L Birder

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Role of the urothelium in urinary bladder dysfunction following spinal cord injury
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Prog Brain Res 152:135-46. 2006
  2. doi request reprint Urinary bladder, cystitis and nerve/urothelial interactions
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Department Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Electronic address
    Auton Neurosci 182:89-94. 2014
  3. doi request reprint Urothelial signaling
    Lori Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Physiol Rev 93:653-80. 2013
  4. doi request reprint Nervous network for lower urinary tract function
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Urol 20:4-12. 2013
  5. pmc Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells
    L A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Acta Physiol (Oxf) 207:123-9. 2013
  6. doi request reprint From urothelial signalling to experiencing a sensation related to the urinary bladder
    L Birder
    Departments of Medicine and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Acta Physiol (Oxf) 207:34-9. 2013
  7. pmc How does the urothelium affect bladder function in health and disease? ICI-RS 2011
    L A Birder
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurourol Urodyn 31:293-9. 2012
  8. ncbi request reprint Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli
    Lori A Birder
    University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Department of Medicine, Pittsburgh, PA 15261, United States
    Vascul Pharmacol 45:221-6. 2006
  9. pmc Mechanisms of disease: involvement of the urothelium in bladder dysfunction
    Lori A Birder
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Nat Clin Pract Urol 4:46-54. 2007
  10. pmc Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat
    Lori Birder
    Department of Medicine, University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 323:227-35. 2007

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Role of the urothelium in urinary bladder dysfunction following spinal cord injury
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Prog Brain Res 152:135-46. 2006
    ..Taken together, these and other findings discussed in this chapter suggest a sensory function for the urothelium and that alterations in urothelial properties may contribute to afferent abnormalities following spinal cord injury...
  2. doi request reprint Urinary bladder, cystitis and nerve/urothelial interactions
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Department Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Electronic address
    Auton Neurosci 182:89-94. 2014
    ..Theories explaining the pathology of bladder pain syndrome are many and include an altered bladder lining and possible contribution of a bacterial agent. ..
  3. doi request reprint Urothelial signaling
    Lori Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Physiol Rev 93:653-80. 2013
    ..Changes in the urothelium/lamina propria ("mucosa") produced by different bladder disorders are discussed, as well as the mucosa as a target for therapeutic interventions...
  4. doi request reprint Nervous network for lower urinary tract function
    Lori A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Urol 20:4-12. 2013
    ..This review will discuss some of the components involved in control of lower urinary tract function, with an emphasis on the sensor and transducer roles of the urothelium...
  5. pmc Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells
    L A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Acta Physiol (Oxf) 207:123-9. 2013
    ..To examine function of both cholinergic (muscarinic) and TRPV1 receptors in human bladder urothelial (HBUC) from non-neurogenic overactive bladder (OAB) patients as compared to control subjects...
  6. doi request reprint From urothelial signalling to experiencing a sensation related to the urinary bladder
    L Birder
    Departments of Medicine and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Acta Physiol (Oxf) 207:34-9. 2013
    ..e. the uroepithelium and bladder afferents) can have a major influence on our sensory systems. In this review, we discuss bladder sensation with a focus on coding events in the periphery...
  7. pmc How does the urothelium affect bladder function in health and disease? ICI-RS 2011
    L A Birder
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurourol Urodyn 31:293-9. 2012
    ..Finally, consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery...
  8. ncbi request reprint Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli
    Lori A Birder
    University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Department of Medicine, Pittsburgh, PA 15261, United States
    Vascul Pharmacol 45:221-6. 2006
    ..These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell-cell interactions may lead to a number of urinary tract abnormalities...
  9. pmc Mechanisms of disease: involvement of the urothelium in bladder dysfunction
    Lori A Birder
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Nat Clin Pract Urol 4:46-54. 2007
    ..Elucidation of mechanisms that influence urothelial function might provide insights into the pathology of bladder dysfunction...
  10. pmc Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat
    Lori Birder
    Department of Medicine, University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 323:227-35. 2007
    ..These data raise the possibility that TRPV4 channels in the urothelium could contribute to abnormal bladder activity...
  11. pmc Urothelial signaling
    Lori A Birder
    University of Pittsburgh School of Medicine, A 1207 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Auton Neurosci 153:33-40. 2010
    ..Here, we review the specialized anatomy of the urothelium and speculate on possible communication mechanisms from urothelial cells to various cell types within the bladder wall...
  12. pmc Beyond neurons: Involvement of urothelial and glial cells in bladder function
    Lori A Birder
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Neurourol Urodyn 29:88-96. 2010
    ..As estrogen fluctuations may modulate the severity of many chronic pelvic pain syndromes, we also examined whether 17beta-estradiol (E2) alters cell signaling in rat urothelial cells...
  13. pmc Neural control of the lower urinary tract: peripheral and spinal mechanisms
    L Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 29:128-39. 2010
    ....
  14. pmc Is the urothelium intelligent?
    L A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Neurourol Urodyn 29:598-602. 2010
    ..The advantage of this approach is that input-output functions can be mathematically formulated, and the importance of different components contributing to abnormal urinary tract function can be calculated...
  15. pmc TRPs in bladder diseases
    Lori A Birder
    University of Pittsburgh School of Medicine, Department of Medicine and Pharmacology, A 1207 Scaife Hall, Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1772:879-84. 2007
    ..I. Nagy, P. Santha, G. Jansco, L. Urban, The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology, European Journal of Pharmacology 500, (2004) 351-369.]...
  16. ncbi request reprint More than just a barrier: urothelium as a drug target for urinary bladder pain
    Lori A Birder
    Univ of Pittsburgh School of Medicine, Dept of Medicine, A 1207 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 289:F489-95. 2005
    ..Taken together, these and other findings highlighted in this review suggest a sensory function for the urothelium. Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction...
  17. ncbi request reprint Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium
    L A Birder
    Dept of Medicine, Laboratory of Epithelial Cell Biology, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Renal Physiol 285:F423-9. 2003
    ..Taken together, these results suggest that FIC results in a novel hypersensitivity to mechanical stimuli that may involve alterations in IP3-sensitive pathways...
  18. ncbi request reprint Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
    L A Birder
    Department of Medicine, Laboratory of Epithelial Cell Biology, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Nat Neurosci 5:856-60. 2002
    ..These findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium...
  19. ncbi request reprint Altered inducible nitric oxide synthase expression and nitric oxide production in the bladder of cats with feline interstitial cystitis
    L A Birder
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Urol 173:625-9. 2005
    ..Thus, in the current study we investigated whether inducible NO synthase (iNOS) mediated NO production is altered in the bladder of cats with a naturally occurring model of IC termed feline IC (FIC)...
  20. ncbi request reprint Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis
    L A Birder
    Dept of Medicine, University of Pittsburgh School of Medicine, A 1207 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 287:F1084-91. 2004
    ..Because the urothelial cells appear to have a sensory function in the bladder, it is possible that the plasticity in urothelial purinergic receptors is linked with the painful bladder symptoms in IC...
  21. ncbi request reprint Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat
    Lori A Birder
    Department of Medicine Laboratory of Epithelial Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 304:272-6. 2003
    ..These findings indicate that nepadutant suppresses the responses of colonic afferent neurons to nociceptive stimuli and that NK2 receptor antagonists may be beneficial in the treatment of sensory symptoms of colitis...
  22. pmc Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists
    A Kanai
    Department of Medicine, University of Pittsburgh School of Medicine, A1224 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 292:F1065-72. 2007
    ..Activity is enhanced by stretch or carbachol and this enhancement is blocked by atropine. It is hypothesized that acetylcholine is released from the urothelium during bladder filling to enhance spontaneous activity...
  23. pmc Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis
    Y Ikeda
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Urol 181:1415-22. 2009
    ..In this study Ca(2+) transients in the bladder wall of domestic cats diagnosed with naturally occurring feline interstitial cystitis were examined...
  24. ncbi request reprint The catabolic fate of nitric oxide: the nitric oxide oxidase and peroxynitrite reductase activities of cytochrome oxidase
    Linda L Pearce
    Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 277:13556-62. 2002
    ..It is proposed that under normal physiological and most pathological (non-inflammatory) conditions, reaction with cytochrome c oxidase is the major route by which NO is removed from mitochondria-rich cells...
  25. ncbi request reprint Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis
    Anthony J Kanai
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 283:F1304-12. 2002
    ..We conclude that MnSOD gene therapy is protective, which could lead to its use in mitigating radiation cystitis and preventing dysfunction of the urinary bladder...
  26. ncbi request reprint Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells
    Lori A Birder
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:8063-70. 2002
    ..These findings are considered in light of recent reports that urothelial cells may exhibit a number of "neuron-like" properties, including the expression of receptors/ion channels similar to those found in sensory neurons...
  27. pmc Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity
    F Aura Kullmann
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 28:1977-87. 2008
    ..These findings suggest that the urothelial-afferent nerve interactions can influence reflex voiding function...
  28. pmc Expression and function of rat urothelial P2Y receptors
    Bikramjit Chopra
    A1207 Scaife Hall, Dept of Medicine, Univ of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 294:F821-9. 2008
    ..This could lead to the release of bioactive mediators such as additional ATP, nitric oxide, and acetylcholine, which can modulate the micturition reflex by acting on suburothelial myofibroblasts and/or pelvic afferent fibers...
  29. ncbi request reprint Abnormal excitability in capsaicin-responsive DRG neurons from cats with feline interstitial cystitis
    Adrian Sculptoreanu
    Department of Pharmacology, University of Pittsburgh, School of Medicine, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Exp Neurol 193:437-43. 2005
    ..Our data suggest that FIC afferent neurons exhibit abnormal firing which may be due to changes in the behavior of K+ currents and show that these changes are restricted to a subpopulation of CAPS-responsive neurons...
  30. pmc Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis
    Adrian Sculptoreanu
    Department of Pharmacology, School of Medicine, University of Pittsburgh, 200 Lathrope Street, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Neurosci Lett 381:42-6. 2005
    ..Our data suggest that FIC afferent neurons exhibit abnormal CAPS responses. The latter may be due to enhanced endogenous activities of PKC...
  31. pmc Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells
    Jonathan M Beckel
    Dept of Pharmacology, Univ of Pittsburgh School of Medicine, A1220 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 290:F103-10. 2006
    ..These results are the first indication that stimulation of nonneuronal nicotinic receptors in the bladder can affect micturition...
  32. pmc Non-neuronal acetylcholine and urinary bladder urothelium
    Ann T Hanna-Mitchell
    University of Pittsburgh School of Medicine Department of Medicine, Pittsburgh, PA 15261, USA
    Life Sci 80:2298-302. 2007
    ..These observations indicate that acetylcholine release from urothelial cells is mediated by different mechanisms than those such as vesicular storage and exocytosis that underlie the release of neurotransmitters from nerves...
  33. pmc ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells
    Edward C Y Wang
    Renal Electrolyte Division and Laboratory of Epithelial Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 115:2412-22. 2005
    ....
  34. pmc Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium
    Bikramjit Chopra
    A1207 Scaife Hall, Department of Medicine Renal Division, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Physiol 562:859-71. 2005
    ..These studies demonstrate that urothelial expression of bradykinin receptors is plastic and is altered by pathology...
  35. pmc Role of urothelial nerve growth factor in human bladder function
    Lori A Birder
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 26:405-9. 2007
    ..To test whether nerve growth factor (NGF) concentration in human bladder urothelium/suburothelium is related to detrusor overactivity (DO), bladder sensation, detrusor contractility, or other aspects of lower urinary tract function...
  36. ncbi request reprint Symposium report on urothelial dysfunction: pathophysiology and novel therapies
    A Kanai
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 175:1624-9. 2006
    ....
  37. ncbi request reprint Bladder Adelta afferent nerve activity in normal cats and cats with feline interstitial cystitis
    James R Roppolo
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 173:1011-5. 2005
    ..In the current study we compared the effect of bladder distention and intravesical infusion of KCl solution on Adelta bladder afferent nerve activity in normal and FIC cats...
  38. pmc Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA
    Chaoming Zhou
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circ Res 98:1040-7. 2006
    ..3 channel mRNA by activating NADPH oxidase. These results link long-term control of cardiac K+ channel gene expression to a physiological reactive oxygen species signaling pathway...
  39. pmc New insights into the pharmacology of the bladder
    Ann T Hanna-Mitchell
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Urol 18:347-52. 2008
    ..This review aims to provide an insight into recent (experimental and clinical) developments in mechanisms of existing therapies as well as novel targets...
  40. ncbi request reprint Localization of P2X and P2Y receptors in dorsal root ganglia of the cat
    Huai Zhen Ruan
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    J Histochem Cytochem 53:1273-82. 2005
    ..A further difference was the low expression of P2Y(1) receptors in cat DRG neurons compared with more than 80% of the neurons in rat. Many small-diameter neurons were NF200-positive in cat, again differing from rat and mouse...
  41. ncbi request reprint Expression of P2X and P2Y receptors in the intramural parasympathetic ganglia of the cat urinary bladder
    Huai Zhen Ruan
    Autonomic Neuroscience Centre, Royal Free and Univ College Medical School, Rowland Hill St, London NW3 2PF, UK
    Am J Physiol Renal Physiol 290:F1143-52. 2006
    ..These novel histochemical properties of cholinergic neurons in the cat bladder suggest that the parasympathetic pathways to the cat bladder may be modulated by complex purinergic synaptic mechanisms...

Research Grants18

  1. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori Birder; Fiscal Year: 2007
    ..Understanding the mechanisms contributing to and maintaining these types of changes may provide important insights for the identification of novel targets for the future clinical management of IC. ..
  2. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2010
    ..Understanding the mechanisms contributing to and maintaining these types of changes may provide important insight for the identification of novel targets for the future clinical management of bladder diseases such as PBS/IC. ..
  3. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2007
    ..Understanding these mechanisms may provide important insight for the identification of novel targets for the future clinical management of bladder dysfunctions. ..
  4. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori Birder; Fiscal Year: 2004
    ..These studies may lead to selective pharmacologic interventions aimed at targeting neural-epithelial release or signaling defects and could provide a new prospective on the pathophysiology and clinical management of bladder disorders. ..
  5. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  6. NITRIC OXIDE IN BLADDER NEURAL EPITHELIAL SIGNALING
    Lori Birder; Fiscal Year: 2001
    ..Thus, selective pharmacologic interventions aimed at altering NO levels could provide a new approach to our understanding and clinical management of bladder disorders. ..