J T Blackard

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Interferon alpha treatment and thyroid dysfunction
    Yaron Tomer
    Division of Endocrinology, Cincinnati VA Medical Center, USA
    Endocrinol Metab Clin North Am 36:1051-66; x-xi. 2007
  2. pmc HIV variability in the liver and evidence of possible compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Ohio 45267, USA
    AIDS Res Hum Retroviruses 27:1117-26. 2011
  3. pmc Effects of HCV on basal and tat-induced HIV LTR activation
    Satarupa Sengupta
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e64956. 2013
  4. ncbi request reprint HIV infection of hepatocytes results in a modest increase in hepatitis C virus expression in vitro
    Ling Kong
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e83728. 2014
  5. pmc Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Thyroid 23:863-70. 2013
  6. pmc Low-level HIV infection of hepatocytes
    Ling Kong
    Division of Digestive Diseases, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Virol J 9:157. 2012
  7. doi request reprint HCV superinfection and reinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, OH, USA
    Antivir Ther 17:1443-8. 2012
  8. ncbi request reprint HIV compartmentalization: a review on a clinically important phenomenon
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Curr HIV Res 10:133-42. 2012
  9. pmc Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Virol 46:140-4. 2009
  10. pmc Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    J Infect Dis 195:1765-73. 2007

Collaborators

Detail Information

Publications41

  1. pmc Interferon alpha treatment and thyroid dysfunction
    Yaron Tomer
    Division of Endocrinology, Cincinnati VA Medical Center, USA
    Endocrinol Metab Clin North Am 36:1051-66; x-xi. 2007
    ..This article reviews the epidemiology and clinical manifestations of IIT and the mechanisms causing IIT, focusing on the role of HCV...
  2. pmc HIV variability in the liver and evidence of possible compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Ohio 45267, USA
    AIDS Res Hum Retroviruses 27:1117-26. 2011
    ..Possible compartmentalization may reflect tissue-specific selection pressures that drive viral adaptation to the liver microenvironment and may facilitate interactions with other hepatotropic viruses...
  3. pmc Effects of HCV on basal and tat-induced HIV LTR activation
    Satarupa Sengupta
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e64956. 2013
    ..Such analyses are important to elucidate the mechanisms by which these viruses interact and could facilitate the development of more effective therapies to treat HIV/HCV co-infection...
  4. ncbi request reprint HIV infection of hepatocytes results in a modest increase in hepatitis C virus expression in vitro
    Ling Kong
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e83728. 2014
    ..These findings suggest that HIV suppression may be a critical factor in controlling liver disease, particularly if the underlying liver disease is not treated. ..
  5. pmc Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Thyroid 23:863-70. 2013
    ..To explore HCV-thyroid interactions at a cellular level, we evaluated whether a human thyroid cell line (ML1) could be infected productively with HCV in vitro...
  6. pmc Low-level HIV infection of hepatocytes
    Ling Kong
    Division of Digestive Diseases, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Virol J 9:157. 2012
    ..There are only limited data on whether HIV infection occurs within the liver; therefore, we explored early and late stages of the HIV life cycle in two hepatocyte cell lines--Huh7.5 and Huh7.5JFH1--as well as in primary human hepatocytes...
  7. doi request reprint HCV superinfection and reinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, OH, USA
    Antivir Ther 17:1443-8. 2012
    ..In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies...
  8. ncbi request reprint HIV compartmentalization: a review on a clinically important phenomenon
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Curr HIV Res 10:133-42. 2012
    ....
  9. pmc Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Virol 46:140-4. 2009
    ..In Egypt, HEV seroprevalence is among the highest in the world; however, only a very limited number of Egyptian HEV sequences are currently available...
  10. pmc Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    J Infect Dis 195:1765-73. 2007
    ..It is provocative to speculate that extrahepatic HCV diversity may be an important determinant of treatment response and thus warrants additional study, particularly during HCV/HIV coinfection...
  11. pmc Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women
    Jason T Blackard
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Microbiol 48:4256-9. 2010
    ..Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication in vivo...
  12. pmc HCV/ HIV co-infection: time to re-evaluate the role of HIV in the liver?
    J T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Viral Hepat 15:323-30. 2008
    ..A comprehensive understanding of virus-virus and virus-cell interactions is critical to the development of novel treatment strategies to combat HCV/HIV co-infection...
  13. doi request reprint Immunological rebound after initiation of highly active antiretroviral therapy in treatment-naive patients
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    AIDS Res Hum Retroviruses 24:499-504. 2008
    ..Future studies of immunological rebound are warranted to further define and characterize immune responses to HAART in diverse populations in order to optimize guidelines for initiation of treatment and assessment of successful responses...
  14. pmc Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization
    Jason T Blackard
    Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Med Virol 84:242-52. 2012
    ..Evidence of compartmentalization within a non-structural genomic region may suggest that viral adaptation to a unique extracellular microenvironment(s) may be required for efficient replication and could contribute to HCV persistence...
  15. ncbi request reprint Hepatitis C virus coinfection and superinfection
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Infect Dis 195:519-24. 2007
    ....
  16. ncbi request reprint Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Hepatology 44:15-22. 2006
    ....
  17. pmc Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro
    C M Martin
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Viral Hepat 19:716-23. 2012
    ....
  18. ncbi request reprint Hepatitis C virus (HCV) diversity in HIV-HCV-coinfected subjects initiating highly active antiretroviral therapy
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 189:1472-81. 2004
    ..These data suggest that there are several mechanisms by which suppression of HIV replication and a reconstituted immune system influence diversity of HCV in HIV-HCV-coinfected subjects...
  19. ncbi request reprint Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 192:258-65. 2005
    ..These data suggest differential regulation of HCV RNA in the serum and PBMC compartments and may partially explain the limited HCV antiviral response rates observed in coinfected persons...
  20. pmc Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals
    C M Martin
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Viral Hepat 17:588-97. 2010
    ..Several of these O-HBV mutations likely contribute to the lack of detectable HBsAg in O-HBV infection by interfering with detection in serologic assays, altering antigen secretion and/or decreasing replicative fitness...
  21. pmc Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication
    Yoichi Hiasa
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 816, 55 Fruit Street, Boston, MA 02114, USA
    J Virol Methods 132:195-203. 2006
    ....
  22. pmc Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens
    Kenneth E Sherman
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0595, USA
    J Infect Dis 201:712-9. 2010
    ..Interferon-based therapy response rates have been disappointingly low. Baseline HCV complexity and the relationship between complexity and viral kinetic parameters has not been well described in HCV/HIV-coinfected subjects...
  23. ncbi request reprint The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients
    Norah J Shire
    Division of Digestive Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Acquir Immune Defic Syndr 44:309-14. 2007
    ..Prevalence estimates vary widely. We determined the prevalence of occult HBV at the University of Cincinnati Infectious Diseases Center (IDC)...
  24. pmc Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women
    Peter D Dryer
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Antimicrob Chemother 64:945-8. 2009
    ..In the current study, we assessed NS5B resistance mutations in treatment-naive individuals from a prospective natural history study of viral infections in women...
  25. pmc HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women
    Jason T Blackard
    Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Clin Infect Dis 52:674-80. 2011
    ..FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women...
  26. ncbi request reprint Intrahepatic cytokine expression is downregulated during HCV/HIV co-infection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Med Virol 78:202-7. 2006
    ..These data suggest that a defect in cytokine activation may occur in HCV/HIV co-infected persons that limits efficient clearance of HCV from the liver...
  27. ncbi request reprint HIV-1 LTR subtype and perinatal transmission
    J T Blackard
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Virology 287:261-5. 2001
    ..These differences in transmission were independent of maternal CD4 at enrollment. Thus, it appears that HIV-1 subtype may be associated with differing rates of perinatal transmission in Tanzania...
  28. pmc Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Virol 83:12925-33. 2009
    ..Our results suggest that the relative susceptibility of Treg to HIV infection compared to Teff varies, depending on both viral and host factors. These variations may play an important role in HIV pathogenesis...
  29. pmc Acute hepatitis C virus infection: a chronic problem
    Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Hepatology 47:321-31. 2008
  30. ncbi request reprint Analysis of the TCR beta variable gene repertoire in chimpanzees: identification of functional homologs to human pseudogenes
    Dirk Meyer-Olson
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 170:4161-9. 2003
    ..Our results predict that the diversity of TCR clonotypes responding to pathogens like HCV will be very similar in both species and will facilitate a molecular dissection of the immune response in chimpanzee models of human diseases...
  31. ncbi request reprint Effects of HCV treatment on cytokine expression during HCV/HIV coinfection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Interferon Cytokine Res 26:834-8. 2006
    ....
  32. ncbi request reprint Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences
    Jason T Blackard
    Research and Evaluation Department, Fenway Community Health, Boston, MA, 02115, USA
    Clin Infect Dis 34:1108-14. 2002
    ..The extent of superinfection and recombination in persons living with HIV is unknown. The implications of HIV superinfection and the generation of recombinant viruses are discussed...
  33. ncbi request reprint Viral factors associated with cytokine expression during HCV/HIV co-infection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Interferon Cytokine Res 27:263-9. 2007
    ..Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated...
  34. ncbi request reprint Hepatitis C virus expression suppresses interferon signaling by degrading STAT1
    Wenyu Lin
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Gastroenterology 128:1034-41. 2005
    ..We used an HCV cell-based expression model to examine the interaction between HCV protein expression and host type I IFN signaling components in the Jak-STAT kinase pathway...
  35. pmc Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Virol 80:9226-35. 2006
    ....
  36. pmc Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals
    Christina M Martin
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, OH 45267, USA
    Cytokine 47:194-8. 2009
    ....
  37. ncbi request reprint HIV superinfection in the era of increased sexual risk-taking
    Jason T Blackard
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Sex Transm Dis 31:201-4. 2004
    ....
  38. ncbi request reprint Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis
    Yoshitaka Kamegaya
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Hepatology 41:660-7. 2005
    ..The accelerated tumor phenotype is attributable to suppression of apoptosis rather than enhanced proliferation. These data implicate HCV E1 and/or E2 in conjunction with core as antiapoptotic, tumor accelerator proteins...
  39. pmc HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity
    Nagako Akeno
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Autoimmun 31:339-44. 2008
    ....
  40. ncbi request reprint GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype
    Carolynne Schwarze-Zander
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 194:410-9. 2006
    ..We therefore investigated (1) the prevalence and genotype of GBV-C in hepatitis C virus (HCV)/HIV-coinfected patients and (2) the impact of HCV treatment on GBV-C RNA clearance...
  41. ncbi request reprint Serum apoptosis markers in acute liver failure: a pilot study
    Anna E Rutherford
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 5:1477-83. 2007
    ..We sought to determine whether circulating apoptotic markers are altered in acute liver failure (ALF), differ with etiology, or predict clinical outcome in this condition...

Research Grants1

  1. Extrahepatic Replication and Viral Evolution of HCV During HCV/HIV Co-infection
    Jason Blackard; Fiscal Year: 2007
    ..This proposal will provide important data on co-factors of virus transmission and identify potential markers of HCV disease progression and treatment failure. ..