GAIL BISHOP

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc A novel polymorphism of the human CD40 receptor with enhanced function
    Anna L Peters
    Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Blood 112:1863-71. 2008
  2. pmc Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Exp Med 199:661-71. 2004
  3. pmc CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation
    Tony J Vanden Bush
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e19468. 2011
  4. pmc Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1
    Kelly M Arcipowski
    Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e42478. 2012
  5. pmc TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells
    Zuoan Yi
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 210:1079-86. 2013
  6. pmc Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
    K D Brown
    Medical Scientist Training Program, University of Iowa, Iowa City 52242, USA
    J Exp Med 193:943-54. 2001
  7. ncbi request reprint Antigen-specific B-lymphocyte activation
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Crit Rev Immunol 23:149-97. 2003
  8. ncbi request reprint The multifaceted roles of TRAFs in the regulation of B-cell function
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Nat Rev Immunol 4:775-86. 2004
  9. ncbi request reprint Multiple roles of TRAF3 signaling in lymphocyte function
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Res 39:22-32. 2007
  10. ncbi request reprint The CD40-CD154 interaction in B cell-T cell liaisons
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cytokine Growth Factor Rev 14:297-309. 2003

Collaborators

  • Thomas J Waldschmidt
  • Kevin D Brown
  • Bruce S Hostager
  • Ping Xie
  • Hai Hui Xue
  • Kathryn R Ely
  • CARLOS SUBAUSTE
  • John Harty
  • M R Gold
  • J C Reed
  • J L Arbiser
  • Melissa E Munroe
  • Tony J Vanden Bush
  • Sokol A Haxhinasto
  • Laura L Stunz
  • Zuoan Yi
  • Kelly M Arcipowski
  • Anna L Peters
  • Riad M Rahhal
  • Sarah L Rowland
  • Rebecca J Benson
  • Lata Mukundan
  • ShuangDing Wu
  • Rosa M Andrade
  • Carissa R Moore
  • Yelena A Barabanova
  • Mekhine Baccam
  • Nongliao Zhu
  • L K Busch
  • I M Catlett
  • Kathy L Moser
  • Patrick M Gaffney
  • Robert M Plenge
  • David M Altshuler
  • Robert R Graham
  • Michael A Apicella
  • Jason M Ellison
  • Molly K McLendon
  • Mikaela M Tremblay
  • Joan E Durbin
  • Jill Suttles
  • Chao Zhou Ni
  • Larry M Wahl
  • Arnold C Satterthwait
  • Lihua Zhang
  • Jun Qi Yang
  • Chenglong Li
  • Matthew Wessendarp
  • Xiuwen Zhu
  • Francisco J Gomez
  • Kimberly Z Head
  • Jose Andres C Portillo
  • Kate Welsh
  • Bongsu Kang
  • Curt D Sigmund
  • Lisa K Busch
  • Jinjong Myoung
  • Lorraine T Tygrett
  • Hee Kap Kang
  • Byung S Kim
  • Charles Vinson
  • So Youn Woo
  • Nancy S Magnuson
  • Rosaline L Lee
  • Luis M Ramirez
  • J A Harton
  • W Litaker
  • J A Frelinger

Detail Information

Publications52

  1. pmc A novel polymorphism of the human CD40 receptor with enhanced function
    Anna L Peters
    Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Blood 112:1863-71. 2008
    ..We have thus identified a novel genetic variant of hCD40 with a gain-of-function immune phenotype...
  2. pmc Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Exp Med 199:661-71. 2004
    ..Our data reveal that CD40 and LMP1 unexpectedly use TRAF3 in different ways, and that TRAF3 is required for LMP1-mediated activation of B cells...
  3. pmc CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation
    Tony J Vanden Bush
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e19468. 2011
    ..These findings point to additional roles of CDKs in cell signaling and reveal potential implications for therapeutic manipulations of this kinase pathway...
  4. pmc Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1
    Kelly M Arcipowski
    Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e42478. 2012
    ..This mode of regulation was not observed for LMP1 and may contribute to the dysregulation of LMP1 compared to CD40 signals...
  5. pmc TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells
    Zuoan Yi
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 210:1079-86. 2013
    ..Collectively, our results reveal that by modulating the relative strength of TCR signaling, TRAF3 is an important regulator of iNKT cell development and functions...
  6. pmc Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
    K D Brown
    Medical Scientist Training Program, University of Iowa, Iowa City 52242, USA
    J Exp Med 193:943-54. 2001
    ..This suggests that LMP1 utilizes a modified CD40 signaling pathway. Failure to regulate TRAFs may contribute to the enhanced capacity of LMP1 to activate B cells as well as promote B cell transformation...
  7. ncbi request reprint Antigen-specific B-lymphocyte activation
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Crit Rev Immunol 23:149-97. 2003
    ..This review seeks to summarize these components, and to highlight recent advances in each area that contribute to a greater understanding of the complex processes involved in B-cell activation...
  8. ncbi request reprint The multifaceted roles of TRAFs in the regulation of B-cell function
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Nat Rev Immunol 4:775-86. 2004
    ..These include activation of kinases and transcription factors, and interactions with other signalling proteins, culminating in the induction or inhibition of biological functions...
  9. ncbi request reprint Multiple roles of TRAF3 signaling in lymphocyte function
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Res 39:22-32. 2007
    ..TRAF3 is also important for signaling via innate immune receptors, as well as an oncogenic mimic of a normal receptor that is implicated in promoting both malignancies and autoimmunity...
  10. ncbi request reprint The CD40-CD154 interaction in B cell-T cell liaisons
    Gail A Bishop
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cytokine Growth Factor Rev 14:297-309. 2003
    ..Understanding both the biological effects of this receptor-ligand interaction, as well as how CD40 signaling pathways are controlled, adds to our detailed picture of the complex interplay between B and T cells...
  11. ncbi request reprint Immunology at the University of Iowa
    Gail A Bishop
    Interdisciplinary Graduate Program in Immunology, The University of Iowa, Iowa City, IA, USA
    Immunol Res 39:1-3. 2007
  12. pmc Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, USA
    J Leukoc Biol 90:1149-57. 2011
    ..Additionally, TRAF3(-/-) B cells displayed enhanced TLR-mediated expression of AID and Ig isotype switching. Thus, TRAF3 plays varied and cell type-specific, biological roles in TLR responses...
  13. ncbi request reprint Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes
    Gail A Bishop
    Department of Microbiology, 3 570 Bowen Science Building, The University of Iowa, Iowa City, IA 52242, USA
    J Leukoc Biol 72:19-23. 2002
    ..For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview...
  14. ncbi request reprint Molecular mechanisms of B-lymphocyte transformation by Epstein-Barr virus
    Gail A Bishop
    Department of Microbiology, 3 570 Bowen Science Bldg, The University of Iowa, Iowa City, IA 52242, USA
    Microbes Infect 4:853-7. 2002
    ..This review provides a brief overview of the EBV-encoded proteins involved in B-cell transformation, and the current state of knowledge about their roles in this process...
  15. ncbi request reprint TRAF proteins in CD40 signaling
    Gail A Bishop
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA
    Adv Exp Med Biol 597:131-51. 2007
    ..This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions...
  16. ncbi request reprint Molecular mechanisms of CD40 signaling
    G A Bishop
    Department of Microbiology, The University of Iowa, Iowa City 52240, USA
    Arch Immunol Ther Exp (Warsz) 49:129-37. 2001
    ..This review will summarize the known important biological roles of CD40, and discuss what is currently known about how CD40 signals...
  17. ncbi request reprint B lymphocyte activation by contact-mediated interactions with T lymphocytes
    G A Bishop
    Departments of Microbiology and Internal Medicine, 3 501 Bowen Science Building, The University of Iowa, and VA Medical Center, 52242, Iowa City, IA, USA
    Curr Opin Immunol 13:278-85. 2001
    ..Recently, advances have been made both in understanding how these various signals regulate B cell effector functions and in identifying many new receptor-ligand pairs that contribute to the regulation of B cell function by T lymphocytes...
  18. ncbi request reprint Signaling by CD40 and its mimics in B cell activation
    G A Bishop
    Dept of Microbiology, The University of Iowa, Iowa City 52242, USA
    Immunol Res 24:97-109. 2001
    ..CD40-mediated B cell activation is mimicked by several biological response modifiers, as well as by a viral oncoprotein encoded by the Epstein-Barr virus (EBV)...
  19. ncbi request reprint The immune response modifier resiquimod mimics CD40-induced B cell activation
    G A Bishop
    Department of Microbiology, VA Medical Center, Iowa City, Iowa 52242, USA
    Cell Immunol 208:9-17. 2001
    ..In addition, it shows synergy with signals delivered by the B cell antigen receptor and heightens CD40-mediated B cell activation, demonstrating that resiquimod can enhance antigen-specific responses in B lymphocytes...
  20. ncbi request reprint Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    G A Bishop
    Department of Microbiology, Graduate Program in Immunology, and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 165:5552-7. 2000
    ..Both signals were partially dependent upon induction of TNF-alpha and IL-6, and the cytoplasmic adaptor molecule TNF receptor-associated factor 2 is involved in both R-848- and CD40-mediated differentiation...
  21. ncbi request reprint Multiple carboxyl-terminal regions of the EBV oncoprotein, latent membrane protein 1, cooperatively regulate signaling to B lymphocytes via TNF receptor-associated factor (TRAF)-dependent and TRAF-independent mechanisms
    L K Busch
    Molecular Biology Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 167:5805-13. 2001
    ..Furthermore, we find that the function of CTAR1, but not CTAR2, correlates with TRAF binding and present evidence that as yet unidentified cytoplasmic proteins may associate with LMP1 to mediate some of its signaling activities...
  22. ncbi request reprint Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling
    B S Hostager
    Departments of Microbiology and Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:15392-8. 2000
    ....
  23. ncbi request reprint Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation
    B S Hostager
    Department of Microbiology, University of Iowa, VA Medical Center, Iowa City 52242, USA
    J Immunol 162:6307-11. 1999
    ..In contrast, TRAF2 appears to play a positive role in B cell differentiation, and this activity is apparent even when its binding site on CD40 is disrupted...
  24. ncbi request reprint Signaling through MHC class II molecules blocks CD95-induced apoptosis
    I M Catlett
    Department of Microbiology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Immunol 166:6019-24. 2001
    ..MHC class II ligation thus blocks proximal signaling events in the CD95-mediated apoptotic pathway...
  25. ncbi request reprint Structure function analysis of the H-2 Abp gene
    J A Harton
    Department of Microbiology, University of Iowa, Iowa City 52242
    Immunogenetics 34:358-65. 1991
    ..Comparison of the amino acid sequence with other A beta chains that have been tested in signal transduction experiments suggests that amino acid 9 may be important to the signaling ability of class II A molecules...
  26. pmc Roles of TRAF molecules in B lymphocyte function
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Cytokine Growth Factor Rev 19:199-207. 2008
    ..In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes...
  27. ncbi request reprint A costimulatory function for T cell CD40
    Melissa E Munroe
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 178:671-82. 2007
    ..These findings reveal potent biologic functions for T cell CD40 and suggest an additional means for amplification of autoimmune responses...
  28. ncbi request reprint Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes
    Riad M Rahhal
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Leukoc Biol 82:813-20. 2007
    ..Further investigation into the potential usefulness of F. tularensis LPS as an adjuvant component of a more optimal subunit vaccine is warranted, as it is now clear that it is not biologically inactive, as assumed previously...
  29. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
    ..These findings indicate that TRAF3 is a critical regulator of peripheral B cell homeostasis and may be implicated in the regulation of peripheral self-tolerance induction...
  30. pmc TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation
    Tony J Vanden Bush
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Eur J Immunol 38:400-9. 2008
    ..In addition, the dual stimulation increased cFos/AP-1 species in stimulated cells, effectively expanding the repertoire of AP-1 dimers as compared to singly stimulated B cells...
  31. pmc Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function
    Hai Hui Xue
    Department of Microbiology, University of Iowa, 51 Newton Road, BSB 3 710, Iowa City, IA 52246, USA
    Mol Cell Biol 28:4300-9. 2008
    ..Our findings argue against such a possibility and rather suggest that GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex...
  32. ncbi request reprint Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K
    Rebecca J Benson
    Medical Scientist Training Program and Immunology Graduate Program, University of Iowa and Veterans Affairs Medical Center, Iowa City 52245, USA
    Eur J Immunol 36:2535-43. 2006
    ..In contrast, CD40 rescue was completely abrogated in TRAF6-deficient B cells, which showed reduced activation of Akt in response to CD40 engagement. These results reveal a new rapid mechanism to balance B cell activation and apoptosis...
  33. ncbi request reprint Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 176:5388-400. 2006
    ....
  34. ncbi request reprint Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture
    Laura L Stunz
    Department of Microbiology, Univeristy of Iowa, Iowa City, Iowa 52242, USA
    Immunity 21:255-66. 2004
    ..Thus, signaling through the LMP1 cytoplasmic tail results in amplified and abnormal mimicry of CD40 functions in vivo, indicating possible ways in which LMP1 contributes to the pathogenesis of EBV-associated human disease...
  35. ncbi request reprint Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling
    Bruce S Hostager
    Department of Pediatrics, Interdisciplinary Program in Immunology, University of Iowa, Iowa City 52242, USA
    J Biol Chem 278:45382-90. 2003
    ..These findings demonstrate previously unappreciated roles for TRAF2 in signaling by TNF receptor family members, using an approach that facilitates the analysis of genes critical to the viability of whole organisms...
  36. ncbi request reprint CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP
    Mekhine Baccam
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:3099-108. 2003
    ..Furthermore, CD40 stimulation led to phosphorylation of c-Jun on its activation domain, implicating CD40-mediated Jun kinase activation in the transcriptional regulation of IL-6 production...
  37. ncbi request reprint A novel interaction between protein kinase D and TNF receptor-associated factor molecules regulates B cell receptor-CD40 synergy
    Sokol A Haxhinasto
    Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:4655-62. 2003
    ..Interestingly, the role of PKD was dependent upon the association of CD40 with TRAF2, and was inhibited by the binding of TRAF3, revealing a novel functional link between these two classes of signaling molecules...
  38. ncbi request reprint Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte activation
    Melissa E Munroe
    Department of Microbiology, The University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Biol Chem 279:53222-31. 2004
    ..CD40 and CD120b used primarily divergent mechanisms to activate NF-kappaB, exemplifying how TNFR family members can use diverse mechanisms to mediate similar downstream events...
  39. ncbi request reprint Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction
    Sokol A Haxhinasto
    Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 169:1145-9. 2002
    ..Furthermore, data suggest an indirect role for TNFR-associated factor-2 in the cooperative signaling...
  40. ncbi request reprint Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:5546-55. 2004
    ..Together, our findings highlight the central importance of TRAF3 in LMP1-mediated signaling, which is critical for EBV persistent infection and EBV-associated pathogenesis...
  41. ncbi request reprint Regulation of TRAF2 signaling by self-induced degradation
    Kevin D Brown
    Department of Microbiology and Internal Medicine, University of Iowa College of Medicine and the Veteran s Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 277:19433-8. 2002
    ..Several approaches show that ubiquitination and proteasomal activity are integral to TRAF2 degradation, and inhibition of this process potentiates CD40 signaling...
  42. ncbi request reprint LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3
    ShuangDing Wu
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:33620-6. 2005
    ....
  43. ncbi request reprint Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b
    Bruce S Hostager
    Department of Microbiology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Immunol 168:3318-22. 2002
    ..Our results indicate a potentially important role for CD120b in the activation of IgM secretion and that TRAF2 is used by CD40 and CD120b in distinct ways...
  44. ncbi request reprint Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes
    Carissa R Moore
    Interdisciplinary Graduate Program in Immunology, Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Immunol 175:3780-9. 2005
    ..Our data indicate that TRAF2 serves as the master regulator of TRAF degradation in response to CD40 signaling, and this function is dependent upon both the TRAF Zn domains and receptor binding position...
  45. ncbi request reprint Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation
    Sokol A Haxhinasto
    Departments of Microbiology, University of Iowa and Veteran s Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 279:2575-82. 2004
    ..These effects were dependent upon TRAF2 and PKD activity. These findings suggest a model in which Btk contributes to the enhancement of the CD40 response by TRAF2 in a PKD-dependent manner...
  46. pmc Role of the major histocompatibility complex class II transmembrane region in antigen presentation and intracellular trafficking
    Yelena A Barabanova
    Department of Microbiology Immunology, North Western University Medical School, Chicago, IL 60611, USA
    Immunology 111:165-72. 2004
    ..Together, our data indicate an important role of the TM domain of the MHC class II molecules in the intracellular trafficking and, consequently, antigen processing and presentation...
  47. ncbi request reprint TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha
    Rosa M Andrade
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 175:6014-21. 2005
    ..These results support a paradigm where TNFR-associated factor 6 signaling downstream of CD40 alters the pattern of response of macrophages to TNF-alpha leading to induction of antimicrobial activity...
  48. ncbi request reprint A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling
    Sarah L Rowland
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80262, USA
    J Immunol 179:4645-53. 2007
    ....
  49. ncbi request reprint TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages
    Lata Mukundan
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 174:1081-90. 2005
    ..These data demonstrate that TRAF6 acts as a critical adapter of both the Src/ERK1/2 and IKK/NF-kappaB proinflammatory signaling pathways in monocytes and macrophages...
  50. ncbi request reprint Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis
    Melissa E Munroe
    Department of Microbiology, University of Iowa, IA 52242, USA
    J Immunol 179:753-63. 2007
    ..These promising findings suggest that the nontoxic anti-inflammatory properties of HNK could be valuable for blocking the autoimmune response...
  51. ncbi request reprint CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-kappa B pathway
    Nongliao Zhu
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 168:744-54. 2002
    ..This suggests that Pim-1 could regulate the survival and proliferation of B cells...

Research Grants32

  1. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2005
    ..To explore the role of TRAF5 in B cell activation. ..
  2. B cell signaling by the EBV transforming protein, LMP1
    GAIL BISHOP; Fiscal Year: 2006
    ..What is the relationship between LMP 1 signals and autoantibody production? B. How does LMP1 expression affect the development and progression of autoimmune disease? ..
  3. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2006
    ..To explore the role of TRAF5 in B cell activation. ..
  4. The Roles of TRAF3 in Lymphocyte Signaling
    GAIL BISHOP; Fiscal Year: 2007
    ..The information to be gained can be used for small molecule drug design and other therapies that manipulate immunity in for vaccines, and treatment of autoimmune and malignant disease. ..
  5. B cell signaling by the EBV transforming protein, LMP1
    GAIL BISHOP; Fiscal Year: 2007
    ..What is the relationship between LMP 1 signals and autoantibody production? B. How does LMP1 expression affect the development and progression of autoimmune disease? ..
  6. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2007
    ..To explore the role of TRAF5 in B cell activation. ..
  7. PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGY
    GAIL BISHOP; Fiscal Year: 2007
    ..This grant is critical to support our continuing efforts in training pre-doctoral students from diverse backgrounds for independent careers as immunologists, and also to providing geographic diversity in graduate training in immunology. ..
  8. The Roles of TRAF3 in Lymphocyte Signaling
    GAIL BISHOP; Fiscal Year: 2009
    ..The information to be gained can be used for small molecule drug design and other therapies that manipulate immunity in for vaccines, and treatment of autoimmune and malignant disease. ..
  9. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2009
    ..To explore the role of TRAF5 in B cell activation. ..
  10. Mechanisms of Alteration of B Lymphocyte Function by LMP1
    GAIL BISHOP; Fiscal Year: 2009
    ..This project seeks to examine the mechanisms by which LMP1 affects B lymphocyte function, and how it mediates effects that contribute to pathogenesis of autoimmunity and B cell cancers. ..
  11. The Roles of TRAF3 in Lymphocyte Signaling
    Gail A Bishop; Fiscal Year: 2010
    ..The information to be gained can be used for small molecule drug design and other therapies that manipulate immunity in for vaccines, and treatment of autoimmune and malignant disease. ..
  12. MOLECULAR MECHANISMS OF CD40 SIGNALING TO B LYMPHOCYTES
    GAIL BISHOP; Fiscal Year: 2005
    ....
  13. B cell signaling by the EBV transforming protein, LMP1
    GAIL BISHOP; Fiscal Year: 2005
    ..What is the relationship between LMP 1 signals and autoantibody production? B. How does LMP1 expression affect the development and progression of autoimmune disease? ..
  14. MECHANISMS OF B CELL ACTIVATION BY CLASS II MHC AND CD40
    GAIL BISHOP; Fiscal Year: 1999
    ....
  15. MECHANISMS OF B CELL ACTIVATION BY CLASS II MHC AND CD40
    GAIL BISHOP; Fiscal Year: 2000
    ....
  16. MOLECULAR MECHANISMS OF D40 SIGNALING TO B LYMPHOCYTES
    GAIL BISHOP; Fiscal Year: 2001
    ....
  17. TRAFs and Rafts in CD40 Signaling to B Lymphocytes
    GAIL BISHOP; Fiscal Year: 2001
    ..abstract_text> ..
  18. MOLECULAR MECHANISMS OF CD40 SIGNALING TO B LYMPHOCYTES
    GAIL BISHOP; Fiscal Year: 2002
    ....
  19. TRAFs and Rafts in CD40 Signaling to B Lymphocytes
    GAIL BISHOP; Fiscal Year: 2002
    ..abstract_text> ..
  20. B cell signaling by the EBV transforming protein, LMP1
    GAIL BISHOP; Fiscal Year: 2003
    ..What is the relationship between LMP 1 signals and autoantibody production? B. How does LMP1 expression affect the development and progression of autoimmune disease? ..
  21. MOLECULAR MECHANISMS OF CD40 SIGNALING TO B LYMPHOCYTES
    GAIL BISHOP; Fiscal Year: 2003
    ....
  22. TRAFs and Rafts in CD40 Signaling to B Lymphocytes
    GAIL BISHOP; Fiscal Year: 2003
    ..abstract_text> ..
  23. MOLECULAR MECHANISMS OF CD40 SIGNALING TO B LYMPHOCYTES
    GAIL BISHOP; Fiscal Year: 2004
    ....
  24. B cell signaling by the EBV transforming protein, LMP1
    GAIL BISHOP; Fiscal Year: 2004
    ..What is the relationship between LMP 1 signals and autoantibody production? B. How does LMP1 expression affect the development and progression of autoimmune disease? ..
  25. TRAFs and Rafts in CD40 Signaling to B Lymphocytes
    GAIL BISHOP; Fiscal Year: 2004
    ..abstract_text> ..
  26. Mechanisms of Alteration of B Lymphocyte Function by LMP1
    Gail A Bishop; Fiscal Year: 2010
    ..This project seeks to examine the mechanisms by which LMP1 affects B lymphocyte function, and how it mediates effects that contribute to pathogenesis of autoimmunity and B cell cancers. ..