Research Topics
| Lawrence T BishSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and ratLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Gene Ther 19:1359-68. 2008..AAV9 should be used in rodent cardiac studies and may be the vector of choice for clinical trials of cardiac gene transfer...- Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skippingLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Mol Ther 20:580-9. 2012.... - Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic miceLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e20856. 2011..Our study suggests that ARB may be an important prophylactic treatment for DMD-associated cardiomyopathy, but will not impact skeletal muscle disease... - Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophyLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Gene Ther 22:1499-509. 2011.... - Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in caninesLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Mol Ther 16:1953-9. 2008..Percutaneous transendocardial injection of scAAV6 is a safe, effective method to achieve efficient cardiac gene transfer... - Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in caninesLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Gene Ther 22:969-77. 2011..AAV6-mediated cardiac gene transfer of shRNA effectively knocks down PLB expression but is associated with severe cardiac toxicity. Toxicity may result from dysregulation of endogenous microRNA pathways... - Myostatin is elevated in congenital heart disease and after mechanical unloadingLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e23818. 2011..Myostatin is a negative regulator of skeletal muscle mass whose activity is upregulated in adult heart failure (HF); however, its role in congenital heart disease (CHD) is unknown... - Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse modelLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e10230. 2010..Myostatin is a negative regulator of cardiac growth, and further studies are warranted to investigate the role of myostatin in the healthy and failing heart... 
Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac functionVasant Jayasankar
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 77:2122-9; discussion 2129. 2004..The induction of localized myocardial hypertrophy presents a novel therapeutic approach for the treatment of ischemic heart failure...- Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathyVasant Jayasankar
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Mol Cell Cardiol 36:531-8. 2004..The induction of regional hypertrophy is a novel approach to treating heart failure, and may be useful to treat or prevent post-infarction ischemic cardiomyopathy... - Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failureVasant Jayasankar
Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Card Surg 20:93-101. 2005..This technique may be useful to treat or prevent postinfarction heart failure... - Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathyVasant Jayasankar
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Circulation 110:II180-6. 2004..The reduction in myocardial fibrosis may be primarily responsible for the improved diastolic function in treated animals. TIMP-1 overexpression is a promising therapeutic target for continued investigation... 
Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophyKevin J Morine
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Muscle Nerve 42:722-30. 2010..No effect on heart mass or function was observed. Our results indicate that activin IIB receptor blockade represents a novel and effective therapeutic strategy for the muscular dystrophies...- Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic miceKevin J Morine
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e9176. 2010..Previously described approaches to blocking myostatin signaling include injection delivery of inhibitory propeptide domain or neutralizing antibodies... - Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodelingMark F Berry
Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Heart Lung Transplant 23:1061-8. 2004..05) and the relaxation time constant (14.6 +/- 0.6 vs 17.9 +/- 1.2 msec; p < 0.05). CONCLUSIONS: TNF inhibition after infarction reduced leukocyte infiltration and extracellular matrix turnover and preserved cardiac function... - Gene transfer of hepatocyte growth factor attenuates postinfarction heart failureVasant Jayasankar
Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Pliladelphia, PA 19104, USA
Circulation 108:II230-6. 2003..This therapy may be useful as an adjunct or alternative to standard revascularization techniques in patients with ischemic heart failure... - Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domainSubhasis Chatterjee
Division of Cardiothoracic Surgery and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 125:1461-9. 2003..Adenovirus-apoptosis repressor with caspase recruitment domain administration offers a potential strategy after myocardial ischemia to protect the heart from late postischemic cardiomyopathy... - Mesenchymal stem cell injection after myocardial infarction improves myocardial complianceMark F Berry
Division of Cardiothoracic Surgery, Department of Physiology, University of Pennsylvania School of Medicine, A700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA
Am J Physiol Heart Circ Physiol 290:H2196-203. 2006..Improving scarred heart muscle compliance could be a functional benefit of cellular cardiomyoplasty... - Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemiaY Joseph Woo
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Thorac Cardiovasc Surg 127:1262-9. 2004..This study sought to evaluate ethyl pyruvate as a myocardial protective agent in a rat model of ischemia-reperfusion injury... - Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canineLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, B400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA, USA
Methods Mol Biol 709:369-78. 2011..Percutaneous transendocardial injection of self-complementary AAV (scAAV)-6 is a safe, effective method for achieving efficient cardiac gene transfer to approximately 60% of the myocardium... - Gene therapy in large animal models of human cardiovascular genetic diseaseMeg M Sleeper
Department of Clinical Studies, University of Pennsylvania Veterinary School, Philadelphia, PA, USA
ILAR J 50:199-205. 2009..g., calcium metabolism, apoptosis) could normalize diseased myocardial function. Gene therapy may offer a promising new approach for the treatment of cardiac disease in both veterinary and human clinical settings... - Adeno-associated virus vector delivery to the heartLawrence T Bish
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Methods Mol Biol 807:219-37. 2011..Each protocol can be used to achieve safe and efficient cardiac gene transfer in the model of choice... - Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogsMeg M Sleeper
Department of Clinical Studies, University of Pennsylvania Veterinary School, Philadelphia, PA 19104, USA
Vet Clin North Am Small Anim Pract 40:717-24. 2010..The authors are currently evaluating this approach to treat canine idiopathic dilated cardiomyopathy... - Status of therapeutic gene transfer to treat cardiovascular disease in dogs and catsMeg Sleeper
Department of Clinical Studies, University of Pennsylvania Veterinary School, 3900 Delancey Street, Philadelphia, PA 19104, USA
J Vet Cardiol 13:131-40. 2011..This review will discuss issues related to gene vector systems, gene delivery strategies and two cardiovascular diseases in dogs successfully treated with therapeutic gene delivery... - Systemic administration of L-arginine benefits mdx skeletal muscle functionElisabeth R Barton
Department of Anatomy and Cell Biology, School of Dental Medicine, 441 Levy Building, 240 South 40th Street, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Muscle Nerve 32:751-60. 2005..Together, these results show that L-arginine treatment can be beneficial to mdx muscle function, perhaps through a combination of enhanced calcium handling and increased utrophin, thereby decreasing muscle degeneration... - Molecular analysis of vector genome structures after liver transduction by conventional and self-complementary adeno-associated viral serotype vectors in murine and nonhuman primate modelsXun Sun
Gene Therapy Program, Department of Pathology, Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Gene Ther 21:750-61. 2010..Molecular structures of persistent genomes of both ss and sc vectors were significantly more heterogeneous in macaque liver, with noticeable structural rearrangements that warrant further characterizations... - Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failureSubhasis Chatterjee
Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Circulation 106:I212-7. 2002..The benefit at 6 weeks is postulated to result from a Bcl-2-mediated reduction in apoptosis and ventricular remodeling. Adeno-Bcl-2 administration offers a potential strategy to protect the heart from late postischemic heart failure...