N Binkley

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
    J Bone Miner Res 27:1821-9. 2012
  2. ncbi Low vitamin D status: definition, prevalence, consequences, and correction
    Neil Binkley
    University of Wisconsin Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA
    Rheum Dis Clin North Am 38:45-59. 2012
  3. ncbi Alendronate/vitamin D3 70 mg/2800 IU with and without additional 2800 IU vitamin D3 for osteoporosis: results from the 24-week extension of a 15-week randomized, controlled trial
    Neil Binkley
    University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Bone 44:639-47. 2009
  4. ncbi Is vitamin D the fountain of youth?
    Neil Binkley
    University of Wisconsin Osteoporosis Research, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Endocr Pract 15:590-6. 2009
  5. ncbi Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
    J Bone Miner Res 22:695-700. 2007
  6. ncbi Correlation among 25-hydroxy-vitamin D assays
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, 2870 University Avenue, Madison, WI 53705, USA
    J Clin Endocrinol Metab 93:1804-8. 2008
  7. ncbi 25-hydroxyvitamin D measurement, 2009: a review for clinicians
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin Madison, Madison, WI 53705, USA
    J Clin Densitom 12:417-27. 2009
  8. ncbi Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Clin Endocrinol Metab 96:981-8. 2011
  9. ncbi Improved GI tolerability with monthly ibandronate in women previously using weekly bisphosphonates
    Neil Binkley
    Department of Medicine, Institute on Aging, Universityof Wisconsin Madison, 2870 University Avenue, Madison, WI 53705, USA
    South Med J 102:486-92. 2009
  10. ncbi Low vitamin D status: definition, prevalence, consequences, and correction
    Neil Binkley
    University of Wisconsin Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA
    Endocrinol Metab Clin North Am 39:287-301, table of contents. 2010

Research Grants

  1. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003

Detail Information

Publications74

  1. ncbi A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
    J Bone Miner Res 27:1821-9. 2012
    ..Oral rsCT was safe and as well tolerated as ssCT nasal spray or placebo. Oral calcitonin may provide an additional treatment alternative for women with postmenopausal osteoporosis...
  2. ncbi Low vitamin D status: definition, prevalence, consequences, and correction
    Neil Binkley
    University of Wisconsin Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA
    Rheum Dis Clin North Am 38:45-59. 2012
    ..Widespread optimization of vitamin D status likely will lead to prevention of many diseases with attendant reduction of morbidity, mortality, and expense...
  3. ncbi Alendronate/vitamin D3 70 mg/2800 IU with and without additional 2800 IU vitamin D3 for osteoporosis: results from the 24-week extension of a 15-week randomized, controlled trial
    Neil Binkley
    University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Bone 44:639-47. 2009
    ..In subjects previously treated with ALN+D2800 for 15 weeks, the addition of 2800 IU D3 for 24 weeks did not produce hypercalcemia nor increase the risk of hypercalciuria...
  4. ncbi Is vitamin D the fountain of youth?
    Neil Binkley
    University of Wisconsin Osteoporosis Research, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Endocr Pract 15:590-6. 2009
    ..To review the role of vitamin D deficiency for both classic and "nonclassic" effects and raise the caution that association does not prove causation...
  5. ncbi Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
    J Bone Miner Res 22:695-700. 2007
    ..No effect on BMD or bone markers of skeletal turnover was observed. This study suggests that warfarin-induced K deficiency does not have skeletal effects...
  6. ncbi Correlation among 25-hydroxy-vitamin D assays
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, 2870 University Avenue, Madison, WI 53705, USA
    J Clin Endocrinol Metab 93:1804-8. 2008
    ..Measurement of circulating 25-hydroxy-vitamin D [25(OH)D]) is the accepted clinical indicator of vitamin D status. However, between-laboratory differences in measurement of this analyte exist, which may confound clinical care...
  7. ncbi 25-hydroxyvitamin D measurement, 2009: a review for clinicians
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin Madison, Madison, WI 53705, USA
    J Clin Densitom 12:417-27. 2009
    ..Selectively obtaining 25(OH)D measurement in individuals at clinical risk for vitamin D deficiency and/or those most likely to promptly experience benefits from supplementation seems appropriate...
  8. ncbi Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Clin Endocrinol Metab 96:981-8. 2011
    ..Whether ergocalciferol (D(2)) and cholecalciferol (D(3)) are equally effective to increase and maintain serum 25-hydroxyvitamin D [25(OH)D] concentration is controversial...
  9. ncbi Improved GI tolerability with monthly ibandronate in women previously using weekly bisphosphonates
    Neil Binkley
    Department of Medicine, Institute on Aging, Universityof Wisconsin Madison, 2870 University Avenue, Madison, WI 53705, USA
    South Med J 102:486-92. 2009
    ....
  10. ncbi Low vitamin D status: definition, prevalence, consequences, and correction
    Neil Binkley
    University of Wisconsin Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA
    Endocrinol Metab Clin North Am 39:287-301, table of contents. 2010
    ..Substantial between-individual variability exists in response to the same administered vitamin D dose. When to monitor 25(OH)D levels has received little attention. Supplementation with vitamin D(3) may be preferable to vitamin D(2)...
  11. ncbi Monthly ibandronate suppresses serum CTX-I within 3 days and maintains a monthly fluctuating pattern of suppression
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Osteoporos Int 20:1595-601. 2009
    ..Ibandronate decreased serum CTX-I levels within 3 days of therapy initiation. Over 6 months, the levels remained suppressed below baseline...
  12. ncbi Osteoporosis in men
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, Institute on Aging, University of Wisconsin, Madison, WI 53705, USA
    Arq Bras Endocrinol Metabol 50:764-74. 2006
    ..Bisphosphonate therapy increases BMD, reduces vertebral fracture risk and is considered the standard of care for osteoporotic men at this point in time...
  13. ncbi What should DXA reports contain? Preferences of ordering health care providers
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
    J Clin Densitom 12:5-10. 2009
    ....
  14. ncbi Evaluation and correction of low vitamin D status
    Neil Binkley
    University of Wisconsin Osteoporosis Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Curr Osteoporos Rep 6:95-9. 2008
    ..Achieving such levels often requires vitamin D supplementation. Vitamin D3 (cholecalciferol) or D2 (ergocalciferol) may be used; whether vitamin D3 is more potent than vitamin D2 in maintaining 25(OH)D is controversial...
  15. ncbi Current status of clinical 25-hydroxyvitamin D measurement: an assessment of between-laboratory agreement
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, WI 53705, United States
    Clin Chim Acta 411:1976-82. 2010
    ..Recent observations raised concern about persisting variability. This quality assurance exercise investigated 25(OH)D result comparability between laboratories...
  16. ncbi Low vitamin D status despite abundant sun exposure
    N Binkley
    University of Wisconsin Osteoporosis Research Program, Madison, WI 53705, USA
    J Clin Endocrinol Metab 92:2130-5. 2007
    ..However, some individuals with seemingly adequate UV exposure have been reported to have low serum 25-hydroxyvitamin D [25(OH)D] concentration, results that might have been confounded by imprecision of the assays used...
  17. ncbi A perspective on male osteoporosis
    Neil Binkley
    Osteoporosis Clinical Center and Research Program and Institute on Aging University of Wisconsin, Madison, WI, USA
    Best Pract Res Clin Rheumatol 23:755-68. 2009
    ....
  18. ncbi Summary of the International Society For Clinical Densitometry 2005 Position Development Conference
    Neil Binkley
    Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    J Bone Miner Res 22:643-5. 2007
  19. ncbi Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Research Program, Madison, Wisconsin 53705, USA
    J Bone Miner Res 24:983-91. 2009
    ..This study does not support a role for vitamin K supplementation in osteoporosis prevention among healthy, postmenopausal, North American women receiving calcium and vitamin D supplementation...
  20. ncbi Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats
    N Binkley
    Institute on Aging, University of Wisconsin Madison, 53706, USA
    Bone 30:897-900. 2002
    ..Finally, femoral biomechanical properties were not affected by phylloquinone or MK4. To conclude, in this study, neither high-dose phylloquinone nor MK4 reduced the ovx-associated increase in bone turnover or decline in DFBMD...
  21. ncbi Rapid correction of low vitamin D status in nursing home residents
    R Przybelski
    University of Wisconsin Osteoporosis Clinical Research Program, Madison, WI 53705, USA
    Osteoporos Int 19:1621-8. 2008
    ..This prospective study finds that ergocalciferol 50,000 IU three times weekly for four weeks effectively and safely corrects vitamin D inadequacy in nursing home residents...
  22. ncbi Bone loss detection in rats using a mouse densitometer
    N Binkley
    University of Wisconsin Institute on Aging, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Bone Miner Res 18:370-5. 2003
    ..988) and ash weight (r = 0.998). Given its comparability to standard DXA plus its rapid scan speed and portability, the PIXImus is useful in evaluating ovx-induced osteopenia in rats...
  23. ncbi Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization
    N Binkley
    Department of Medicine, Osteoporosis Clinical Center and Research Program, University of Wisconsin Madison, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    J Clin Endocrinol Metab 89:3152-7. 2004
    ..If the medical community is to make progress in correcting widespread hypovitaminosis D, 25OHD measurement must be standardized...
  24. ncbi Serum retinyl esters are not elevated in postmenopausal women with and without osteoporosis whose preformed vitamin A intakes are high
    Kristina L Penniston
    Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
    Am J Clin Nutr 84:1350-6. 2006
    ..However, retinyl ester concentration (percentage of total VA) was marginally associated with osteoporosis and should be further investigated...
  25. ncbi Densitometric diagnosis of osteoporosis in men: effect of measurement site and normative database
    Nellie Vallarta-Ast
    Department of Radiology, William S. Middleton VAMC, Madison, WI, USA
    J Clin Densitom 5:383-89. 2002
    ..This situation will be exacerbated by utilization of a female normative database; more men with prior fracture may be categorized as not meeting a pharmaceutical intervention threshold...
  26. ncbi Vertebral fracture assessment: impact of instrument and reader
    B Buehring
    University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Osteoporos Int 21:487-94. 2010
    ..We hypothesized that a newer generation densitometer increases the number of evaluable vertebrae and vertebral fractures detected. We also explored the impact of reader experience on vertebral fracture assessment (VFA) interpretation...
  27. ncbi An evaluation of densitometric vertebral fracture assessment in men
    N Vallarta-Ast
    University of Wisconsin Osteoporosis Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Osteoporos Int 18:1405-10. 2007
    ..A bimodal fracture distribution was observed, identifying fractures in 17% of men with no fracture history. Osteopenia or height loss of > or = 2.5'' may be indications for VFA in men...
  28. ncbi Central region-of-interest analysis of lumbar spine densitometry demonstrates lower bone mass in older rhesus monkeys
    D Krueger
    University of Wisconsin Institute on Aging and Wisconsin Regional Primate Research Center, Madison 53706, USA
    Bone 24:29-33. 1999
    ..This suggests that alternative analysis techniques, such as CROI, may be more appropriate to evaluate bone density in nonhuman primates, and potentially in people...
  29. ncbi An overlying fat panniculus affects femur bone mass measurement
    Neil Binkley
    University of Wisconsin Institute on Aging, Madison 53706, USA
    J Clin Densitom 6:199-204. 2003
    ..When a fat panniculus overlays the proximal femur scan area, its retraction should be part of routine densitometric practice...
  30. ncbi Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis
    Zhifang Yang
    University of Wisconsin UW Madison, Dept Nutritional Sciences, Madison, WI 53706, USA
    Int J Vitam Nutr Res 78:105-11. 2008
    ..Carotenoids that may have beneficial skeletal effects are lower in women with osteoporosis. Research is needed to identify potential protective mechanisms or utilization of carotenoids during osteoporosis...
  31. ncbi Osteoporosis in men
    Neil Binkley
    Osteoporosis Clinical Center and Research Program and Institute on Aging, University of Wisconsin Madison, USA
    WMJ 101:28-32. 2002
    ..Finally pharmacologic agents to treat osteoporosis have recently been approved in men. This review highlights current understanding of epidemiology, pathophysiology, diagnosis, and treatment of osteoporosis in men...
  32. ncbi Effect of female database use for T-score derivation in men
    Livia M Wiemann
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI 53705, USA
    J Clin Densitom 10:244-8. 2007
    ..In conclusion, using female databases to derive male T-scores results in "improvement" of diagnostic classification for a substantial number of men with fewer being classified as having low bone mass...
  33. ncbi An atlas improves interobserver agreement regarding application of the ISCD vertebral body exclusion criteria
    Karen E Hansen
    Osteoporosis Research Center, University of Wisconsin, Madison, WI 53792, USA
    J Clin Densitom 10:359-64. 2007
    ..Furthermore, correlations in T-score improved in 7 of 10 physician pairs after atlas review. We conclude that an interactive atlas promotes uniform lumbar spine DXA interpretation...
  34. ncbi Progressive bone deficit in epilepsy
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, 600 Highland Ave H6 574 CSC, Madison, WI 53792 5132, USA
    Neurology 70:170-6. 2008
    ..The objective was to determine the timing of the BMD deficit in ambulatory children with epilepsy...
  35. ncbi Combination therapy for osteoporosis: considerations and controversy
    Neil Binkley
    University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Curr Osteoporos Rep 3:150-4. 2005
    ..Given the absence of demonstrated fracture reduction benefit, increased cost and likely increase in adverse events, combination therapy is not currently recommended...
  36. ncbi Gender differences in bone mineral density in epilepsy
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Epilepsia 49:125-31. 2008
    ..Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy...
  37. ncbi Calcium supplement ingestion may alter lumbar spine bone mineral density measurement
    Diane Krueger
    University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, 53705, USA
    J Clin Densitom 9:159-63. 2006
    ..In conclusion, calcium tablet intake may affect measured L1-L4 BMD within 30 minutes of ingestion. As such, it is appropriate to request patients abstain from calcium tablet ingestion prior to a spine DXA examination...
  38. ncbi Evaluation and measurement of bone mass
    Mary E Elliott
    University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, USA
    Epilepsy Behav 5:S16-23. 2004
    ..Laboratory assessment to identify secondary causes of osteoporosis, such as low vitamin D status in patients taking AEDs, is useful, but the role of markers of bone turnover in clinical practice has not been well defined...
  39. ncbi Lateral vertebral assessment: a valuable technique to detect clinically significant vertebral fractures
    Neil Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
    Osteoporos Int 16:1513-8. 2005
    ..In conclusion, the low-radiation, dual-energy LVA technique provides a rapid and convenient way for clinicians to identify patients with, and without, grade 2 or 3 vertebral fractures, thereby enhancing care of osteoporotic patients...
  40. ncbi The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial
    Hector F DeLuca
    Deltanoid Pharmaceuticals and the Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Bone Miner Res 26:538-45. 2011
    ....
  41. ncbi Use of the lowest vertebral body T-score to diagnose lumbar osteoporosis in men: is "cherry picking" appropriate?
    Karen E Hansen
    Rheumatology Section, Department of Medicine, University of Wisconsin, Madison, WI and Veterans Hospital, Madison, WI 53750, USA
    J Clin Densitom 7:376-81. 2004
    ..Prospective studies are needed to determine which of these three methods of lumbar spine analysis best predicts future fragility fracture in men and women...
  42. ncbi Recalculation of the NHANES database SD improves T-score agreement and reduces osteoporosis prevalence
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA
    J Bone Miner Res 20:195-201. 2005
    ..Use of a recalculated young-normal SD for the GE Lunar-adjusted NHANES III database improved diagnostic agreement and is recommended...
  43. ncbi HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays
    Gary L Lensmeyer
    Clinical Toxicology Laboratory, University of Wisconsin Hospital and Clinics, Department of Pathology, University of Wisconsin Madison, Madison, WI 53792, USA
    Clin Chem 52:1120-6. 2006
    ..Unfortunately, variability among 25(OH)D assays limits clinician ability to monitor VitD status, supplementation, and toxicity...
  44. ncbi Interobserver reproducibility of criteria for vertebral body exclusion
    Karen E Hansen
    Rheumatology Section, Department of Medicine, University of Wisconsin, William S Middleton Veterans Hospital, Madison, Wisconsin, USA
    J Bone Miner Res 20:501-8. 2005
    ..Our results suggest that reproducibility may be improved by specifically addressing the sources of interobserver disagreement...
  45. ncbi Combination therapy for osteoporosis: considerations and controversy
    Neil Binkley
    University of Wisconsin Madison, Osteoporosis Clinical Center and Research Program, 2870 University Avenue, Suite 100, Madison, WI 53705, USA
    Curr Rheumatol Rep 7:61-5. 2005
    ..Given the absence of demonstrated fracture reduction benefit, increased cost and likely increase in adverse events, combination therapy is not currently recommended...
  46. ncbi The C-3 epimer of 25-hydroxyvitamin D(3) is present in adult serum
    G Lensmeyer
    University of Wisconsin Hospital and Clinics Clinical Toxicology Laboratory, Madison, Wisconsin 53705, USA
    J Clin Endocrinol Metab 97:163-8. 2012
    ..The physiological importance of 3-epi-25(OH)D(3) is uncertain but might affect 25-hydroxyvitamin D test results and thereby reliability of the 25-hydroxyvitamin D(3) [25(OH)D(3)] measurement...
  47. ncbi "Evidence-based" or "logic-based" medicine?
    R D Blank
    Geriatrics Research, Education, and Clinical Center, William S Middleton Veterans Hospital, Madison, WI, USA
    Osteoporos Int 21:1681-3. 2010
    ..We therefore disagree with the notion that a densitometric threshold for treatment should be applied to patients over age 50 who suffer low trauma distal radius fracture...
  48. ncbi Vitamin D: clinical measurement and use
    N Binkley
    Osteoporosis Research Program, University of Wisconsin, Madison, WI 53706, USA
    J Musculoskelet Neuronal Interact 6:338-40. 2006
  49. ncbi Effect of phylloquinone supplementation on glucose homeostasis in humans
    Rajiv Kumar
    Nephrology Research Unit, Divisions of Nephrology and Hypertension and the Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Am J Clin Nutr 92:1528-32. 2010
    ..Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice...
  50. ncbi Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development Conference
    Sanford Baim
    Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Densitom 11:75-91. 2008
    ....
  51. ncbi Low vitamin D status: time to recognize and correct a Wisconsin epidemic
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Center and Research Program, 2870 University Ave, Ste 100, Madison, WI 53705, USA
    WMJ 106:466-72. 2007
    ..This review details vitamin D physiology and the prevalence of low vitamin D status in Wisconsin and elsewhere, and provides approaches to optimizing vitamin D status...
  52. ncbi Official positions of the International Society for Clinical Densitometry and Executive Summary of the 2005 Position Development Conference
    Neil Binkley
    University of Wisconsin, Madison, WI, USA
    J Clin Densitom 9:4-14. 2006
    ..This report describes the methodology of the 2005 PDC and presents a summary of all ISCD Official Positions...
  53. ncbi Does low vitamin D status contribute to "age-related" morbidity?
    Neil Binkley
    University of Wisconsin Madison Institute on Aging and School of Medicine and Public Health, Madison, Wisconsin, USA
    J Bone Miner Res 22:V55-8. 2007
    ..This overview will explore the evidence for, and potential involvement of, vitamin D deficiency in nonbone conditions that are currently accepted as "age-related" morbidity among older adults...
  54. ncbi Addition of right lateral decubitus positioning improves vertebral visualization with VFA in selected patients
    Nellie Vallarta-Ast
    William S Middleton Veterans Administration Medical Center, Madison, WI, USA
    J Clin Densitom 9:375-9. 2006
    ..We conclude that in selected patients with suboptimal vertebral visualization on VFA, addition of reverse positioning improves visualization and may enhance vertebral fracture detection...
  55. ncbi Slight abduction/adduction deviations in femur positioning for dual-energy X-ray absorptiometry are inconsequential
    Byram H Ozer
    Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI, USA
    J Clin Densitom 13:10-7. 2010
    ..001 to +0.006g/cm(2)) at all proximal femur regions of interest. In this study, the use of a fixed-width bilateral femur positioner and associated deviations in femur alignment have little consequence on BMD measurement...
  56. ncbi Effect of dehydroepiandrosterone sulfate on carnitine acetyl transferase activity and L-carnitine levels in oophorectomized rats
    K M Chiu
    Institute of Aging Department of Medicine, University of Wisconsin Madison, USA
    Biochim Biophys Acta 1344:201-9. 1997
    ..In conclusion, DHEAS may modulate L-carnitine level and CAT activity in estrogen deficient rats. The potential role of DHEAS in the regulation of fatty acid oxidation in postmenopausal women is worthy of investigation...
  57. ncbi Are Wisconsin physicians knowledgeable about male osteoporosis?
    Neil Binkley
    Department of Medicine, Institute on Aging, University of Wisconsin, Madison, Wis, USA
    WMJ 102:51-7. 2003
    ..These data suggest that knowledge regarding male osteoporosis has been conveyed to practicing physicians. Evaluation of methods by which physicians will translate this knowledge into action, thereby optimizing patient care, are needed...
  58. ncbi Is lateral spine densitometric assessment equivalent to lateral radiography?
    Neil Binkley
    University of Wisconsin, Institute on Aging, Madison 53706, USA
    J Bone Miner Res 17:1162-3. 2002
  59. ncbi Jumping mechanography: a potential tool for sarcopenia evaluation in older individuals
    Bjoern Buehring
    University of Wisconsin Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, WI, USA
    J Clin Densitom 13:283-91. 2010
    ..Older age was negatively correlated, whereas lean mass positively correlated with jump power and height. JM appears to be a safe and potentially useful method to assess muscular function in older adults...
  60. ncbi 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 87:1738-42. 2008
    ..Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans...
  61. ncbi Official positions of the International Society for Clinical Densitometry
    Edward S Leib
    South Med J 97:107-10. 2004
  62. ncbi Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
    Michael F Holick
    Boston University School of Medicine, 715 Albany Street, M1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 90:3215-24. 2005
    ..To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis...
  63. ncbi Official positions of the International Society for Clinical Densitometry
    Edward S Leib
    International Society for Clinical Densitometry International Society for Clinical Densitometry, West Hartford, CT 06117 2507, USA
    J Clin Densitom 7:1-6. 2004
    ....
  64. ncbi A randomized, placebo-controlled, 6-month study of once-weekly alendronate oral solution for postmenopausal osteoporosis
    Byron Cryer
    Division of Digestive Diseases, Dallas Veterans Affairs Medical Center, Dallas, Texas 75216, USA
    Am J Geriatr Pharmacother 3:127-36. 2005
    ..This study evaluated the overall safety and tolerability of once-weekly (OW) alendronate 70 mg oral solution (OS) versus OW placebo OS...
  65. ncbi Low bone mass prevalence and osteoporosis risk factor assessment in African American Wisconsin women
    Srividya Kidambi
    Department of Endocrinology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    WMJ 104:59-65. 2005
    ..Data regarding risk factors for, and prevalence of, low bone mass and awareness of osteoporosis risk in African American (AA) women are limited...
  66. ncbi Laboratory reporting of 25-hydroxyvitamin D results: potential for clinical misinterpretation
    Neil Binkley
    Clin Chem 52:2124-5. 2006
  67. ncbi Bone density testing in older women and its association with patient age
    Joan M Neuner
    Department of Medicine and Health Policy Institute, Center for Patient Care and Outcomes Research and Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Am Geriatr Soc 54:485-9. 2006
    ..To measure the early adoption of bone density testing and examine the association between older age and such testing...
  68. ncbi Official positions of the International Society for Clinical Densitometry
    E Michael Lewiecki
    Osteoporos Int 17:1700-1. 2006
  69. ncbi Diagnostic agreement at the total hip using different DXA systems and the NHANES III database
    Gary M Kiebzak
    Center for Orthopaedic Research and Education, St Luke s Episcopal Hospital, Houston, TX 77025, USA
    J Clin Densitom 10:132-7. 2007
    ..11 vs 0.32 for lumbar spine (p less than 0.001). Use of the NHANES III standardized database results in good diagnostic agreement at total hip between Prodigy and Delphi...
  70. ncbi DXA quality matters
    E Michael Lewiecki
    New Mexico Clinical Research and Osteoporosis Center, Albuquerque, NM 87106, USA
    J Clin Densitom 9:388-92. 2006
    ..We also suggest that they provide demonstration of proficiency in bone densitometry in order to assure patients, referring healthcare providers, and payers of medical services that these skills have been acquired and maintained...
  71. ncbi Vertebral fracture assessment: the 2005 ISCD Official Positions
    Tamara Vokes
    Section of Endocrinology, University of Chicago, Chicago, IL 60637, and Metro West Medical Center, Framingham, MA, USA
    J Clin Densitom 9:37-46. 2006
    ..The ISCD Official Positions with respect to the above issues, as well as the rationale and evidence used to derive these positions, are presented here...
  72. ncbi Standards for performing DXA in individuals with secondary causes of osteoporosis
    Aliya A Khan
    Division of Endocrinology, McMaster University, Hamilton, Ontario, Canada, and Hanover General Hospital, PA, USA
    J Clin Densitom 9:47-57. 2006
    ..Dual-energy X-ray absorptiometry is a valuable tool in assessing skeletal health in individuals with secondary causes of osteoporosis...
  73. ncbi Position Development Conference of the International Society for Clinical Densitometry. Vancouver, BC, July 15-17, 2005
    Edward S Leib
    University of Vermont Medicine, 111 Colchester Avenue, Burlington, VT 05401, USA
    J Rheumatol 33:2319-21. 2006
    ..The Official Positions reached at this conference enumerated in this report have been published in The Journal of Clinical Densitometry, and can be found at www.iscd.org...
  74. ncbi Vertebral Fracture Assessment: the 2007 ISCD Official Positions
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN, USA Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    J Clin Densitom 11:92-108. 2008
    ..is the sensitivity and specificity for detection of vertebral fractures with this method; (4) When should additional spine imaging be performed following a VFA; and (5) What are the reporting obligations for those interpreting VFA images?..

Research Grants4

  1. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..