Elizabeth H Blackburn

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, MC 2200, San Francisco, California 94158 2517, USA
    Nat Med 12:1133-8. 2006
  2. doi request reprint Walking the walk from genes through telomere maintenance to cancer risk
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Cancer Prev Res (Phila) 4:473-5. 2011
  3. doi request reprint Cancer interception
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cancer Prev Res (Phila) 4:787-92. 2011
  4. pmc Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres
    Lifeng Xu
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Mol Cell 28:315-27. 2007
  5. pmc A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response
    Jeffrey J Seidel
    Department of Biochemistry and Biophysics, 600 16th Street, Room S316, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Mol Cell Biol 28:5736-46. 2008
  6. pmc Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression
    Shang Li
    Department of Biochemistry and Biophysics, University of California, San Francisco, Box 2200, San Francisco, CA 94143 2200, USA
    Cell 136:50-61. 2009
  7. pmc A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:14713-8. 2004
  8. pmc Mec1 function in the DNA damage response does not require its interaction with Tel2
    Carol M Anderson
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Cell Cycle 7:3695-8. 2008
  9. pmc ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
    Bradley A Stohr
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 2200, USA
    Cancer Res 68:5309-17. 2008
  10. ncbi request reprint Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA
    Mehdi Nosrati
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Department of Dermatology, University of California San Francisco Cancer Center, San Francisco, California 94115, USA
    Clin Cancer Res 10:4983-90. 2004

Research Grants

  1. The Function of Telomerase and Telomeres
    Elizabeth H Blackburn; Fiscal Year: 2010
  2. The Function of Telomerase and Telomeres
    Elizabeth Blackburn; Fiscal Year: 2006
  3. Responses to perturbing telomeres in human cells
    Elizabeth Blackburn; Fiscal Year: 2006
  4. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth Blackburn; Fiscal Year: 2007
  5. The Function of Telomerase and Telomeres
    Elizabeth Blackburn; Fiscal Year: 2007
  6. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth H Blackburn; Fiscal Year: 2010
  7. FUNCTION OF TELOMERASE AND TELOMERES
    Elizabeth Blackburn; Fiscal Year: 2002
  8. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth Blackburn; Fiscal Year: 2009

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, MC 2200, San Francisco, California 94158 2517, USA
    Nat Med 12:1133-8. 2006
  2. doi request reprint Walking the walk from genes through telomere maintenance to cancer risk
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Cancer Prev Res (Phila) 4:473-5. 2011
    ..One of these SNPs predicted risk for bladder cancer, an effect partially mediated by telomere length. Interventions that could forestall telomere shortening should be explored for their potential to reduce cancer risks...
  3. doi request reprint Cancer interception
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cancer Prev Res (Phila) 4:787-92. 2011
    ..Keeping the medical community and public at large informed about possibilities for actively intercepting cancer will be important for gaining acceptance of this increasingly powerful approach to lessening the cancer burden...
  4. pmc Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres
    Lifeng Xu
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Mol Cell 28:315-27. 2007
    ....
  5. pmc A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response
    Jeffrey J Seidel
    Department of Biochemistry and Biophysics, 600 16th Street, Room S316, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Mol Cell Biol 28:5736-46. 2008
    ..Together, these results define a conserved sequence motif within an otherwise poorly defined region of the Tel1/ATM kinase family proteins that is essential for normal Tel1 function in Saccharomyces cerevisiae...
  6. pmc Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression
    Shang Li
    Department of Biochemistry and Biophysics, University of California, San Francisco, Box 2200, San Francisco, CA 94143 2200, USA
    Cell 136:50-61. 2009
    ..These results provide a direct mechanistic link between coordination of telomere elongation and cell-cycle progression in vivo...
  7. pmc A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:14713-8. 2004
    ..These results, combined with previous studies on telomerase RNAs from other budding yeasts, vertebrates, and ciliates, define a minimal universal core for telomerase RNAs...
  8. pmc Mec1 function in the DNA damage response does not require its interaction with Tel2
    Carol M Anderson
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Cell Cycle 7:3695-8. 2008
    ..These results suggest that the model of Tel2 as solely a global regulator of PIKK stability is insufficient. Rather, Tel2 can specifically and differentially regulate the function of individual PIKKs...
  9. pmc ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
    Bradley A Stohr
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 2200, USA
    Cancer Res 68:5309-17. 2008
    ..Our results identify ATM as a key mediator of the MT-hTer-47A dysfunctional telomere response, even in cells lacking wild-type p53, and provide evidence that telomere fusions contribute to MT-hTer-47A cytotoxicity...
  10. ncbi request reprint Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA
    Mehdi Nosrati
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Department of Dermatology, University of California San Francisco Cancer Center, San Francisco, California 94115, USA
    Clin Cancer Res 10:4983-90. 2004
    ..To test ribozymes targeting mouse telomerase RNA (mTER) for suppression of the progression of B16-F10 murine melanoma metastases in vivo...
  11. pmc Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Mol Biol Cell 15:1623-34. 2004
    ..These results suggest that mutant telomere sequences elicit a checkpoint that is genetically distinct from those activated by deletion of telomerase or DNA damage...
  12. pmc The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion
    Bradley A Stohr
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 39:307-14. 2010
    ....
  13. ncbi request reprint Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006
    ..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
  14. ncbi request reprint Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells
    Amir Goldkorn
    Department of Internal Medicine, Division of Hematology and Oncology, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 66:5763-71. 2006
    ..Hence, the effects of MT-hTer/siRNA require a telomerase that is both catalytically competent to polymerize DNA and able to act on telomeres in cells...
  15. pmc Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
    Carol M Anderson
    Department of Biochemistry, University of California, San Francisco, California 94143, USA
    Genes Dev 22:854-9. 2008
    ..Computational analysis revealed structural homology between Tel2 and Ddc2 (ATRIP in vertebrates), a partner of Mec1, suggesting a common structural principle used by partners of phoshoinositide 3-kinase-like kinases...
  16. pmc Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length
    Aoife O'Donovan
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Brain Behav Immun 26:573-9. 2012
    ..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging...
  17. ncbi request reprint Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
    Shang Li
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 280:23709-17. 2005
    ....
  18. pmc Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
    Lifeng Xu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Cell Biol 167:819-30. 2004
    ..In telophase, hRif1 localized to chromosomes, and in interphase, it was intranuclear. These results define a novel subcellular localization behavior for hRif1 during the cell cycle...
  19. pmc The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis
    Imke Listerman
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 73:2817-28. 2013
    ..Our results reveal that a major hTERT splice variant can confer a growth advantage to cancer cells independent of telomere maintenance, suggesting that hTERT makes multiple contributions to cancer pathophysiology...
  20. pmc Genes and pathways downstream of telomerase in melanoma metastasis
    Sepideh Bagheri
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 103:11306-11. 2006
    ..These studies have important implications for understanding the mechanisms by which telomerase promotes tumor invasion and metastasis...
  21. pmc Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions
    Svetlana Makovets
    University of California, San Francisco, Department of Biochemistry and Biophysics, San Francisco, California 94143 2200, USA
    Mol Cell Biol 24:4019-31. 2004
    ..The telomeric replication fork pause was specific to yeast telomeric sequence and was independent of the Sir and Rif proteins, major known components of yeast telomeric heterochromatin...
  22. pmc Dynamics of telomerase activity in response to acute psychological stress
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
    Brain Behav Immun 24:531-9. 2010
    ....
  23. ncbi request reprint Processive utilization of the human telomerase template: lack of a requirement for template switching
    Melissa A Rivera
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    J Biol Chem 279:53770-81. 2004
    ....
  24. pmc Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site
    Tanya L Williams
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    J Biol Chem 285:35814-24. 2010
    ..We suggest that Rap1 binding to multiple sites in a telomere array does not, by itself, promote formation of a more energetically stabile complex...
  25. pmc Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length
    Daniel L Levy
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Mol Cell Biol 24:10857-67. 2004
    ..We propose that a nucleation and spreading mechanism is involved in forming the higher-order telomere structure that regulates telomere length...
  26. pmc Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Genes Dev 18:387-96. 2004
    ..Hence, we propose that yPinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA...
  27. pmc The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2009
    ..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity...
  28. pmc Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study
    Omer T Njajou
    Departments of Medicine and Institute for Human Genetics, 513 Parnassus Street, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    J Gerontol A Biol Sci Med Sci 64:860-4. 2009
    ..TL, however, was positively associated with more YHL (beta = 0.08 +/- 0.04, p = .03). Findings suggest that TL may not be a strong biomarker of survival in older individuals, but it may be an informative biomarker of healthy aging...
  29. pmc Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length
    Sonja Entringer
    Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
    Am J Obstet Gynecol 208:134.e1-7. 2013
    ..The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length...
  30. pmc Telomere shortening in formerly abused and never abused women
    Janice Humphreys
    Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
    Biol Res Nurs 14:115-23. 2012
    ..Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging...
  31. pmc Telomeres and telomerase
    Simon R W L Chan
    University of California, San Francisco, Biochemistry and Biophysics, Box 2200, San Francisco, CA 94143 2200, USA
    Philos Trans R Soc Lond B Biol Sci 359:109-21. 2004
    ..Telomerase acts to prevent such fusions. The molecular consequences of telomere failure, and the molecular contributors to telomere function, with an emphasis on telomerase, are discussed here...
  32. ncbi request reprint The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2008
    ..0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity...
  33. ncbi request reprint Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    Simon W L Chan
    Department of Biochemistry and Biophysics, Box 2200, University of California, San Francisco, 94143, USA
    Mol Cell 11:1379-87. 2003
    ..Thus, telomerase and Tel1p function in telomere protection as well as in telomere elongation...
  34. pmc Comprehensive structure-function analysis of the core domain of human telomerase RNA
    Hinh Ly
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 23:6849-56. 2003
    ..Additionally, we provide evidence that naturally occurring hTER sequence polymorphisms found in some patients with aplastic anemia can inhibit telomerase activity by disrupting critical structures within the hTER core domain...
  35. pmc The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase
    Svetlana Makovets
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Genetics 178:245-57. 2008
    ....
  36. pmc Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
    Ramin Farzaneh-Far
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 303:250-7. 2010
    ..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
  37. pmc DNA damage signalling prevents deleterious telomere addition at DNA breaks
    Svetlana Makovets
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Nat Cell Biol 11:1383-6. 2009
    ..These findings uncover a new regulatory mechanism that coordinates competing DNA end-processing activities and thereby promotes DNA repair accuracy and genome integrity...
  38. pmc Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood
    Sonja Entringer
    Department of Pediatrics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:E513-8. 2011
    ..This observation may help shed light on an important biological pathway underlying the developmental origins of adult health and disease risk...
  39. pmc Chronic stress elevates telomerase activity in rats
    Annaliese K Beery
    Robert Wood Johnson Health and Society Scholar at University of California at San Francisco, San Francisco, CA 04143, USA
    Biol Lett 8:1063-6. 2012
    ..This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence...
  40. ncbi request reprint Catalytically active human telomerase mutants with allele-specific biological properties
    Moses Kim
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143 2200, USA
    Exp Cell Res 288:277-87. 2003
    ..These results uncover further hTERT allele-specific phenotypes that uncouple telomerase activity, net telomere lengthening and life span extension...
  41. ncbi request reprint Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    Shang Li
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 64:4833-40. 2004
    ..Hence, anti-wild-type-hTER short-interfering RNA and MT-hTers may act through distinct pathways and, particularly in combination, represent a promising approach to anticancer therapies...
  42. ncbi request reprint Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    FEBS Lett 579:859-62. 2005
    ..The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here...
  43. doi request reprint Increased telomerase activity and comprehensive lifestyle changes: a pilot study
    Dean Ornish
    Department of Medicine, University of California, San Francisco, CA, USA
    Lancet Oncol 9:1048-57. 2008
    ..We aimed to assess whether 3 months of intensive lifestyle changes increased telomerase activity in peripheral blood mononuclear cells (PBMC)...
  44. pmc Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 6:e17837. 2011
    ..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation...
  45. pmc Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study
    Aoife O'Donovan
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19687. 2011
    ..However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction...
  46. pmc Visualization of actin filaments and monomers in somatic cell nuclei
    Brittany J Belin
    University of California, San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 24:982-94. 2013
    ..Our results instead suggest that actin filaments form part of a large, viscoelastic structure in the nucleoplasm and may act as scaffolds that help organize nuclear contents...
  47. pmc A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase
    Hinh Ly
    Departments of Pathology Microbiology, and Immunology, and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Genes Dev 17:1078-83. 2003
    ..Such RNA-RNA interaction mirrors a known property of retroviral reverse transcriptases, which use homodimeric viral genomic RNA substrates...
  48. pmc A novel pseudoknot element is essential for the action of a yeast telomerase
    Yehuda Tzfati
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Genes Dev 17:1779-88. 2003
    ..We propose that such disruption of the pseudoknot, and potentially the predicted telomerase RNA conformation, affects polymerization to cause the observed shifts in template usage...
  49. pmc The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    Shivani Nautiyal
    Department of Biochemistry, University of California, Box 0448, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:9316-21. 2002
    ..The telomerase deletion signature genes define new candidates for involvement in cellular responses to altered telomere structure or function...
  50. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...
  51. ncbi request reprint Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Mol Cancer Res 3:477-82. 2005
  52. doi request reprint An investigation of the effects of the core protein telomerase reverse transcriptase on wnt signaling in breast cancer cells
    Imke Listerman
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA
    Mol Cell Biol 34:280-9. 2014
    ..In summary, our evidence fails to support the idea of a biologically consistent hTERT interaction with the Wnt pathway in human breast cancer cells, and any detectable influence of hTERT depended on cell type and experimental system. ..
  53. pmc Shorter leukocyte telomere length in midlife women with poor sleep quality
    Aric A Prather
    Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
    J Aging Res 2011:721390. 2011
    ..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging...
  54. ncbi request reprint New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin
    Simon W L Chan
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, CA 94143 0448, USA
    Oncogene 21:553-63. 2002
    ....
  55. pmc Telomere length is paternally inherited and is associated with parental lifespan
    Omer T Njajou
    Department of Medicine and Institute of Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:12135-9. 2007
    ..Our data, which are based on one of the largest family studies of human TL, support a link between TL and aging and lifespan and suggest a strong genetic influence, possibly via an imprinting mechanism, on TL regulation...
  56. doi request reprint Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
    Baohui Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 155:1479-91. 2013
    ..This CRISPR imaging tool has potential to significantly improve the capacity to study the conformation and dynamics of native chromosomes in living human cells. ..
  57. pmc A molecular switch underlies a human telomerase disease
    Luis R Comolli
    Departments of Pharmaceutical Chemistry and Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:16998-7003. 2002
    ..Phylogenetic covariation in the P2b and P3 sequences of 35 species provides a compelling set of "natural" compensatory base pairing changes supporting the existence of the crucial molecular switch...
  58. ncbi request reprint A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity
    Maria Isabel N Cano
    Department of Stomatology, University of California, San Francisco, California 94143 0422, USA
    J Biol Chem 277:896-906. 2002
    ..The molecular masses of the peptides showed no homologies with other proteins from trypanosomes or with any protein in the data bases screened...
  59. pmc A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity
    Anita G Seto
    Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309 0215, USA
    RNA 9:1323-32. 2003
    ..In addition, the in vitro activity of the paired element mutant indicates that the RNA element has additional functions in enzyme processivity and in directing template usage by telomerase...
  60. ncbi request reprint Tracking telomerase
    Carol W Greider
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Cell 116:S83-6, 1 p following S86. 2004
  61. pmc A bulged stem tethers Est1p to telomerase RNA in budding yeast
    Anita G Seto
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 0215, USA
    Genes Dev 16:2800-12. 2002
    ..We propose that this RNA structure links the enzymatic core of telomerase with Est1p, thereby allowing Est1p to recruit or activate telomerase at the telomere...
  62. ncbi request reprint Cell biology: Shaggy mouse tales
    Elizabeth H Blackburn
    Nature 436:922-3. 2005
  63. ncbi request reprint Lasker honors cell biologists, psychiatrist
    Bridget M Kuehn
    JAMA 296:1451-2. 2006
  64. pmc Dynamics of telomeric DNA turnover in yeast
    Michael J McEachern
    Department of Genetics, Life Sciences Building, University of Georgia, Athens, Georgia 30602 7223, USA
    Genetics 160:63-73. 2002
    ..These results indicate that most DNA turnover in functionally normal telomeres is due to gradual replicative sequence loss and additions by telomerase but that there are other processes that also contribute to turnover...
  65. pmc Telomerase core components protect Candida telomeres from aberrant overhang accumulation
    Min Hsu
    Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:11682-7. 2007
    ..Altogether, our data support the notion that the Candida telomerase core components mediate a protective function through a mechanism that is independent of its catalytic activity...
  66. pmc Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita
    Hinh Ly
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Blood 106:1246-52. 2005
    ....

Research Grants24

  1. The Function of Telomerase and Telomeres
    Elizabeth H Blackburn; Fiscal Year: 2010
    ....
  2. The Function of Telomerase and Telomeres
    Elizabeth Blackburn; Fiscal Year: 2006
    ..Based on models to be tested, and using purified telomere components, telomeric complexes will be examined by electron microscopy. ..
  3. Responses to perturbing telomeres in human cells
    Elizabeth Blackburn; Fiscal Year: 2006
    ..The goal is a fuller understanding of the role(s) in cancer and aging played by telomerase activation. ..
  4. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth Blackburn; Fiscal Year: 2007
    ..Our work will advance the basic understanding of cancer telomere biology, which will be important to develop novel therapeutic strategies to exploit the unique telomerase status of cancer cells. ..
  5. The Function of Telomerase and Telomeres
    Elizabeth Blackburn; Fiscal Year: 2007
    ....
  6. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth H Blackburn; Fiscal Year: 2010
    ..Our work will advance the basic understanding of cancer telomere biology, which will be important to develop novel therapeutic strategies to exploit the unique telomerase status of cancer cells. ..
  7. FUNCTION OF TELOMERASE AND TELOMERES
    Elizabeth Blackburn; Fiscal Year: 2002
    ..4) study the mechanism of genomic rearrangements in ciliate development, using an in vitro reaction system we have developed. ..
  8. Cancer cell telomere dynamics and responses to perturbations
    Elizabeth Blackburn; Fiscal Year: 2009
    ..Our work will advance the basic understanding of cancer telomere biology, which will be important to develop novel therapeutic strategies to exploit the unique telomerase status of cancer cells. ..