DANIEL DAVID BIKLE

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism
    Daniel D Bikle
    Department of Medicine, University of California San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 128:2357-61. 2008
  2. doi request reprint Vitamin D and cancer: the promise not yet fulfilled
    Daniel D Bikle
    Endocrine Research Unit, Departments of Medicine and Dermatology, VA Medical Center and University of California San Francisco, 4150 Clement St 111N, San Francisco, CA, 94121, USA
    Endocrine 46:29-38. 2014
  3. pmc Protective role of vitamin D signaling in skin cancer formation
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 136:271-9. 2013
  4. pmc Protective actions of vitamin D in UVB induced skin cancer
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    Photochem Photobiol Sci 11:1808-16. 2012
  5. pmc Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Curr Mol Pharmacol 5:135-42. 2012
  6. pmc Vitamin D and bone
    Daniel D Bikle
    University of California, San Francisco, San Francisco, CA, USA
    Curr Osteoporos Rep 10:151-9. 2012
  7. pmc Vitamin D and the skin: Physiology and pathophysiology
    Daniel D Bikle
    Veterans Affairs Medical Center University of California, San Francisco, San Francisco, CA 94121, USA
    Rev Endocr Metab Disord 13:3-19. 2012
  8. pmc Nonclassic actions of vitamin D
    Daniel Bikle
    Veterans Affairs Medical Center 111N, 4150 Clement Street, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 94:26-34. 2009
  9. doi request reprint Vitamin D and the immune system: role in protection against bacterial infection
    Daniel D Bikle
    Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Curr Opin Nephrol Hypertens 17:348-52. 2008
  10. doi request reprint Integrins, insulin like growth factors, and the skeletal response to load
    D D Bikle
    Medicine and Dermatology, University of California San Francisco, San Francisco, CA, USA
    Osteoporos Int 19:1237-46. 2008

Collaborators

Detail Information

Publications62

  1. doi request reprint Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism
    Daniel D Bikle
    Department of Medicine, University of California San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 128:2357-61. 2008
    ..Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?..
  2. doi request reprint Vitamin D and cancer: the promise not yet fulfilled
    Daniel D Bikle
    Endocrine Research Unit, Departments of Medicine and Dermatology, VA Medical Center and University of California San Francisco, 4150 Clement St 111N, San Francisco, CA, 94121, USA
    Endocrine 46:29-38. 2014
    ....
  3. pmc Protective role of vitamin D signaling in skin cancer formation
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 136:271-9. 2013
    ..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  4. pmc Protective actions of vitamin D in UVB induced skin cancer
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    Photochem Photobiol Sci 11:1808-16. 2012
    ..We will then explore three potential mechanisms for this protection: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR)...
  5. pmc Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Curr Mol Pharmacol 5:135-42. 2012
    ....
  6. pmc Vitamin D and bone
    Daniel D Bikle
    University of California, San Francisco, San Francisco, CA, USA
    Curr Osteoporos Rep 10:151-9. 2012
    ..This review discusses the relative importance of the direct versus indirect actions of vitamin D on bone, and provides guidelines for the clinical use of vitamin D to prevent/treat bone loss and fractures...
  7. pmc Vitamin D and the skin: Physiology and pathophysiology
    Daniel D Bikle
    Veterans Affairs Medical Center University of California, San Francisco, San Francisco, CA 94121, USA
    Rev Endocr Metab Disord 13:3-19. 2012
    ..This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated...
  8. pmc Nonclassic actions of vitamin D
    Daniel Bikle
    Veterans Affairs Medical Center 111N, 4150 Clement Street, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 94:26-34. 2009
    ..This review was intended to highlight the actions of 1,25(OH)(2)D in several of these tissues but starts with a review of vitamin D production, metabolism, and molecular mechanism...
  9. doi request reprint Vitamin D and the immune system: role in protection against bacterial infection
    Daniel D Bikle
    Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Curr Opin Nephrol Hypertens 17:348-52. 2008
    ..Immunity is both adaptive and innate, and vitamin D signaling is operative in both. This review will examine these actions of vitamin D, in particular the role of vitamin D in host defense against infection...
  10. doi request reprint Integrins, insulin like growth factors, and the skeletal response to load
    D D Bikle
    Medicine and Dermatology, University of California San Francisco, San Francisco, CA, USA
    Osteoporos Int 19:1237-46. 2008
    ..Disruption of this interaction blocks IGF signaling and results in bone loss...
  11. ncbi request reprint What is new in vitamin D: 2006-2007
    Daniel D Bikle
    Medicine and Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
    Curr Opin Rheumatol 19:383-8. 2007
    ..This review focuses on recent developments in a number of areas to bring the reader up to the current state of knowledge in this field...
  12. ncbi request reprint Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators
    D Bikle
    Endocrine Research Unit, University of California, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 103:396-404. 2007
    ....
  13. ncbi request reprint Vitamin D and immune function: understanding common pathways
    Daniel D Bikle
    Veterans Affairs Medical Center 111N, San Francisco, CA 94121, USA
    Curr Osteoporos Rep 7:58-63. 2009
    ....
  14. doi request reprint Vitamin D and the skin
    Daniel D Bikle
    Veterans Affairs Medical Center, University of California, 4150 Clement St 111N, San Francisco, CA 94121, USA
    J Bone Miner Metab 28:117-30. 2010
    ..This review examines the various functions of vitamin D and its receptor, and to the extent known explores the mechanisms by which these functions are regulated...
  15. pmc Vitamin D: newly discovered actions require reconsideration of physiologic requirements
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Trends Endocrinol Metab 21:375-84. 2010
    ..In this review, these newer applications are summarized and therapeutic considerations are provided...
  16. pmc Differential regulation of epidermal function by VDR coactivators
    D D Bikle
    Endocrine Research Unit, Department of Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 121:308-13. 2010
    ..These findings provide a basis by which we can understand how one receptor (VDR) and one ligand (1,25(OH)2D3) can regulate a large number of genes in a sequential and differentiation specific fashion...
  17. ncbi request reprint Vitamin D: an ancient hormone
    Daniel D Bikle
    San Francisco Veterans Affairs Medical Center, University of California at San Francisco, CA, USA
    Exp Dermatol 20:7-13. 2011
    ..In this article, I make the case that vitamin D signalling evolved to enable the organism to effectively regulate calcium flux, storage and signalling and that such regulation is critical for the evolutionary process...
  18. pmc Vitamin D metabolism and function in the skin
    Daniel D Bikle
    Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 347:80-9. 2011
    ..This review will examine the regulation of vitamin D production and metabolism in the skin, and explore the various functions regulated by 1,25(OH)(2)D and its receptor...
  19. ncbi request reprint The vitamin D receptor: a tumor suppressor in skin
    DANIEL DAVID BIKLE
    Department of Medicine, University of California San Francisco, San Francisco Veterans Affairs Medical Center, 94121, USA
    Discov Med 11:7-17. 2011
    ..These results lead us to the hypothesis that the VDR with its ligand 1,25(OH)(2)D(3) functions as a tumor suppressor with respect to epidermal tumor formation in response to UVR by regulating Hh and beta-catenin signaling...
  20. ncbi request reprint The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
    ..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores...
  21. ncbi request reprint Role of IGF-I signaling in regulating osteoclastogenesis
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 21:1350-8. 2006
    ..These changes lead to impaired bone resorption, resulting in high BV/TV in IGF-I null mice...
  22. ncbi request reprint Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
    ..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes...
  23. ncbi request reprint Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 128:816-24. 2008
    ....
  24. ncbi request reprint PTH differentially regulates expression of RANKL and OPG
    John C Huang
    Department of Growth and Development, Division of Orthodontics, University of California San Francisco School of Dentistry, San Francisco, California, USA
    J Bone Miner Res 19:235-44. 2004
    ..OPG:RANKL ratios indicate that PTH may induce a possible switch in the regulatory mechanism of osteoclastogenesis where OPG is inhibited early and RANKL is increased at late stages of osteoblast differentiation...
  25. pmc Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
    J Clin Invest 117:803-11. 2007
    ..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection...
  26. ncbi request reprint Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma
    Lee Chuan Yang
    Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
    J Cell Physiol 195:249-59. 2003
    ..Failure to regulate PKC [alpha] in SCC4 may underlie at least part of the failure of calcium to promote differentiation in these cells...
  27. ncbi request reprint Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone
    Melita M Dvorak
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, University of California, San Francisco, California 94121, USA
    Endocrinology 148:3156-63. 2007
    ....
  28. ncbi request reprint Insulin-like growth factor-I is essential for embryonic bone development
    Yongmei Wang
    Department of Medicine, Endocrine Unit, 111N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Endocrinology 147:4753-61. 2006
    ..Our results indicate that IGF-I plays an important role in skeletal development by promoting chondrocyte proliferation and maturation while inhibiting apoptosis to form bones of appropriate size and strength...
  29. ncbi request reprint Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3
    Nathaniel P Hawker
    Department of Medicine, Endocrine Research Unit, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
    J Invest Dermatol 127:874-80. 2007
    ..Additionally, each individual differentiation marker that was assayed has a different specificity for the coactivators that regulate its expression...
  30. ncbi request reprint Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
    J Bone Miner Res 17:1570-8. 2002
    ..These results indicate that IGF-I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH...
  31. ncbi request reprint Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways
    Takeshi Sakata
    Department of Medicine, University of California, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 19:436-46. 2004
    ..These results show that skeletal unloading induces resistance to IGF-I by inhibiting activation of the IGF-I signaling pathways at least in part through downregulation of integrin signaling...
  32. ncbi request reprint Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
    Yuko Oda
    Departments of Medicine and Endocrinology, University of California San Francisco, and Veterans Affairs Medical Center San Francisco, 41150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 103:776-80. 2007
    ..These results support the concept that the selective use of coactivators by VDR underlies the selective regulation of gene expression in keratinocyte proliferation and differentiation...
  33. ncbi request reprint The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
    ..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models...
  34. ncbi request reprint The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
    ..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation...
  35. ncbi request reprint Vitamin D regulated keratinocyte differentiation
    Daniel D Bikle
    Medicine and Dermatology Endocrine Research Unit, VA Medical Center, University of California, San Francisco, California, USA
    J Cell Biochem 92:436-44. 2004
    ..This review will examine the mechanisms by which calcium and 1,25(OH)(2)D(3) interact to control epidermal differentiation...
  36. ncbi request reprint Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
    ..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes...
  37. doi request reprint The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation
    Yuko Oda
    Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 130:2377-88. 2010
    ..These results show that keratinocytes use the transcriptional coactivator mediator to regulate VDR functions and control keratinocyte proliferation and differentiation...
  38. ncbi request reprint The impact of skeletal unloading on bone formation
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
    Gravit Space Biol Bull 16:45-54. 2003
    ....
  39. ncbi request reprint Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation
    Yuko Oda
    Departments of Medicine and Endocrinology University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Mol Endocrinol 17:2329-39. 2003
    ....
  40. ncbi request reprint Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003
    ....
  41. ncbi request reprint Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate
    Hana Dolezalova
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    J Cell Biochem 88:732-43. 2003
    ..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis...
  42. ncbi request reprint The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, USA
    J Invest Dermatol 119:1109-13. 2002
    ....
  43. ncbi request reprint The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:36987-90. 2002
    ..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis...
  44. ncbi request reprint Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth
    Zhongjion Xie
    Endocrine Unit, VA Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 118:11-6. 2002
    ....
  45. pmc Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 20:1695-704. 2009
    ..This signaling pathway is critical for Cao-induced generation of the second messengers IP3 and Cai and keratinocyte differentiation...
  46. pmc Quantification of the vitamin D receptor-coregulator interaction
    Arnaud Teichert
    Endocrine Unit, University of California, San Francisco, San Francisco, California 94121, USA
    Biochemistry 48:1454-61. 2009
    ....
  47. pmc Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    Yuko Oda
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 129:1367-78. 2009
    ..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized...
  48. ncbi request reprint The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
    J Biol Chem 282:8695-703. 2007
    ....
  49. ncbi request reprint Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117 1080, USA
    J Endocrinol 189:279-87. 2006
    ..These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone...
  50. ncbi request reprint Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006
    ..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling...
  51. ncbi request reprint IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 22:1329-37. 2007
    ..We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation...
  52. ncbi request reprint Hairless suppresses vitamin D receptor transactivation in human keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Endocrinology 147:314-23. 2006
    ..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes...
  53. ncbi request reprint Vitamin D and skin cancer: a problem in gene regulation
    Daniel D Bikle
    Endocrine Research Unit, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 97:83-91. 2005
    ....
  54. ncbi request reprint Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
    ..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling...
  55. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
    ..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation...
  56. ncbi request reprint Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 124:187-97. 2005
    ..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R...
  57. ncbi request reprint Vitamin D and skin cancer
    Daniel D Bikle
    Endocrine Research Unit, VA Medical Center, University of California, San Francisco, CA 94121, USA
    J Nutr 134:3472S-3478S. 2004
    ....
  58. ncbi request reprint Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation
    Yuko Oda
    Department of Medicine, University of California San Francisco, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:273-6. 2004
    ....
  59. ncbi request reprint Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading
    Benjamin M Boudignon
    Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California, USA
    J Appl Physiol (1985) 103:125-31. 2007
    ....
  60. ncbi request reprint Vitamin D insufficiency/deficiency in gastrointestinal disorders
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    J Bone Miner Res 22:V50-4. 2007
    ..Treatment involves adequate vitamin D and calcium supplementation to achieve normal serum 25(OH)D, PTH, and serum and urine calcium levels...
  61. doi request reprint Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review
    Vivian Y Pao
    Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Miner Res 24:1135-9. 2009
    ....
  62. doi request reprint Growth hormone/insulin-like growth factor-1/PTH axis in bone
    Daniel D Bikle
    J Bone Miner Res 23:581-3. 2008

Research Grants28

  1. Vitamin D Receptor Coactivators in Keratinocytes
    Daniel Bikle; Fiscal Year: 2007
    ..abstract_text> ..
  2. IGF-1 MEDIATES THE ANABOLIC EFFECTS OF PTH ON BONE
    Daniel Bikle; Fiscal Year: 2005
    ..The results of these experiments should determine the degree to which PTH is dependent on IGF-1 for producing its anabolic actions on bone, and initiate the exploration into the mechanisms by which this occurs. ..
  3. Vitamin D Receptor Coactivators in Keratinocytes
    Daniel Bikle; Fiscal Year: 2009
    ....
  4. Integrin Regulation of IGF-1 Responsiveness in Bone During Mechanical Loading
    DANIEL DAVID BIKLE; Fiscal Year: 2010
    ..This failure is associated with loss of integrin expression. This project will evaluate the interaction between integrin and IGF-1 signaling in the skeletal response to mechanical load. ..
  5. IGF-1 MEDIATES THE ANABOLIC EFFECTS OF PTH ON BONE
    DANIEL DAVID BIKLE; Fiscal Year: 2010
    ..This proposal will investigate this potential by examining the role of IGF-I signaling in those cells stimulated by PTH to form new bone. ..
  6. VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    Daniel Bikle; Fiscal Year: 2003
    ..abstract_text> ..
  7. REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    Daniel Bikle; Fiscal Year: 2001
    ..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
  8. Vitamin D Receptor Coactivators in Keratinocytes
    DANIEL DAVID BIKLE; Fiscal Year: 2010
    ....