N H Bishopric

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi Evolution of the heart from bacteria to man
    Nanette H Bishopric
    Department of Molecular and Cellular Pharmacology, University of Miami, Miami, Florida 33101, USA
    Ann N Y Acad Sci 1047:13-29. 2005
  2. ncbi Molecular mechanisms of apoptosis in the cardiac myocyte
    N H Bishopric
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Curr Opin Pharmacol 1:141-50. 2001
  3. ncbi Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis
    P Andreka
    Department of Molecular and Cellular Pharmacology, University of Miami, FL, USA
    Circ Res 88:305-12. 2001
  4. ncbi Oxidation of zinc finger transcription factors: physiological consequences
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, FL 33136, USA
    Antioxid Redox Signal 3:535-48. 2001
  5. ncbi Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP
    K Yamashita
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, Florida 33149, USA
    J Biol Chem 276:12645-53. 2001
  6. ncbi Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1
    K Yamashita
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, Florida, USA
    Circ Res 88:609-14. 2001
  7. ncbi Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Florida 33136, USA
    J Clin Invest 104:239-52. 1999
  8. ncbi Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D
    T I Slepak
    Department of Molecular and Cellular Pharmacology, University of Miami, Florida 33101, USA
    J Biol Chem 276:7575-85. 2001
  9. ncbi Molecular aspects and gene therapy prospects for diastolic failure
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Florida, USA
    Cardiol Clin 18:621-35. 2000
  10. ncbi Nitric oxide and promotion of cardiac myocyte apoptosis
    Peter Andreka
    Semmelweis University Faculty of Medicine, 2nd Department of Medicine, Budapest, Hungary
    Mol Cell Biochem 263:35-53. 2004

Collaborators

  • K A Webster
  • J Kajstura
  • P Anversa
  • Mark S Turner
  • Nambi Aiyar
  • Regina M Graham
  • Donna P Frazier
  • Peter Andreka
  • Christopher J Dougherty
  • Jian Qin Wei
  • Lori A Kubasiak
  • John W Thompson
  • Huifang Li
  • K Yamashita
  • Robert J Myerburg
  • James J Ley
  • Todd E Miller
  • Thanh H Tran
  • T I Slepak
  • Amber Wilson
  • J Zang
  • P Andreka
  • D J Discher
  • David A Becker
  • Tatiana I Slepak
  • James M Mitrani
  • Ricardo Prado
  • Lina A Shehadeh
  • Myron D Ginsberg
  • Monica Pessanha
  • Paul J Benke
  • Lijing You
  • Jianqin Wei
  • Claudia O Rodrigues
  • Wen Cheng Xiong
  • Thanh Tran
  • Wen-Cheng Xiong
  • Shannon Haliko
  • Bernard J Wasserlauf
  • Maria-Grazia Spiga
  • Leslie C Olson
  • Olga M Hernandez
  • Eliot H Ohlstein
  • Howard Prentice
  • J Hu
  • B J Wasserlauf
  • M N Hicks
  • A O'Dowd
  • C Dougherty
  • H Prentice

Detail Information

Publications32

  1. ncbi Evolution of the heart from bacteria to man
    Nanette H Bishopric
    Department of Molecular and Cellular Pharmacology, University of Miami, Miami, Florida 33101, USA
    Ann N Y Acad Sci 1047:13-29. 2005
    ....
  2. ncbi Molecular mechanisms of apoptosis in the cardiac myocyte
    N H Bishopric
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Curr Opin Pharmacol 1:141-50. 2001
    ....
  3. ncbi Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis
    P Andreka
    Department of Molecular and Cellular Pharmacology, University of Miami, FL, USA
    Circ Res 88:305-12. 2001
    ..Early, transient activation of JNK serves both to delay and to reduce the total extent of apoptosis in cardiac myocytes...
  4. ncbi Oxidation of zinc finger transcription factors: physiological consequences
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, FL 33136, USA
    Antioxid Redox Signal 3:535-48. 2001
    ....
  5. ncbi Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP
    K Yamashita
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, Florida 33149, USA
    J Biol Chem 276:12645-53. 2001
    ..The results support essential roles for AP-1, GATA-2, and NF-1 in stabilizing the binding of HIF-1 and promoting recruitment of p300/CBP to the ET-1 hypoxia response complex...
  6. ncbi Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1
    K Yamashita
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, Florida, USA
    Circ Res 88:609-14. 2001
    ..These results demonstrate that Akt phosphorylation during I/R is modulated by IGF-1 and prevents apoptosis in hearts that overexpress the IGF-1 transgene...
  7. ncbi Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Florida 33136, USA
    J Clin Invest 104:239-52. 1999
    ..We conclude that acidosis, reoxygenation, and reperfusion, but not hypoxia (or ischemia) alone, are strong stimuli for programmed cell death that is substantially independent of p53...
  8. ncbi Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D
    T I Slepak
    Department of Molecular and Cellular Pharmacology, University of Miami, Florida 33101, USA
    J Biol Chem 276:7575-85. 2001
    ..These results show that, in the intact cell, p300 interactions with its protein targets are highly selective and that MEF-2D is the preferred channel for p300-mediated transcriptional control in the heart...
  9. ncbi Molecular aspects and gene therapy prospects for diastolic failure
    K A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Florida, USA
    Cardiol Clin 18:621-35. 2000
    ..Such techniques may involve modifying the phosphorylation sites in vitro and replacing wild type proteins in the failing heart with the modified forms, again using regulated AAV vectors for gene delivery...
  10. ncbi Nitric oxide and promotion of cardiac myocyte apoptosis
    Peter Andreka
    Semmelweis University Faculty of Medicine, 2nd Department of Medicine, Budapest, Hungary
    Mol Cell Biochem 263:35-53. 2004
    ..We will also review evidence implicating NO in the pathophysiology of heart failure, in the context of the extensive and sometimes contradictory body of research on NO and cell survival...
  11. ncbi BNip3 and signal-specific programmed death in the heart
    Keith A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, 1600 NW 10th Avenue, RMSB 6038, Miami, FL 33136, USA
    J Mol Cell Cardiol 38:35-45. 2005
    ..The sequential induction and activation of BNip3 by hypoxia and acidosis provide a molecular basis for the observation that chronic hypoxia at neutral pH does not promote apoptosis or activate caspases in neonatal cardiac myocytes...
  12. ncbi Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3
    Donna P Frazier
    Department of Pharmacology and the Vascular Biology Institute, University of Miami Medical Center, Florida 33136, USA
    Antioxid Redox Signal 8:1625-34. 2006
    ..These results demonstrate a pH-sensitive shift in the stability and apparent hydrophobicity of Bnip3 monomers that correlates closely with membrane binding and function...
  13. ncbi Redox stress and the contributions of BH3-only proteins to infarction
    Keith A Webster
    Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute, University of Miami Medical Center, Florida 33395, USA
    Antioxid Redox Signal 8:1667-76. 2006
    ..Here we review the evidence for these cell-death pathways and discuss their relevance to ischemic disease and infarction...
  14. ncbi PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation
    Donna P Frazier
    Department of Molecular and Cellular Pharmacology, Vascular Biology Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Heart Circ Physiol 292:H1675-84. 2007
    ..These results identify two new components, PKC and TAK-1, that have not been previously described in this signaling pathway...
  15. ncbi Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation
    Regina M Graham
    Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Antioxid Redox Signal 9:1309-15. 2007
    ..Elevated levels of the phosphoprotein correlated with initiation of Bnip3-dependent death, whereas the dephosphorylated species correlated with extreme acidosis...
  16. ncbi A unique pathway of cardiac myocyte death caused by hypoxia-acidosis
    Regina M Graham
    Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute, University of Miami Medical Center, Miami, FL 33101, USA
    J Exp Biol 207:3189-200. 2004
    ..The article also contains new evidence that chronic hypoxia at neutral pH does not promote apoptosis or activate caspases in neonatal cardiac myocytes...
  17. ncbi Apoptosis inhibitors for heart disease
    Keith A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, 1600 NW 10th Avenue, RMSB 6038, Miami, Fla 33136, USA
    Circulation 108:2954-6. 2003
  18. ncbi Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300
    Jian Qin Wei
    University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology, Miami, FL, USA
    Circulation 118:934-46. 2008
    ..However, the importance of p300 in the modulation of cardiac growth in vivo is unknown...
  19. ncbi Transplantation of stem cells to the heart:
    Robert J Myerburg
    J Cardiovasc Electrophysiol 14:849-50. 2003
  20. ncbi Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
    Lori A Kubasiak
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 99:12825-30. 2002
    ..Overexpression of wild-type BNIP3, but not a translocation-defective mutant, activated cardiac myocyte death only when the myocytes were acidic. This pathway may figure significantly in muscle loss during myocardial ischemia...
  21. ncbi Angiotensin signaling and apoptosis in the neonatal heart: necessary evils?
    Nanette H Bishopric
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, PO Box 016189 R 189, Miami, FL 33101, USA
    Pediatr Res 52:322-4. 2002
  22. ncbi Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress
    Christopher J Dougherty
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, 1600 NW 10th Avenue, RMSB 6038, Miami, FL 33136, U.S.A
    Biochem J 362:561-71. 2002
    ..The results suggest that JNK activation is protective and that the pathway is largely independent of p38 MAPK or secreted TNFalpha...
  23. ncbi Mesenchymal stem cell-derived IL-10 and recovery from infarction: a third pitch for the chord
    Nanette H Bishopric
    Circ Res 103:125-7. 2008
  24. ncbi Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injury
    James J Ley
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33101, United States
    Biochem Pharmacol 75:448-56. 2008
    ....
  25. ncbi Jun kinase delays caspase-9 activation by interaction with the apoptosome
    Thanh H Tran
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Biol Chem 282:20340-50. 2007
    ..We propose that this interaction delays formation of the active apoptosome, promoting cell survival during short bursts of oxidative stress...
  26. ncbi Whole blood RNA offers a rapid, comprehensive approach to genetic diagnosis of cardiovascular diseases
    Todd E Miller
    Department of Medicine, Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Genet Med 9:23-33. 2007
    ..Genetic testing for these disorders is labor-intensive and expensive. We sought to develop a more rapid, comprehensive, and cost-effective approach...
  27. ncbi Bucindolol displays intrinsic sympathomimetic activity in human myocardium
    Peter Andreka
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33101, USA
    Circulation 105:2429-34. 2002
    ..Bucindolol has partial agonist properties in rat myocardium, but whether it has agonist activity in human heart is controversial. To address this, we measured the ability of bucindolol to increase cAMP accumulation in human myocardium...
  28. ncbi A thousand times NO
    Nanette H Bishopric
    J Mol Cell Cardiol 34:601-6. 2002
  29. ncbi Preventing apoptosis with thioredoxin: ASK me how
    Nanette H Bishopric
    Circ Res 90:1237-9. 2002
  30. ncbi Gene and cell therapy for heart disease
    Regina M Graham
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Florida 33136, USA
    IUBMB Life 54:59-66. 2002
    ....
  31. ncbi Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels
    Mark S Turner
    Department of Molecular and Cellular Pharmacology, University of Miami, Fla, USA
    Circ Res 95:726-33. 2004
    ..The role of this regulated phosphorylation in the adaptation to ischemia remains to be determined...
  32. ncbi Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation
    Christopher J Dougherty
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    FASEB J 18:1060-70. 2004
    ..The signaling pathway is unique for the reoxygenation stimulus and provides a framework for other non-receptor-mediated pathways of MAPK activation...