Research Topics
Genomes and Genes
| Daniel D BikleSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Calcium- and vitamin D-regulated keratinocyte differentiationD D Bikle
Department of Medicine, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
Mol Cell Endocrinol 177:161-71. 2001..Thus, the regulation of keratinocyte differentiation by calcium and 1,25(OH)(2)D involves a number of signaling pathways including PLC and PKC activation, leading to the induction of proteins required for the differentiation process...- Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier functionD D Bikle
Department of Medicine, Veterans Affairs Medical Center, University of California, 4150 Clement Street 111N, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 89:347-53. 2004..Thus 1,25(OH)(2)D is essential for normal epidermal differentiation, most likely by inducing the proteins and mediating the calcium signaling in the epidermis required for the generation and maintenance of the barrier... - Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiationD D Bikle
Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 89:355-60. 2004..Thus in vivo and in vitro, calcium and 1,25(OH)(2)D interact at multiple levels to regulate epidermal differentiation... - Vitamin D and skin cancerDaniel D Bikle
Endocrine Research Unit, VA Medical Center, University of California, San Francisco, CA 94121, USA
J Nutr 134:3472S-3478S. 2004.... - Vitamin D and skin cancer: a problem in gene regulationDaniel D Bikle
Endocrine Research Unit, Veterans Affairs Medical Center 111N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 97:83-91. 2005.... - The impact of skeletal unloading on bone formationDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
Gravit Space Biol Bull 16:45-54. 2003.... - Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?Daniel D Bikle
Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
Recent Results Cancer Res 164:111-22. 2003.... - Development and progression of alopecia in the vitamin D receptor null mouseDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
J Cell Physiol 207:340-53. 2006..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling... - Vitamin D regulated keratinocyte differentiationDaniel D Bikle
Medicine and Dermatology Endocrine Research Unit, VA Medical Center, University of California, San Francisco, California, USA
J Cell Biochem 92:436-44. 2004..This review will examine the mechanisms by which calcium and 1,25(OH)(2)D(3) interact to control epidermal differentiation... - 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasisD D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
J Invest Dermatol 122:984-92. 2004.... - Vitamin D regulated keratinocyte differentiation: role of coactivatorsD D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
J Cell Biochem 88:290-5. 2003..These studies suggest that at least part of the sequential activation of genes required during keratinocyte differentiation is regulated by the change (availability) of these different coactivator complexes... - The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3Daniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, USA
J Invest Dermatol 119:1109-13. 2002.... - Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-IYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
J Endocrinol 189:279-87. 2006..These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone... - Role of IGF-I signaling in regulating osteoclastogenesisYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 21:1350-8. 2006..These changes lead to impaired bone resorption, resulting in high BV/TV in IGF-I null mice... - IGF-I receptor is required for the anabolic actions of parathyroid hormone on boneYongmei Wang
Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 22:1329-37. 2007..We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation... - Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytesChia Ling Tu
Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
J Biol Chem 283:3519-28. 2008..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling... - Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3Jürgen Schauber
Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
J Invest Dermatol 128:816-24. 2008.... 
The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiationYuko Oda
Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 130:2377-88. 2010..These results show that keratinocytes use the transcriptional coactivator mediator to regulate VDR functions and control keratinocyte proliferation and differentiation...
Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnoverMelita M Dvorak-Ewell
Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
J Bone Miner Res 26:2935-47. 2011....- Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiationYuko Oda
Department of Medicine, University of California San Francisco, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 89:273-6. 2004.... - IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathwayYongmei Wang
Endocrine Unit, University of California, Veterans Affairs Medical Center, San Francisco, CA, USA
J Bone Miner Res 26:1437-46. 2011..Our data indicate that the IGF-1R in chondrocytes controls cell growth, survival, and differentiation in embryonic and postnatal GPs in part by suppression of Pthrp expression... - Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of miceMohammad Shahnazari
Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, CA 94121, USA
Am J Physiol Endocrinol Metab 303:E1354-62. 2012..These strain-specific differences suggest that genetics plays an important role in determining the osteoblast and osteoclast populations on the bone surface and the dynamics of bone loss in response to skeletal unloading... - Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier functionChia Ling Tu
Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 132:2350-9. 2012..3%) diet. Deleting CaR perturbs the epidermal Ca(2+) gradient and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role for the CaR in normal epidermal development... - Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signalingRoger K Long
Department of Medicine, University of California, Davis, CA, USA
J Bone Miner Res 26:2948-58. 2011.... - Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formationYuko Oda
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 129:1367-78. 2009..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized... - Insulin-like growth factor-I is essential for embryonic bone developmentYongmei Wang
Department of Medicine, Endocrine Unit, 111N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
Endocrinology 147:4753-61. 2006..Our results indicate that IGF-I plays an important role in skeletal development by promoting chondrocyte proliferation and maturation while inhibiting apoptosis to form bones of appropriate size and strength... - SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's diseaseAnna Celli
Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
J Invest Dermatol 132:1188-95. 2012.... - Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiationYuko Oda
Departments of Medicine and Endocrinology, University of California San Francisco, and Veterans Affairs Medical Center San Francisco, 41150 Clement Street, San Francisco, CA 94121, USA
J Steroid Biochem Mol Biol 103:776-80. 2007..These results support the concept that the selective use of coactivators by VDR underlies the selective regulation of gene expression in keratinocyte proliferation and differentiation... - Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloadingBenjamin M Boudignon
Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California, USA
J Appl Physiol 103:125-31. 2007.... - Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse boneDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
J Bone Miner Res 17:1570-8. 2002..These results indicate that IGF-I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH... - The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytesChia Ling Tu
Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
J Invest Dermatol 127:1074-83. 2007..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores... - Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiationZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California at San Francisco, San Francisco, CA 94121, USA
Mol Biol Cell 20:1695-704. 2009..This signaling pathway is critical for Cao-induced generation of the second messengers IP3 and Cai and keratinocyte differentiation... - The role of the calcium-sensing receptor in epidermal differentiationChia Ling Tu
Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
Cell Calcium 35:265-73. 2004..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models... - Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterationsYuko Oda
Department of Medicine and Endocrinology, University of California, San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 132:1075-83. 2012..These results indicate that MED1 has a critical role in regulating hair/epidermal proliferation and differentiation... - Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growthZhongjion Xie
Endocrine Unit, VA Medical Center, University of California, San Francisco, California 94121, USA
J Invest Dermatol 118:11-6. 2002.... - Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1Zhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
Mol Biol Cell 16:3236-46. 2005..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation... - Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous boneMelita M Dvorak
Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, University of California, San Francisco, California 94121, USA
Endocrinology 148:3156-63. 2007.... - The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin AChia Ling Tu
Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
J Invest Dermatol 131:1119-28. 2011..These results indicate that Rho is a downstream mediator of CaR in the regulation of Ca(2+)(o)-induced E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation... - Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiationLaszlo Komuves
Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
J Cell Physiol 192:45-54. 2002..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes... - Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null miceArnaud E Teichert
Endocrine Unit, Department of Dermatology, University of California, San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 131:2289-97. 2011..Our results suggest that increased expression of Shh in the keratinocytes of the VDR-null animal activates the Hh pathway, predisposing the skin to the development of both malignant and benign epidermal neoplasms... - Vitamin D metabolism and function in the skinDaniel D Bikle
Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
Mol Cell Endocrinol 347:80-9. 2011..This review will examine the regulation of vitamin D production and metabolism in the skin, and explore the various functions regulated by 1,25(OH)(2)D and its receptor... - Hairless suppresses vitamin D receptor transactivation in human keratinocytesZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
Endocrinology 147:314-23. 2006..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes... - Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ storesMartin J Behne
Department of Dermatology, University of California, San Francisco, California, USA
J Invest Dermatol 121:688-94. 2003..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes... - Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanismJürgen Schauber
Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
J Clin Invest 117:803-11. 2007..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection... - The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiationZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
J Biol Chem 282:8695-703. 2007.... - Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiationYuko Oda
Departments of Medicine and Endocrinology University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
Mol Endocrinol 17:2329-39. 2003.... - PTH differentially regulates expression of RANKL and OPGJohn C Huang
Department of Growth and Development, Division of Orthodontics, University of California San Francisco School of Dentistry, San Francisco, California, USA
J Bone Miner Res 19:235-44. 2004..OPG:RANKL ratios indicate that PTH may induce a possible switch in the regulatory mechanism of osteoclastogenesis where OPG is inhibited early and RANKL is increased at late stages of osteoblast differentiation... - Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3Nathaniel P Hawker
Department of Medicine, Endocrine Research Unit, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
J Invest Dermatol 127:874-80. 2007..Additionally, each individual differentiation marker that was assayed has a different specificity for the coactivators that regulate its expression... - Vitamin D and the skinDaniel D Bikle
Veterans Affairs Medical Center, University of California, 4150 Clement St 111N, San Francisco, CA 94121, USA
J Bone Miner Metab 28:117-30. 2010..This review examines the various functions of vitamin D and its receptor, and to the extent known explores the mechanisms by which these functions are regulated... - Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathwaysTakeshi Sakata
Department of Medicine, University of California, Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 19:436-46. 2004.... - Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinomaLee Chuan Yang
Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
J Cell Physiol 195:249-59. 2003..Failure to regulate PKC [alpha] in SCC4 may underlie at least part of the failure of calcium to promote differentiation in these cells... - Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytesChia Ling Tu
Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
J Invest Dermatol 124:187-97. 2005..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R... - PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infectionBeda Muehleisen
Division of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA
Sci Transl Med 4:135ra66. 2012..These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide production... - Vitamin D: an ancient hormoneDaniel D Bikle
San Francisco Veterans Affairs Medical Center, University of California at San Francisco, CA, USA
Exp Dermatol 20:7-13. 2011..In this article, I make the case that vitamin D signalling evolved to enable the organism to effectively regulate calcium flux, storage and signalling and that such regulation is critical for the evolutionary process... - Quantification of the vitamin D receptor-coregulator interactionArnaud Teichert
Endocrine Unit, University of California, San Francisco, San Francisco, California 94121, USA
Biochemistry 48:1454-61. 2009.... - The effect of LXR activators on AP-1 proteins in keratinocytesMatthias Schmuth
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 123:41-8. 2004..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation... - Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormoneDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
Curr Mol Pharmacol 5:135-42. 2012.... - Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphateHana Dolezalova
Department of Medicine, University of California, San Francisco, CA 94143-0711, USA
J Cell Biochem 88:732-43. 2003..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis... - Vitamin D and the skin: Physiology and pathophysiologyDaniel D Bikle
Veterans Affairs Medical Center University of California, San Francisco, San Francisco, CA 94121, USA
Rev Endocr Metab Disord 13:3-19. 2012..This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated... - Vitamin D: newly discovered actions require reconsideration of physiologic requirementsDaniel D Bikle
Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
Trends Endocrinol Metab 21:375-84. 2010..In this review, these newer applications are summarized and therapeutic considerations are provided... - What is new in vitamin D: 2006-2007Daniel D Bikle
Medicine and Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, California, USA
Curr Opin Rheumatol 19:383-8. 2007..This review focuses on recent developments in a number of areas to bring the reader up to the current state of knowledge in this field... - Vitamin D receptor, UVR, and skin cancer: a potential protective mechanismDaniel D Bikle
Department of Medicine, University of California San Francisco VA Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 128:2357-61. 2008..Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?.. - Vitamin D and immune function: understanding common pathwaysDaniel D Bikle
Veterans Affairs Medical Center 111N, San Francisco, CA 94121, USA
Curr Osteoporos Rep 7:58-63. 2009.... - The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytesZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
J Biol Chem 277:36987-90. 2002..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis... - Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature reviewVivian Y Pao
Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Bone Miner Res 24:1135-9. 2009.... - Vitamin D regulation of immune functionDaniel D Bikle
Department of Medicine and Dermatology, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
Vitam Horm 86:1-21. 2011..In this review, I examine the regulation by 1,25(OH)(2)D of immune function, then assess the evidence implicating vitamin D deficiency in human disease resulting from immune dysfunction... - Vitamin D and the immune system: role in protection against bacterial infectionDaniel D Bikle
Veterans Affairs Medical Center, San Francisco, California 94121, USA
Curr Opin Nephrol Hypertens 17:348-52. 2008..Immunity is both adaptive and innate, and vitamin D signaling is operative in both. This review will examine these actions of vitamin D, in particular the role of vitamin D in host defense against infection... - Vitamin D insufficiency/deficiency in gastrointestinal disordersDaniel D Bikle
Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
J Bone Miner Res 22:V50-4. 2007..Treatment involves adequate vitamin D and calcium supplementation to achieve normal serum 25(OH)D, PTH, and serum and urine calcium levels... - Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 miceJay Cao
Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Bone Miner Res 18:270-7. 2003..These changes favor increased osteoclast over osteoblast activity, and may explain, in part, the imbalance in bone formation and resorption associated with aging...