Research Topics
| N C BinkleySummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Vitamin D and osteoporosis-related fractureNeil Binkley
University of Wisconsin Osteoporosis Clinical Research Program, University of Wisconsin Madison, WI 53705, USA
Arch Biochem Biophys 523:115-22. 2012..These recommendations are likely to evolve as additional data becomes available...- Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adultsN C Binkley
Institute on Aging, Department of Medicine, University of Wisconsin, Madison, WI, USA
Am J Clin Nutr 72:1523-8. 2000..Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common... - Combination therapy for osteoporosis: considerations and controversyNeil Binkley
University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Curr Osteoporos Rep 3:150-4. 2005..Given the absence of demonstrated fracture reduction benefit, increased cost and likely increase in adverse events, combination therapy is not currently recommended... - Lateral vertebral assessment: a valuable technique to detect clinically significant vertebral fracturesNeil Binkley
Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
Osteoporos Int 16:1513-8. 2005..In conclusion, the low-radiation, dual-energy LVA technique provides a rapid and convenient way for clinicians to identify patients with, and without, grade 2 or 3 vertebral fractures, thereby enhancing care of osteoporotic patients... - Combination therapy for osteoporosis: considerations and controversyNeil Binkley
University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Curr Rheumatol Rep 7:61-5. 2005..Given the absence of demonstrated fracture reduction benefit, increased cost and likely increase in adverse events, combination therapy is not currently recommended... - Recalculation of the NHANES database SD improves T-score agreement and reduces osteoporosis prevalenceNeil Binkley
University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA
J Bone Miner Res 20:195-201. 2005..Use of a recalculated young-normal SD for the GE Lunar-adjusted NHANES III database improved diagnostic agreement and is recommended... - Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardizationN Binkley
Department of Medicine, Osteoporosis Clinical Center and Research Program, University of Wisconsin Madison, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
J Clin Endocrinol Metab 89:3152-7. 2004..If the medical community is to make progress in correcting widespread hypovitaminosis D, 25OHD measurement must be standardized... - An overlying fat panniculus affects femur bone mass measurementNeil Binkley
University of Wisconsin Institute on Aging, Madison 53706, USA
J Clin Densitom 6:199-204. 2003..When a fat panniculus overlays the proximal femur scan area, its retraction should be part of routine densitometric practice... - Bone loss detection in rats using a mouse densitometerN Binkley
University of Wisconsin Institute on Aging, University of Wisconsin, Madison, Wisconsin 53706, USA
J Bone Miner Res 18:370-5. 2003..988) and ash weight (r = 0.998). Given its comparability to standard DXA plus its rapid scan speed and portability, the PIXImus is useful in evaluating ovx-induced osteopenia in rats... - Vitamin K supplementation does not affect ovariectomy-induced bone loss in ratsN Binkley
Institute on Aging, University of Wisconsin Madison, 53706, USA
Bone 30:897-900. 2002..Finally, femoral biomechanical properties were not affected by phylloquinone or MK4. To conclude, in this study, neither high-dose phylloquinone nor MK4 reduced the ovx-associated increase in bone turnover or decline in DFBMD... - Osteoporosis in menNeil Binkley
Osteoporosis Clinical Center and Research Program and Institute on Aging, University of Wisconsin Madison, USA
WMJ 101:28-32. 2002..Finally pharmacologic agents to treat osteoporosis have recently been approved in men. This review highlights current understanding of epidemiology, pathophysiology, diagnosis, and treatment of osteoporosis in men... - A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylationNeil C Binkley
Institute on Aging, Department of Medicine, University of Wisconsin, Madison, USA
Am J Clin Nutr 76:1055-60. 2002..Dietary vitamin K is usually inadequate to maximize serum osteocalcin gamma-carboxylation. Phylloquinone supplementation increases osteocalcin gamma-carboxylation; however, the amount required to maximize carboxylation is not known... - Patient variables impact lumbar spine dual energy X-ray absorptiometry precisionR D Blank
Osteoporosis Clinical Center and Research Program, University of Wisconsin, and GRECC, William S Middleton Veterans Hospital, Madison, WI, USA
Osteoporos Int 17:768-74. 2006..Changes in bone mineral density are used to monitor osteoporosis therapy. To determine whether a change in bone mass is clinically significant, the precision of bone mineral density measurements must be known... - 2MD, a new anabolic agent for osteoporosis treatmentL A Plum
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI, 53706 1544, USA
Osteoporos Int 17:704-15. 2006..This analog has now been extensively tested in aged ovariectomized female rats maintained on a diet adequate in calcium and phosphorus... - Densitometric diagnosis of osteoporosis in men: effect of measurement site and normative databaseNellie Vallarta-Ast
Department of Radiology, William S. Middleton VAMC, Madison, WI, USA
J Clin Densitom 5:383-89. 2002..This situation will be exacerbated by utilization of a female normative database; more men with prior fracture may be categorized as not meeting a pharmaceutical intervention threshold... - Serum retinyl esters are not elevated in postmenopausal women with and without osteoporosis whose preformed vitamin A intakes are highKristina L Penniston
Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
Am J Clin Nutr 84:1350-6. 2006..However, retinyl ester concentration (percentage of total VA) was marginally associated with osteoporosis and should be further investigated... - Management of glucocorticoid-induced osteoporosis in male veteransM E Elliott
School of Pharmacy, University of Wisconsin, Madison 53706 1515, USA
Ann Pharmacother 34:1380-4. 2000..5 mg/d, provision of hormone replacement therapy as needed, calcium and vitamin D supplementation as necessary, and antiresorptive therapy for low BMD... - Current status of clinical 25-hydroxyvitamin D measurement: an assessment of between-laboratory agreementNeil Binkley
University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, WI 53705, United States
Clin Chim Acta 411:1976-82. 2010..Recent observations raised concern about persisting variability. This quality assurance exercise investigated 25(OH)D result comparability between laboratories... - What should DXA reports contain? Preferences of ordering health care providersNeil Binkley
Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
J Clin Densitom 12:5-10. 2009.... - Is vitamin D the fountain of youth?Neil Binkley
University of Wisconsin Osteoporosis Research, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Endocr Pract 15:590-6. 2009..To review the role of vitamin D deficiency for both classic and "nonclassic" effects and raise the caution that association does not prove causation... - Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeysNeil Binkley
University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
J Bone Miner Res 22:695-700. 2007..No effect on BMD or bone markers of skeletal turnover was observed. This study suggests that warfarin-induced K deficiency does not have skeletal effects... - Summary of the International Society For Clinical Densitometry 2005 Position Development ConferenceNeil Binkley
Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
J Bone Miner Res 22:643-5. 2007 - Effect of female database use for T-score derivation in menLivia M Wiemann
Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
J Clin Densitom 10:244-8. 2007..In conclusion, using female databases to derive male T-scores results in "improvement" of diagnostic classification for a substantial number of men with fewer being classified as having low bone mass... - Low vitamin D status: definition, prevalence, consequences, and correctionNeil Binkley
University of Wisconsin Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA
Endocrinol Metab Clin North Am 39:287-301, table of contents. 2010..Substantial between-individual variability exists in response to the same administered vitamin D dose. When to monitor 25(OH)D levels has received little attention. Supplementation with vitamin D(3) may be preferable to vitamin D(2)... - Gender differences in bone mineral density in epilepsyRaj D Sheth
Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, USA
Epilepsia 49:125-31. 2008..Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy... - Improved GI tolerability with monthly ibandronate in women previously using weekly bisphosphonatesNeil Binkley
Department of Medicine, Institute on Aging, Universityof Wisconsin Madison, 2870 University Avenue, Madison, WI 53705, USA
South Med J 102:486-92. 2009.... - Alendronate/vitamin D3 70 mg/2800 IU with and without additional 2800 IU vitamin D3 for osteoporosis: results from the 24-week extension of a 15-week randomized, controlled trialNeil Binkley
University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Bone 44:639-47. 2009..In subjects previously treated with ALN+D2800 for 15 weeks, the addition of 2800 IU D3 for 24 weeks did not produce hypercalcemia nor increase the risk of hypercalciuria... - Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American womenNeil Binkley
University of Wisconsin Osteoporosis Clinical Research Program, Madison, Wisconsin 53705, USA
J Bone Miner Res 24:983-91. 2009..This study does not support a role for vitamin K supplementation in osteoporosis prevention among healthy, postmenopausal, North American women receiving calcium and vitamin D supplementation... - Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosisZhifang Yang
University of Wisconsin UW Madison, Dept Nutritional Sciences, Madison, WI 53706, USA
Int J Vitam Nutr Res 78:105-11. 2008..Carotenoids that may have beneficial skeletal effects are lower in women with osteoporosis. Research is needed to identify potential protective mechanisms or utilization of carotenoids during osteoporosis... - Evaluation and correction of low vitamin D statusNeil Binkley
University of Wisconsin Osteoporosis Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Curr Osteoporos Rep 6:95-9. 2008..Achieving such levels often requires vitamin D supplementation. Vitamin D3 (cholecalciferol) or D2 (ergocalciferol) may be used; whether vitamin D3 is more potent than vitamin D2 in maintaining 25(OH)D is controversial... - A perspective on male osteoporosisNeil Binkley
Osteoporosis Clinical Center and Research Program and Institute on Aging University of Wisconsin, Madison, WI, USA
Best Pract Res Clin Rheumatol 23:755-68. 2009.... - Progressive bone deficit in epilepsyRaj D Sheth
Department of Neurology, University of Wisconsin Madison, 600 Highland Ave H6 574 CSC, Madison, WI 53792 5132, USA
Neurology 70:170-6. 2008..The objective was to determine the timing of the BMD deficit in ambulatory children with epilepsy... - An atlas improves interobserver agreement regarding application of the ISCD vertebral body exclusion criteriaKaren E Hansen
Osteoporosis Research Center, University of Wisconsin, Madison, WI 53792, USA
J Clin Densitom 10:359-64. 2007..Furthermore, correlations in T-score improved in 7 of 10 physician pairs after atlas review. We conclude that an interactive atlas promotes uniform lumbar spine DXA interpretation... - Osteoporosis in menNeil Binkley
Osteoporosis Clinical Center and Research Program, Institute on Aging, University of Wisconsin, Madison, WI 53705, USA
Arq Bras Endocrinol Metabol 50:764-74. 2006..Bisphosphonate therapy increases BMD, reduces vertebral fracture risk and is considered the standard of care for osteoporotic men at this point in time... - Evaluation and measurement of bone massMary E Elliott
University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, USA
Epilepsy Behav 5:S16-23. 2004..Laboratory assessment to identify secondary causes of osteoporosis, such as low vitamin D status in patients taking AEDs, is useful, but the role of markers of bone turnover in clinical practice has not been well defined... - Use of the lowest vertebral body T-score to diagnose lumbar osteoporosis in men: is "cherry picking" appropriate?Karen E Hansen
Rheumatology Section, Department of Medicine, University of Wisconsin, Madison, WI and Veterans Hospital, Madison, WI 53750, USA
J Clin Densitom 7:376-81. 2004..Prospective studies are needed to determine which of these three methods of lumbar spine analysis best predicts future fragility fracture in men and women... - Interobserver reproducibility of criteria for vertebral body exclusionKaren E Hansen
Rheumatology Section, Department of Medicine, University of Wisconsin, William S Middleton Veterans Hospital, Madison, Wisconsin, USA
J Bone Miner Res 20:501-8. 2005..Our results suggest that reproducibility may be improved by specifically addressing the sources of interobserver disagreement... - HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assaysGary L Lensmeyer
Clinical Toxicology Laboratory, University of Wisconsin Hospital and Clinics, Department of Pathology, University of Wisconsin Madison, Madison, WI 53792, USA
Clin Chem 52:1120-6. 2006..Unfortunately, variability among 25(OH)D assays limits clinician ability to monitor VitD status, supplementation, and toxicity... - 25-hydroxyvitamin D measurement, 2009: a review for cliniciansNeil Binkley
Osteoporosis Clinical Center and Research Program, University of Wisconsin Madison, Madison, WI 53705, USA
J Clin Densitom 12:417-27. 2009..Selectively obtaining 25(OH)D measurement in individuals at clinical risk for vitamin D deficiency and/or those most likely to promptly experience benefits from supplementation seems appropriate... - Calcium supplement ingestion may alter lumbar spine bone mineral density measurementDiane Krueger
University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, 53705, USA
J Clin Densitom 9:159-63. 2006..In conclusion, calcium tablet intake may affect measured L1-L4 BMD within 30 minutes of ingestion. As such, it is appropriate to request patients abstain from calcium tablet ingestion prior to a spine DXA examination... - Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development ConferenceSanford Baim
Medical College of Wisconsin, Milwaukee, WI, USA
J Clin Densitom 11:75-91. 2008.... - Addition of right lateral decubitus positioning improves vertebral visualization with VFA in selected patientsNellie Vallarta-Ast
William S Middleton Veterans Administration Medical Center, Madison, WI, USA
J Clin Densitom 9:375-9. 2006..We conclude that in selected patients with suboptimal vertebral visualization on VFA, addition of reverse positioning improves visualization and may enhance vertebral fracture detection... - Effect of phylloquinone supplementation on glucose homeostasis in humansRajiv Kumar
Nephrology Research Unit, Divisions of Nephrology and Hypertension and the Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, Rochester, MN, USA
Am J Clin Nutr 92:1528-32. 2010..Under-?-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice... - Does low vitamin D status contribute to "age-related" morbidity?Neil Binkley
University of Wisconsin Madison Institute on Aging and School of Medicine and Public Health, Madison, Wisconsin, USA
J Bone Miner Res 22:V55-8. 2007..This overview will explore the evidence for, and potential involvement of, vitamin D deficiency in nonbone conditions that are currently accepted as "age-related" morbidity among older adults... - Low vitamin D status: time to recognize and correct a Wisconsin epidemicNeil Binkley
University of Wisconsin Osteoporosis Clinical Center and Research Program, 2870 University Ave, Ste 100, Madison, WI 53705, USA
WMJ 106:466-72. 2007..This review details vitamin D physiology and the prevalence of low vitamin D status in Wisconsin and elsewhere, and provides approaches to optimizing vitamin D status... - Official positions of the International Society for Clinical Densitometry and Executive Summary of the 2005 Position Development ConferenceNeil Binkley
University of Wisconsin, Madison, WI, USA
J Clin Densitom 9:4-14. 2006..This report describes the methodology of the 2005 PDC and presents a summary of all ISCD Official Positions... - Slight abduction/adduction deviations in femur positioning for dual-energy X-ray absorptiometry are inconsequentialByram H Ozer
Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI, USA
J Clin Densitom 13:10-7. 2010..001 to +0.006g/cm(2)) at all proximal femur regions of interest. In this study, the use of a fixed-width bilateral femur positioner and associated deviations in femur alignment have little consequence on BMD measurement... - Is lateral spine densitometric assessment equivalent to lateral radiography?Neil Binkley
University of Wisconsin, Institute on Aging, Madison 53706, USA
J Bone Miner Res 17:1162-3. 2002 - Are Wisconsin physicians knowledgeable about male osteoporosis?Neil Binkley
Department of Medicine, Institute on Aging, University of Wisconsin, Madison, Wis, USA
WMJ 102:51-7. 2003..These data suggest that knowledge regarding male osteoporosis has been conveyed to practicing physicians. Evaluation of methods by which physicians will translate this knowledge into action, thereby optimizing patient care, are needed... - Jumping mechanography: a potential tool for sarcopenia evaluation in older individualsBjoern Buehring
University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
J Clin Densitom 13:283-91. 2010..Older age was negatively correlated, whereas lean mass positively correlated with jump power and height. JM appears to be a safe and potentially useful method to assess muscular function in older adults... - Osteoporosis assessment strategies for male nursing home residentsMary E Elliott
University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, USA
Maturitas 48:225-33. 2004.... - Pharmacy-based bone mass measurement to assess osteoporosis riskMary E Elliott
School of Pharmacy, University of Wisconsin, Madison WI, USA
Ann Pharmacother 36:571-7. 2002..Compounding this risk is low calcium intake. Community screening of rural, elderly women by peripheral bone density measurement can lead to medical interventions in such individuals... - Short-term vitamin A supplementation does not affect bone turnover in menTisha N Kawahara
Institute on Aging, University of Wisconsin Madison, Madison, WI, USA
J Nutr 132:1169-72. 2002..Thus, it is unlikely that short-term administration of vitamin A would contribute to the development of osteoporosis. Whether long-term vitamin A supplementation might have adverse skeletal effects remains to be determined... - Between-meal risedronate does not alter bone turnover in nursing home residentsSabina Agrawal
Osteoporosis Clinical Center and Research Program, University of Wisconsin, 2870 University Avenue, Madison, WI 53705, USA
J Am Geriatr Soc 54:790-5. 2006..To assess the effect of between-meal weekly risedronate and daily calcium 630 mg and vitamin D 400 IU on bone turnover markers... - Acceptability of pharmacy-based bone density measurement by women and primary healthcare providersPaul F Lata
University of Wisconsin Schools of Pharmacy and Medicine, Madison, WI 53705, USA
Menopause 9:449-55. 2002.... - Executive summary International Society for Clinical Densitometry position development conference Denver, Colorado July 20-22, 2001Leon Lenchik
J Clin Densitom 5:S1-3. 2002..The ISCD is a not-for-profit multidisciplinary society whose main mission is to promote quality in the performance and interpretation of bone densitometry examinations... - Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis DMary E Elliott
School of Pharmacy, University of Wisconsin, Madison 53705, USA
Pharmacotherapy 23:702-10. 2003.... - Position Development ConferenceLeon Lenchik
Division of Radiologic Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA
South Med J 96:724-5. 2003..A second Position Development Conference will be held in July 2003 in Cincinnati, OH. For information, visit the ISCD web site: http://www.iscd.org/... - Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive functionRobert J Przybelski
School of Medicine and Public Health, University of Wisconsin Madison, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
Arch Biochem Biophys 460:202-5. 2007..In conclusion, the positive, significant correlation between serum 25(OH)D concentration and MMSE in these patients suggests a potential role for vitamin D in cognitive function of older adults... - Artifactual reduction in bone density as a result of technetium-99m MDP for bone scanning: report of two casesPennapa S Chan
Endocrine-Diabetes Center, St. Luke's Medical Center, Milwaukee, WI, USA
J Clin Densitom 7:457-8. 2004..Clinicians and technologists should be aware that technetium-99m used for bone scanning could cause artifactual reduction in DXA-measured bone mineral density... - Osteoporosis screening by community pharmacists: use of National Osteoporosis Foundation resourcesMary E Elliott
School of Pharmacy, University of Wisconsin Madison, 53705, USA
J Am Pharm Assoc (Wash) 42:101-10; quiz 110-1. 2002.... - What are the criteria by which a densitometric diagnosis of osteoporosis can be made in males and non-Caucasians?Neil C Binkley
J Clin Densitom 5:S19-27. 2002.... - Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D statusBruce W Hollis
Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
J Steroid Biochem Mol Biol 103:631-4. 2007..Thus, the relationship between circulating vitamin D and 25(OH)D may represent what "normal" vitamin D status should be...