Lindsay Black

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Condensed genome structure
    Lindsay W Black
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    Adv Exp Med Biol 726:469-87. 2012
  2. pmc Structure and assembly of bacteriophage T4 head
    Venigalla B Rao
    Department of Biology, The Catholic University of America, Washington, DC, USA
    Virol J 7:356. 2010
  3. ncbi request reprint Mechanistic coupling of bacteriophage T4 DNA packaging to components of the replication-dependent late transcription machinery
    Lindsay W Black
    Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland 21201 1503, USA
    J Biol Chem 281:25635-43. 2006
  4. ncbi request reprint A bipartite bacteriophage T4 SOC and HOC randomized peptide display library: detection and analysis of phage T4 terminase (gp17) and late sigma factor (gp55) interaction
    Naglis Malys
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 319:289-304. 2002
  5. pmc Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target
    Dalin Rifat
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201 1503, USA
    J Mol Biol 375:720-34. 2008
  6. pmc Portal control of viral prohead expansion and DNA packaging
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Virology 391:44-50. 2009
  7. pmc Single-molecule and FRET fluorescence correlation spectroscopy analyses of phage DNA packaging: colocalization of packaged phage T4 DNA ends within the capsid
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    J Mol Biol 395:1102-13. 2010
  8. pmc Exclusion of glucosyl-hydroxymethylcytosine DNA containing bacteriophages is overcome by the injected protein inhibitor IPI*
    Catherine L Bair
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 366:779-89. 2007
  9. pmc DNA crunching by a viral packaging motor: Compression of a procapsid-portal stalled Y-DNA substrate
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    Virology 398:224-32. 2010
  10. pmc A type IV modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified DNAs
    Catherine L Bair
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 366:768-78. 2007

Research Grants

Collaborators

  • Krishanu Ray
  • Naglis Malys
  • Catherine L Bair
  • Richard G Baumann
  • Dalin Rifat
  • Venigalla B Rao
  • Chandran R Sabanayagam
  • David J Weber
  • Nathan T Wright
  • Kristen M Varney
  • Joseph R Lakowicz
  • Mark Oram
  • Julienne Mullaney

Detail Information

Publications13

  1. pmc Condensed genome structure
    Lindsay W Black
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    Adv Exp Med Biol 726:469-87. 2012
    ..Although no such single-phage condensed genome structure is known exactly, it is known that a single general structure is unlikely to apply to all such phages...
  2. pmc Structure and assembly of bacteriophage T4 head
    Venigalla B Rao
    Department of Biology, The Catholic University of America, Washington, DC, USA
    Virol J 7:356. 2010
    ..The current evidence suggests a mechanism in which electrostatic forces generated by ATP hydrolysis drive the DNA translocation by alternating the motor between tensed and relaxed states...
  3. ncbi request reprint Mechanistic coupling of bacteriophage T4 DNA packaging to components of the replication-dependent late transcription machinery
    Lindsay W Black
    Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland 21201 1503, USA
    J Biol Chem 281:25635-43. 2006
    ..The results suggest a close mechanistic connection in vivo between DNA packaging and developmentally concurrent replication-dependent late transcription...
  4. ncbi request reprint A bipartite bacteriophage T4 SOC and HOC randomized peptide display library: detection and analysis of phage T4 terminase (gp17) and late sigma factor (gp55) interaction
    Naglis Malys
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 319:289-304. 2002
    ..These results suggest that the T4 terminase interaction with T4 late sigma factor gp55 plays a role in DNA packaging in vivo. The gp55 interaction may function to load the terminase onto DNA for packaging...
  5. pmc Restriction endonuclease inhibitor IPI* of bacteriophage T4: a novel structure for a dedicated target
    Dalin Rifat
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201 1503, USA
    J Mol Biol 375:720-34. 2008
    ....
  6. pmc Portal control of viral prohead expansion and DNA packaging
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Virology 391:44-50. 2009
    ..These data suggest the portal controls the expansion of the major capsid protein lattice during prohead maturation, and that this expansion is necessary for DNA protection but not for packaging...
  7. pmc Single-molecule and FRET fluorescence correlation spectroscopy analyses of phage DNA packaging: colocalization of packaged phage T4 DNA ends within the capsid
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    J Mol Biol 395:1102-13. 2010
    ..The analysis suggests that a DNA loop, rather than a DNA end, is translocated by the packaging motor to fill the procapsid...
  8. pmc Exclusion of glucosyl-hydroxymethylcytosine DNA containing bacteriophages is overcome by the injected protein inhibitor IPI*
    Catherine L Bair
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 366:779-89. 2007
    ....
  9. pmc DNA crunching by a viral packaging motor: Compression of a procapsid-portal stalled Y-DNA substrate
    Krishanu Ray
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    Virology 398:224-32. 2010
    ..Torsional compression of duplex DNA is thus implicated in the mechanism of DNA translocation...
  10. pmc A type IV modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified DNAs
    Catherine L Bair
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201 1503, USA
    J Mol Biol 366:768-78. 2007
    ..IPI* thus represents a third generation bacteriophage defense against restriction nucleases of the Gmr type...
  11. ncbi request reprint Isolation and characterization of T4 bacteriophage gp17 terminase, a large subunit multimer with enhanced ATPase activity
    Richard G Baumann
    Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland 21201 1503, USA
    J Biol Chem 278:4618-27. 2003
    ....
  12. ncbi request reprint Portal fusion protein constraints on function in DNA packaging of bacteriophage T4
    Richard G Baumann
    USNA, Department of Chemistry, Mailstop 9B, 572 Holloway Road, Annapolis, MD 21402 5070, USA
    Mol Microbiol 61:16-32. 2006
    ....
  13. pmc Viral DNA packaging studied by fluorescence correlation spectroscopy
    Chandran R Sabanayagam
    Biophys J 93:L17-9. 2007
    ..Without ATP, no packaging was observed, and there was no evidence of substrate association with the prohead...

Research Grants20

  1. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 2001
    ....
  2. Phase T4 Head Assembly and Initiation of Infection
    Lindsay Black; Fiscal Year: 2007
    ..Evolutionary expansion and polymorphism of IPI locus genes among the T-even phages likely correspond to polymorphism of HmC adducts as specific targets for this type of previously undiscovered restriction endonuclease. ..
  3. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 2009
    ..Finally, understanding viral packaging has an important bearing on the mechanism of closely related enzymes of importance to fundamental DNA processes, e.g. helicases and NTP driven DNA translocating restriction endonucleases. ..
  4. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 1980
    ..These experiments have lead to a model for DNA packaging: that DNA is actively packaged by an enzymatic mechanism through proteins situated at the apex of the head which pump the DNA into the head by inducing torsion in the DNA molecule...
  5. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay W Black; Fiscal Year: 2010
    ..Finally, understanding viral packaging has an important bearing on the mechanism of closely related enzymes of importance to fundamental DNA processes, e.g. helicases and NTP driven DNA translocating restriction endonucleases. ..