Lawrence T Bish

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 19:1359-68. 2008
  2. pmc Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Ther 20:580-9. 2012
  3. pmc Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 22:969-77. 2011
  4. pmc Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 22:1499-509. 2011
  5. pmc Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 16:1953-9. 2008
  6. pmc Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e20856. 2011
  7. pmc Myostatin is elevated in congenital heart disease and after mechanical unloading
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23818. 2011
  8. pmc Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10230. 2010
  9. ncbi Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 77:2122-9; discussion 2129. 2004
  10. ncbi Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathy
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Mol Cell Cardiol 36:531-8. 2004

Collaborators

Detail Information

Publications28

  1. pmc Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 19:1359-68. 2008
    ..AAV9 should be used in rodent cardiac studies and may be the vector of choice for clinical trials of cardiac gene transfer...
  2. pmc Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Ther 20:580-9. 2012
    ....
  3. pmc Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 22:969-77. 2011
    ..AAV6-mediated cardiac gene transfer of shRNA effectively knocks down PLB expression but is associated with severe cardiac toxicity. Toxicity may result from dysregulation of endogenous microRNA pathways...
  4. pmc Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 22:1499-509. 2011
    ....
  5. pmc Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 16:1953-9. 2008
    ..Percutaneous transendocardial injection of scAAV6 is a safe, effective method to achieve efficient cardiac gene transfer...
  6. pmc Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e20856. 2011
    ..Our study suggests that ARB may be an important prophylactic treatment for DMD-associated cardiomyopathy, but will not impact skeletal muscle disease...
  7. pmc Myostatin is elevated in congenital heart disease and after mechanical unloading
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23818. 2011
    ..Myostatin is a negative regulator of skeletal muscle mass whose activity is upregulated in adult heart failure (HF); however, its role in congenital heart disease (CHD) is unknown...
  8. pmc Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10230. 2010
    ..Myostatin is a negative regulator of cardiac growth, and further studies are warranted to investigate the role of myostatin in the healthy and failing heart...
  9. ncbi Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 77:2122-9; discussion 2129. 2004
    ..We hypothesized that localized myocardial hypertrophy induced by gene transfer of growth hormone could inhibit remodeling and preserve cardiac function after myocardial infarction...
  10. ncbi Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathy
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Mol Cell Cardiol 36:531-8. 2004
    ..We hypothesized that local myocardial overexpression of GH could prevent ventricular remodeling and heart failure following myocardial infarction (MI) in rats...
  11. ncbi Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure
    Vasant Jayasankar
    Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Card Surg 20:93-101. 2005
    ..This study was designed to investigate the ability of HGF to prevent heart failure in a rat model of experimental MI...
  12. ncbi Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Circulation 110:II180-6. 2004
    ..This study evaluated the effects of MMP inhibition by gene transfer of TIMP-1 in a rat model of ischemic cardiomyopathy...
  13. doi Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy
    Kevin J Morine
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Muscle Nerve 42:722-30. 2010
    ..No effect on heart mass or function was observed. Our results indicate that activin IIB receptor blockade represents a novel and effective therapeutic strategy for the muscular dystrophies...
  14. pmc Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice
    Kevin J Morine
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e9176. 2010
    ..Previously described approaches to blocking myostatin signaling include injection delivery of inhibitory propeptide domain or neutralizing antibodies...
  15. ncbi Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodeling
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Heart Lung Transplant 23:1061-8. 2004
    ..This study examined the effects of the administration of a TNF inhibitor immediately after myocardial infarction on the development of heart failure...
  16. ncbi Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure
    Vasant Jayasankar
    Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Pliladelphia, PA 19104, USA
    Circulation 108:II230-6. 2003
    ..Hepatocyte Growth Factor (HGF) has potent angiogenic and anti-apoptotic activities, and this study evaluated the functional and biochemical effects of HGF gene transfer in a rat model of postinfarction heart failure...
  17. ncbi Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain
    Subhasis Chatterjee
    Division of Cardiothoracic Surgery and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 125:1461-9. 2003
    ..This study was designed to assess the efficacy of in vivo viral gene transfer of the antiapoptotic factor apoptosis repressor with caspase recruitment domain to block apoptosis and preserve ventricular geometry and function...
  18. ncbi Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
    Mark F Berry
    Division of Cardiothoracic Surgery, Department of Physiology, University of Pennsylvania School of Medicine, A700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
    Am J Physiol Heart Circ Physiol 290:H2196-203. 2006
    ..Improving scarred heart muscle compliance could be a functional benefit of cellular cardiomyoplasty...
  19. ncbi Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Thorac Cardiovasc Surg 127:1262-9. 2004
    ..This study sought to evaluate ethyl pyruvate as a myocardial protective agent in a rat model of ischemia-reperfusion injury...
  20. doi Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, B400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA
    Methods Mol Biol 709:369-78. 2011
    ..Percutaneous transendocardial injection of self-complementary AAV (scAAV)-6 is a safe, effective method for achieving efficient cardiac gene transfer to approximately 60% of the myocardium...
  21. pmc Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression
    Shu Jen Chen
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Gene Ther Methods 24:270-8. 2013
    ..Somatic gene transfer in vivo is being considered in therapeutic applications, although its most substantial value will be in basic applications such as target validation and development of animal models...
  22. ncbi Gene therapy in large animal models of human cardiovascular genetic disease
    Meg M Sleeper
    Department of Clinical Studies, University of Pennsylvania Veterinary School, Philadelphia, PA, USA
    ILAR J 50:199-205. 2009
    ..g., calcium metabolism, apoptosis) could normalize diseased myocardial function. Gene therapy may offer a promising new approach for the treatment of cardiac disease in both veterinary and human clinical settings...
  23. doi Adeno-associated virus vector delivery to the heart
    Lawrence T Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 807:219-37. 2011
    ..Each protocol can be used to achieve safe and efficient cardiac gene transfer in the model of choice...
  24. doi Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats
    Meg Sleeper
    Department of Clinical Studies, University of Pennsylvania Veterinary School, 3900 Delancey Street, Philadelphia, PA 19104, USA
    J Vet Cardiol 13:131-40. 2011
    ..This review will discuss issues related to gene vector systems, gene delivery strategies and two cardiovascular diseases in dogs successfully treated with therapeutic gene delivery...
  25. doi Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs
    Meg M Sleeper
    Department of Clinical Studies, University of Pennsylvania Veterinary School, Philadelphia, PA 19104, USA
    Vet Clin North Am Small Anim Pract 40:717-24. 2010
    ..The authors are currently evaluating this approach to treat canine idiopathic dilated cardiomyopathy...
  26. ncbi Systemic administration of L-arginine benefits mdx skeletal muscle function
    Elisabeth R Barton
    Department of Anatomy and Cell Biology, School of Dental Medicine, 441 Levy Building, 240 South 40th Street, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Muscle Nerve 32:751-60. 2005
    ..Together, these results show that L-arginine treatment can be beneficial to mdx muscle function, perhaps through a combination of enhanced calcium handling and increased utrophin, thereby decreasing muscle degeneration...
  27. pmc Molecular analysis of vector genome structures after liver transduction by conventional and self-complementary adeno-associated viral serotype vectors in murine and nonhuman primate models
    Xun Sun
    Gene Therapy Program, Department of Pathology, Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 21:750-61. 2010
    ..Molecular structures of persistent genomes of both ss and sc vectors were significantly more heterogeneous in macaque liver, with noticeable structural rearrangements that warrant further characterizations...
  28. ncbi Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure
    Subhasis Chatterjee
    Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 106:I212-7. 2002
    ..This study was designed to assess the effect of in vivo viral gene transfer of the anti-apoptotic factor Bcl-2 to block apoptosis and preserve ventricular geometry and function...