E M Blalock

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress
    Nada M Porter
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 7:e40128. 2012
  2. pmc Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age
    Heather M Buechel
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 6:e18387. 2011
  3. pmc Post hoc pattern matching: assigning significance to statistically defined expression patterns in single channel microarray data
    Randall Hulshizer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    BMC Bioinformatics 8:240. 2007
  4. pmc Statistical implications of pooling RNA samples for microarray experiments
    Xuejun Peng
    Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
    BMC Bioinformatics 4:26. 2003
  5. ncbi request reprint Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation
    E M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, 800 Rose St MS 309, Lexington, KY 40536 0084, USA
    Ageing Res Rev 4:481-512. 2005
  6. ncbi request reprint Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices
    E M Blalock
    Department of Pharmacology, College of Medicine, University of Kentucky, MS 310 UKMC, Lexington, KY 40536, USA
    Epilepsy Res 43:211-26. 2001
  7. pmc Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Chem Neuroanat 42:118-26. 2011
  8. pmc Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 30:6058-71. 2010
  9. pmc Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture
    C M Norris
    Department of Molecular and Biomedical Pharmacology, College of Medicine, MS 310 UKMC, University of Kentucky, Lexington, KY 40536 0298, USA
    Neuroscience 110:213-25. 2002
  10. pmc Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices
    K C Chen
    Department of Pharmacology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 97:4357-62. 2000

Collaborators

Detail Information

Publications13

  1. pmc Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress
    Nada M Porter
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 7:e40128. 2012
    ..Further, sleep architecture changes with age suggest an age-related loss of sleep. Here, we hypothesized that sleep deprivation in young subjects would elicit both stress and aging-like transcriptional responses...
  2. pmc Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age
    Heather M Buechel
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 6:e18387. 2011
    ..Despite sleep disruption's well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep's relationship to cognitive aging...
  3. pmc Post hoc pattern matching: assigning significance to statistically defined expression patterns in single channel microarray data
    Randall Hulshizer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    BMC Bioinformatics 8:240. 2007
    ..Finally, different patterns may have different probabilities of occurring by chance, importantly influencing researchers' conclusions about a pattern and its constituent genes...
  4. pmc Statistical implications of pooling RNA samples for microarray experiments
    Xuejun Peng
    Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
    BMC Bioinformatics 4:26. 2003
    ..However, the statistical, technical and financial implications of pooling have not been explicitly investigated...
  5. ncbi request reprint Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation
    E M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, 800 Rose St MS 309, Lexington, KY 40536 0084, USA
    Ageing Res Rev 4:481-512. 2005
    ..We also review how work by ourselves and others with this powerful technology is leading to new insights into the complex processes of brain aging and AD, and to novel, more comprehensive models of aging-related brain change...
  6. ncbi request reprint Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices
    E M Blalock
    Department of Pharmacology, College of Medicine, University of Kentucky, MS 310 UKMC, Lexington, KY 40536, USA
    Epilepsy Res 43:211-26. 2001
    ....
  7. pmc Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Chem Neuroanat 42:118-26. 2011
    ....
  8. pmc Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 30:6058-71. 2010
    ..In turn, these MSI-associated neuroenergetic changes may promote inflammation, neuronal vulnerability, and risk of cognitive impairment/AD...
  9. pmc Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture
    C M Norris
    Department of Molecular and Biomedical Pharmacology, College of Medicine, MS 310 UKMC, University of Kentucky, Lexington, KY 40536 0298, USA
    Neuroscience 110:213-25. 2002
    ..Moreover, this action appears to be increased concomitantly with the well-characterized increase in L-type Ca(2+) channel availability in hippocampal neurons with age-in-culture...
  10. pmc Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices
    K C Chen
    Department of Pharmacology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 97:4357-62. 2000
    ..Thus, these studies support the possibility that the level of alpha(1D) gene expression regulates the density of functional L-VSCCs...
  11. pmc Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release
    C M Norris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305, UKMC, Lexington, KY 40536 0298, USA
    J Neurophysiol 96:2488-500. 2006
    ....
  12. ncbi request reprint The neurobiology of aging
    K M Kelly
    Department of Neurology, Drexel University College of Medicine, Allegheny General Hospital, 940 S Tower, 320 E North Ave, Pittsburgh, PA 15212, USA
    Epilepsy Res 68:S5-20. 2006
    ..Lastly, application of microarray gene chip technology to aging brain studies was presented and use of the hippocampal "zipper slice" preparation to study aged neurons was described...