K B Bjugstad

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
  2. ncbi Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity
    K B Bjugstad
    Department Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Inherit Metab Dis 29:612-9. 2006
  3. ncbi Biocompatibility of PEG-based hydrogels in primate brain
    K B Bjugstad
    Department Pediatrics, University Colorado Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell Transplant 17:409-15. 2008
  4. ncbi Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
  5. ncbi Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF
    D E Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 515:31-40. 2009
  6. ncbi Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate
    J R Sladek
    Department of Pediatrics, The University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Transplant 17:427-44. 2008
  7. ncbi AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Exp Neurol 211:252-8. 2008
  8. ncbi Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time
    K B Bjugstad
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
    J Biomed Mater Res A 95:79-91. 2010
  9. ncbi IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures
    K B Bjugstad
    Division of Clinical Pharmacology and Toxicology, University of Colorado Health Science Center, Denver, Colorado, USA
    J Inherit Metab Dis 24:631-47. 2001
  10. ncbi Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007

Research Grants

  1. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2007

Detail Information

Publications14

  1. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
    ..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
  2. ncbi Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity
    K B Bjugstad
    Department Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Inherit Metab Dis 29:612-9. 2006
    ..Increased sensitivity to 3NP early in life may model the developmental window for the striatal damage observed in human GA I...
  3. ncbi Biocompatibility of PEG-based hydrogels in primate brain
    K B Bjugstad
    Department Pediatrics, University Colorado Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell Transplant 17:409-15. 2008
    ....
  4. ncbi Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
    ..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
  5. ncbi Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF
    D E Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 515:31-40. 2009
    ....
  6. ncbi Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate
    J R Sladek
    Department of Pediatrics, The University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Transplant 17:427-44. 2008
    ..Further study will assess the degree to which this approach can be used to restore motor balance in the nonhuman primate following neural transplantation...
  7. ncbi AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Exp Neurol 211:252-8. 2008
    ..Thus, the addition of GDNF gene therapy to neural transplantation may be a useful strategy to improve treatment for Parkinson's disease...
  8. ncbi Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time
    K B Bjugstad
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
    J Biomed Mater Res A 95:79-91. 2010
    ....
  9. ncbi IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures
    K B Bjugstad
    Division of Clinical Pharmacology and Toxicology, University of Colorado Health Science Center, Denver, Colorado, USA
    J Inherit Metab Dis 24:631-47. 2001
    ..Striatal neurons were rescued from death by bFGF and IGF-1 but not by glutamate antagonist, suggesting that toxicity in this embryonic system is not necessarily mediated by glutamate receptors...
  10. ncbi Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  11. ncbi Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice
    D S Kern
    Department of Pediatrics, University of Colorado Denver, 12800 E 19th Avenue, Aurora, CO 80045, USA
    Cell Transplant 20:371-9. 2011
    ..Lastly, it is speculated that the unique abilities of NSC to migrate and express growth factors might be a contributing factor to reducing tau/reelin accumulation in aging DS and AD...
  12. ncbi Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial
    Cynthia McRae
    College of Education, University of Denver, Denver, CO 80208, USA
    Arch Gen Psychiatry 61:412-20. 2004
    ..This portion of the study investigated the quality of life (QOL) of participants during the 1 year of double-blind follow-up...
  13. ncbi Intracerebroventricular infusions of gp120 inhibit weight gain and induce atrophy in the hippocampus and neostriatum without affecting cognition
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO, USA
    J NeuroAIDS 2:15-31. 2004
    ..Thus, gp120 alone can cause ADC-related neuropathologic and weight changes, but gp120 alone was not sufficient to induce impairments in spatial learning and memory...
  14. ncbi Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats
    Lone M Veng
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Cell Transplant 11:5-16. 2002
    ..Our results show that MHC class II-deficient xenografts survive transplantation for at least 6 weeks in the absence of immunosuppression, reduce rotational asymmetry, and provoke lesser immune reaction than wt grafts...

Research Grants3

  1. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2007
    ..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. ..