Konstantin Birukov

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:453-64. 2002
  2. pmc A role for VEGFR2 activation in endothelial responses caused by barrier disruptive OxPAPC concentrations
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Lung Injury Center, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e30957. 2012
  3. pmc Mechanical forces stimulate endothelial microparticle generation via caspase-dependent apoptosis-independent mechanism
    Anne Clémence Vion
    Department of Paris Cardiovascular Research Center, Paris Descartes University, Paris Sorbonne City, Paris, France
    Pulm Circ 3:95-9. 2013
  4. doi request reprint Barrier enhancing signals in pulmonary edema
    Konstantin G Birukov
    Lung Injury Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Compr Physiol 3:429-84. 2013
  5. pmc Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury
    Angelo Y Meliton
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 304:L689-700. 2013
  6. pmc Endothelial barrier disruption and recovery is controlled by substrate stiffness
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Microvasc Res 87:50-7. 2013
  7. pmc Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Dept of Medicine, University of Chicago, Chicago, IL 60637, USA
    Eur Respir J 41:165-76. 2013
  8. pmc VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Cell Physiol 227:3405-16. 2012
  9. pmc Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Dept of Medicine, Univ of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 302:L965-75. 2012
  10. pmc Differential regulation of endothelial cell permeability by high and low doses of oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine
    Vitaliy Starosta
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Office N611, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 46:331-41. 2012

Research Grants

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:453-64. 2002
    ..Our results suggest a potential role for cortactin in the SS-induced EC cortical cytoskeletal remodeling and demonstrate a novel mechanism of Rac GTPase-dependent regulation of the pulmonary endothelial cytoskeleton by SS...
  2. pmc A role for VEGFR2 activation in endothelial responses caused by barrier disruptive OxPAPC concentrations
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Lung Injury Center, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e30957. 2012
    ..This study examined a role of VEGFR2 in barrier dysfunction caused by high concentrations of OxPAPC and evaluated downstream signaling mechanisms resulting from the effect of OxPAPC in EC from pulmonary and systemic circulation...
  3. pmc Mechanical forces stimulate endothelial microparticle generation via caspase-dependent apoptosis-independent mechanism
    Anne Clémence Vion
    Department of Paris Cardiovascular Research Center, Paris Descartes University, Paris Sorbonne City, Paris, France
    Pulm Circ 3:95-9. 2013
    ..These results suggest a novel mechanism that may contribute to VILI-associated vascular dysfunction...
  4. doi request reprint Barrier enhancing signals in pulmonary edema
    Konstantin G Birukov
    Lung Injury Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Compr Physiol 3:429-84. 2013
    ....
  5. pmc Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury
    Angelo Y Meliton
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 304:L689-700. 2013
    ..These results demonstrate a novel role for gVPLA2 as the downstream effector of pathological mechanical stretch leading to an inflammatory response associated with VILI...
  6. pmc Endothelial barrier disruption and recovery is controlled by substrate stiffness
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Microvasc Res 87:50-7. 2013
    ..The optimal conditions for the Rho/Rac signaling switch, which provides an effective and reversible EC cytoskeletal and permeability response to agonist, are reached in cells grown on the matrix of physiologically relevant stiffness...
  7. pmc Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Dept of Medicine, University of Chicago, Chicago, IL 60637, USA
    Eur Respir J 41:165-76. 2013
    ..Iloprost-induced elevation of intracellular cAMP triggers Rac signalling, which attenuates LPS-induced NF-κB and p38 MAPK inflammatory pathways and the Rho-dependent mechanism of endothelial permeability...
  8. pmc VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Cell Physiol 227:3405-16. 2012
    ..These results suggest that VE-cadherin outside-in signaling controls locally Rac activity stimulated by barrier protective agonists. This control is essential for maximal EC barrier enhancement and accelerated barrier recovery...
  9. pmc Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Dept of Medicine, Univ of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 302:L965-75. 2012
    ....
  10. pmc Differential regulation of endothelial cell permeability by high and low doses of oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine
    Vitaliy Starosta
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Office N611, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 46:331-41. 2012
    ....
  11. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
    ....
  12. pmc Small GTPases in mechanosensitive regulation of endothelial barrier
    Konstantin G Birukov
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
    Microvasc Res 77:46-52. 2009
    ..This review will discuss a role of Rho family of small GTPases in the mechanochemical regulation of pulmonary endothelial permeability associated with ventilator induced lung injury...
  13. pmc Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids
    Anna A Birukova
    Dept of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L593-602. 2008
    ....
  14. pmc Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Microvasc Res 79:128-38. 2010
    ..This study dissected for the first time PKA and Epac pathways of lung EC barrier protection caused by cAMP elevation and identified Rac GTPase as a hub for PKA and Epac signaling leading to enhancement of lung vascular barrier...
  15. pmc Cyclic stretch, reactive oxygen species, and vascular remodeling
    Konstantin G Birukov
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:1651-67. 2009
    ....
  16. ncbi request reprint Oxidized lipids: the two faces of vascular inflammation
    Konstantin G Birukov
    Department of Medicine, University of Chicago, 929 East 57th Street, W410, Chicago, IL 60637, USA
    Curr Atheroscler Rep 8:223-31. 2006
    ....
  17. pmc Rap1 mediates protective effects of iloprost against ventilator-induced lung injury
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol (1985) 107:1900-10. 2009
    ..These data describe for the first time protective effects for Rap1-dependent signaling against ventilator-induced lung injury and pulmonary endothelial barrier dysfunction...
  18. pmc Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids
    Anna A Birukova
    Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Physiol 226:2052-62. 2011
    ..These results show for the first time a role of Rap1-mediated association between adherens junctions and tight junction complexes in the OxPAPC-induced pulmonary vascular EC barrier protection...
  19. pmc Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L612-23. 2008
    ..These results support the importance of HGF-VEGF balance in control of acute lung injury/acute respiratory distress syndrome severity via small GTPase-dependent regulation of lung endothelial permeability...
  20. pmc Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th Street, CIS Bldg, W410, Chicago, IL 60637, USA
    Microvasc Res 73:173-81. 2007
    ....
  21. ncbi request reprint Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Physiol 211:608-17. 2007
    ..These results show for the first time that Tiam1 and betaPIX mediate OxPAPC-induced Rac activation, cytoskeletal remodeling, and barrier protective response in pulmonary endothelium...
  22. pmc Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, Chicago, IL 60637, USA
    Exp Cell Res 313:2504-20. 2007
    ..These mechanisms may mediate protective effects of PGs against agonist-induced lung vascular barrier dysfunction in vitro and against mechanical stress-induced lung injury in vivo...
  23. pmc Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer
    Anna A Birukova
    Division of Biomedical Sciences, Department of Medicine, Section of Pulmonary and Critical Care Medicine University of Chicago, Chicago, Illinois 60637, USA
    Nanomedicine 5:30-41. 2009
    ..Attenuation of thrombin-induced permeability correlates well with stiffness changes from the cell center to periphery. These results directly link for the first time the patterns of cell stiffness with specific EC permeability responses...
  24. ncbi request reprint Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 293:L199-211. 2007
    ..In turn, paxillin knockdown by specific siRNA attenuated AJ enhancement in response to OxPAPC. These results show for the first time the novel interactions between FA and AJ protein complexes critical for EC barrier regulation by OxPAPC...
  25. pmc Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 40:99-107. 2009
    ..Our results also support a model of pulmonary EC barrier recovery during resolution of ALI via switch from VEGF to HGF signaling...
  26. pmc Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
    Xiaoguang Sun
    Department of Medicine, Division of Biological Sciences, The University of Chicago, 5841 Maryland Ave, Chicago, IL 60637 1470, USA
    Microvasc Res 77:304-13. 2009
    ..These results demonstrate a mechanism of S1P-induced endothelial barrier enhancement via beta-catenin-linked adherens junction and focal adhesion interaction...
  27. pmc Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, Ill 60637, USA
    Transl Res 155:44-54. 2010
    ..This study characterizes for the first time the protective effects of iloprost in the in vitro and in vivo 2-hit models of VILI and supports consideration of iloprost as a new therapeutic treatment of VILI...
  28. pmc Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch
    Anna A Birukova
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Pathol 168:1749-61. 2006
    ..These results suggest a critical role for the CS amplitude and the balance between Rac and Rho in mechanochemical regulation of lung EC barrier...
  29. pmc Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levels
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Exp Cell Res 314:3466-77. 2008
    ....
  30. pmc Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids
    Patrick A Singleton
    Department of Medicine, Division of Biomedical Sciences, Section of Pulmonary and Critical Medicine, University of Chicago, Ill 60637, USA
    Circ Res 104:978-86. 2009
    ..Taken together, these results suggest Akt-dependent transactivation of S1P(1) within CEMs is important for OxPAPC-mediated cortical actin rearrangement and EC barrier protection...
  31. pmc Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Lung Injury Center, Dept of Medicine, Univ of Chicago, 5841 S Maryland Ave, Office N613, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 299:L652-63. 2010
    ..Our data suggest a direct role for ANP in endothelial barrier regulation via modulation of small GTPase signaling...
  32. ncbi request reprint GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction
    Anna A Birukova
    Sect of Pulmonary and Critical Care, Dept of Medicine, Biological Sciences Div, Univ of Chicago, 929 E 57th St, W410, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 290:L540-8. 2006
    ....
  33. pmc Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin
    Fernando Teran Arce
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Biophys J 95:886-94. 2008
    ....
  34. pmc Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Physiol 215:715-24. 2008
    ..These results suggest a novel mechanism of ANP protective effects against agonist-induced pulmonary EC barrier dysfunction via inhibition of Rho signaling by Epac/Rap1-Rac and PKA signaling cascades...
  35. ncbi request reprint HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
    FASEB J 21:2776-86. 2007
    ....
  36. ncbi request reprint Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 292:L924-35. 2007
    ....
  37. ncbi request reprint Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 17:407-16. 2003
    ..These studies convincingly demonstrate that novel interactions between the apoptotic machinery and EC MLCK exist that regulate the endothelial contractile apparatus in TNF-alpha-induced apoptosis...
  38. pmc Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin
    Jacob Kach
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 304:L757-64. 2013
    ..In conclusion, differentiated pulmonary myofibroblasts gain responsiveness to ADM via increased CRLR expression, suggesting the possibility of using ADM for targeting pathological myofibroblasts without affecting normal fibroblasts...
  39. pmc SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
    Senthilkumar B Rajamohan
    Department of Surgery, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Mol Cell Biol 29:4116-29. 2009
    ..These data demonstrate that the activity of PARP1 is under the control of SIRT1, which is necessary for survival of cells under stress conditions...
  40. pmc Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 298:L837-48. 2010
    ..These data show for the first time the critical involvement of microtubules and microtubule-associated GEF-H1 in lung vascular endothelial barrier dysfunction induced by pathological mechanical strain...
  41. pmc G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C
    Ricky Malhotra
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 285:13748-60. 2010
    ..Cross-talk between hypertrophic signaling at the level of PKC and beta-AR signaling regulated by GRK2 may be an important mechanism in the transition from compensatory ventricular hypertrophy to heart failure...
  42. pmc Oxidized phospholipids in control of inflammation and endothelial barrier
    Panfeng Fu
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill 60637, USA
    Transl Res 153:166-76. 2009
    ..These compounds may represent a new group of therapeutic agents for the treatment of lung syndromes associated with acute inflammation and lung vascular leak...
  43. ncbi request reprint Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin
    Jeffrey R Jacobson
    Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:662-70. 2004
    ..These novel observations have broad clinical implications in numerous vascular pathobiologies characterized by alterations in vascular integrity including inflammation, angiogenesis, and acute lung injury...
  44. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
    ....
  45. ncbi request reprint Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:64-77. 2004
    ....
  46. ncbi request reprint Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction
    Natalia V Bogatcheva
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
    Am J Physiol Lung Cell Mol Physiol 285:L415-26. 2003
    ..Together, these events result in stress fiber destabilization and profound actin rearrangement in bovine endothelium, which may result in the physiological alterations observed in these models...
  47. ncbi request reprint Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Univ School of Medicine, 5501 Hopkins Bayview Circle, JHAAC, 5A 42, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 285:L785-97. 2003
    ..Thus our study demonstrates a critical role for the magnitude of CS in regulation of agonist-mediated pulmonary endothelial cell permeability and strongly suggests phenotypic regulation of HPAEC barrier properties by CS...
  48. ncbi request reprint S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 94:1193-203. 2003
    ..These results suggest a role of FA rearrangement in S1P-mediated barrier enhancement via Rac- and GIT-mediated processes...
  49. ncbi request reprint Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FASEB J 17:2240-9. 2003
    ..These observations highlight the differential mechanisms of focal adhesion protein complex remodeling and FAK activation by S1P and thrombin and link differential FA remodeling to EC barrier regulation...
  50. ncbi request reprint Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase
    Steven M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:24692-700. 2004
    ..These data support novel roles for the cytoskeletal proteins cortactin and EC MLCK in mediating lung vascular barrier augmentation evoked by S1P...
  51. ncbi request reprint Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 201:55-70. 2004
    ....
  52. pmc EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation
    Srinivas Papaiahgari
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 36:304-12. 2007
    ..Collectively, these novel findings suggest that EGFR-activated signaling and actin remodeling act in concert to regulate the CS-induced Nrf2-ARE transcriptional response and subsequent AOE expression...
  53. ncbi request reprint Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI...
  54. ncbi request reprint ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FEBS Lett 579:4031-7. 2005
    ..Thus, our data demonstrate for the first time direct link between TGF-beta1-mediated activation of ALK5/Smad and EC barrier dysfunction...
  55. ncbi request reprint Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Cell Physiol 204:934-47. 2005
    ..These results suggest a novel role for MT dynamics in the TGF-beta1-mediated Rho regulation, EC barrier dysfunction, and actin remodeling...
  56. ncbi request reprint MAP kinases in lung endothelial permeability induced by microtubule disassembly
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, MFL Center Tower, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 289:L75-84. 2005
    ..These data suggest a direct link between p38 MAPK activation, remodeling of MT network, and EC barrier regulation...
  57. ncbi request reprint Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, 5200 Eastern Avenue, Mason F Lord Building, Center Tower, Room 677, Baltimore, MD 21224, USA
    Exp Cell Res 304:40-9. 2005
    ..Thus, our results suggest common signaling and cytoskeletal mechanisms shared by mechanical and chemical factors involved in EC barrier regulation...
  58. ncbi request reprint Novel role of microtubules in thrombin-induced endothelial barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Ave, MFL Center Tower 660, Baltimore, MD 21224, USA
    FASEB J 18:1879-90. 2004
    ..Collectively, our data demonstrate for the first time a critical involvement of MT disassembly in thrombin-induced EC barrier dysfunction and indicate G-protein-dependent mechanisms of thrombin-induced MT alteration...
  59. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
    ..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function...
  60. ncbi request reprint Differential regulation of human lung epithelial and endothelial barrier function by thrombin
    Kamon Kawkitinarong
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 31:517-27. 2004
    ....
  61. pmc Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury
    Stephanie Nonas
    Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Crit Care Med 173:1130-8. 2006
    ....
  62. ncbi request reprint Focal adhesions: paradigm for a signaling nexus
    Lewis H Romer
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4904, USA
    Circ Res 98:606-16. 2006
    ....
  63. ncbi request reprint Novel interaction of cortactin with endothelial cell myosin light chain kinase
    Steven M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 298:511-9. 2002
    ..These data suggest that cortactin-EC MLCK interaction may be a novel determinant of endothelial cortical actin-based cytoskeletal rearrangement...

Research Grants14

  1. Mechanisms of Prostacyclin-Mediated Lung Endothelial Barrier Protection
    Konstantin G Birukov; Fiscal Year: 2010
    ....
  2. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2005
    ....
  3. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2007
    ....
  4. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2004
    ....
  5. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2005
    ....
  6. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2006
    ....
  7. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2009
    ....
  8. Mechanisms of Prostacyclin-Mediated Lung Endothelial Barrier Protection
    Konstantin Birukov; Fiscal Year: 2009
    ....
  9. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  10. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2004
    ....
  11. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2006
    ....
  12. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2005
    ....
  13. Control of lung permeability by oxidized phospholipids
    Konstantin G Birukov; Fiscal Year: 2010
    ....