Guoying Bing

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Lipopolysaccharide animal models for Parkinson's disease
    Mei Liu
    Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Parkinsons Dis 2011:327089. 2011
  2. pmc Striatal neuroinflammation promotes Parkinsonism in rats
    Dong Young Choi
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 4:e5482. 2009
  3. pmc Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice
    Qingshan Wang
    Neuropsychopharmacology and Toxicology Program, College of PharmacyKangwon National University, Chunchon 200 701, South Korea
    J Neuroinflammation 9:124. 2012
  4. ncbi request reprint Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles
    Guoying Bing
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536 0098, USA
    Neurobiol Aging 27:823-30. 2006
  5. pmc Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats
    Mei Liu
    Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Neurochem 112:773-83. 2010
  6. doi request reprint Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 219:228-38. 2009
  7. pmc Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurosci Res 87:1913-21. 2009
  8. ncbi request reprint Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity
    Don M Gash
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Ann Neurol 63:184-92. 2008
  9. ncbi request reprint Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurochem 100:1375-86. 2007
  10. pmc Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
    Bin Xing
    Department of Anatomy and Neurobiology, 310 Davis Mills Building, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Neuroinflammation 5:4. 2008

Collaborators

Detail Information

Publications35

  1. pmc Lipopolysaccharide animal models for Parkinson's disease
    Mei Liu
    Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Parkinsons Dis 2011:327089. 2011
    ....
  2. pmc Striatal neuroinflammation promotes Parkinsonism in rats
    Dong Young Choi
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 4:e5482. 2009
    ..However, it remains unclear how neuroinflammatory factors contribute to dopaminergic neuronal death in PD...
  3. pmc Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice
    Qingshan Wang
    Neuropsychopharmacology and Toxicology Program, College of PharmacyKangwon National University, Chunchon 200 701, South Korea
    J Neuroinflammation 9:124. 2012
    ..The present study was performed to investigate whether endogenous dynorphin has neuroprotective roles in vivo...
  4. ncbi request reprint Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles
    Guoying Bing
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536 0098, USA
    Neurobiol Aging 27:823-30. 2006
    ..The induced fluorophore, thus, has unique properties, and its generation likely depends on the particular conformation of paired helical filaments, which may in turn depend on tau hyperphosphorylation...
  5. pmc Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats
    Mei Liu
    Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Neurochem 112:773-83. 2010
    ..Overall, our animal model exhibits some important features of Parkinsonism, and further supports that trichloroethylene may be an environmental risk factors for Parkinson's disease...
  6. doi request reprint Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 219:228-38. 2009
    ..The above findings demonstrate an age-dependent inhibitory effect of dynorphins on striatal dopamine synthesis via modulation of TH activity...
  7. pmc Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurosci Res 87:1913-21. 2009
    ..Thus, this novel PD-related model should be further characterized and strongly considered as a tool for future drug studies...
  8. ncbi request reprint Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity
    Don M Gash
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Ann Neurol 63:184-92. 2008
    ..To analyze a cluster of 30 industrial coworkers with Parkinson's disease and parkinsonism subjected to long-term (8-33 years) chronic exposure to trichloroethylene...
  9. ncbi request reprint Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurochem 100:1375-86. 2007
    ....
  10. pmc Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
    Bin Xing
    Department of Anatomy and Neurobiology, 310 Davis Mills Building, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Neuroinflammation 5:4. 2008
    ....
  11. ncbi request reprint Inflammation and age-related iron accumulation in F344 rats
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington KY 40536 0098, USA
    Curr Aging Sci 1:112-21. 2008
    ..This may enhance oxidative stress, exacerbate microglia activation, and drive the progression of PD...
  12. pmc Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity
    Bin Xing
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    J Neuroimmunol 225:43-51. 2010
    ..It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia...
  13. ncbi request reprint P38 MAP kinase is activated at early stages in Alzheimer's disease brain
    Anyang Sun
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536 0098, USA
    Exp Neurol 183:394-405. 2003
    ..The p38 activation may also be linked to neurodegeneration through mechanisms other than neurofibrillary tangle formation...
  14. doi request reprint Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra
    Toyoko Arimoto
    Department of Anatomy and Neurobiology, University of Kentucky, Medical Center, KY 40536, USA Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Neurobiol Aging 28:894-906. 2007
    ..Our results provide evidence that LPS induces apoptotic cell death in SNpc, which is likely through the expression of Fas, Bax, caspase-3, and the pro-inflammatory cytokines...
  15. ncbi request reprint Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity
    Bin Xing
    University of Kentucky, Chandler Medical Center, Department of Anatomy and Neurobiology, 800 Rose Street, 310 Davis Mills Building, Lexington, KY 40536 0298, USA
    J Neuroimmunol 192:89-98. 2007
    ..Therefore, the anti-inflammatory properties of pioglitazone may be useful for ameliorating the progression of Parkinson's disease...
  16. ncbi request reprint Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin
    Mei Liu
    310 Davis Mills Building, Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Eur J Neurosci 23:2027-34. 2006
    ..Our studies suggest that mEH may play a role in pathogenesis of neurodegeneration in response to environmental stress...
  17. pmc Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits
    Andrew Sauerbeck
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 234:85-94. 2012
    ..These studies provide further evidence for the connection between TCE, TBI, and PD and lend support to the concept that PD develops from a multifactorial injury scenario...
  18. pmc Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat
    Daniel R van Bregt
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Exp Neurol 234:8-19. 2012
    ..Compensatory mechanisms may preserve dopamine signaling acutely, but subsequent SN damage with aging or additional injury may expose clinical symptomatology of motor ataxias and dementia...
  19. ncbi request reprint Fenbendazole treatment may influence lipopolysaccharide effects in rat brain
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA
    Comp Med 57:487-92. 2007
    ..Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ...
  20. pmc Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury
    Andrew Sauerbeck
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 227:128-35. 2011
    ..From these studies we conclude that following TBI Pioglitazone is capable ameliorating multiple aspects of neuropathology. These studies provide further support for the use of PPAR ligands, specifically Pioglitazone, for neuroprotection...
  21. ncbi request reprint Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment
    Mei Liu
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 86:2792-801. 2008
    ..These data suggested that mEH deficiency facilitates TH phosphorylation in the nigrostriatal dopamine system, which may be associated with an increased resistance of dopaminergic neurons to environmental toxins...
  22. pmc Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
    Randy L Hunter
    Department of Anatomy and Neurobiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Neurosci Lett 432:198-201. 2008
    ..We report that intrastriatal lipopolysaccharide (LPS) increases striatal PPAR-gamma, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes...
  23. ncbi request reprint Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra
    Michael F Salvatore
    Department of Anatomy and Neurobiology, Center for Sensor Technology, and the Morris K Udall Parkinson s Disease Research Center of Excellence, University of Kentucky Medical Center, Lexington, Kentucky, USA
    J Neurochem 90:245-54. 2004
    ....
  24. ncbi request reprint Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats
    Dong Young Choi
    Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY 40536 0298, USA
    Neurobiol Aging 31:1649-53. 2010
    ..These results imply that an exaggerated neuroinflammatory response that occurs with aging might be involved in the increase in prevalence of neurodegenerative diseases like Parkinson's disease...
  25. pmc Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system
    Andrew Sauerbeck
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    J Neurosci Methods 198:36-43. 2011
    ....
  26. ncbi request reprint Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, 310 Whitney Henrickson Facility, Lexington, Kentucky 40536, USA
    Behav Brain Res 161:254-62. 2005
    ..Although the underlying mechanisms have yet to be elucidated, the results suggest that chronic increases in endogenous dynorphin expression with age, especially in frontal cortex, may adversely affect learning and memory...
  27. ncbi request reprint Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration
    Toyoko Arimoto
    Department of Anatomy and Neurobiology, Medical Center, University of Kentucky, 800 Rose Street, Room MN 225, Lexington, KY 40536 5276, USA
    Neurobiol Dis 12:35-45. 2003
    ..These results demonstrate that LPS induces the expression of iNOS in activated microglia in the SN, and that NO and/or its metabolites may play a crucial role in inflammation-mediated degeneration of dopaminergic neurons...
  28. ncbi request reprint Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls
    Anyang Sun
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Exp Neurol 175:10-22. 2002
    ..Neurofibrillary tangles were associated with lower M2 expression in AD. These data indicate that beta-secretase M2 may not be straightforwardly involved in amyloid plaque formation in AD brain...
  29. ncbi request reprint Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections
    Anyang Sun
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536 0098, USA
    J Histochem Cytochem 50:463-72. 2002
    ..This study suggests that the improved thioflavin-S staining is a simple, sensitive, and consistent method for demonstration of neurofibrillary pathology...
  30. doi request reprint Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    Cell Signal 20:645-58. 2008
    ..These results suggest that KA-mediated mitochondrial oxidative stress contributed to hippocampal degeneration in the senile-prone mouse...
  31. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
    ..Thus, Pin1 is pivotal in protecting against age-dependent neurodegeneration, providing insight into the pathogenesis and treatment of Alzheimer's disease and other tauopathies...
  32. ncbi request reprint Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:769-83. 2003
    ..Combined, our results suggest that metabolism of DM to DX is not essential for DM to exert its effect. They also suggest that DM provides neuroprotection from kainic acid via sigma-1 receptor modulation...
  33. ncbi request reprint Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Brain Res Mol Brain Res 108:60-70. 2002
    ..c.v.) significantly attenuated KA-induced seizures and neuronal damages in a dose-related manner. Therefore, our results suggest that TGF-beta3 plays an important role in protective mechanisms against KA-induced neurodegeneration...
  34. ncbi request reprint Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    Neurochem Int 50:791-9. 2007
    ..These results suggest that DM prevents TMT-induced neurotoxicity, at least in part, via sigma(1) receptor stimulation...
  35. ncbi request reprint Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Kangwon National University, 200 701, Chunchon, South Korea
    Behav Brain Res 131:211-20. 2002
    ..Therefore, our data suggests that mice in the senescence model are more susceptible to KA-induced seizures/oxidative damage, and that oxidative damage could be one of the casual factors in the accumulation of lipofuscin...

Research Grants9

  1. MICROGLIA ACTIVATION INDUCES PARKINSONISM IN RATS
    Guoying Bing; Fiscal Year: 2001
    ..abstract_text> ..
  2. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2003
    ..abstract_text> ..
  3. MICROGLIA ACTIVATION INDUCES PARKINSONISM IN RATS
    Guoying Bing; Fiscal Year: 2000
    ..abstract_text> ..
  4. MICROGLIA ACTIVATION INDUCES PARKINSONISM
    Guoying Bing; Fiscal Year: 1999
    ..abstract_text> ..
  5. MICROGLIA ACTIVATION INDUCES PARKINSONISM IN RATS
    Guoying Bing; Fiscal Year: 2002
    ..abstract_text> ..
  6. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2004
    ..abstract_text> ..
  7. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2005
    ..abstract_text> ..
  8. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2006
    ..abstract_text> ..
  9. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2007
    ..abstract_text> ..