Paul C Billings

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin
    Paul C Billings
    Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28003-9. 2002
  2. pmc Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP)
    Paul C Billings
    The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 23:305-13. 2008
  3. pmc Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Bone Miner Res 26:2647-55. 2011
  4. ncbi request reprint HSPG modulation of BMP signaling in fibrodysplasia ossificans progressiva cells
    Michael P O'Connell
    Department of Orthopaedic Surgery, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    J Cell Biochem 102:1493-503. 2007
  5. pmc Circulating osteogenic precursor cells in heterotopic bone formation
    Robin K Suda
    Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Stem Cells 27:2209-19. 2009
  6. ncbi request reprint Dysregulation of the BMP-4 signaling pathway in fibrodysplasia ossificans progressiva
    Frederick S Kaplan
    University of Pennsylvania School of Medicine, Department of Orthopaedic Surgery, Silverstein Two, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1068:54-65. 2006
  7. pmc Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses
    Julianne Huegel
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Biol 377:100-12. 2013
  8. ncbi request reprint Over-expression of BMP4 and BMP5 in a child with axial skeletal malformations and heterotopic ossification: a new syndrome
    George J Feldman
    Department of Orthopaedic Surgery, Center for Research in FOP and Related Disorders, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Med Genet A 143:699-706. 2007
  9. ncbi request reprint Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells
    Xiangyang Jiao
    Center For Research in Fibrodysplasia Ossificans Progressiva FOP and Related Disorders and the Department of Orthopaedics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1080-6. 2007
  10. ncbi request reprint Effects of Bowman-Birk inhibitor on rat colon carcinogenesis
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nutr Cancer 43:174-86. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin
    Paul C Billings
    Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28003-9. 2002
    ..Our results identify FN and Col I as two ligands of (beta)ig-h3 in the ECM...
  2. pmc Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP)
    Paul C Billings
    The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 23:305-13. 2008
    ..We isolated such cells from discarded primary teeth of patients with FOP and controls and discovered dysregulation of BMP signaling and rapid osteoblast differentiation in FOP cells compared with control cells...
  3. pmc Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Bone Miner Res 26:2647-55. 2011
    ..Taken together, these data suggest that Gnas is a key regulator of fate decisions in adipose-derived mesenchymal progenitor cells, specifically those which are involved in bone formation...
  4. ncbi request reprint HSPG modulation of BMP signaling in fibrodysplasia ossificans progressiva cells
    Michael P O'Connell
    Department of Orthopaedic Surgery, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    J Cell Biochem 102:1493-503. 2007
    ..These data support that HSPG modulation of BMP signaling is altered in cells from patients with FOP and that altered HSPG-related BMP signaling may play a role in the pathogenesis of the disease...
  5. pmc Circulating osteogenic precursor cells in heterotopic bone formation
    Robin K Suda
    Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Stem Cells 27:2209-19. 2009
    ..Thus, bone formation is not limited to cells of the mesenchymal lineage, and circulating cells of hematopoietic origin can also serve as osteogenic precursors at remote sites of tissue inflammation...
  6. ncbi request reprint Dysregulation of the BMP-4 signaling pathway in fibrodysplasia ossificans progressiva
    Frederick S Kaplan
    University of Pennsylvania School of Medicine, Department of Orthopaedic Surgery, Silverstein Two, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1068:54-65. 2006
    ..Signaling pathways that fit these criteria are the BMP signaling pathway and its interacting pathways. A large body of data suggest that the BMP-4 signaling pathway is dysregulated in FOP...
  7. pmc Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses
    Julianne Huegel
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Biol 377:100-12. 2013
    ..Alterations in these mechanisms may contribute to exostosis formation in HME, particularly at the expense of regions rich in progenitor cells including the groove of Ranvier...
  8. ncbi request reprint Over-expression of BMP4 and BMP5 in a child with axial skeletal malformations and heterotopic ossification: a new syndrome
    George J Feldman
    Department of Orthopaedic Surgery, Center for Research in FOP and Related Disorders, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Med Genet A 143:699-706. 2007
    ..Our data suggest that dysregulated expression of BMP4 and BMP5 genes is associated with an array of human axial skeletal abnormalities similar to the short ear mouse and FOP...
  9. ncbi request reprint Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells
    Xiangyang Jiao
    Center For Research in Fibrodysplasia Ossificans Progressiva FOP and Related Disorders and the Department of Orthopaedics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1080-6. 2007
    ..The addition of exogenous heparin, a widely used anticoagulant, reduced BMP2 signaling. Our results suggest that cell surface HSPGs mediate BMP2 internalization and modulate BMP2 osteogenic activity...
  10. ncbi request reprint Effects of Bowman-Birk inhibitor on rat colon carcinogenesis
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nutr Cancer 43:174-86. 2002
    ..No adverse side effects on the pancreas or animal growth were observed in rats treated with PBBI or BBIC. These results demonstrate that PBBI and BBIC may be used to prevent colon cancer without significant adverse side effects...
  11. pmc Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles
    Jessie E P Sun
    Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Integr Biol (Camb) 4:84-92. 2012
    ..Thus, the results reported here describe the mechanistic characteristics of αIIbβ3-ligand interactions, confirming the utility of peptide-functionalized latex beads for the quantitative analysis of molecular recognition...
  12. pmc Computational design of a β-peptide that targets transmembrane helices
    Scott J Shandler
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    J Am Chem Soc 133:12378-81. 2011
    ..The designed peptide (β-CHAMP) interacts with the isolated target TM domain of the protein and activates the intact integrin in vitro...
  13. pmc Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices
    Hua Zhu
    Hematology Oncology Division, Department of Medicine, School of Medicine, University of Pennsylvania, 914 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    J Mol Biol 401:882-91. 2010
    ..We conclude that the alphaIIbbeta3 TM heterodimer shows the hallmark of finely tuned heterodimeric interaction, while homomeric interaction is less specific...
  14. pmc Consensus motif for integrin transmembrane helix association
    Bryan W Berger
    Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:703-8. 2010
    ..Thus, this highly conserved dissociable motif plays a vital and widespread role as an on-off switch that can integrate with other control elements during integrin activation...
  15. ncbi request reprint A novel noncollagenous protein encoded by an alternative transcript of the chick type III collagen gene is expressed in cartilage, bone and muscle
    Arthur J Cohen
    Department of Biochemistry, School of Dental Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6003, USA
    Mech Dev 114:177-80. 2002
    ..These results demonstrate an unexpected economy of genome utilization in which a single gene, using alternative promoters, gives rise to two unrelated proteins, type III collagen and Col3alt...
  16. ncbi request reprint Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP)
    Jennifer L Fiori
    Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6081, USA
    J Bone Miner Res 21:902-9. 2006
    ..FOP lymphocytes exhibit defects in the BMP-p38 MAPK pathway, suggesting that altered BMP signaling underlies ectopic bone formation in this disease...
  17. ncbi request reprint Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA
    Lourdes Serrano DE LA Peña
    Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6081, USA
    J Bone Miner Res 20:1168-76. 2005
    ....
  18. ncbi request reprint Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs
    Tsuyoshi Shimo
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6003, USA
    Dev Dyn 224:267-78. 2002
    ....
  19. ncbi request reprint Expression and roles of connective tissue growth factor in Meckel's cartilage development
    Tsuyoshi Shimo
    Department of Orthopaedic Surgery, Thomas Jefferson University Medical School, Philadelphia, Pennsylvania
    Dev Dyn 231:136-47. 2004
    ..CTGF may aid chondrogenesis by acting down-stream of transforming growth factor-beta and stimulating cell-cell interactions and expression of condensation-associated genes...