Robert Blanchard

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint Effects of D-amphetamine on defensive behaviors related to fear and anxiety
    Chris M Markham
    University of Hawaii at Manoa, Psychology, 2333 Campus Road, Honolulu, 96826, USA
    Pharmacol Biochem Behav 83:490-9. 2006
  2. pmc BTBR T+tf/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate
    D Caroline Blanchard
    Pacific Biosciences Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, USA
    Neurosci Biobehav Rev 36:285-96. 2012
  3. pmc Imaging the neural circuitry and chemical control of aggressive motivation
    Craig F Ferris
    Center for Translational Neuroimaging, Northeastern University, Boston, Massachusetts, USA
    BMC Neurosci 9:111. 2008
  4. doi request reprint Risk assessment as an evolved threat detection and analysis process
    D Caroline Blanchard
    Pacific Biosciences Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, United States
    Neurosci Biobehav Rev 35:991-8. 2011
  5. doi request reprint Animal welfare beyond the cage...and beyond the evidence?
    Robert J Blanchard
    Department of Psychology, University of Hawaii at Manoa, 2538 McCarthy Avenue, Honolulu, HI 96822, USA
    J Appl Anim Welf Sci 13:89-95. 2010
  6. ncbi request reprint Amygdala lesions produce analgesia in a novel, ethologically relevant acute pain test
    M A Hebert
    Bekesy Laboratory of Neurobiology, The University of Hawaii at Manoa, Honolulu 96822, USA
    Physiol Behav 67:99-105. 1999
  7. ncbi request reprint Lesions of structures showing FOS expression to cat presentation: effects on responsivity to a Cat, Cat odor, and nonpredator threat
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Neurosci Biobehav Rev 29:1243-53. 2005
  8. ncbi request reprint Conditioning and residual emotionality effects of predator stimuli: some reflections on stress and emotion
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1177-85. 2003
  9. ncbi request reprint What can animal aggression research tell us about human aggression?
    D Caroline Blanchard
    Pacific Biomedical Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA
    Horm Behav 44:171-7. 2003
  10. ncbi request reprint Problems in the study of rodent aggression
    Robert J Blanchard
    Department of Psychology, University of Hawaii, Honolulu, HI 96822, USA
    Horm Behav 44:161-70. 2003

Research Grants

  1. The Genetic Control of Social Behavior in the Mouse
    Robert Blanchard; Fiscal Year: 2009
  2. The Genetic Control of Social Behavior in the Mouse
    Robert J Blanchard; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Effects of D-amphetamine on defensive behaviors related to fear and anxiety
    Chris M Markham
    University of Hawaii at Manoa, Psychology, 2333 Campus Road, Honolulu, 96826, USA
    Pharmacol Biochem Behav 83:490-9. 2006
    ..The results are in agreement with those of another psychostimulant, cocaine, and support a previously hypothesized link between flight and panic...
  2. pmc BTBR T+tf/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate
    D Caroline Blanchard
    Pacific Biosciences Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, USA
    Neurosci Biobehav Rev 36:285-96. 2012
    ....
  3. pmc Imaging the neural circuitry and chemical control of aggressive motivation
    Craig F Ferris
    Center for Translational Neuroimaging, Northeastern University, Boston, Massachusetts, USA
    BMC Neurosci 9:111. 2008
    ....
  4. doi request reprint Risk assessment as an evolved threat detection and analysis process
    D Caroline Blanchard
    Pacific Biosciences Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, United States
    Neurosci Biobehav Rev 35:991-8. 2011
    ..An especially intriguing possibility is that mirror neurons may respond to some of the same types of situational differences that are analyzed during risk assessment, suggesting an additional functional role for these neurons...
  5. doi request reprint Animal welfare beyond the cage...and beyond the evidence?
    Robert J Blanchard
    Department of Psychology, University of Hawaii at Manoa, 2538 McCarthy Avenue, Honolulu, HI 96822, USA
    J Appl Anim Welf Sci 13:89-95. 2010
    ..This pattern of disconnections between data and conclusions is so pervasive as to demolish the scientific value of the exposition...
  6. ncbi request reprint Amygdala lesions produce analgesia in a novel, ethologically relevant acute pain test
    M A Hebert
    Bekesy Laboratory of Neurobiology, The University of Hawaii at Manoa, Honolulu 96822, USA
    Physiol Behav 67:99-105. 1999
    ..These findings suggest a possible dissociation between anxiety and pain perception with an important (nonaffective) role for the amygdala in the latter...
  7. ncbi request reprint Lesions of structures showing FOS expression to cat presentation: effects on responsivity to a Cat, Cat odor, and nonpredator threat
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Neurosci Biobehav Rev 29:1243-53. 2005
    ....
  8. ncbi request reprint Conditioning and residual emotionality effects of predator stimuli: some reflections on stress and emotion
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1177-85. 2003
    ..That such stimuli fail to support rapid aversive conditioning suggests the need for a reanalysis of the characteristics required for an effective aversive US...
  9. ncbi request reprint What can animal aggression research tell us about human aggression?
    D Caroline Blanchard
    Pacific Biomedical Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA
    Horm Behav 44:171-7. 2003
    ..While defensive aggression has been very little researched in people, it may represent a different phenomenon than angry aggression, again providing a parallel to the offense-defense distinction of laboratory rodent studies...
  10. ncbi request reprint Problems in the study of rodent aggression
    Robert J Blanchard
    Department of Psychology, University of Hawaii, Honolulu, HI 96822, USA
    Horm Behav 44:161-70. 2003
    ....
  11. ncbi request reprint Dorsal premammillary nucleus differentially modulates defensive behaviors induced by different threat stimuli in rats
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Neurosci Lett 345:145-8. 2003
    ....
  12. ncbi request reprint Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic
    D C Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Hawaii, USA
    Neurosci Biobehav Rev 25:205-18. 2001
    ....
  13. ncbi request reprint Animal models of social stress: effects on behavior and brain neurochemical systems
    R J Blanchard
    Department of Psychology, University of Hawaii at Manoa, 2430 Campus Road, Honolulu, HI 96822, USA
    Physiol Behav 73:261-71. 2001
    ....
  14. ncbi request reprint Human defensive behaviors to threat scenarios show parallels to fear- and anxiety-related defense patterns of non-human mammals
    D C Blanchard
    Pacific Biomedical Research Center, Bekesy Laboratory of Neurobiology, University of Hawaii, 193 East West Road, Honolulu, HI 96822 2359, USA
    Neurosci Biobehav Rev 25:761-70. 2001
    ..Although the scenario approach, and this application, have specific limitations, these results provide substantial suggestion of congruence between human and non-human mammal defense systems...
  15. ncbi request reprint The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, 1993 East West Road, Honolulu 96822, USA
    Eur J Pharmacol 463:97-116. 2003
    ..This review suggests that the Mouse Defense Test Battery is a sensitive and appropriate tool for preclinical evaluation of drugs potentially effective against defense-related disorders such as anxiety and panic...
  16. ncbi request reprint Bringing natural behaviors into the laboratory: a tribute to Paul MacLean
    Robert J Blanchard
    Department of Psychology, University of Hawaii, East West Road, Honolulu, HI 96822, USA
    Physiol Behav 79:515-24. 2003
    ..Investigation of natural behaviors in adequate stimulus contexts does not represent an antiexperimental stance but one that supplements and enhances the generalizability of more conventional experimental laboratory approaches...
  17. ncbi request reprint Rat 22kHz ultrasonic vocalizations as alarm cries
    Yoav Litvin
    University of Hawaii at Manoa, Department of Psychology, 2430 Campus Rd, Honolulu, HI 96822, USA
    Behav Brain Res 182:166-72. 2007
    ..Furthermore, the integration of data from field studies and laboratory experiments may prove useful in evaluation of the relationship between each type of cry and emotional (fear or anxiety-like) states in mammals...
  18. pmc CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors
    Yoav Litvin
    Department of Psychology, University of Hawaii at Manoa, 2430 Campus Rd, Honolulu, HI 96822, USA
    Horm Behav 52:244-51. 2007
    ..Collectively, these results implicate CRF1 in the dPAG as a mediator of temporally and spatially dependent avoidance in response to controllable and constant stimuli...
  19. pmc Scent marking behavior in male C57BL/6J mice: sexual and developmental determination
    Hiroyuki Arakawa
    Pacific Bioscience Research Center, University of Hawaii at Manoa, 1993 East West Road, Honolulu, HI 96822, USA
    Behav Brain Res 182:73-9. 2007
    ..Although highly inbred strains have similar odor components, C57 males are able to detect and deposit urine marks after puberty as social communication depending on age, sex, and genetic differences in the opponents...
  20. ncbi request reprint A pinch or a lesion: a reconceptualization of biting consequences in mice
    Yoav Litvin
    Department of Psychology, University of Hawaii, Manoa, Honolulu 96822, USA
    Aggress Behav 33:545-51. 2007
    ..This apparent nonwounding fighting pattern contradicts the current evaluation of rodent wounding severity in this paradigm and can therefore refine the usage of this model and of the protocols associated with it...
  21. ncbi request reprint Cortagine: behavioral and autonomic function of the selective CRF receptor subtype 1 agonist
    Catherine Borna Farrokhi
    Department of Psychology, University of Hawaii, Honolulu, HI 96822, USA
    CNS Drug Rev 13:423-43. 2007
    ..Finally, we also discuss preliminary findings of autonomic activation obtained by central injection of cortagine that support CRF1 involvement in the modulation of heart rate and heart rate variability...
  22. pmc A new test paradigm for social recognition evidenced by urinary scent marking behavior in C57BL/6J mice
    Hiroyuki Arakawa
    Pacific Biosciences Research Center, University of Hawaii at Manoa, HI, USA
    Behav Brain Res 190:97-104. 2008
    ..familiar C57 males; likely due to similarities in their odor patterns. The data also indicate that scent marking can differentiate novel from familiar contexts...
  23. doi request reprint Defensive responses to predator threat in the rat and mouse
    D Caroline Blanchard
    University of Hawaii, Honolulu, Hawaii, USA
    Curr Protoc Neurosci . 2005
    ..These factors indicate the need for selective, reliable, and convenient tests of defensiveness to predators and predator odors using rat and mouse subjects...
  24. pmc Effects of intra-PAG infusion of ovine CRF on defensive behaviors in Swiss-Webster mice
    Eduardo F Carvalho-Netto
    Psychobiology Graduate Program, University of Sao Paulo, Ribeirao Preto, SP 14040 901, Brazil Laboratory of Pharmacology, Sao Paulo State University, Araraquara, SP 14801 902, Brazil
    Behav Brain Res 176:222-9. 2007
    ..Our data indicate that CRF systems may be functionally involved in unconditioned defenses to a predator, consonant with a role for DPAG CRF systems in the regulation of emotionality...
  25. pmc Colony formation of C57BL/6J mice in visible burrow system: identification of eusocial behaviors in a background strain for genetic animal models of autism
    Hiroyuki Arakawa
    Pacific Bioscience Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Behav Brain Res 176:27-39. 2007
    ..These findings suggest two potentially useful measures of eusocial behavior in mice, of possible value for genetic mouse models of autism; that is, huddling together and approaches to the front but not the back, of conspecifics...
  26. ncbi request reprint Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats
    Nathan S Pentkowski
    Department of Psychology, University of Hawaii, Honolulu, Hawaii 96822 2294, USA
    Eur J Neurosci 23:2185-96. 2006
    ..These results suggest a specific role for the ventral, not dorsal, hippocampus in modulating anxiety-like behaviors in certain animal models of defense...
  27. ncbi request reprint Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli
    D Caroline Blanchard
    Pacific Biomedical Research Center, Bekesy Laboratory of Neurobiology, University of Hawaii at Manoa, Honolulu 96822 2359, USA
    Behav Neurosci 117:360-8. 2003
    ..Predator feces may also be less effective as a UCS because they are poorly predictive of the actual presence of the predator, suggesting the need for a reevaluation of UCS functions in aversive conditioning...
  28. ncbi request reprint Infralimbic D2 receptor influences on anxiety-like behavior and active memory/attention in CD-1 mice
    Philip M Wall
    Pacific Biomedical Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:395-410. 2003
    ....
  29. ncbi request reprint Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
    Catherine Farrokhi
    Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA
    Pharmacol Biochem Behav 77:465-9. 2004
    ....
  30. ncbi request reprint The rat exposure test: a model of mouse defensive behaviors
    Mu Yang
    Pacific Biomedical Research Center, University of Hawaii, Honolulu 96822, USA
    Physiol Behav 81:465-73. 2004
    ..In particular, SAP levels were substantial in all strains tested, suggesting the usefulness of this test in assessment of the role of risk assessment in defense...
  31. ncbi request reprint Modulation of predatory odor processing following lesions to the dorsal premammillary nucleus
    Chris M Markham
    Department of Psychology, University of Hawaii, 2333 Campus Road, Honolulu, HI 96822 USA
    Neurosci Lett 372:22-6. 2004
    ..These results confirm earlier findings of attenuation in defensiveness following electrolytic PMd lesions while extending these findings to suggest that the reduced defensiveness occurs specifically in response to predatory odors...
  32. ncbi request reprint Trends of reproductive hormones in male rats during psychosocial stress: role of glucocorticoid metabolism in behavioral dominance
    Matthew P Hardy
    Population Council Rockefeller University, New York, New York 10021, USA
    Biol Reprod 67:1750-5. 2002
    ....
  33. pmc Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB)
    Mu Yang
    Department of Psychology, University of Hawaii at Manoa, Honolulu, 96822, USA
    Behav Brain Res 171:1-8. 2006
    ....
  34. ncbi request reprint Defensive behavior
    Iain S McGregor
    Neurosci Biobehav Rev 29:1121-2. 2005
  35. ncbi request reprint AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters
    Robert J Blanchard
    Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA
    Pharmacol Biochem Behav 80:189-94. 2005
    ..These findings agree with previous research on V1b receptor effects in suggesting that antagonism of this receptor may be useful in modulating a range of emotional responses to highly stressful or threatening conditions...
  36. ncbi request reprint Some suggestions for revitalizing aggression research
    Robert J Blanchard
    Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA
    Novartis Found Symp 268:4-12; discussion 13-9, 96-9. 2005
    ..Placing aggression research in an ethological context and focusing on its biomedical relevance may help to counter forces suppressing this work...

Research Grants2

  1. The Genetic Control of Social Behavior in the Mouse
    Robert Blanchard; Fiscal Year: 2009
    ....
  2. The Genetic Control of Social Behavior in the Mouse
    Robert J Blanchard; Fiscal Year: 2010
    ....