Research Topics
Genomes and Genes
| DANIEL DAVID BIKLESummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Vitamin D receptor, UVR, and skin cancer: a potential protective mechanismDaniel D Bikle
Department of Medicine, University of California San Francisco VA Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 128:2357-61. 2008..Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?..
Protective actions of vitamin D in UVB induced skin cancerDaniel D Bikle
Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
Photochem Photobiol Sci 11:1808-16. 2012..We will then explore three potential mechanisms for this protection: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR)...
Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormoneDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
Curr Mol Pharmacol 5:135-42. 2012....- Vitamin D and boneDaniel D Bikle
University of California, San Francisco, San Francisco, CA, USA
Curr Osteoporos Rep 10:151-9. 2012..This review discusses the relative importance of the direct versus indirect actions of vitamin D on bone, and provides guidelines for the clinical use of vitamin D to prevent/treat bone loss and fractures... - Vitamin D and the skin: Physiology and pathophysiologyDaniel D Bikle
Veterans Affairs Medical Center University of California, San Francisco, San Francisco, CA 94121, USA
Rev Endocr Metab Disord 13:3-19. 2012..This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated... - Nonclassic actions of vitamin DDaniel Bikle
Veterans Affairs Medical Center 111N, 4150 Clement Street, San Francisco, California 94121, USA
J Clin Endocrinol Metab 94:26-34. 2009..This review was intended to highlight the actions of 1,25(OH)(2)D in several of these tissues but starts with a review of vitamin D production, metabolism, and molecular mechanism... - Vitamin D: newly discovered actions require reconsideration of physiologic requirementsDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
Trends Endocrinol Metab 21:375-84. 2010..In this review, these newer applications are summarized and therapeutic considerations are provided... - Vitamin D and the skinDaniel D Bikle
Veterans Affairs Medical Center, University of California, 4150 Clement St 111N, San Francisco, CA 94121, USA
J Bone Miner Metab 28:117-30. 2010..This review examines the various functions of vitamin D and its receptor, and to the extent known explores the mechanisms by which these functions are regulated... - Vitamin D and immune function: understanding common pathwaysDaniel D Bikle
Veterans Affairs Medical Center 111N, San Francisco, CA 94121, USA
Curr Osteoporos Rep 7:58-63. 2009.... - Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulatorsD Bikle
Endocrine Research Unit, University of California, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 103:396-404. 2007.... - Differential regulation of epidermal function by VDR coactivatorsD D Bikle
Endocrine Research Unit, Department of Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 121:308-13. 2010..These findings provide a basis by which we can understand how one receptor (VDR) and one ligand (1,25(OH)2D3) can regulate a large number of genes in a sequential and differentiation specific fashion... - Vitamin D: an ancient hormoneDaniel D Bikle
San Francisco Veterans Affairs Medical Center, University of California at San Francisco, CA, USA
Exp Dermatol 20:7-13. 2011..In this article, I make the case that vitamin D signalling evolved to enable the organism to effectively regulate calcium flux, storage and signalling and that such regulation is critical for the evolutionary process... - The vitamin D receptor: a tumor suppressor in skinDANIEL DAVID BIKLE
Department of Medicine, University of California San Francisco, San Francisco Veterans Affairs Medical Center, 94121, USA
Discov Med 11:7-17. 2011..These results lead us to the hypothesis that the VDR with its ligand 1,25(OH)(2)D(3) functions as a tumor suppressor with respect to epidermal tumor formation in response to UVR by regulating Hh and beta-catenin signaling... - Vitamin D and the immune system: role in protection against bacterial infectionDaniel D Bikle
Veterans Affairs Medical Center, San Francisco, California 94121, USA
Curr Opin Nephrol Hypertens 17:348-52. 2008..Immunity is both adaptive and innate, and vitamin D signaling is operative in both. This review will examine these actions of vitamin D, in particular the role of vitamin D in host defense against infection... - Vitamin D metabolism and function in the skinDaniel D Bikle
Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
Mol Cell Endocrinol 347:80-9. 2011..This review will examine the regulation of vitamin D production and metabolism in the skin, and explore the various functions regulated by 1,25(OH)(2)D and its receptor... - What is new in vitamin D: 2006-2007Daniel D Bikle
Medicine and Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
Curr Opin Rheumatol 19:383-8. 2007..This review focuses on recent developments in a number of areas to bring the reader up to the current state of knowledge in this field... - Integrins, insulin like growth factors, and the skeletal response to loadD D Bikle
Medicine and Dermatology, University of California San Francisco, San Francisco, CA, USA
Osteoporos Int 19:1237-46. 2008..Disruption of this interaction blocks IGF signaling and results in bone loss... - The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytesChia Ling Tu
Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
J Invest Dermatol 127:1074-83. 2007..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores... - Role of IGF-I signaling in regulating osteoclastogenesisYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 21:1350-8. 2006..These changes lead to impaired bone resorption, resulting in high BV/TV in IGF-I null mice... - Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiationLaszlo Komuves
Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
J Cell Physiol 192:45-54. 2002..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes... - PTH differentially regulates expression of RANKL and OPGJohn C Huang
Department of Growth and Development, Division of Orthodontics, University of California San Francisco School of Dentistry, San Francisco, California, USA
J Bone Miner Res 19:235-44. 2004..OPG:RANKL ratios indicate that PTH may induce a possible switch in the regulatory mechanism of osteoclastogenesis where OPG is inhibited early and RANKL is increased at late stages of osteoblast differentiation... - Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanismJürgen Schauber
Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
J Clin Invest 117:803-11. 2007..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection... - Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinomaLee Chuan Yang
Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
J Cell Physiol 195:249-59. 2003..Failure to regulate PKC [alpha] in SCC4 may underlie at least part of the failure of calcium to promote differentiation in these cells... - Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3Jürgen Schauber
Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
J Invest Dermatol 128:816-24. 2008.... - Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3Nathaniel P Hawker
Department of Medicine, Endocrine Research Unit, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
J Invest Dermatol 127:874-80. 2007..Additionally, each individual differentiation marker that was assayed has a different specificity for the coactivators that regulate its expression... - Insulin-like growth factor-I is essential for embryonic bone developmentYongmei Wang
Department of Medicine, Endocrine Unit, 111N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
Endocrinology 147:4753-61. 2006..Our results indicate that IGF-I plays an important role in skeletal development by promoting chondrocyte proliferation and maturation while inhibiting apoptosis to form bones of appropriate size and strength... - Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous boneMelita M Dvorak
Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, University of California, San Francisco, California 94121, USA
Endocrinology 148:3156-63. 2007.... - Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathwaysTakeshi Sakata
Department of Medicine, University of California, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 19:436-46. 2004.... - Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse boneDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
J Bone Miner Res 17:1570-8. 2002..These results indicate that IGF-I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH... - Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formationYuko Oda
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 129:1367-78. 2009..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized... - Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytesChia Ling Tu
Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
J Biol Chem 283:3519-28. 2008..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling... - Quantification of the vitamin D receptor-coregulator interactionArnaud Teichert
Endocrine Unit, University of California, San Francisco, San Francisco, California 94121, USA
Biochemistry 48:1454-61. 2009.... - The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiationYuko Oda
Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 130:2377-88. 2010..These results show that keratinocytes use the transcriptional coactivator mediator to regulate VDR functions and control keratinocyte proliferation and differentiation... - Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiationZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
Mol Biol Cell 20:1695-704. 2009..This signaling pathway is critical for Cao-induced generation of the second messengers IP3 and Cai and keratinocyte differentiation... - IGF-I receptor is required for the anabolic actions of parathyroid hormone on boneYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 22:1329-37. 2007..We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation... - Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiationYuko Oda
Department of Medicine, University of California San Francisco, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 89:273-6. 2004.... - The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3Daniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, USA
J Invest Dermatol 119:1109-13. 2002.... - The role of the calcium-sensing receptor in epidermal differentiationChia Ling Tu
Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
Cell Calcium 35:265-73. 2004..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models... - The effect of LXR activators on AP-1 proteins in keratinocytesMatthias Schmuth
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 123:41-8. 2004..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation... - Vitamin D regulated keratinocyte differentiationDaniel D Bikle
Medicine and Dermatology Endocrine Research Unit, VA Medical Center, University of California, San Francisco, California, USA
J Cell Biochem 92:436-44. 2004..This review will examine the mechanisms by which calcium and 1,25(OH)(2)D(3) interact to control epidermal differentiation... - Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ storesMartin J Behne
Department of Dermatology, University of California, San Francisco, California, USA
J Invest Dermatol 121:688-94. 2003..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes... - The impact of skeletal unloading on bone formationDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
Gravit Space Biol Bull 16:45-54. 2003.... - Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?Daniel D Bikle
Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
Recent Results Cancer Res 164:111-22. 2003.... - Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiationYuko Oda
Departments of Medicine and Endocrinology University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
Mol Endocrinol 17:2329-39. 2003.... - Vitamin D and skin cancerDaniel D Bikle
Endocrine Research Unit, VA Medical Center, University of California, San Francisco, CA 94121, USA
J Nutr 134:3472S-3478S. 2004.... - Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytesChia Ling Tu
Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
J Invest Dermatol 124:187-97. 2005..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R... - Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1Zhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
Mol Biol Cell 16:3236-46. 2005..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation... - The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiationZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
J Biol Chem 282:8695-703. 2007.... - Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiationYuko Oda
Departments of Medicine and Endocrinology, University of California San Francisco, and Veterans Affairs Medical Center San Francisco, 41150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 103:776-80. 2007..These results support the concept that the selective use of coactivators by VDR underlies the selective regulation of gene expression in keratinocyte proliferation and differentiation... - Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growthZhongjion Xie
Endocrine Unit, VA Medical Center, University of California, San Francisco, California 94121, USA
J Invest Dermatol 118:11-6. 2002.... - Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-IYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
J Endocrinol 189:279-87. 2006..These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone... - The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytesZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
J Biol Chem 277:36987-90. 2002..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis... - Development and progression of alopecia in the vitamin D receptor null mouseDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
J Cell Physiol 207:340-53. 2006..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling... - Hairless suppresses vitamin D receptor transactivation in human keratinocytesZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
Endocrinology 147:314-23. 2006..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes... - Vitamin D and skin cancer: a problem in gene regulationDaniel D Bikle
Endocrine Research Unit, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 97:83-91. 2005.... - Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphateHana Dolezalova
Department of Medicine, University of California, San Francisco, CA 94143-0711, USA
J Cell Biochem 88:732-43. 2003..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis... - Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloadingBenjamin M Boudignon
Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California, USA
J Appl Physiol 103:125-31. 2007.... - Vitamin D insufficiency/deficiency in gastrointestinal disordersDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
J Bone Miner Res 22:V50-4. 2007..Treatment involves adequate vitamin D and calcium supplementation to achieve normal serum 25(OH)D, PTH, and serum and urine calcium levels... - Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature reviewVivian Y Pao
Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Bone Miner Res 24:1135-9. 2009.... - Growth hormone/insulin-like growth factor-1/PTH axis in boneDaniel D Bikle
J Bone Miner Res 23:581-3. 2008
Research Grants
- Vitamin D Receptor Coactivators in KeratinocytesDaniel Bikle; Fiscal Year: 2007..abstract_text> ..
- IGF-1 MEDIATES THE ANABOLIC EFFECTS OF PTH ON BONEDaniel Bikle; Fiscal Year: 2005..The results of these experiments should determine the degree to which PTH is dependent on IGF-1 for producing its anabolic actions on bone, and initiate the exploration into the mechanisms by which this occurs. ..
- Vitamin D Receptor Coactivators in KeratinocytesDaniel Bikle; Fiscal Year: 2009....
- Integrin Regulation of IGF-1 Responsiveness in Bone During Mechanical LoadingDANIEL DAVID BIKLE; Fiscal Year: 2010..This failure is associated with loss of integrin expression. This project will evaluate the interaction between integrin and IGF-1 signaling in the skeletal response to mechanical load. ..
- IGF-1 MEDIATES THE ANABOLIC EFFECTS OF PTH ON BONEDANIEL DAVID BIKLE; Fiscal Year: 2010..This proposal will investigate this potential by examining the role of IGF-I signaling in those cells stimulated by PTH to form new bone. ..
- VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTESDaniel Bikle; Fiscal Year: 2003..abstract_text> ..
- REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN DDaniel Bikle; Fiscal Year: 2001..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
- Vitamin D Receptor Coactivators in KeratinocytesDANIEL DAVID BIKLE; Fiscal Year: 2010....