Affiliation: University of California
Bilder D, Irvine K. Taking Stock of the Drosophila Research Ecosystem. Genetics. 2017;206:1227-1236 pubmed publisher
..Overall, there has never been a better time to be a fly pusher. ..
Bilder D, Haigo S. Expanding the morphogenetic repertoire: perspectives from the Drosophila egg. Dev Cell. 2012;22:12-23 pubmed publisher
..We review here what is known about Drosophila egg elongation, compare it to other instances of morphogenesis, and highlight several issues of general developmental relevance. ..
de Vreede G, Morrison H, Houser A, Boileau R, Andersen D, Colombani J, et al
. A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation. Dev Cell. 2018;45:595-605.e4 pubmed publisher
..Our results suggest that N-linked glycosylation sets the threshold of TNF receptor signaling by modifying ligand-receptor interactions and that cells may alter this modification to respond appropriately to physiological cues. ..
de Vreede G, Schoenfeld J, Windler S, Morrison H, Lu H, Bilder D. The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization. Development. 2014;141:2796-802 pubmed publisher
..We propose that the Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo. ..
Skwarek L, Windler S, de Vreede G, Rogers G, Bilder D. The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells. Development. 2014;141:2978-83 pubmed publisher
..The involvement of the Slmb E3 ligase in epithelial polarity, specifically limiting Par complex activity to distinguish the basolateral domain, points to parallels with polarization of the C. elegans zygote. ..
Figueroa Clarevega A, Bilder D. Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting. Dev Cell. 2015;33:47-55 pubmed publisher
..Importantly, knocking down ImpL2, specifically in the tumor, ameliorates wasting phenotypes. We propose that the tumor-secreted IGFBP creates insulin resistance in distant tissues, thus driving a systemic wasting response. ..
Chen D, Lipari K, Dehghan Y, Streichan S, Bilder D. Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity. Cell Rep. 2016;15:1125-33 pubmed publisher
Bilder D. The Maturation of Development. Dev Cell. 2016;38:569-70 pubmed publisher
Chen D, Crest J, Bilder D. A Cell Migration Tracking Tool Supports Coupling of Tissue Rotation to Elongation. Cell Rep. 2017;21:559-569 pubmed publisher
..The M-TRAIL approach could be applied to track and quantitate in vivo cell motility in other tissues and organisms. ..