G Blanck

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint IFN-gamma inducibility of class II transactivator is specifically lacking in human tumour lines: relevance to retinoblastoma protein rescue of IFN-gamma inducibility of the HLA class II genes
    Y Lu
    Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa 33612, USA
    Immunol Cell Biol 75:325-32. 1997
  2. ncbi request reprint High level class II trans-activator induction does not occur with transient activation of the IFN-gamma signaling pathway
    D D Eason
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 166:1041-8. 2001
  3. ncbi request reprint Varying functions of specific major histocompatibility class II transactivator promoter III and IV elements in melanoma cell lines
    B L Goodwin
    Department of Biochemistry and Molecular Biology, College of Medicine and Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Cell Growth Differ 12:327-35. 2001
  4. pmc Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation
    A Osborne
    Department of Biochemistry and Molecular Biology, College of Medicine, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Mol Cell Biol 21:6495-506. 2001
  5. ncbi request reprint Loss of MHC class II inducibility in hyperplastic tissue in Rb-defective mice
    D D Eason
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, MDC 7, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA
    Cancer Lett 171:209-14. 2001
  6. ncbi request reprint Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding
    D D Eason
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, MDC 7, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Biochim Biophys Acta 1446:140-4. 1999
  7. ncbi request reprint Impaired class II transactivator expression in mice lacking interferon regulatory factor-2
    H Xi
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida, FL33612, USA
    Oncogene 20:4219-27. 2001

Collaborators

  • H Zhang
  • Y Lu
  • J M Boss
  • D D Eason
  • H Xi
  • A T Shepherd
  • B L Goodwin
  • A Osborne
  • R Tejiram
  • E Seto
  • N Ghosh
  • B Goodwin
  • D Coppola
  • S Livingston
  • W M Yang
  • K L Wright
  • U Nagarajan

Detail Information

Publications7

  1. ncbi request reprint IFN-gamma inducibility of class II transactivator is specifically lacking in human tumour lines: relevance to retinoblastoma protein rescue of IFN-gamma inducibility of the HLA class II genes
    Y Lu
    Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa 33612, USA
    Immunol Cell Biol 75:325-32. 1997
    ..Examination of additional cell lines for GBP and CIITA induction revealed that a specific lack of the CIITA IFN-gamma response is common in human tumour lines. The possible role of CIITA defects in tumorigenesis is discussed...
  2. ncbi request reprint High level class II trans-activator induction does not occur with transient activation of the IFN-gamma signaling pathway
    D D Eason
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 166:1041-8. 2001
    ..The induction of a high level of CIITA is dependent on sustained IFN-gamma signaling. The possible implications of this result for tumorigenesis are discussed...
  3. ncbi request reprint Varying functions of specific major histocompatibility class II transactivator promoter III and IV elements in melanoma cell lines
    B L Goodwin
    Department of Biochemistry and Molecular Biology, College of Medicine and Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Cell Growth Differ 12:327-35. 2001
    ..In cells with constitutively active promoter IV, the promoter IV IRF-E is most likely activated by IRF-2. The relevance of these results to the pathway of melanoma development is discussed...
  4. pmc Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation
    A Osborne
    Department of Biochemistry and Molecular Biology, College of Medicine, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Mol Cell Biol 21:6495-506. 2001
    ....
  5. ncbi request reprint Loss of MHC class II inducibility in hyperplastic tissue in Rb-defective mice
    D D Eason
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, MDC 7, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA
    Cancer Lett 171:209-14. 2001
    ..MHC class II IAbeta is not induced by IFN-gamma in Rb-deficient neoplastic cells, but remains inducible in related normal tissue...
  6. ncbi request reprint Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding
    D D Eason
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, MDC 7, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Biochim Biophys Acta 1446:140-4. 1999
    ..The IRF-1 (W11R) mutation abolishes IRF-1 DNA binding and transactivating activities demonstrating the critical role of this invariant tryptophan in IRF-1 function...
  7. ncbi request reprint Impaired class II transactivator expression in mice lacking interferon regulatory factor-2
    H Xi
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida, FL33612, USA
    Oncogene 20:4219-27. 2001
    ..These data indicate that IRF-2, like IRF-1, plays a critical role in the regulation of the endogenous CIITA gene. The implications in understanding the previously described phenotypes of IRF-2 defective mice are discussed...