PHACES syndrome: a case reportKatharine E Wallen
Division of Pediatric Hematology Oncology, The University of North Carolina, Chapel Hill, NC 27599 7236, USA
J Pediatr Hematol Oncol 31:203-5. 2009..Cerebellar pilocytic astrocytoma may be a rare manifestation of the posterior fossa malformations of PHACES...
- Monitoring pulmonary complications in long-term childhood cancer survivors: guidelines for the primary care physicianAllen Liles
Department of Medicine Pediatrics, The University of North Carolina, Women s Hospital UNC, Chapel Hill, NC 27599, USA
Cleve Clin J Med 75:531-9. 2008..The Children's Oncology Group (COG) has issued guidelines on this topic (www.survivorshipguidelines.org). This review summarizies the findings of the COG Guideline Task Force on Pulmonary Complications with respect to pulmonary toxicity...
- IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growthDon W Coulter
Division of Hematology Oncology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7220, USA
Anticancer Res 28:1509-16. 2008..Inhibition of IGF1R signaling can be accomplished by other agents, including rapamycin or temsirolimus, which target mTOR (mammalian target of rapamycin)...
- Visceral larval migrans masquerading as metastatic disease in a toddler with Wilms tumorAndrew Anderson
Department of Radiology, University of North Carolina School of Medicine, 3325 Old Infirmary Bldg, Campus Box 7510, Chapel Hill, NC 27599 7510, USA
Pediatr Radiol 36:265-7. 2006..This case illustrates that toxocariasis should be considered as a rare differential diagnostic possibility for multiple liver lesions and multifocal peripheral pulmonary opacities in young children with Wilms tumor...
- Multifocal bone marrow involvement in cat-scratch diseaseSean J Hipp
Departments of Pediatrics, University of North Carolina, Chapel Hill, NC 27599 7593, USA
Pediatr Infect Dis J 24:472-4. 2005..In both cases, magnetic resonance imaging revealed multiple enhancing bone marrow lesions consistent with clinical symptoms. Microbiologic diagnoses were established serologically...
- Thymic carcinoma in a child with HIV infectionMorgan McDonald
Division of Pediatric Hematology Oncology, The University of North Carolina, Chapel Hill, North Carolina 27599 7220, USA
Pediatr Blood Cancer 49:1004-7. 2007..This case extends the spectrum of pediatric malignancy in the setting of HIV and suggests that patients with presumed benign thymic cysts require ongoing surveillance...
- Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor studyKimberly F Whelan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatr Blood Cancer 54:103-9. 2010..Approximately 80% of children currently survive 5 years following diagnosis of their cancer. Studies based on limited data have implicated certain cancer therapies in the development of ocular sequelae in these survivors...
- Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor StudyDaniel A Mulrooney
Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
Cancer 112:2071-9. 2008..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)...
- Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonusJessica Bell
Department of Pediatrics, Division of Pediatric Hematology Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Pediatr Blood Cancer 50:370-1. 2008..2;q15). The patient's OM was recalcitrant to conventional therapies, but showed significant improvement following treatment with rituximab...
- Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: outcome compared with conventional chemotherapy: a report from the Children's Oncology GroupJonathan L Finlay
The Children s Center for Cancer and Blood Diseases, Department of Pediatrics, Children s Hospital, Los Angeles, California 90027, USA
Pediatr Blood Cancer 51:806-11. 2008..Children and adolescents with malignant astrocytomas recurring after initial treatment have a dismal prognosis, with only rare patients surviving 1-year beyond recurrence. The purpose of this study was to attempt to improve their survival...
- Maternal medication use and neuroblastoma in offspringMichael N Cook
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Epidemiol 159:721-31. 2004..4, 95% confidence interval: 1.4, 8.4). This preliminary finding may be due to bias, confounding, or chance, and additional studies are needed for confirmation...
- Residential pesticide exposure and neuroblastomaJ L Daniels
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
Epidemiology 12:20-7. 2001..There was no evidence of differential pesticide effects in subgroups of neuroblastoma defined by MYCN oncogene amplification or tumor stage...
- Positive association between congenital anomalies and risk of neuroblastomaFlorence Menegaux
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Pediatr Blood Cancer 45:649-55. 2005..27, CI = 1.22-15.0) had an elevated, but imprecise neuroblastoma risk. CONCLUSIONS: Our findings support the hypothesis of an association between neuroblastoma and congenital, especially urogenital and cardiac, anomalies...
- Hearing genes and cisplatin deafness: a pilot studyChristine Knoll
Division of Pediatric Hematology-Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7220, USA
Laryngoscope 116:72-4. 2006..35). CONCLUSIONS: It is not likely that any of the five hearing genes we examined contribute to cisplatin ototoxicity. Further study may be warranted to look at other hearing genes as possible predictors of cisplatin ototoxicity...
- Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing DisciplineWendy Landier
Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
J Clin Oncol 22:4979-90. 2004..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org...