E H Blackburn

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Mol Cancer Res 3:477-82. 2005
  2. ncbi request reprint The end of the (DNA) line
    E H Blackburn
    Departments of Biochemistry and Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    Nat Struct Biol 7:847-50. 2000
  3. pmc Reason as our guide
    Elizabeth Blackburn
    Department of Biochemistry and Biophysics at the University of California, San Francisco, USA
    PLoS Biol 2:E116. 2004
  4. ncbi request reprint Switching and signaling at the telomere
    E H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 106:661-73. 2001
  5. ncbi request reprint Thoughts of a former Council member
    Elizabeth Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    Perspect Biol Med 48:172-80. 2005
  6. pmc Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
    C D Smith
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0448, USA
    Mol Biol Cell 14:556-70. 2003
  7. ncbi request reprint The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review
    E H Blackburn
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Biochemistry (Mosc) 62:1196-201. 1997
  8. ncbi request reprint Bioethics and the political distortion of biomedical science
    Elizabeth Blackburn
    University of California, San Francisco, School of Medicine, USA
    N Engl J Med 350:1379-80. 2004
  9. pmc Dietary restraint and telomere length in pre- and postmenopausal women
    Amy Kiefer
    UCSF Department of Psychiatry, University of California, San Francisco, California, USA
    Psychosom Med 70:845-9. 2008
  10. pmc Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres
    Elissa Epel
    University of California San Francisco, Department of Psychiatry, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1172:34-53. 2009

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Mol Cancer Res 3:477-82. 2005
  2. ncbi request reprint The end of the (DNA) line
    E H Blackburn
    Departments of Biochemistry and Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    Nat Struct Biol 7:847-50. 2000
    ..Mutational studies indicate that telomerase enzyme function results from a collaboration of both protein and RNA functional groups contributed by TERT and TER...
  3. pmc Reason as our guide
    Elizabeth Blackburn
    Department of Biochemistry and Biophysics at the University of California, San Francisco, USA
    PLoS Biol 2:E116. 2004
  4. ncbi request reprint Switching and signaling at the telomere
    E H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Cell 106:661-73. 2001
    ..Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA...
  5. ncbi request reprint Thoughts of a former Council member
    Elizabeth Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    Perspect Biol Med 48:172-80. 2005
  6. pmc Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
    C D Smith
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0448, USA
    Mol Biol Cell 14:556-70. 2003
    ..We provide evidence for dynamic remodeling of these components at telomeres...
  7. ncbi request reprint The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review
    E H Blackburn
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Biochemistry (Mosc) 62:1196-201. 1997
    ..We propose that this complex plays a key role in regulating access of telomerase to the telomere...
  8. ncbi request reprint Bioethics and the political distortion of biomedical science
    Elizabeth Blackburn
    University of California, San Francisco, School of Medicine, USA
    N Engl J Med 350:1379-80. 2004
  9. pmc Dietary restraint and telomere length in pre- and postmenopausal women
    Amy Kiefer
    UCSF Department of Psychiatry, University of California, San Francisco, California, USA
    Psychosom Med 70:845-9. 2008
    ....
  10. pmc Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres
    Elissa Epel
    University of California San Francisco, Department of Psychiatry, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1172:34-53. 2009
    ..Aspects of this model are currently being tested in ongoing trials of mindfulness meditation...
  11. pmc Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, United States
    J Immunol Methods 352:71-80. 2010
    ..55, r<0.001), indicating possible common mechanisms for telomerase activity regulation in these two cell subtypes. These data will facilitate the understanding of leukocyte aging and its relationship to human health...
  12. pmc Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study
    Ramin Farzaneh-Far
    Division of Cardiology, San Francisco General Hospital, San Francisco, California, USA
    PLoS ONE 5:e8612. 2010
    ..We sought to investigate the longitudinal trajectory of telomere length, and to identify the independent predictors of telomere shortening, in persons with coronary artery disease...
  13. pmc The power of exercise: buffering the effect of chronic stress on telomere length
    Eli Puterman
    Department of Psychiatry, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e10837. 2010
    ..We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening...
  14. ncbi request reprint Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
    S W Chan
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Curr Biol 11:1240-50. 2001
    ..We tested whether the ATM kinases are required for telomerase enzyme activity or whether it is their action on the telomere that allows telomeric DNA synthesis...
  15. pmc A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
    M M Kim
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA
    Proc Natl Acad Sci U S A 98:7982-7. 2001
    ..These results support the potential use of mutant-template telomerase RNA expression as an antineoplastic strategy...
  16. ncbi request reprint Telomerase: Dr Jekyll or Mr Hyde?
    J C Prescott
    University of California San Francisco Deptartment of Microbiology and Immunology San Francisco, California 94143 0414, USA
    Curr Opin Genet Dev 9:368-73. 1999
    ..Telomerase activation preceded oncogenic transformation in some human cell types, yet was lacking in other transformed cells. These advances highlight the potentials of telomerase-based therapeutics and warn of their pitfalls...
  17. ncbi request reprint Expression and suppression of human telomerase RNA
    S Li
    Department of Biochemistry and Biophysics, University of California, San Fransisco, California 94158 2517, USA
    Cold Spring Harb Symp Quant Biol 71:211-5. 2006
    ..Together with other results, these findings establish that the crucial elements of the hTER gene affecting RNA-processing efficiency to produce the mature hTER RNA are the promoter and internal telomerase RNA-coding sequences...
  18. pmc Aspergillus nidulans maintains short telomeres throughout development
    A Bhattacharyya
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Nucleic Acids Res 25:1426-31. 1997
    ..We demonstrate that telomere length is remarkably stable in different cell types and at altered growth temperatures, suggesting a highly regulated mechanism for length control...
  19. pmc Shorter telomeres are associated with obesity and weight gain in the elderly
    O T Njajou
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Int J Obes (Lond) 36:1176-9. 2012
    ..Therefore, we set out to test the hypothesis that TL may be a risk factor for increased adiposity using data from a large population-based cohort study...
  20. pmc Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women
    A O'Donovan
    Department of Psychiatry, University of California San Francisco, 3333 California Street, Suite 465, Box 0848, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 23:446-9. 2009
    ..These findings suggest that dispositional pessimism may increase IL-6 and accelerate rate of telomere shortening. Mechanistic causal relationships between these parameters need to be investigated...
  21. pmc Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres
    Lifeng Xu
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 2200, USA
    Mol Cell 28:315-27. 2007
    ....
  22. pmc Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length
    Daniel L Levy
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Mol Cell Biol 24:10857-67. 2004
    ..We propose that a nucleation and spreading mechanism is involved in forming the higher-order telomere structure that regulates telomere length...
  23. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...
  24. ncbi request reprint Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    FEBS Lett 579:859-62. 2005
    ..The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here...
  25. ncbi request reprint Cell biology: Shaggy mouse tales
    Elizabeth H Blackburn
    Nature 436:922-3. 2005
  26. pmc ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
    Bradley A Stohr
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 2200, USA
    Cancer Res 68:5309-17. 2008
    ..Our results identify ATM as a key mediator of the MT-hTer-47A dysfunctional telomere response, even in cells lacking wild-type p53, and provide evidence that telomere fusions contribute to MT-hTer-47A cytotoxicity...
  27. ncbi request reprint Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006
    ..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
  28. ncbi request reprint Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells
    Amir Goldkorn
    Department of Internal Medicine, Division of Hematology and Oncology, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 66:5763-71. 2006
    ..Hence, the effects of MT-hTer/siRNA require a telomerase that is both catalytically competent to polymerize DNA and able to act on telomeres in cells...
  29. ncbi request reprint Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
    Elizabeth H Blackburn
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, MC 2200, San Francisco, California 94158 2517, USA
    Nat Med 12:1133-8. 2006
  30. ncbi request reprint Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA
    Mehdi Nosrati
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Department of Dermatology, University of California San Francisco Cancer Center, San Francisco, California 94115, USA
    Clin Cancer Res 10:4983-90. 2004
    ..To test ribozymes targeting mouse telomerase RNA (mTER) for suppression of the progression of B16-F10 murine melanoma metastases in vivo...
  31. ncbi request reprint Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    Simon W L Chan
    Department of Biochemistry and Biophysics, Box 2200, University of California, San Francisco, 94143, USA
    Mol Cell 11:1379-87. 2003
    ..Thus, telomerase and Tel1p function in telomere protection as well as in telomere elongation...
  32. ncbi request reprint Catalytically active human telomerase mutants with allele-specific biological properties
    Moses Kim
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143 2200, USA
    Exp Cell Res 288:277-87. 2003
    ..These results uncover further hTERT allele-specific phenotypes that uncouple telomerase activity, net telomere lengthening and life span extension...
  33. pmc Telomeres and telomerase
    Simon R W L Chan
    University of California, San Francisco, Biochemistry and Biophysics, Box 2200, San Francisco, CA 94143 2200, USA
    Philos Trans R Soc Lond B Biol Sci 359:109-21. 2004
    ..Telomerase acts to prevent such fusions. The molecular consequences of telomere failure, and the molecular contributors to telomere function, with an emphasis on telomerase, are discussed here...
  34. ncbi request reprint New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin
    Simon W L Chan
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, CA 94143 0448, USA
    Oncogene 21:553-63. 2002
    ....
  35. pmc A bulged stem tethers Est1p to telomerase RNA in budding yeast
    Anita G Seto
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 0215, USA
    Genes Dev 16:2800-12. 2002
    ..We propose that this RNA structure links the enzymatic core of telomerase with Est1p, thereby allowing Est1p to recruit or activate telomerase at the telomere...
  36. pmc Telomerase core components protect Candida telomeres from aberrant overhang accumulation
    Min Hsu
    Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:11682-7. 2007
    ..Altogether, our data support the notion that the Candida telomerase core components mediate a protective function through a mechanism that is independent of its catalytic activity...
  37. pmc Telomere length is paternally inherited and is associated with parental lifespan
    Omer T Njajou
    Department of Medicine and Institute of Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:12135-9. 2007
    ..Our data, which are based on one of the largest family studies of human TL, support a link between TL and aging and lifespan and suggest a strong genetic influence, possibly via an imprinting mechanism, on TL regulation...
  38. pmc A novel pseudoknot element is essential for the action of a yeast telomerase
    Yehuda Tzfati
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Genes Dev 17:1779-88. 2003
    ..We propose that such disruption of the pseudoknot, and potentially the predicted telomerase RNA conformation, affects polymerization to cause the observed shifts in template usage...
  39. pmc The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase
    Svetlana Makovets
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Genetics 178:245-57. 2008
    ....
  40. pmc Dynamics of telomeric DNA turnover in yeast
    Michael J McEachern
    Department of Genetics, Life Sciences Building, University of Georgia, Athens, Georgia 30602 7223, USA
    Genetics 160:63-73. 2002
    ..These results indicate that most DNA turnover in functionally normal telomeres is due to gradual replicative sequence loss and additions by telomerase but that there are other processes that also contribute to turnover...
  41. ncbi request reprint A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity
    Maria Isabel N Cano
    Department of Stomatology, University of California, San Francisco, California 94143 0422, USA
    J Biol Chem 277:896-906. 2002
    ..The molecular masses of the peptides showed no homologies with other proteins from trypanosomes or with any protein in the data bases screened...
  42. pmc A molecular switch underlies a human telomerase disease
    Luis R Comolli
    Departments of Pharmaceutical Chemistry and Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:16998-7003. 2002
    ..Phylogenetic covariation in the P2b and P3 sequences of 35 species provides a compelling set of "natural" compensatory base pairing changes supporting the existence of the crucial molecular switch...
  43. pmc The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    Shivani Nautiyal
    Department of Biochemistry, University of California, Box 0448, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:9316-21. 2002
    ..The telomerase deletion signature genes define new candidates for involvement in cellular responses to altered telomere structure or function...
  44. pmc A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase
    Hinh Ly
    Departments of Pathology Microbiology, and Immunology, and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Genes Dev 17:1078-83. 2003
    ..Such RNA-RNA interaction mirrors a known property of retroviral reverse transcriptases, which use homodimeric viral genomic RNA substrates...
  45. pmc Comprehensive structure-function analysis of the core domain of human telomerase RNA
    Hinh Ly
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 23:6849-56. 2003
    ..Additionally, we provide evidence that naturally occurring hTER sequence polymorphisms found in some patients with aplastic anemia can inhibit telomerase activity by disrupting critical structures within the hTER core domain...
  46. ncbi request reprint Lasker honors cell biologists, psychiatrist
    Bridget M Kuehn
    JAMA 296:1451-2. 2006
  47. ncbi request reprint Processive utilization of the human telomerase template: lack of a requirement for template switching
    Melissa A Rivera
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    J Biol Chem 279:53770-81. 2004
    ....
  48. ncbi request reprint Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    Shang Li
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 64:4833-40. 2004
    ..Hence, anti-wild-type-hTER short-interfering RNA and MT-hTers may act through distinct pathways and, particularly in combination, represent a promising approach to anticancer therapies...
  49. pmc Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions
    Svetlana Makovets
    University of California, San Francisco, Department of Biochemistry and Biophysics, San Francisco, California 94143 2200, USA
    Mol Cell Biol 24:4019-31. 2004
    ..The telomeric replication fork pause was specific to yeast telomeric sequence and was independent of the Sir and Rif proteins, major known components of yeast telomeric heterochromatin...
  50. pmc Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
    Lifeng Xu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Cell Biol 167:819-30. 2004
    ..In telophase, hRif1 localized to chromosomes, and in interphase, it was intranuclear. These results define a novel subcellular localization behavior for hRif1 during the cell cycle...
  51. ncbi request reprint Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
    Shang Li
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 280:23709-17. 2005
    ....
  52. pmc A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:14713-8. 2004
    ..These results, combined with previous studies on telomerase RNAs from other budding yeasts, vertebrates, and ciliates, define a minimal universal core for telomerase RNAs...
  53. pmc Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita
    Hinh Ly
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Blood 106:1246-52. 2005
    ....
  54. ncbi request reprint Tracking telomerase
    Carol W Greider
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Cell 116:S83-6, 1 p following S86. 2004
  55. pmc Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Genes Dev 18:387-96. 2004
    ..Hence, we propose that yPinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA...
  56. pmc Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 2200, USA
    Mol Biol Cell 15:1623-34. 2004
    ..These results suggest that mutant telomere sequences elicit a checkpoint that is genetically distinct from those activated by deletion of telomerase or DNA damage...
  57. pmc A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity
    Anita G Seto
    Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309 0215, USA
    RNA 9:1323-32. 2003
    ..In addition, the in vitro activity of the paired element mutant indicates that the RNA element has additional functions in enzyme processivity and in directing template usage by telomerase...
  58. pmc Genes and pathways downstream of telomerase in melanoma metastasis
    Sepideh Bagheri
    Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 103:11306-11. 2006
    ..These studies have important implications for understanding the mechanisms by which telomerase promotes tumor invasion and metastasis...
  59. pmc A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response
    Jeffrey J Seidel
    Department of Biochemistry and Biophysics, 600 16th Street, Room S316, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Mol Cell Biol 28:5736-46. 2008
    ..Together, these results define a conserved sequence motif within an otherwise poorly defined region of the Tel1/ATM kinase family proteins that is essential for normal Tel1 function in Saccharomyces cerevisiae...