E H Blackburn

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review
    E H Blackburn
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Biochemistry (Mosc) 62:1196-201. 1997
  2. pmc Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome
    G M Kapler
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Genetics 137:455-66. 1994
  3. ncbi request reprint Switching and signaling at the telomere
    E H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 106:661-73. 2001
  4. pmc Architecture of telomerase RNA
    A Bhattacharyya
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    EMBO J 13:5721-31. 1994
  5. pmc A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
    M M Kim
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA
    Proc Natl Acad Sci U S A 98:7982-7. 2001
  6. ncbi request reprint The end of the (DNA) line
    E H Blackburn
    Departments of Biochemistry and Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    Nat Struct Biol 7:847-50. 2000
  7. pmc Shorter telomeres are associated with obesity and weight gain in the elderly
    O T Njajou
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Int J Obes (Lond) 36:1176-9. 2012
  8. pmc Aspergillus nidulans maintains short telomeres throughout development
    A Bhattacharyya
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Nucleic Acids Res 25:1426-31. 1997
  9. pmc Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
    C D Smith
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0448, USA
    Mol Biol Cell 14:556-70. 2003
  10. ncbi request reprint Expression and suppression of human telomerase RNA
    S Li
    Department of Biochemistry and Biophysics, University of California, San Fransisco, California 94158 2517, USA
    Cold Spring Harb Symp Quant Biol 71:211-5. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review
    E H Blackburn
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Biochemistry (Mosc) 62:1196-201. 1997
    ..We propose that this complex plays a key role in regulating access of telomerase to the telomere...
  2. pmc Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome
    G M Kapler
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Genetics 137:455-66. 1994
    ..Based on our current understanding of rDNA maturation processes, we suggest that the rmm10 mutation affects rDNA excision rather than subsequent rDNA amplification/replication...
  3. ncbi request reprint Switching and signaling at the telomere
    E H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 106:661-73. 2001
    ..Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA...
  4. pmc Architecture of telomerase RNA
    A Bhattacharyya
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    EMBO J 13:5721-31. 1994
    ....
  5. pmc A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
    M M Kim
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA
    Proc Natl Acad Sci U S A 98:7982-7. 2001
    ..These results support the potential use of mutant-template telomerase RNA expression as an antineoplastic strategy...
  6. ncbi request reprint The end of the (DNA) line
    E H Blackburn
    Departments of Biochemistry and Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    Nat Struct Biol 7:847-50. 2000
    ..Mutational studies indicate that telomerase enzyme function results from a collaboration of both protein and RNA functional groups contributed by TERT and TER...
  7. pmc Shorter telomeres are associated with obesity and weight gain in the elderly
    O T Njajou
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Int J Obes (Lond) 36:1176-9. 2012
    ..Therefore, we set out to test the hypothesis that TL may be a risk factor for increased adiposity using data from a large population-based cohort study...
  8. pmc Aspergillus nidulans maintains short telomeres throughout development
    A Bhattacharyya
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Nucleic Acids Res 25:1426-31. 1997
    ..We demonstrate that telomere length is remarkably stable in different cell types and at altered growth temperatures, suggesting a highly regulated mechanism for length control...
  9. pmc Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
    C D Smith
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0448, USA
    Mol Biol Cell 14:556-70. 2003
    ..We provide evidence for dynamic remodeling of these components at telomeres...
  10. ncbi request reprint Expression and suppression of human telomerase RNA
    S Li
    Department of Biochemistry and Biophysics, University of California, San Fransisco, California 94158 2517, USA
    Cold Spring Harb Symp Quant Biol 71:211-5. 2006
    ..Together with other results, these findings establish that the crucial elements of the hTER gene affecting RNA-processing efficiency to produce the mature hTER RNA are the promoter and internal telomerase RNA-coding sequences...