E M Blalock
Affiliation: University of Kentucky
- Post hoc pattern matching: assigning significance to statistically defined expression patterns in single channel microarray dataRandall Hulshizer
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
BMC Bioinformatics 8:240. 2007..Finally, different patterns may have different probabilities of occurring by chance, importantly influencing researchers' conclusions about a pattern and its constituent genes...
- Statistical implications of pooling RNA samples for microarray experimentsXuejun Peng
Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
BMC Bioinformatics 4:26. 2003..However, the statistical, technical and financial implications of pooling have not been explicitly investigated...
- Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's diseaseEric M Blalock
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
J Chem Neuroanat 42:118-26. 2011....
- Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slicesE M Blalock
Department of Pharmacology, College of Medicine, University of Kentucky, MS 310 UKMC, Lexington, KY 40536, USA
Epilepsy Res 43:211-26. 2001....
- Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlationE M Blalock
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, 800 Rose St MS 309, Lexington, KY 40536 0084, USA
Ageing Res Rev 4:481-512. 2005..We also review how work by ourselves and others with this powerful technology is leading to new insights into the complex processes of brain aging and AD, and to novel, more comprehensive models of aging-related brain change...
- Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeysEric M Blalock
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 30:6058-71. 2010..In turn, these MSI-associated neuroenergetic changes may promote inflammation, neuronal vulnerability, and risk of cognitive impairment/AD...
- Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in cultureC M Norris
Department of Molecular and Biomedical Pharmacology, College of Medicine, MS 310 UKMC, University of Kentucky, Lexington, KY 40536 0298, USA
Neuroscience 110:213-25. 2002..Moreover, this action appears to be increased concomitantly with the well-characterized increase in L-type Ca(2+) channel availability in hippocampal neurons with age-in-culture...
- Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slicesK C Chen
Department of Pharmacology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
Proc Natl Acad Sci U S A 97:4357-62. 2000..Thus, these studies support the possibility that the level of alpha(1D) gene expression regulates the density of functional L-VSCCs...
- Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate releaseC M Norris
Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS-305, UKMC, Lexington, KY 40536-0298, USA
J Neurophysiol 96:2488-500. 2006....
- The neurobiology of agingK M Kelly
Department of Neurology, Drexel University College of Medicine, Allegheny General Hospital, 940 S Tower, 320 E North Ave, Pittsburgh, PA 15212, USA
Epilepsy Res 68:S5-20. 2006..Lastly, application of microarray gene chip technology to aging brain studies was presented and use of the hippocampal "zipper slice" preparation to study aged neurons was described...