Daniel D Bikle

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, 4150 Clement Street 111N, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:347-53. 2004
  2. ncbi Vitamin D and skin cancer
    Daniel D Bikle
    Endocrine Research Unit, VA Medical Center, University of California, San Francisco, CA 94121, USA
    J Nutr 134:3472S-3478S. 2004
  3. ncbi Calcium- and vitamin D-regulated keratinocyte differentiation
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 177:161-71. 2001
  4. ncbi The impact of skeletal unloading on bone formation
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
    Gravit Space Biol Bull 16:45-54. 2003
  5. ncbi 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
    J Invest Dermatol 122:984-92. 2004
  6. ncbi Vitamin D regulated keratinocyte differentiation
    Daniel D Bikle
    Medicine and Dermatology Endocrine Research Unit, VA Medical Center, University of California, San Francisco, California, USA
    J Cell Biochem 92:436-44. 2004
  7. ncbi Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:355-60. 2004
  8. ncbi Vitamin D and skin cancer: a problem in gene regulation
    Daniel D Bikle
    Endocrine Research Unit, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 97:83-91. 2005
  9. ncbi Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006
  10. ncbi Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003

Collaborators

Detail Information

Publications74

  1. ncbi Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, 4150 Clement Street 111N, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:347-53. 2004
    ..Thus 1,25(OH)(2)D is essential for normal epidermal differentiation, most likely by inducing the proteins and mediating the calcium signaling in the epidermis required for the generation and maintenance of the barrier...
  2. ncbi Vitamin D and skin cancer
    Daniel D Bikle
    Endocrine Research Unit, VA Medical Center, University of California, San Francisco, CA 94121, USA
    J Nutr 134:3472S-3478S. 2004
    ....
  3. ncbi Calcium- and vitamin D-regulated keratinocyte differentiation
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 177:161-71. 2001
    ..Thus, the regulation of keratinocyte differentiation by calcium and 1,25(OH)(2)D involves a number of signaling pathways including PLC and PKC activation, leading to the induction of proteins required for the differentiation process...
  4. ncbi The impact of skeletal unloading on bone formation
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
    Gravit Space Biol Bull 16:45-54. 2003
    ....
  5. ncbi 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
    J Invest Dermatol 122:984-92. 2004
    ....
  6. ncbi Vitamin D regulated keratinocyte differentiation
    Daniel D Bikle
    Medicine and Dermatology Endocrine Research Unit, VA Medical Center, University of California, San Francisco, California, USA
    J Cell Biochem 92:436-44. 2004
    ..This review will examine the mechanisms by which calcium and 1,25(OH)(2)D(3) interact to control epidermal differentiation...
  7. ncbi Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:355-60. 2004
    ..Thus in vivo and in vitro, calcium and 1,25(OH)(2)D interact at multiple levels to regulate epidermal differentiation...
  8. ncbi Vitamin D and skin cancer: a problem in gene regulation
    Daniel D Bikle
    Endocrine Research Unit, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 97:83-91. 2005
    ....
  9. ncbi Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006
    ..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling...
  10. ncbi Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003
    ....
  11. ncbi The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, USA
    J Invest Dermatol 119:1109-13. 2002
    ....
  12. ncbi Vitamin D regulated keratinocyte differentiation: role of coactivators
    D D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    J Cell Biochem 88:290-5. 2003
    ..These studies suggest that at least part of the sequential activation of genes required during keratinocyte differentiation is regulated by the change (availability) of these different coactivator complexes...
  13. ncbi Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117 1080, USA
    J Endocrinol 189:279-87. 2006
    ..These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone...
  14. ncbi IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 22:1329-37. 2007
    ..We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation...
  15. ncbi Role of IGF-I signaling in regulating osteoclastogenesis
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 21:1350-8. 2006
    ..These changes lead to impaired bone resorption, resulting in high BV/TV in IGF-I null mice...
  16. ncbi The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation
    Yuko Oda
    Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 130:2377-88. 2010
    ..These results show that keratinocytes use the transcriptional coactivator mediator to regulate VDR functions and control keratinocyte proliferation and differentiation...
  17. ncbi Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 128:816-24. 2008
    ....
  18. ncbi Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
    ..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling...
  19. pmc Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover
    Melita M Dvorak-Ewell
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Bone Miner Res 26:2935-47. 2011
    ....
  20. ncbi Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation
    Yuko Oda
    Department of Medicine, University of California San Francisco, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 89:273-6. 2004
    ....
  21. pmc IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway
    Yongmei Wang
    Endocrine Unit, University of California, Veterans Affairs Medical Center, San Francisco, CA, USA
    J Bone Miner Res 26:1437-46. 2011
    ..Our data indicate that the IGF-1R in chondrocytes controls cell growth, survival, and differentiation in embryonic and postnatal GPs in part by suppression of Pthrp expression...
  22. pmc Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice
    Mohammad Shahnazari
    Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, CA 94121, USA
    Am J Physiol Endocrinol Metab 303:E1354-62. 2012
    ..These strain-specific differences suggest that genetics plays an important role in determining the osteoblast and osteoclast populations on the bone surface and the dynamics of bone loss in response to skeletal unloading...
  23. pmc Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
    Chia Ling Tu
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:2350-9. 2012
    ..3%) diet. Deleting CaR perturbs the epidermal Ca(2+) gradient and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role for the CaR in normal epidermal development...
  24. pmc Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling
    Roger K Long
    Department of Medicine, University of California, Davis, CA, USA
    J Bone Miner Res 26:2948-58. 2011
    ....
  25. ncbi Insulin-like growth factor-I is essential for embryonic bone development
    Yongmei Wang
    Department of Medicine, Endocrine Unit, 111N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Endocrinology 147:4753-61. 2006
    ..Our results indicate that IGF-I plays an important role in skeletal development by promoting chondrocyte proliferation and maturation while inhibiting apoptosis to form bones of appropriate size and strength...
  26. pmc Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    Yuko Oda
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 129:1367-78. 2009
    ..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized...
  27. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ....
  28. ncbi Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading
    Benjamin M Boudignon
    Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California, USA
    J Appl Physiol (1985) 103:125-31. 2007
    ....
  29. ncbi Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
    Yuko Oda
    Departments of Medicine and Endocrinology, University of California San Francisco, and Veterans Affairs Medical Center San Francisco, 41150 Clement Street, San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 103:776-80. 2007
    ..These results support the concept that the selective use of coactivators by VDR underlies the selective regulation of gene expression in keratinocyte proliferation and differentiation...
  30. pmc Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 20:1695-704. 2009
    ..This signaling pathway is critical for Cao-induced generation of the second messengers IP3 and Cai and keratinocyte differentiation...
  31. ncbi Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
    J Bone Miner Res 17:1570-8. 2002
    ..These results indicate that IGF-I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH...
  32. ncbi The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
    ..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores...
  33. ncbi The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
    ..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models...
  34. pmc Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations
    Yuko Oda
    Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:1075-83. 2012
    ..These results indicate that MED1 has a critical role in regulating hair/epidermal proliferation and differentiation...
  35. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
    ..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation...
  36. ncbi Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth
    Zhongjion Xie
    Endocrine Unit, VA Medical Center, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 118:11-6. 2002
    ....
  37. ncbi Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone
    Melita M Dvorak
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, University of California, San Francisco, California 94121, USA
    Endocrinology 148:3156-63. 2007
    ....
  38. ncbi 1α,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway
    Yan J Jiang
    Endocrine Unit, Department of Medicine and Dermatology, VA Medical Center and University of California at San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 136:229-32. 2013
    ..Further study using VDR or β-catenin single null mice is necessary to compare with the data from double null mice. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  39. pmc The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 131:1119-28. 2011
    ..These results indicate that Rho is a downstream mediator of CaR in the regulation of Ca(2+)(o)-induced E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation...
  40. ncbi Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
    ..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes...
  41. pmc Protective role of vitamin D signaling in skin cancer formation
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 136:271-9. 2013
    ..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  42. pmc Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice
    Arnaud E Teichert
    Endocrine Unit, Department of Dermatology, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 131:2289-97. 2011
    ..Our results suggest that increased expression of Shh in the keratinocytes of the VDR-null animal activates the Hh pathway, predisposing the skin to the development of both malignant and benign epidermal neoplasms...
  43. pmc Vitamin D metabolism and function in the skin
    Daniel D Bikle
    Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 347:80-9. 2011
    ..This review will examine the regulation of vitamin D production and metabolism in the skin, and explore the various functions regulated by 1,25(OH)(2)D and its receptor...
  44. ncbi Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation
    Yuko Oda
    Departments of Medicine and Endocrinology University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Mol Endocrinol 17:2329-39. 2003
    ....
  45. ncbi PTH differentially regulates expression of RANKL and OPG
    John C Huang
    Department of Growth and Development, Division of Orthodontics, University of California San Francisco School of Dentistry, San Francisco, California, USA
    J Bone Miner Res 19:235-44. 2004
    ..OPG:RANKL ratios indicate that PTH may induce a possible switch in the regulatory mechanism of osteoclastogenesis where OPG is inhibited early and RANKL is increased at late stages of osteoblast differentiation...
  46. doi Vitamin D and the skin
    Daniel D Bikle
    Veterans Affairs Medical Center, University of California, 4150 Clement St 111N, San Francisco, CA 94121, USA
    J Bone Miner Metab 28:117-30. 2010
    ..This review examines the various functions of vitamin D and its receptor, and to the extent known explores the mechanisms by which these functions are regulated...
  47. ncbi Hairless suppresses vitamin D receptor transactivation in human keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Endocrinology 147:314-23. 2006
    ..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes...
  48. ncbi Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3
    Nathaniel P Hawker
    Department of Medicine, Endocrine Research Unit, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
    J Invest Dermatol 127:874-80. 2007
    ..Additionally, each individual differentiation marker that was assayed has a different specificity for the coactivators that regulate its expression...
  49. pmc Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
    J Clin Invest 117:803-11. 2007
    ..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection...
  50. ncbi The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
    J Biol Chem 282:8695-703. 2007
    ....
  51. ncbi Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
    ..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes...
  52. ncbi Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma
    Lee Chuan Yang
    Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
    J Cell Physiol 195:249-59. 2003
    ..Failure to regulate PKC [alpha] in SCC4 may underlie at least part of the failure of calcium to promote differentiation in these cells...
  53. ncbi Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways
    Takeshi Sakata
    Department of Medicine, University of California, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 19:436-46. 2004
    ..These results show that skeletal unloading induces resistance to IGF-I by inhibiting activation of the IGF-I signaling pathways at least in part through downregulation of integrin signaling...
  54. pmc Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
    Chia Ling Tu
    Endocrine Unit, Veterans Affair Medical Center and The University of California, San Francisco, CA, USA
    Best Pract Res Clin Endocrinol Metab 27:415-27. 2013
    ..The concepts derived from in vitro gene knockdown experiments have been evaluated and confirmed in three mouse models in vivo. ..
  55. ncbi Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 124:187-97. 2005
    ..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R...
  56. ncbi Ceramides stimulate caspase-14 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    Exp Dermatol 22:113-8. 2013
    ..These studies show that ceramides, an important structural lipid, stimulate caspase-14 expression providing a mechanism for coordinately regulating the formation of lipid lamellar membranes with the formation of corneocytes...
  57. pmc PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection
    Beda Muehleisen
    Division of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA
    Sci Transl Med 4:135ra66. 2012
    ..These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide production...
  58. ncbi Vitamin D: an ancient hormone
    Daniel D Bikle
    San Francisco Veterans Affairs Medical Center, University of California at San Francisco, CA, USA
    Exp Dermatol 20:7-13. 2011
    ..In this article, I make the case that vitamin D signalling evolved to enable the organism to effectively regulate calcium flux, storage and signalling and that such regulation is critical for the evolutionary process...
  59. pmc Quantification of the vitamin D receptor-coregulator interaction
    Arnaud Teichert
    Endocrine Unit, University of California, San Francisco, San Francisco, California 94121, USA
    Biochemistry 48:1454-61. 2009
    ....
  60. ncbi The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
    ..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation...
  61. pmc Protective actions of vitamin D in UVB induced skin cancer
    Daniel D Bikle
    Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA, USA
    Photochem Photobiol Sci 11:1808-16. 2012
    ..We will then explore three potential mechanisms for this protection: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR)...
  62. pmc Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Curr Mol Pharmacol 5:135-42. 2012
    ....
  63. ncbi Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate
    Hana Dolezalova
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    J Cell Biochem 88:732-43. 2003
    ..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis...
  64. pmc Vitamin D and the skin: Physiology and pathophysiology
    Daniel D Bikle
    Veterans Affairs Medical Center University of California, San Francisco, San Francisco, CA 94121, USA
    Rev Endocr Metab Disord 13:3-19. 2012
    ..This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated...
  65. doi Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism
    Daniel D Bikle
    Department of Medicine, University of California San Francisco VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 128:2357-61. 2008
    ..Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?..
  66. ncbi Vitamin D and immune function: understanding common pathways
    Daniel D Bikle
    Veterans Affairs Medical Center 111N, San Francisco, CA 94121, USA
    Curr Osteoporos Rep 7:58-63. 2009
    ....
  67. pmc Vitamin D: newly discovered actions require reconsideration of physiologic requirements
    Daniel D Bikle
    Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Trends Endocrinol Metab 21:375-84. 2010
    ..In this review, these newer applications are summarized and therapeutic considerations are provided...
  68. ncbi What is new in vitamin D: 2006-2007
    Daniel D Bikle
    Medicine and Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
    Curr Opin Rheumatol 19:383-8. 2007
    ..This review focuses on recent developments in a number of areas to bring the reader up to the current state of knowledge in this field...
  69. ncbi The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:36987-90. 2002
    ..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis...
  70. doi Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review
    Vivian Y Pao
    Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Miner Res 24:1135-9. 2009
    ....
  71. doi Vitamin D regulation of immune function
    Daniel D Bikle
    Department of Medicine and Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    Vitam Horm 86:1-21. 2011
    ..In this review, I examine the regulation by 1,25(OH)(2)D of immune function, then assess the evidence implicating vitamin D deficiency in human disease resulting from immune dysfunction...
  72. doi Vitamin D and the immune system: role in protection against bacterial infection
    Daniel D Bikle
    Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Curr Opin Nephrol Hypertens 17:348-52. 2008
    ..Immunity is both adaptive and innate, and vitamin D signaling is operative in both. This review will examine these actions of vitamin D, in particular the role of vitamin D in host defense against infection...
  73. ncbi Vitamin D insufficiency/deficiency in gastrointestinal disorders
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    J Bone Miner Res 22:V50-4. 2007
    ..Treatment involves adequate vitamin D and calcium supplementation to achieve normal serum 25(OH)D, PTH, and serum and urine calcium levels...
  74. ncbi Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice
    Jay Cao
    Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Bone Miner Res 18:270-7. 2003
    ..These changes favor increased osteoclast over osteoblast activity, and may explain, in part, the imbalance in bone formation and resorption associated with aging...