Jason T Blackard

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women
    Jason T Blackard
    Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Clin Infect Dis 52:674-80. 2011
  2. pmc Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women
    Jason T Blackard
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Microbiol 48:4256-9. 2010
  3. pmc HIV variability in the liver and evidence of possible compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Ohio 45267, USA
    AIDS Res Hum Retroviruses 27:1117-26. 2011
  4. pmc Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Med Virol 84:242-52. 2012
  5. pmc Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women
    Peter D Dryer
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Antimicrob Chemother 64:945-8. 2009
  6. pmc Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Thyroid 23:863-70. 2013
  7. doi request reprint Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons
    Christina M Martin
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Med Virol 83:1142-50. 2011
  8. pmc Effects of HCV on basal and tat-induced HIV LTR activation
    Satarupa Sengupta
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e64956. 2013
  9. pmc Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens
    Kenneth E Sherman
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0595, USA
    J Infect Dis 201:712-9. 2010
  10. ncbi request reprint Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
    J Med Virol 86:1332-41. 2014

Detail Information

Publications26

  1. pmc HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women
    Jason T Blackard
    Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Clin Infect Dis 52:674-80. 2011
    ..FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women...
  2. pmc Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women
    Jason T Blackard
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Microbiol 48:4256-9. 2010
    ..Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication in vivo...
  3. pmc HIV variability in the liver and evidence of possible compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Ohio 45267, USA
    AIDS Res Hum Retroviruses 27:1117-26. 2011
    ..Possible compartmentalization may reflect tissue-specific selection pressures that drive viral adaptation to the liver microenvironment and may facilitate interactions with other hepatotropic viruses...
  4. pmc Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Med Virol 84:242-52. 2012
    ..Evidence of compartmentalization within a non-structural genomic region may suggest that viral adaptation to a unique extracellular microenvironment(s) may be required for efficient replication and could contribute to HCV persistence...
  5. pmc Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women
    Peter D Dryer
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Antimicrob Chemother 64:945-8. 2009
    ..In the current study, we assessed NS5B resistance mutations in treatment-naive individuals from a prospective natural history study of viral infections in women...
  6. pmc Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Thyroid 23:863-70. 2013
    ..To explore HCV-thyroid interactions at a cellular level, we evaluated whether a human thyroid cell line (ML1) could be infected productively with HCV in vitro...
  7. doi request reprint Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons
    Christina M Martin
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Med Virol 83:1142-50. 2011
    ..Recombination between HBV genotypes may represent an important evolutionary strategy that enhances overall pathogenic potential and/or alters the downstream effects of the HBV X protein...
  8. pmc Effects of HCV on basal and tat-induced HIV LTR activation
    Satarupa Sengupta
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e64956. 2013
    ..Such analyses are important to elucidate the mechanisms by which these viruses interact and could facilitate the development of more effective therapies to treat HIV/HCV co-infection...
  9. pmc Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens
    Kenneth E Sherman
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0595, USA
    J Infect Dis 201:712-9. 2010
    ..Interferon-based therapy response rates have been disappointingly low. Baseline HCV complexity and the relationship between complexity and viral kinetic parameters has not been well described in HCV/HIV-coinfected subjects...
  10. ncbi request reprint Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
    J Med Virol 86:1332-41. 2014
    ..J. Med. Virol. 86:1332-1341, 2014. © 2014 Wiley Periodicals, Inc. ..
  11. pmc Low-level HIV infection of hepatocytes
    Ling Kong
    Division of Digestive Diseases, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Virol J 9:157. 2012
    ..There are only limited data on whether HIV infection occurs within the liver; therefore, we explored early and late stages of the HIV life cycle in two hepatocyte cell lines--Huh7.5 and Huh7.5JFH1--as well as in primary human hepatocytes...
  12. pmc Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    J Infect Dis 195:1765-73. 2007
    ..It is provocative to speculate that extrahepatic HCV diversity may be an important determinant of treatment response and thus warrants additional study, particularly during HCV/HIV coinfection...
  13. pmc Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals
    Christina M Martin
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, OH 45267, USA
    Cytokine 47:194-8. 2009
    ....
  14. doi request reprint Immunological rebound after initiation of highly active antiretroviral therapy in treatment-naive patients
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    AIDS Res Hum Retroviruses 24:499-504. 2008
    ..Future studies of immunological rebound are warranted to further define and characterize immune responses to HAART in diverse populations in order to optimize guidelines for initiation of treatment and assessment of successful responses...
  15. pmc Acute hepatitis C virus infection: a chronic problem
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Hepatology 47:321-31. 2008
  16. pmc Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Virol 46:140-4. 2009
    ..In Egypt, HEV seroprevalence is among the highest in the world; however, only a very limited number of Egyptian HEV sequences are currently available...
  17. pmc Interferon alpha treatment and thyroid dysfunction
    Yaron Tomer
    Division of Endocrinology, Cincinnati VA Medical Center, USA
    Endocrinol Metab Clin North Am 36:1051-66; x-xi. 2007
    ..This article reviews the epidemiology and clinical manifestations of IIT and the mechanisms causing IIT, focusing on the role of HCV...
  18. doi request reprint HCV superinfection and reinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, OH, USA
    Antivir Ther 17:1443-8. 2012
    ..In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies...
  19. pmc Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Virol 83:12925-33. 2009
    ..Our results suggest that the relative susceptibility of Treg to HIV infection compared to Teff varies, depending on both viral and host factors. These variations may play an important role in HIV pathogenesis...
  20. pmc HIV infection of hepatocytes results in a modest increase in hepatitis C virus expression in vitro
    Ling Kong
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e83728. 2014
    ..These findings suggest that HIV suppression may be a critical factor in controlling liver disease, particularly if the underlying liver disease is not treated. ..
  21. ncbi request reprint HIV compartmentalization: a review on a clinically important phenomenon
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Curr HIV Res 10:133-42. 2012
    ....
  22. ncbi request reprint Hepatitis C virus coinfection and superinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Infect Dis 195:519-24. 2007
    ....
  23. ncbi request reprint The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients
    Norah J Shire
    Division of Digestive Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Acquir Immune Defic Syndr 44:309-14. 2007
    ..Prevalence estimates vary widely. We determined the prevalence of occult HBV at the University of Cincinnati Infectious Diseases Center (IDC)...
  24. pmc Limited infection with occult hepatitis B virus in drug users in the USA
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Hepatol Res 43:413-7. 2013
    ....
  25. pmc HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity
    Nagako Akeno
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Autoimmun 31:339-44. 2008
    ....
  26. ncbi request reprint Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Hepatology 44:15-22. 2006
    ....