W H Biggs

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    W H Biggs
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 96:7421-6. 1999
  2. ncbi Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    W H Biggs
    Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
    Mamm Genome 12:416-25. 2001
  3. ncbi Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase
    W H Biggs
    Howard Hughes Medical Institute, University of California, Los Angeles 90024
    Proc Natl Acad Sci U S A 89:6295-9. 1992
  4. ncbi A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
    D Brunner
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 76:875-88. 1994
  5. ncbi The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway
    W H Biggs
    Howard Hughes Medical Institute, UCLA School of Medicine
    EMBO J 13:1628-35. 1994

Collaborators

Detail Information

Publications5

  1. ncbi Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    W H Biggs
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 96:7421-6. 1999
    ..These results indicate that phosphorylation by PKB/Akt negatively regulates FKHR1 by promoting export from the nucleus...
  2. ncbi Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    W H Biggs
    Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
    Mamm Genome 12:416-25. 2001
    ..Further characterization will provide insight into the roles of members of the FKHR subfamily of forkhead-related genes during both normal and neoplastic development...
  3. ncbi Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase
    W H Biggs
    Howard Hughes Medical Institute, University of California, Los Angeles 90024
    Proc Natl Acad Sci U S A 89:6295-9. 1992
    ..Biochemical and histological studies reveal its expression in the eye imaginal disc. These studies provide a first step in a genetic analysis of ERK function...
  4. ncbi A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
    D Brunner
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 76:875-88. 1994
    ..Activation of MAP kinase by the rlSem mutation is both necessary and sufficient to activate multiple signaling pathways controlled by receptor tyrosine kinases...
  5. ncbi The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway
    W H Biggs
    Howard Hughes Medical Institute, UCLA School of Medicine
    EMBO J 13:1628-35. 1994
    ..In this report we present evidence that a Drosophila MAP kinase, ERK-A, is encoded by the rolled locus and is required downstream of raf in the Sev signal transduction pathway...