Affiliation: University of California
Yeom K, Mitchell S, Linares A, Zheng S, Lin C, Wang X, et al
. Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proc Natl Acad Sci U S A. 2018;115:E11061-E11070 pubmed publisher
..Notably, induction of neuronal differentiation observed upon PTBP1 knockdown likely results from direct derepression of miR-124, in addition to indirect effects previously described. ..
Vuong C, Wei W, Lee J, Lin C, Damianov A, de la Torre Ubieta L, et al
. Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1. Neuron. 2018;98:127-141.e7 pubmed publisher
..The regulation of interneuron-specific Vamp1 by Rbfox1 provides a paradigm for broadly expressed RNA-binding proteins performing specialized functions in defined neuronal subtypes. ..
Ying Y, Wang X, Vuong C, Lin C, Damianov A, Black D. Splicing Activation by Rbfox Requires Self-Aggregation through Its Tyrosine-Rich Domain. Cell. 2017;170:312-323.e10 pubmed publisher
..Rather than simple recruitment of individual regulators to a target exon, alternative splicing choices also depend on the higher-order assembly of these regulators within the nucleus. ..
Damianov A, Ying Y, Lin C, Lee J, Tran D, Vashisht A, et al
. Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR. Cell. 2016;165:606-19 pubmed publisher
..The function of this multimeric LASR complex has implications for deciphering the regulatory codes controlling splicing networks. ..
Vuong J, Lin C, Zhang M, Chen L, Black D, Zheng S. PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing. Cell Rep. 2016;17:2766-2775 pubmed publisher
..Nevertheless, the two paralogs displayed similar RNA binding across the transcriptome, indicating that their differential targeting does not derive from their RNA interactions, but from possible different cofactor interactions. ..