Research Topics
Genomes and Genes
Species | Boris BirmaherSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Child comorbidity, maternal mood disorder, and perceptions of family functioning among bipolar youthChristianne Esposito-Smythers
Department of Psychiatry, Brown Medical School, Providence, RI 02912, USA
J Am Acad Child Adolesc Psychiatry 45:955-64. 2006..To examine the association between youth comorbid psychiatric disorders, maternal mood disorder, and perceptions of family cohesion and conflict among youth diagnosed with pediatric bipolar disorder (PBD)...
Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) studyBoris Birmaher
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:795-804. 2009..The authors sought to assess the longitudinal course of youths with bipolar spectrum disorders over a 4-year period...- Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?Boris Birmaher
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:63-70. 2004..To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder... - Course and outcome of bipolar spectrum disorder in children and adolescents: a review of the existing literatureBoris Birmaher
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Dev Psychopathol 18:1023-35. 2006..Thus, early recognition and treatment of BP in children and adolescents is of utmost importance... - Clinical course of children and adolescents with bipolar spectrum disordersBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Arch Gen Psychiatry 63:175-83. 2006..Despite the high morbidity associated with bipolar disorder (BP), few studies have prospectively studied the course of this illness in youth... - Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disordersBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Bipolar Disord 11:52-62. 2009..To compare the most severe lifetime (current or past) mood symptoms, duration of illness, and rates of lifetime comorbid disorders among youth with bipolar spectrum disorders [BP (bipolar-I, bipolar-II and bipolar-not otherwise specified)]... - Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS)Boris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Am J Psychiatry 167:321-30. 2010..The authors evaluated lifetime prevalence and specificity of DSM-IV psychiatric disorders and severity of depressive and manic symptoms at intake in preschool offspring of parents with bipolar I and II disorders... - Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring studyBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Arch Gen Psychiatry 66:287-96. 2009..Whether offspring of parents with bipolar disorder (BP) are at specifically high risk to develop BP and other psychiatric disorders has not been adequately studied... - Psychosocial functioning in youths at high risk to develop major depressive disorderBoris Birmaher
Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:839-46. 2004..To compare the psychosocial functioning of children and adolescents at high risk of major depressive disorder with youths with acute major depressive disorder and healthy controls... - Phenomenology of children and adolescents with bipolar spectrum disordersDavid Axelson
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
Arch Gen Psychiatry 63:1139-48. 2006..Children and adolescents who present with manic symptoms frequently do not meet the full DSM-IV criteria for bipolar I disorder (BP-I)... - Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment studyJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Exp Child Psychol 110:241-57. 2011.... - Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controlsDiana J Whalen
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Pediatr Psychol 33:358-67. 2008..We examined caffeine use and its relation to sleep and affect in youth's natural environments... - Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) studyDavid A Brent
University of Pittsburgh School of Medicine, Western University School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 112, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 166:418-26. 2009..The authors sought to identify predictors of self-harm adverse events in treatment-resistant, depressed adolescents during the first 12 weeks of treatment... - Negative life events in children and adolescents with bipolar disorderSoledad Romero
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
J Clin Psychiatry 70:1452-60. 2009.... - Clinical differences between suicidal and nonsuicidal depressed children and adolescentsRémy P Barbe
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 66:492-8. 2005..To examine the clinical symptoms and comorbid psychiatric disorders of depressed children and adolescents with and without clinically significant suicidal ideation... - Expressed emotion in mothers of currently depressed, remitted, high-risk, and low-risk youth: links to child depression status and longitudinal courseJennifer S Silk
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Child Adolesc Psychol 38:36-47. 2009..Higher initial critical expressed emotion was associated with a greater likelihood of having a future onset of a depressive episode in high-risk and depressed participants. Diagnostic groups did not differ in Emotional Overinvolvement... - Family environment and suicidal ideation among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Arch Suicide Res 13:378-88. 2009..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss... - Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behaviorNadine M Melhem
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Psychiatry 164:1364-70. 2007..The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior... - Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depressionDana L McMakin
University of Pittsburgh, Western PsychiatricInstitute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 51:404-11. 2012..To identify symptom dimensions of depression that predict recovery among selective serotonin reuptake inhibitor (SSRI) treatment-resistant adolescents undergoing second-step treatment... - Psychosocial functioning among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
J Affect Disord 114:174-83. 2009..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population... - The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorderRasim Somer Diler
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Child Adolesc Psychopharmacol 19:23-30. 2009..The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old... - What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?Mary A Fristad
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
Bipolar Disord 14:497-506. 2012.... - Familial and individual correlates of nonsuicidal self-injury in the offspring of mood-disordered parentsLara J Cox
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 73:813-20. 2012..To examine the demographic and clinical correlates of nonsuicidal self-injury... - Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) studyRobert L Findling
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
J Clin Psychiatry 71:1664-72. 2010..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally... - Preliminary findings regarding overweight and obesity in pediatric bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 69:1953-9. 2008..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder... - Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007.... - Significance of cigarette smoking among youths with bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Addict 17:364-71. 2008..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD... - Schedule for affective disorders and schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children--a preliminary psychometric studyBoris Birmaher
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Psychiatr Res 43:680-6. 2009.... - Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlatesRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 71:1344-50. 2010..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder. We aimed to examine the prevalence and correlates of comorbid anxiety disorders among youth with bipolar disorder... - Substance use disorders among adolescents with bipolar spectrum disordersBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 10:469-78. 2008..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)... - Familial transmission of mood disorders: convergence and divergence with transmission of suicidal behaviorDavid A Brent
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:1259-66. 2004..In this study, the authors examine the factors associated with the familial transmission of these two related conditions to learn which are shared or unique risk factors for familial transmission... - Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorderErika E Forbes
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cogn Affect Behav Neurosci 10:107-18. 2010..Final levels of severity and anxiety symptoms were associated with pretreatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity... - Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disordersRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 73:87-94. 2012..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder... - Dimensional psychopathology in offspring of parents with bipolar disorderRasim Somer Diler
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Bipolar Disord 13:670-8. 2011..To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL)... - Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sampleL Eugene Arnold
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Bipolar Disord 13:509-21. 2011..To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study... - Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA studyJoan Rosenbaum Asarnow
University of California Los Angeles UCLA, Department of Psychiatry, Los Angeles, CA 90095 6968, USA
J Am Acad Child Adolesc Psychiatry 50:772-81. 2011..To evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression... - Psychosocial functioning in offspring of parents with bipolar disorderTolulope Bella
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Affect Disord 133:204-11. 2011..Offspring of parents with bipolar disorder are at increased risk for a range of psychopathology, including bipolar disorder. It is not clear if they also have impairments in their psychosocial functioning... - History of suicide attempts in pediatric bipolar disorder: factors associated with increased riskTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Bipolar Disord 7:525-35. 2005..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population... - Altered striatal activation predicting real-world positive affect in adolescent major depressive disorderErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:64-73. 2009..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts... - Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behaviorDavid A Brent
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Am J Psychiatry 160:1486-93. 2003.... - Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?Cecile D Ladouceur
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:532-9. 2008..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD... - Familial transmission of suicidal behavior: factors mediating the relationship between childhood abuse and offspring suicide attemptsBeth S Brodsky
Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York 10032, USA
J Clin Psychiatry 69:584-96. 2008..The current study investigates the relationship between reported childhood abuse and the familial transmission of suicidal behavior and other related risk factors... - Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: an exploratory studyW Burleson Daviss
Western Psychiatric Institute and Clinic, Pittsburgh, PA, and the University of Pittsburgh, Pittsburgh, PA 15213, USA
Ther Drug Monit 28:190-8. 2006..009). These preliminary findings suggest that plasma levels of bupropion and metabolites, particularly hydroxybupropion, may predict acute antidepressant response in depressed youths taking bupropion SR... - Phenomenology of panic disorder in youthRasim Somer Diler
Division of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Depress Anxiety 20:39-43. 2004..Subjects with both panic and non-panic anxiety disorders were more likely to have comorbid major depression and conduct disorders than those with other non-anxiety disorders... - Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory studyJohn V Campo
Department of Pyschiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:1234-42. 2004..To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders... - Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) studyDavid Brent
Western Psychiatric Institute and Clinic, 3811 O Hara St, Rm 315 Bellefield Towers, Pittsburgh, PA 15213, USA
Am J Psychiatry 167:190-7. 2010..The authors sought to assess the relationship between candidate genes and two clinical outcomes, namely, symptomatic improvement and the occurrence of suicidal events, in a sample of treatment-resistant depressed adolescents... - Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms studyDavid Axelson
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
J Clin Psychiatry 73:1342-50. 2012..Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal stability, and association with parental psychiatric disorders... - Predictors of prospectively examined suicide attempts among youth with bipolar disorderTina R Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Arch Gen Psychiatry 69:1113-22. 2012..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder... - Real-world affect and social context as predictors of treatment response in child and adolescent depression and anxiety: an ecological momentary assessment studyErika E Forbes
University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 22:37-47. 2012..Individual differences in the social and affective dynamics of daily life could help to elucidate the characteristics of youth who respond to treatment... - Differential patterns of abnormal activity and connectivity in the amygdala-prefrontal circuitry in bipolar-I and bipolar-NOS youthCecile D Ladouceur
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 50:1275-89.e2. 2011..We sought to examine patterns of activity and connectivity in youth with BP-NOS relative to youth with bipolar disorder type I (BP-I) and healthy controls (HC)... - Mother-child interactions in depressed children and children at high risk and low risk for future depressionLaura J Dietz
Department of Psychiatry at the University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:574-82. 2008..To compare mother-child interactions and parenting styles in families of children with major depressive disorder, youths at high risk for depression, and healthy controls... - Risk for suicidal ideation among the offspring of bipolar parents: results from the Bipolar Offspring Study (BIOS)Tina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Suicide Res 15:207-22. 2011..Offspring of parents with bipolar disorder are at elevated risk for suicidal ideation as compared with offspring of controls. Suicide risk assessment in this population should attend to specific risk factors identified... - Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patientsDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Psychiatr Serv 60:888-97. 2009..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder... - Aggression, hostility, and irritability in children at risk for bipolar disorderTiffany R Farchione
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 9:496-503. 2007..To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP)... - Emergent suicidality in a clinical psychotherapy trial for adolescent depressionJeffrey A Bridge
Western Psychiatric Institute and Clinic, Child and Adolescent Psychiatry, 3811 O'Hara St, BFT 311, Pittsburgh, PA 15213-2592, USA
Am J Psychiatry 162:2173-5. 2005..To evaluate accurately the role of treatment in emergent suicidality, it is important to assess self-reported suicidality at intake and to balance treatment groups on this key predictor of emergent suicidality... - MRI study of thalamus volumes in juvenile patients with bipolar disorderE Serap Monkul
MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Depress Anxiety 23:347-52. 2006..Any differences in thalamus size that may exist between patients with bipolar disorder and healthy controls must amount to small effect sizes... - Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorderBarbara K Chen
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Biol Psychiatry 56:399-405. 2004..48, p = .03). CONCLUSIONS: The direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder... - Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
Psychiatry Res 138:43-9. 2005..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents... - Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorderSimerjit Kaur
Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Am J Psychiatry 162:1637-43. 2005..64 cm3 [SD=0.21] versus 2.71 cm3 [SD=0.10]). CONCLUSIONS: The findings indicate smaller cingulate volumes in children and adolescents with bipolar disorder, suggesting that such abnormalities may be present early in the illness course... - Child mania rating scale: development, reliability, and validityMani N Pavuluri
Department of Psychiatry, University of Illinois at Chicago, 60612, USA
J Am Acad Child Adolesc Psychiatry 45:550-60. 2006..To develop a reliable and valid parent-report screening instrument for mania, based on DSM-IVsymptoms... - MRI study of the cerebellum in young bipolar patientsE Serap Monkul
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder... - Objective sleep in pediatric anxiety disorders and major depressive disorderErika E Forbes
University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:148-55. 2008..To examine objective and subjective sleep problems in early-onset anxiety and depression... - "I won, but I'm not getting my hopes up": depression moderates the relationship of outcomes and reward anticipationThomas M Olino
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Psychiatry Res 194:393-5. 2011..This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression... - Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems... - Fluoxetine for the treatment of childhood anxiety disorders: open-label, long-term extension to a controlled trialDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1263-70. 2005..To assess the efficacy of fluoxetine for the long-term treatment of children and adolescents with anxiety disorders, including generalized anxiety disorder, separation anxiety disorder, and/or social phobia... - Phenomenology, longitudinal course, and outcome of children and adolescents with bipolar spectrum disordersRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Child Adolesc Psychiatr Clin N Am 18:273-89, vii. 2009..Thus, early diagnosis and treatment of pediatric bipolar is of utmost importance... - First episode of depression in children at low and high familial risk for depressionDouglas E Williamson
Department of Child and Adolescent Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:291-7. 2004..To examine the development of first-onset major depressive disorder (MDD) in children at high and low familial risk for depression in a prospective study... 
Associations of lifetime depression with trauma exposure, other environmental adversities, and impairment in adolescents with ADHDW Burleson Daviss
Department of Psychiatry, University of Texas Health Science Center of San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Abnorm Child Psychol 37:857-71. 2009....- Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1107-15. 2006..This study investigated whether processing emotionally salient information such as emotional facial expressions influences the performance on a cognitive control task in pediatric anxiety and depression... - Abnormal corpus callosum myelination in pediatric bipolar patientsSheila C Caetano
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J Affect Disord 108:297-301. 2008..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients... - Is bipolar disorder specifically associated with panic disorder in youths?Boris Birmaher
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Clin Psychiatry 63:414-9. 2002..To replicate previous findings of high rates of bipolar disorder (BPD) in patients with panic disorder (PD) and determine if youths with both PD and BPD have more severe illness... - Steady-state clinical pharmacokinetics of bupropion extended-release in youthsW Burleson Daviss
Western Psychiatric Institute and Clinic, University of Pittsburgh, USA
J Am Acad Child Adolesc Psychiatry 45:1503-9. 2006..To examine in children and adolescents the 24-hour, steady-state clinical pharmacokinetics of an extended-release (XL) formulation of bupropion (Wellbutrin XL)... - Replicable differences in preferred circadian phase between bipolar disorder patients and control individualsJoel Wood
Departments of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States
Psychiatry Res 166:201-9. 2009..Individuals with elevated depressive mood scores are more likely to be evening types. Our results suggest a replicable relationship between circadian phase and morbid mood states... - Peri-sleep-onset cortisol levels in children and adolescents with affective disordersErika E Forbes
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Biol Psychiatry 59:24-30. 2006..Evidence also indicates that pubertal development may influence the expression of HPA dysregulation. We hypothesized that adolescents with depression and youth with anxiety disorders exhibit elevated peri-sleep-onset cortisol... - Altered emotional processing in pediatric anxiety, depression, and comorbid anxiety-depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Abnorm Child Psychol 33:165-77. 2005..Further, research is needed to replicate this study and delineate underlying neural mechanisms... - Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescentsDavid A Axelson
Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 162:802-4. 2005..CONCLUSIONS: Platelet serotonin reuptake inhibition may be an appropriate surrogate biological marker for the pharmacodynamic activity of SSRIs in depressed adolescents... - Recurrent abdominal pain, anxiety, and depression in primary careJohn V Campo
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Pediatrics 113:817-24. 2004..Our aim was to determine whether RAP is associated with psychiatric symptoms and disorders, anxious temperament, and functional impairment in pediatric primary care... - Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trialDavid Brent
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 299:901-13. 2008..There are no data to guide clinicians on subsequent treatment strategy... - Pediatric anxiety disorders: management in primary careDara Sakolsky
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213 2592, USA
Curr Opin Pediatr 20:538-43. 2008..These disorders can result in significant academic, social, and familial impairment. Early identification in pediatric primary care and effective management may help improve outcomes... - Superior temporal gyrus volumes in pediatric generalized anxiety disorderMichael D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Program (Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Biol Psychiatry 51:553-62. 2002..CONCLUSIONS: These data agree with previous work implicating posterior right-hemispheric regions in anxiety disorders and may suggest developmental alterations in pediatric GAD... - Measuring mood and complex behavior in natural environments: use of ecological momentary assessment in pediatric affective disordersDavid A Axelson
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 13:253-66. 2003..Potential applications of the EMA methodology to the study of neurobehavioral systems and the pathophysiology of pediatric affective disorders are discussed... - The stressful life events schedule for children and adolescents: development and validationDouglas E Williamson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Psychiatry Res 119:225-41. 2003..48). The results of this study indicate that the SLES has good psychometric properties. The SLES is a useful, cost-effective tool for assessing stressful life events in children and adolescents... - Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder: a reviewJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 30:1824-33. 2005..However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Texas Children's Medication Algorithm Project: update from Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive DisorderCarroll W Hughes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 46:667-86. 2007..To revise and update consensus guidelines for medication treatment algorithms for childhood major depressive disorder based on new scientific evidence and expert clinical consensus when evidence is lacking... - Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians StudyAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:382-90. 2009..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder... - Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and wakingMichele A Bertocci
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1158-66. 2005..These findings raise provocative questions regarding the nature of sleep complaints associated with early-onset depression... - Accuracy of brief and full forms of the Child Mania Rating ScaleDavid B Henry
Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60608, USA
J Clin Psychol 64:368-81. 2008..93 with 11 items from the full CMRS-P that were not used in constructing the brief version, and showed accuracy comparable to the full scale in differentiating BD from ADHD, and in discriminating among bipolar subtypes... - Stressful life events in anxious and depressed childrenDouglas E Williamson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA Williamson
J Child Adolesc Psychopharmacol 15:571-80. 2005..The aim of this study was to examine the occurrence of stressful life events in anxious and depressed children... - Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attemptersDavid A Brent
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 59:801-7. 2002..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear... - Course and outcome of child and adolescent major depressive disorderBoris Birmaher
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, 3811 O Hara Street, Pittsburgh, PA 15213 3811, USA
Child Adolesc Psychiatr Clin N Am 11:619-37, x. 2002..Depressed youth who present with psychosis, psychomotor retardation, pharmacological induced hypomania/mania, and/or family history of bipolar disorder are at high risk to develop bipolar disorder... - Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?John V Campo
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 42:1221-6. 2003..The authors' aim was to determine whether inadvertent gastrointestinal (GI) distress to serotonergic challenge predicted future major depressive and/or anxiety disorders in exposed children... - Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localizationCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1073-82. 2006.... - Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trialTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 46:820-30. 2007..To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder... - Lifetime history of sexual abuse, clinical presentation, and outcome in a clinical trial for adolescent depressionRémy P Barbe
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Clin Psychiatry 65:77-83. 2004..To investigate the impact of sexual abuse on clinical presentation and treatment outcome in depressed adolescents... - Childhood anxiety in a diverse primary care population: parent-child reports, ethnicity and SCARED factor structureFrances J Wren
Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Standford, CA 94305 5719, USA
J Am Acad Child Adolesc Psychiatry 46:332-40. 2007.... - Psychopharmacologic treatment of pediatric major depressive disorderKhrista Boylan
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main St W Box 2000, Hamilton, ON L8N 3Z5, Canada
Psychopharmacology (Berl) 191:27-38. 2007..The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth... - Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical courseUma Rao
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90024 1759, USA
J Affect Disord 70:273-80. 2002..This investigation was designed to assess whether some of the observed variability is related to undifferentiated unipolar and bipolar disorders in a sample that was reported previously... - Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 47:515-25. 2008..Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder... - Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosisEric A Youngstrom
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
Bipolar Disord 10:194-214. 2008..To find, review, and critically evaluate evidence pertaining to the phenomenology of pediatric bipolar disorder and its validity as a diagnosis... - Steady-state pharmacokinetics of bupropion SR in juvenile patientsW Burleson Daviss
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:349-57. 2005..To examine the steady-state pharmacokinetic properties of bupropion sustained release (SR) and their potential developmental differences in youths...
Research Grants
- Longitudinal Assessment of Manic Symptoms (LAMS)Boris Birmaher; Fiscal Year: 2007..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
- Course and Outcome for Bipolar Disorder in YouthBoris Birmaher; Fiscal Year: 2007....
- Children of Bipolar Parents: A High Risk Follow-Up StudyBoris Birmaher; Fiscal Year: 2009..Moreover, as described in detail in the proposal, BIOS is becoming a national resource for other neurocognitive, imaging, genetic, and psychometric studies. ..
- Longitudinal Assessment of Manic Symptoms (LAMS)Boris Birmaher; Fiscal Year: 2009..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
- Course and Outcome for Bipolar Disorder in YouthBoris Birmaher; Fiscal Year: 2009....
- Children of Bipolar Parents: A High Risk Follow-Up StudyBoris Birmaher; Fiscal Year: 2010..Moreover, as described in detail in the proposal, BIOS is becoming a national resource for other neurocognitive, imaging, genetic, and psychometric studies. ..
- 2/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)Boris Birmaher; Fiscal Year: 2010..abstract_text> ..
- Course and Outcome for Bipolar Disorder in YouthBoris Birmaher; Fiscal Year: 2010....
- Child/Adolescent Anxiety Multimodal Treatment StudyBoris Birmaher; Fiscal Year: 2007....
- Longitudinal Assessment of Manic Symptoms (LAMS)Boris Birmaher; Fiscal Year: 2006..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
- Children of Bipolar Parents: A High Risk Follow-Up StudyBoris Birmaher; Fiscal Year: 2005..This unique prospective study will have important implications for early-detection, intervention, and prevention of childhood-onset of BPD. ..
- Longitudinal Assessment of Manic SymptomsMARY LOUISE PHILLIPS; Fiscal Year: 2010....