Kirby I Bland

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Commentary on Itani's presidential address
    Kirby I Bland
    Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South 502 BDB, Birmingham, AL 35294, USA
    Am J Surg 196:323-5. 2008
  2. ncbi request reprint Hiram Polk and the American Journal of Surgery
    Kirby I Bland
    Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, 502 BDB, Birmingham, AL 35294, USA
    Am J Surg 190:338-43. 2005
  3. ncbi request reprint Contemporary trends in student selection of medical specialties: the potential impact on general surgery
    Kirby I Bland
    Department of Surgery, The University of Alabama at Birmingham, USA
    Arch Surg 137:259-67. 2002
  4. ncbi request reprint Concerning trends and outcomes for National Institutes of Health funding of cancer research
    Kirby I Bland
    Department of Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Surg Oncol 95:161-6. 2007
  5. ncbi request reprint p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage
    Wen Hong Kan
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 294:H2627-36. 2008
  6. pmc Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury
    Wen Hong Kan
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 105:1076-82. 2008
  7. pmc Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses
    Shaolong Yang
    The University of Alabama at Birmingham, 1670 University Blvd, G094 Volker Hall, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 85:1015-26. 2009
  8. doi request reprint Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process
    Takashi Kawasaki
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 294:C754-64. 2008
  9. ncbi request reprint Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Leukoc Biol 82:1019-26. 2007
  10. ncbi request reprint Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway
    Huang Ping Yu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 82:774-80. 2007

Detail Information

Publications112 found, 100 shown here

  1. doi request reprint Commentary on Itani's presidential address
    Kirby I Bland
    Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South 502 BDB, Birmingham, AL 35294, USA
    Am J Surg 196:323-5. 2008
  2. ncbi request reprint Hiram Polk and the American Journal of Surgery
    Kirby I Bland
    Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, 502 BDB, Birmingham, AL 35294, USA
    Am J Surg 190:338-43. 2005
  3. ncbi request reprint Contemporary trends in student selection of medical specialties: the potential impact on general surgery
    Kirby I Bland
    Department of Surgery, The University of Alabama at Birmingham, USA
    Arch Surg 137:259-67. 2002
    ..The trend toward controllable lifestyle vs noncontrollable lifestyle specialties is affecting the number of students desiring a career in general surgery...
  4. ncbi request reprint Concerning trends and outcomes for National Institutes of Health funding of cancer research
    Kirby I Bland
    Department of Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Surg Oncol 95:161-6. 2007
    ....
  5. ncbi request reprint p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage
    Wen Hong Kan
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 294:H2627-36. 2008
    ..The salutary effects of E2 on cardiac functions and tissue protection following trauma-hemorrhage are mediated, in part, through activation of p38 MAPK and subsequent eNOS expression and phosphorylation...
  6. pmc Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury
    Wen Hong Kan
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 105:1076-82. 2008
    ..These results indicate that increased expression of iNOS following trauma-hemorrhage plays an important role in the induction of hepatic damage under such conditions...
  7. pmc Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses
    Shaolong Yang
    The University of Alabama at Birmingham, 1670 University Blvd, G094 Volker Hall, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 85:1015-26. 2009
    ..Thus, enhanced HO-1 in PE and E2 OVX females modulates inflammatory responses and protects liver following T-H...
  8. doi request reprint Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process
    Takashi Kawasaki
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 294:C754-64. 2008
    ..Hyporesponsiveness of splenic DCs was also found after stimulation with the TLR2 agonist zymosan. Our results may thus explain the profound immunosuppression that is known to occur under those conditions...
  9. ncbi request reprint Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Leukoc Biol 82:1019-26. 2007
    ..These results suggest that the salutary effects of E2 on hepatic injury following trauma-hemorrhage are in part mediated via an ER-related, Akt-dependent up-regulation of HO-1...
  10. ncbi request reprint Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway
    Huang Ping Yu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 82:774-80. 2007
    ..Thus, the PI-3K/Akt pathway plays a critical role in mediating the nongenomic, salutary effects of E2 on attenuation of shock-induced intestinal tissue damage...
  11. ncbi request reprint Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Dept of Surgery, Univ of Alabama, at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 293:C978-84. 2007
    ....
  12. pmc Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis
    Wen Hong Kan
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 105:595-602. 2008
    ..Thus administration of flutamide following trauma-hemorrhage protects against liver injury via reduced inflammation, cellular oxidative stress, and apoptosis...
  13. pmc 17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha
    Takashi Kawasaki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 45:376-85. 2008
    ..Since PPT administration following trauma-hemorrhage was more effective in normalizing splenic DC functions than DPN, the salutary effects of 17beta-estradiol on splenic DC functions are mediated predominantly via ER-alpha...
  14. ncbi request reprint Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cell Physiol 214:662-72. 2008
    ....
  15. ncbi request reprint Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cell Physiol 211:364-70. 2007
    ..Taken together, these findings suggest that downregulation of TLR4-dependent ATP production is critical to 17beta-estradiol-mediated immunoprotection in Kupffer cells following trauma-hemorrhage...
  16. pmc Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhage
    Takashi Kawasaki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cytokine 51:166-72. 2010
    ..E2, PPT or DPN administration normalized these parameters. Since PPT or DPN administration following T-H was effective in normalizing PP T cell functions, the salutary effects of E2 are mediated via ER-alpha and ER-beta...
  17. pmc Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage
    Takashi Kawasaki
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 296:C124-30. 2009
    ..The depression in IL-15 production by splenic DCs could contribute to the host's enhanced susceptibility to infections following T-H...
  18. doi request reprint Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Surgery 145:226-34. 2009
    ..The aim of this study is to elucidate whether ERK plays any role in 17beta-estradiol (E2)-mediated attenuation of lung injury and pro-inflammatory mediators after trauma-hemorrhage...
  19. pmc Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation
    Chi Hsun Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham, 35294, USA
    J Immunol 182:4406-14. 2009
    ..Thus, activation of Akt plays a crucial role in mediating the salutary effect of estrogen in restoring trauma-hemorrhage-induced suppression of Kupffer cell phagocytosis...
  20. pmc Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation
    Chi Hsun Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Ann Surg 250:995-1001. 2009
    ..We hypothesized that the differences might result from a differential activation of hypoxia-inducible factor (HIF)-1alpha and phosphoinositide 3-kinase (PI3K)/Akt pathway under those conditions...
  21. pmc Suppression of activation and costimulatory signaling in splenic CD4+ T cells after trauma-hemorrhage reduces T-cell function: a mechanism of post-traumatic immune suppression
    Chi Hsun Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Am J Pathol 175:1504-14. 2009
    ..Dysregulation of the T-cell costimulatory pathway is therefore likely to be a significant contributor to post-traumatic immune suppression...
  22. pmc The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: direct modulation of CINC-1 production by Kupffer cells
    Tomoharu Shimizu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
    Cytokine 43:88-92. 2008
    ..In summary, the salutary effects of E2 against hepatic injury are mediated predominantly via ER-alpha which directly modulates KC CINC-1 production and hepatic neutrophil accumulation following T-H...
  23. pmc 17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Immunol 44:2165-72. 2007
    ....
  24. doi request reprint Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, USA
    Crit Care Med 37:2338-44. 2009
    ....
  25. ncbi request reprint Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage
    Shaolong Yang
    Center for Surgical Research and Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Mol Cell Cardiol 42:620-30. 2007
    ....
  26. pmc Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-alpha and ER-beta
    Fariba Moeinpour
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Mol Med 14:689-96. 2008
    ..PPT and DPN administration were equally effective in normalizing the inflammatory response of keratinocytes, indicating that both ER-alpha and ER-beta mediate the salutary effects of estrogen on keratinocytes after trauma-hemorrhage...
  27. ncbi request reprint Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1227-32. 2007
    ..These results suggest that the protective effects of E(2) on lung injury following trauma-hemorrhage are mediated via downregulation of lung MIF and TLR4-induced cytokine/chemokine production...
  28. doi request reprint Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G
    Wen Hong Kan
    Department of Surgery, Center for Surgical Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Ann Surg 248:294-302. 2008
    ....
  29. pmc Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway
    Tomoharu Shimizu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Ann Surg 245:297-304. 2007
    ..To determine the mechanism by which flutamide administration following trauma-hemorrhage (T-H) decreases cytokine production and hepatic injury under those conditions...
  30. ncbi request reprint 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Surgery 140:141-8. 2006
    ..We hypothesized that E2 mediates its salutary effects via ER-alpha and normalization of MAPK under those conditions...
  31. pmc Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    Cytokine 42:32-8. 2008
    ..These findings suggest E2 effects on T cell cytokine production following T-H are mediated at least in part via non-genomic pathway and these non-genomic effects are likely mediated via MAPK pathways...
  32. pmc The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage
    Huang Ping Yu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Ann Surg 245:971-7. 2007
    ..To determine whether the nongenomic actions of E2 have any beneficial effect on cardiac function following trauma-hemorrhage and whether those effects are mediated via the PI3K/Akt pathway...
  33. pmc The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage
    Tomoharu Shimizu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Hepatol 46:1047-54. 2007
    ..The aim of this study was to determine which of the estrogen receptor (ER) subtypes plays a predominant role in ameliorating hepatic damage following trauma-hemorrhage...
  34. ncbi request reprint Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis
    Michael Frink
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Ann Surg 246:836-43. 2007
    ..The aim of this study was to evaluate whether pretreatment with finasteride, a 5alpha-reductase inhibitor, improves immune functions after trauma-hemorrhage...
  35. ncbi request reprint TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage
    Michael Frink
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Mol Immunol 44:2625-30. 2007
    ..These findings suggest that functional TLR4 signaling is critical in mediating the inflammatory response following trauma hemorrhage. Thus, modulation of the TLR4 after injury may serve as a future therapeutic target in trauma patients...
  36. ncbi request reprint Metabolic modulators following trauma sepsis: sex hormones
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Crit Care Med 35:S621-9. 2007
    ..Additionally, sex steroids regulate inflammatory cytokines that cause hypermetabolism/catabolism via acute phase response, leading to increased morbidity and mortality...
  37. ncbi request reprint Estrus cycle: influence on cardiac function following trauma-hemorrhage
    Shaolong Yang
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 291:H2807-15. 2006
    ..These data collectively suggest that the estrus cycle plays an important role in cardiac function following TH. The salutary effect seen in PE following TH is likely due to a decrease in NF-kappaB-dependent cardiac IL-6 pathway...
  38. doi request reprint Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Shock 30:372-8. 2008
    ..These results suggest that p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels plays an important role in E2-mediated restoration of cardiac function after trauma-hemorrhage...
  39. ncbi request reprint Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage
    Takeshi Matsutani
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G 094 Volker Hall, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Am J Surg 193:61-8. 2007
    ..This study examined whether there is any difference in the lung cytokine and cytokeratin 19 levels between young and middle-aged mice after bone fracture and soft-tissue trauma hemorrhage (Fx-TH)...
  40. pmc Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations
    Raghavan Raju
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Mol Med 14:213-21. 2008
    ..The results of the studies exemplify the promise of estrogen as a therapeutic adjunct in treating adverse pathophysiological conditions following trauma-hemorrhage...
  41. ncbi request reprint 17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage
    Michael Frink
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Am J Physiol Lung Cell Mol Physiol 292:L585-91. 2007
    ..These results suggest that E2 prevents lung neutrophil infiltration and organ damage in part by decreasing KC during posttraumatic immune response...
  42. ncbi request reprint Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice
    Takeshi Matsutani
    Center for Surgical Research, University of Alabama, G 094 Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 292:G268-74. 2007
    ..These results collectively suggest that the extent of hepatic damage following Fx-TH is dependent on the age of the subject...
  43. pmc Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor
    Jianguo Chen
    Ctr for Surgical Research, The Univ of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 295:G1131-7. 2008
    ..Thus Ang II plays a role in producing small intestine inflammation following T-H, and the salutary effects of E2 on intestinal inflammation are mediated in part by Ang II and AT1R downregulation...
  44. ncbi request reprint Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Mol Cell Cardiol 41:511-21. 2006
    ..Thus, E2 and ERbeta-mediated cardioprotection following T-H appears to be mediated via mitochondrial ERbeta-dependent MRC-IV activity and inhibition of mitochondrial apoptotic signaling pathways...
  45. ncbi request reprint 17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage
    Zheng F Ba
    Center for Surgical Research and Dept of Surgery, Univ of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 292:H245-50. 2007
    ..Thus, E(2) administration attenuates ET-1-induced vasoconstriction following trauma-hemorrhage via an ER-beta-mediated pathway that is dependent on endothelium-derived NO synthesis...
  46. ncbi request reprint Prognostic factors and preoperative radiation therapy associated with sphincter preservation in patients with resectable rectal cancer
    J Harrison Howard
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35243, USA
    Am J Surg 195:239-43. 2008
    ..This study evaluates the importance of patient and tumor factors, receipt of preoperative radiation therapy, and American Joint Committee on Cancer stage for sphincter preservation (SP) in patients with rectal cancer...
  47. pmc 17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage
    Fariba Moeinpour
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Mol Immunol 44:3317-23. 2007
    ..These findings suggest that 17beta-estradiol normalizes epidermal keratinocytes inflammatory responses following trauma-hemorrhage by preventing the upregulation of TLR4-mediated MAPK activation...
  48. pmc A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage
    Tomoharu Shimizu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Ann Surg 244:131-8. 2006
    ..To examine the mechanism by which androstenediol improves cardiac function following trauma-hemorrhage (T-H)...
  49. ncbi request reprint Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice
    Takashi Kawasaki
    Center for Surgical Research and Department of Surgery, University of Alabama, 1670 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 177:4514-20. 2006
    ..This depression in Ag presentation could contribute to the host's enhanced susceptibility to sepsis following T-H...
  50. ncbi request reprint Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 34:76-84. 2006
    ....
  51. doi request reprint Pharmacologic prophylaxis against venous thromboembolic complications is not mandatory for all laparoscopic Roux-en-Y gastric bypass procedures
    Ronald H Clements
    Department of Surgery, Section of Gastrointestinal Surgery, University of Alabama Birmingham, Birmingham, AL, USA
    J Am Coll Surg 208:917-21; discussion 921-3. 2009
    ..The aim of this study is to report the rate of VTE and bleeding complications using no prophylactic pharmacologic anticoagulation among patients undergoing laparoscopic Roux-en-Y gastric bypass...
  52. ncbi request reprint Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis
    Ailing Lu
    Center for Surgical Research, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Endocrinol Metab 292:E585-93. 2007
    ..These findings suggest that 17beta-estradiol attenuated H(2)O(2)-induced apoptosis via ER-dependent activation of caspase-9 and -3 in rat endothelial cells through mitochondria...
  53. doi request reprint Mechanism of the anti-inflammatory effect Of 17beta-estradiol on brain following trauma-hemorrhage
    Hiroya Akabori
    Department of Surgery, Center for Surgical Research, University of Alabama at Birmingham, Alabama, USA
    Shock 33:43-8. 2010
    ..Thus, T-H induces inflammatory responses even in the hypothalamus, and E2 seems to be a useful adjunct for down-regulating microglial cell-mediated inflammatory response after T-H...
  54. pmc Trauma and immune response--effect of gender differences
    Mashkoor A Choudhry
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Injury 38:1382-91. 2007
    ..Since these cells are also the cells that produce cytokines, local synthesis of active steroids in these cells may become the significant factor in modulating their cytokine production...
  55. doi request reprint L-Methionine inhibits growth of human pancreatic cancer cells
    Maximo A Benavides
    Departments of aSurgery bPharmacology, University of Sao Paulo Ribeirao Preto, Sao Paulo, Brazil cDepartment of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois Departments of dSurgery ePathology, College of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Anticancer Drugs 25:200-3. 2014
    ..Some of the differences in the effects of methionine between cell lines may be related to disparate p53 status. These findings warrant further studies on the potential therapeutic benefit of L-methionine against pancreatic cancer. ..
  56. doi request reprint Recurrent retroperitoneal sarcoma: impact of biology and therapy on outcomes
    Stephen R Grobmyer
    Department of Surgery, Division of Surgical Oncology, University of Florida, Gainesville, FL 32610, USA
    J Am Coll Surg 210:602-8, 608-10. 2010
    ..Local recurrence remains the major cause of death in patients with retroperitoneal sarcoma (RPS). There is no consensus regarding management of patients with recurrent RPS...
  57. pmc MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia
    Rui Zheng
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Mol Med 12:65-73. 2006
    ..Administration of Src inhibitor in hypoxic males prevented increased IL-6 production. Thus, differential regulation of MyD88 and Src in males and females plays an important role in sex-specific immune response following hypoxia...
  58. ncbi request reprint Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice
    Takashi Kawasaki
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 291:C1049-55. 2006
    ..The enhanced immunosuppressive effects of lidocaine could contribute to the host's enhanced susceptibility to infection following T-H...
  59. ncbi request reprint Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, Alabama 35294 0019, USA
    FASEB J 20:1109-17. 2006
    ..These findings suggest that the salutary effects of E2 on cardiac function following T-H are mediated via ERbeta up-regulation of PGC-1alpha through Tfam-dependent pathway...
  60. ncbi request reprint Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis
    Thomas Dienstknecht
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 25:110-8. 2004
    ..Thus, events occurring in the tissue-fixed cells are not necessarily reflected in the circulating PBMC population...
  61. ncbi request reprint Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30)
    Venkatram R Atigadda
    Department of Chemistry, University of Alabama at Birmingham, 901 South 14th Street, Birmingham, AL 35294, USA
    J Med Chem 46:3766-9. 2003
    ..Here, we describe a modified synthesis that yields up to 100 g of 1. We further demonstrate that 1 is very effective in the prevention of N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity...
  62. pmc Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling
    Zhaoli Liu
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biol Ther 8:1840-51. 2009
    ..These results suggest that KLF4 could contribute to breast tumor progression by activating synthesis of Notch1 and by promoting signaling through a non-canonical Notch1 pathway...
  63. ncbi request reprint Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer
    Andres Forero-Torres
    Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Clin Breast Cancer 10:275-80. 2010
    ....
  64. ncbi request reprint Mouse genetic background influences severity of immune responses following trauma-hemorrhage
    Takeshi Matsutani
    Center for Surgical Research, University of Alabama at Birmingham, 35294 0019, USA
    Cytokine 30:168-76. 2005
    ..Thus, genetic background appears to significantly influence the severity of immune responses in males following trauma-hemorrhage...
  65. ncbi request reprint Gender and susceptibility to sepsis following trauma
    Mashkoor A Choudhry
    Center for Surgical Research, The University of Alabama at Birmingham, Volker Hall, G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Endocr Metab Immune Disord Drug Targets 6:127-35. 2006
    ..The findings obtained from these studies will help in designing innovative therapeutic approaches for the treatment of trauma patients...
  66. ncbi request reprint Hyperparathyroidism and vitamin D deficiency after laparoscopic gastric bypass
    Ronald H Clements
    Department of Surgery, Section of Gastrointestinal Surgery, University of Alabama Birmingham, Birmingham, Alabama, USA
    Am Surg 74:469-474; discussion 474-5. 2008
    ..There is a weak inverse correlation between Vit D and PTH. Further research is needed to elucidate the causes, treatments, and significance of HPT after LGB...
  67. ncbi request reprint Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury
    Martin G Schwacha
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Cell Physiol 282:C263-70. 2002
    ..Thus elevated Mphi COX-2 activity, independent of IL-10, suppresses Mphi IL-12 production after thermal injury and may play an important role in the observed immunosuppression under such conditions...
  68. ncbi request reprint Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery
    Mashkoor A Choudhry
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Heart Circ Physiol 288:H716-21. 2005
    ..Although a hypoxic insult to the liver would result in a release of proinflammatory mediators, a similar insult to the intestine will likely perturb both intestinal immune cell and barrier functions, as observed in our previous study...
  69. ncbi request reprint Gender differences in acute response to trauma-hemorrhage
    Mashkoor A Choudhry
    Department of Surgery, University of Alabama, Birmingham, AL 35294 0019, USA
    Shock 24:101-6. 2005
    ..The information gained from the experimental studies will help in designing innovative therapeutic approaches for the treatment of trauma patients...
  70. doi request reprint Durable improvements in efficiency, safety, and satisfaction in the operating room
    Martin J Heslin
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Am Coll Surg 206:1083-9; discussion 1089-90. 2008
    ..A staff-retention crisis resulted, which threatened the viability of the OR and the institution. We report the changes implemented to efficiently deliver safe patient care in a supportive environment for surgeons and OR staff...
  71. ncbi request reprint 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers
    Clinton J Grubbs
    Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Lett 201:17-24. 2003
    ..6; and controls, 6.0. Thus, the combination of the agents resulted in an increased effect in preventing mammary cancers; suggesting that cancer cell proliferation was inhibited by the compounds blocking different pathways...
  72. ncbi request reprint When is sentinel node biopsy for breast cancer contraindicated?
    Helen Krontiras
    Department of Surgery, University of Alabama School of Medicine, Boshell Diabetes Building1808, 7th Avenue South, Birmingham, AL 35233, USA
    Surg Oncol 12:207-10. 2003
    ..The current data regarding contraindications for the use of sentinel lymph node biopsy and lymphatic mapping is reviewed...
  73. ncbi request reprint Endocrine targets in experimental shock
    Irshad H Chaudry
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294 0019, USA
    J Trauma 54:S118-25. 2003
    ....
  74. pmc Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer
    Samuel W Beenken
    Department of Surgery, University of Alabama at Birmingham, Suite 620 WTI, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Ann Surg 237:732-8; discussion 738-9. 2003
    ..To assess the significance of axillary lymph node status and tumor size for predicting locoregional recurrence (LRR) and overall survival after mastectomy for breast cancer and to discuss the utility of postmastectomy radiation therapy...
  75. ncbi request reprint Incorporating laparoscopic fellowship does not increase morbidity or mortality in a university-based bariatric practice
    Ronald H Clements
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0016, USA
    J Am Coll Surg 204:824-8; discussion 828-30. 2007
    ..The aim of this article is to determine if the addition of an MIS fellowship program has any impact on morbidity and mortality in a university-based bariatric program...
  76. ncbi request reprint Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis
    Joachim F Kuebler
    Center for Surgical Research, University of Alabama at Birmingham, Volker Hall G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Arch Surg 137:74-9. 2002
    ..Therefore, we hypothesized that 17beta-estradiol administration following trauma-hemorrhage would also improve cardiac output, splanchnic perfusion, and oxygen utilization, even after the induction of subsequent sepsis...
  77. pmc Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis
    Markus W Knoferl
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Ann Surg 235:105-12. 2002
    ..To determine whether reduction of circulating female sex hormones by ovariectomy causes suppression of macrophage (Mphi) function after trauma-hemorrhage and increases susceptibility to subsequent sepsis...
  78. pmc Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer
    Martin J Heslin
    Surgical Oncology Research Laboratory, Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann Surg 241:941-6; discussion 946-7. 2005
    ..Also, to evaluate the expression of 15-LOX-1 in human normal mucosa, adenoma, and carcinoma with correlation to overall survival...
  79. ncbi request reprint Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers
    Clinton J Grubbs
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Carcinogenesis 27:1232-9. 2006
    ..In summary, a short-term in vivo method has been identified for screening newly synthesized retinoids both for chemopreventive efficacy and for their adverse effect on serum triglycerides...
  80. pmc Tamoxifen (TMX)/Fas induced growth inhibition of human cholangiocarcinoma (HCC) by gamma interferon (IFN-gamma)
    Selwyn M Vickers
    Department of Surgery, The University of Alabama at Birmingham and Veterans Administration Medical Center, USA
    Ann Surg 235:872-8. 2002
    ..To evaluate the response of human cholangoicarcinoma cells to TMX treatment through the Fas pathway by pretreatment with IFN-gamma...
  81. ncbi request reprint Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase
    Laszlo Szalay
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 289:H92-8. 2005
    ..Thus the salutary effects of estradiol administration on organ function after trauma-hemorrhage are mediated in part via upregulation of HO-1 expression and activity...
  82. ncbi request reprint Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins
    Huang Ping Yu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    J Mol Cell Cardiol 40:185-94. 2006
    ..Thus, the salutary effects of E2 on cardiac function are mediated via ER-beta and ER-beta-induced up-regulation of Hsp likely plays a significant role in the E2-mediated cardioprotection after T-H...
  83. ncbi request reprint Differential fluid regulation during and after soft tissue trauma and hemorrhagic shock in males and proestrus females
    Joachim F Kuebler
    Center for Surgical Research, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Shock 20:144-8. 2003
    ..The increased circulating blood volume could contribute the improved immune and organ functions in proestrus females under those conditions...
  84. pmc Impact of obesity on resource utilization for general surgical procedures
    Mary T Hawn
    Department of Surgery, University of Alabama at Birmingham, Alabama, USA
    Ann Surg 241:821-6; discussion 826-8. 2005
    ..To determine the impact of the obesity epidemic on workload for general surgeons...
  85. ncbi request reprint Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5alpha-dihydrotestosterone
    Christian P Schneider
    Department of Research, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Appl Physiol 95:104-12. 2003
    ....
  86. ncbi request reprint Gender dimorphism in immune responses following trauma and hemorrhage
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Immunol Res 26:63-76. 2002
    ..Thus, regulation of sex hormone synthesis or their receptor activity appears to be a useful therapeutic approach for patients to cope with the deleterious sequelae of severe trauma and hemorrhage...
  87. ncbi request reprint Immunoprotection in proestrus females following trauma-hemorrhage: the pivotal role of estrogen receptors
    Markus W Knoferl
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, Volker Hall, G094 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Cell Immunol 222:27-34. 2003
    ..These findings indicate that the ability of proestrus females to maintain immune function following trauma-hemorrhage is estrogen-dependent and mediated via estrogen receptors...
  88. ncbi request reprint Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    Ashka Y Pandya
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Clin Cancer Res 10:2709-19. 2004
    ..Although KLF4 expression is increased in most cases of breast cancer, it was unknown whether these cases represent a distinct subtype with a different clinical outcome...
  89. ncbi request reprint Current understanding of gender dimorphism in hepatic pathophysiology
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Surg Res 128:147-56. 2005
    ..In this article, current progress in our understanding the gender difference in the hepatic pathophysiology under the condition of hepatic stress is reviewed and discussed...
  90. ncbi request reprint PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 289:H2665-72. 2005
    ..These results indicate that E2 and flutamide upregulate PGC-1 via the ER. Thus PGC-1 upregulation appears to be the common mechanism by which E2 and flutamide mediate their salutary effects on cardiac function after T-H...
  91. pmc Factors associated with local recurrence after skin-sparing mastectomy and immediate breast reconstruction for invasive breast cancer
    Heriberto Medina-Franco
    Department of Surgery, Section of Surgical Oncology, University of Alabama at Birmingham, USA
    Ann Surg 235:814-9. 2002
    ..To examine the incidence of local recurrence (LR) and factors associated with it in a population of patients who underwent skin-sparing mastectomy (SSM) and immediate reconstruction for invasive carcinoma...
  92. ncbi request reprint Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis
    Laszlo Szalay
    Center for Surgical Research, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 291:G260-6. 2006
    ....
  93. ncbi request reprint Neoadjuvant and adjuvant therapy for rectal cancer
    J Pablo Arnoletti
    Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7th Avenue South, KB321, Birmingham, AL 35294, USA
    Surg Oncol Clin N Am 15:147-57. 2006
    ..The armamentarium of avail-able therapies is evolving rapidly, and hopefully local control rates and overall survival of rectal cancer patients will continue to improve in the near future...
  94. ncbi request reprint Past and contemporary contributions to cancer therapy by fellows of the Southern Surgical Association
    Kirby I Bland
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Am Coll Surg 204:735-52. 2007
  95. ncbi request reprint Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function
    Shaolong Yang
    Center for Surgical Research, The Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 287:H2183-91. 2004
    ..Thus there is an inverse correlation between cardiomyocyte IL-6 levels and cardiac function after T-H. The salutary effects of E2 on cardiac function after T-H may be due in part to decreased IL-6 synthesis in cardiomyocytes...
  96. ncbi request reprint The role of the mitochondrion in trauma and shock
    William J Hubbard
    Center for Surgical Research, Department of Surgery, University of Alabama, Birmingham, AL 35294 0019, USA
    Shock 22:395-402. 2004
    ....
  97. ncbi request reprint Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock
    Balazs Toth
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Mol Med 11:357-64. 2003
    ..Thus, decreased PMN priming and activation in proestrus females, compared to males, occurs following T-H resulting in decreased cellular injury and organ damage that is likely to contribute to improved outcome under those conditions...
  98. ncbi request reprint Results of long-term follow-up for transanal excision for rectal cancer
    Quintin H Gonzalez
    Section of Gastrointestinal Surgery, Department of Surgery, University of Alabama at Birmingham, Alabama, USA
    Am Surg 69:675-8; discussion 678. 2003
    ..Important selection criteria include early T stage, well or moderate differentiation, relatively small tumor size, and negative microscopic margins. The roles of radiation and chemotherapy remain controversial...
  99. ncbi request reprint Upregulation of hepatic prolactin receptor gene expression by 17beta-estradiol following trauma-hemorrhage
    Yukihiro Yokoyama
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Appl Physiol 95:2530-6. 2003
    ..Thus E2 treatment after T-H in males appears to directly upregulate PRL-R long-form gene expression in hepatocytes. However, the upregulation of the PRL-R short form might involve the interaction of multiple cell types in the liver...
  100. ncbi request reprint Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 286:G942-6. 2004
    ..These results indicate that IL-10 production by Kupffer cells early after T-H may play a pivotal role in attenuating the proinflammatory cytokine environment, possibly in an autocrine/paracrine manner...
  101. ncbi request reprint Learning to operate in a restricted duty hours environment
    J David Richardson
    Am J Surg 190:354-5. 2005