E Bier

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Drosophila, the golden bug, emerges as a tool for human genetics
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92039, USA
    Nat Rev Genet 6:9-23. 2005
  2. ncbi request reprint Drawing lines in the Drosophila wing: initiation of wing vein development
    E Bier
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Curr Opin Genet Dev 10:393-8. 2000
  3. ncbi request reprint Localized activation of RTK/MAPK pathways during Drosophila development
    E Bier
    Department of Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Bioessays 20:189-94. 1998
  4. ncbi request reprint Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
  5. ncbi request reprint The knirps and knirps-related genes organize development of the second wing vein in Drosophila
    K Lunde
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093, USA
    Development 125:4145-54. 1998
  6. ncbi request reprint brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
    A Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 226:255-66. 2000
  7. ncbi request reprint rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development
    A Guichard
    Department of Biology, University of California San Diego, La Jolla CA 92093 0349, USA
    Development 126:2663-76. 1999
  8. ncbi request reprint Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity
    K Yu
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0349, USA
    Development 127:2143-54. 2000
  9. ncbi request reprint The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing
    M A Sturtevant
    Department of Biology, University of California, San Diego, La Jolla 92093 0116, USA
    Development 124:21-32. 1997
  10. ncbi request reprint The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development
    K Yu
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093, USA
    Development 122:4033-44. 1996

Collaborators

  • Helena Araujo
  • K Howard
  • R W Padgett
  • M Gribskov
  • S Chien
  • Lawrence T Reiter
  • Yong Tao Zhang
  • ARTHUR LANDER
  • Rolf Bodmer
  • S Srinivasan
  • J Marsh
  • David Kimelman
  • Michael Karin
  • Annabel Guichard
  • B Biehs
  • Claudia Mieko Mizutani
  • M A Sturtevant
  • A Guichard
  • Stanley J P Iyadurai
  • K Yu
  • Takatoshi Nakagawa
  • Orna Cook
  • Dave Kosman
  • Kweon Yu
  • Brian Biehs
  • Karen Lunde
  • Jean Karim Hériché
  • M Roark
  • Sarah Mische
  • Min Gang Li
  • Yungui He
  • William Brown
  • John T Robinson
  • Thomas S Hays
  • Lingzhi Ma
  • Jin Mo Park
  • Néva Meyer
  • Henk Roelink
  • Beatriz Cruz-Moreno
  • K Lunde
  • Rui Sousa-Neves
  • Michael Rizen
  • Hong zhong Zhang
  • Rik Derynck
  • Frederic Y M Wan
  • Anne Bang
  • Diane Hu
  • Carolina Perez Castro
  • Qing Nie
  • Jill Helms
  • Peter Vilmos
  • Yang Xiao
  • Petra Heine
  • W Gregory Cox
  • William McGinnis
  • Kyung Hwa Kang
  • Claudia M Mizutani
  • J W O'neill
  • Ujwal Pyati
  • Derek Lemons
  • Jennifer L Trimble
  • Dan Ang
  • Ulrich Nauber
  • Kirsten A Guss
  • PATRICK H O'FARRELL
  • V Francois
  • Y T Ip
  • Georgianna Zimm
  • J F Emery
  • K E Rashka
  • M Ronshaugen
  • O Shimmi
  • M B O'Connor
  • L Wickline
  • J Chacko
  • U Nauber
  • R Noll
  • E Marin
  • N Colley
  • R K Blackman
  • M Levine
  • R R Gollapudi
  • D Kosman
  • R E Park

Detail Information

Publications40

  1. ncbi request reprint Drosophila, the golden bug, emerges as a tool for human genetics
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92039, USA
    Nat Rev Genet 6:9-23. 2005
    ..The general principles by which D. melanogaster can be used to understand human disease, together with several specific examples, are considered in this review...
  2. ncbi request reprint Drawing lines in the Drosophila wing: initiation of wing vein development
    E Bier
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Curr Opin Genet Dev 10:393-8. 2000
    ..As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes...
  3. ncbi request reprint Localized activation of RTK/MAPK pathways during Drosophila development
    E Bier
    Department of Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Bioessays 20:189-94. 1998
    ..The ability to visualize the output of RTK signaling also permits detailed establishment of epistatic relationships between signaling components of RTK cascades...
  4. ncbi request reprint Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins...
  5. ncbi request reprint The knirps and knirps-related genes organize development of the second wing vein in Drosophila
    K Lunde
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093, USA
    Development 125:4145-54. 1998
    ..We propose a model in which the combined activities of kni and knrl organize development of the L2 vein in the appropriate position...
  6. ncbi request reprint brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
    A Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 226:255-66. 2000
    ..We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium...
  7. ncbi request reprint rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development
    A Guichard
    Department of Biology, University of California San Diego, La Jolla CA 92093 0349, USA
    Development 126:2663-76. 1999
    ..In contrast, spi does not play an essential role in the wing. These data indicate that rho and S act in concert, but independently of spi, to promote vein development through the EGFR/MAPK signaling pathway...
  8. ncbi request reprint Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity
    K Yu
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0349, USA
    Development 127:2143-54. 2000
    ....
  9. ncbi request reprint The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing
    M A Sturtevant
    Department of Biology, University of California, San Diego, La Jolla 92093 0116, USA
    Development 124:21-32. 1997
    ..We discuss how these data provide the final link connecting the formation of a linear adult structure to the establishment of a boundary by the maternal Bicoid morphogen gradient in the blastoderm embryo...
  10. ncbi request reprint The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development
    K Yu
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093, USA
    Development 122:4033-44. 1996
    ..These data support the view that Sog is a dedicated Dpp antagonist...
  11. ncbi request reprint Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression
    J F Emery
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Development 121:3549-60. 1995
    ..We discuss the implications of the striking organizational similarities of the dpn, scrt, and sna pan-neural enhancers...
  12. ncbi request reprint The Drosophila rhomboid protein is concentrated in patches at the apical cell surface
    M A Sturtevant
    Department of Biology, University of California San Diego, La Jolla 92093, USA
    Dev Biol 174:298-309. 1996
    ..A limiting cellular component also appears to be required for concentrating Rho in plaques. We discuss clustering of Rho in plasma membrane patches with respect to the proposed role of Rho in promoting EGF-R signaling...
  13. ncbi request reprint sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo
    H Araujo
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA
    Development 127:3631-44. 2000
    ..These results broaden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a novel form of crossregulation between the NF(kappa)B and TGF(beta) signaling pathways in pattern formation...
  14. ncbi request reprint The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm
    B Biehs
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Genes Dev 10:2922-34. 1996
    ....
  15. ncbi request reprint The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway
    M A Sturtevant
    Department of Biology, University of California, San Diego
    Genes Dev 7:961-73. 1993
    ..We discuss models for how localized expression of Rho may amplify signaling mediated by ubiquitously distributed ligand and receptor components...
  16. ncbi request reprint Anti-neural-inhibition: a conserved mechanism for neural induction
    E Bier
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0349, USA
    Cell 89:681-4. 1997
  17. ncbi request reprint New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy
    R Noll
    Department of Biology, University of California, San Diego, La Jolla 92093
    Development 120:2329-38. 1994
    ..Enhancer piracy may prove to be a general strategy for obtaining dominant alleles of a gene of interest in diverse insects, worms, plants, and potentially in vertebrates such as mice and fish...
  18. ncbi request reprint Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements
    Y T Ip
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Development 120:199-207. 1994
    ..The separate control of CNS and PNS sna expression and independence of proneural gene regulation add to a growing body of evidence that current genetic models of neurogenesis are substantially incomplete...
  19. pmc A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    L T Reiter
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093-0349, USA
    Genome Res 11:1114-25. 2001
    ..The Homophila database is available at http://homophila.sdsc.edu...
  20. ncbi request reprint The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
    Y T Ip
    Biology Department, University of California, San Diego, La Jolla 92093 0322
    Genes Dev 6:1728-39. 1992
    ..This suggests that the dl and bcd morphogens use a similar mechanism to make stripes in the Drosophila embryo...
  21. ncbi request reprint Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes
    J W O'neill
    University of California, San Diego, La Jolla
    Biotechniques 17:870, 874-5. 1994
    ....
  22. ncbi request reprint Drosophila, an emerging model for cardiac disease
    Ethan Bier
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Gene 342:1-11. 2004
    ....
  23. pmc Formation of the BMP activity gradient in the Drosophila embryo
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Dev Cell 8:915-24. 2005
    ....
  24. pmc Anthrax lethal factor and edema factor act on conserved targets in Drosophila
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093 0349, USA
    Proc Natl Acad Sci U S A 103:3244-9. 2006
    ....
  25. pmc Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase
    Lawrence T Reiter
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093, USA
    Hum Mol Genet 15:2825-35. 2006
    ....
  26. pmc Antioxidants put Parkinson flies back in the PINK
    Ethan Bier
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0349, USA
    Proc Natl Acad Sci U S A 103:13269-70. 2006
  27. pmc Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e313. 2006
    ..We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes...
  28. pmc Dynein and Star interact in EGFR signaling and ligand trafficking
    Stanley J P Iyadurai
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN 55455, USA
    J Cell Sci 121:2643-51. 2008
    ..Our direct observations of live S2 cells show that export of Spitz-GFP from the endoplasmic reticulum, as well as the trafficking of Spitz-GFP vesicles, depends on both Star and dynein...
  29. ncbi request reprint Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  30. pmc Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein
    Kweon Yu
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
    Genetics 166:1323-36. 2004
    ..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities...
  31. pmc Homophila: human disease gene cognates in Drosophila
    Samson Chien
    San Diego Supercomputer Center and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Nucleic Acids Res 30:149-51. 2002
    ..Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu...
  32. ncbi request reprint Creation of a Sog morphogen gradient in the Drosophila embryo
    Shaila Srinivasan
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Cell 2:91-101. 2002
    ..In addition, we find that Dynamin-dependent retrieval of Sog acts in parallel with degradation by Tld as a dorsal sink for active Sog...
  33. pmc A screen for dominant mutations applied to components in the Drosophila EGF-R pathway
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Proc Natl Acad Sci U S A 99:3752-7. 2002
    ..The isolation of dominant alleles in several different genes suggests that NOVA mutagenesis should be widely applicable and emerge as an effective tool for generating dominant mutations in genes of unknown function...
  34. ncbi request reprint Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins
    Lawrence T Reiter
    University of California, San Diego, Section of Cell and Developmental Biology, La Jolla, California 92093 0349, USA
    Expert Opin Ther Targets 6:387-99. 2002
    ....
  35. ncbi request reprint Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila
    Karen Lunde
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Development 130:235-48. 2003
    ..These experiments provide a mechanistic basis for understanding how kni and knrl link AP patterning to morphogenesis of the L2 vein by orchestrating the expression of a selective subset of vein-promoting genes in the L2 primordium...
  36. pmc Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila
    Jean Karim Hériché
    Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Street, San Francisco, CA 94143 0448, USA
    BMC Genet 4:9. 2003
    ..SCF action contributes to cell cycle progression but few of the key targets of its action have been identified...
  37. ncbi request reprint Integrins modulate Sog activity in the Drosophila wing
    Helena Araujo
    Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, 21941 970, Rio de Janeiro, Brazil
    Development 130:3851-64. 2003
    ..We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism...
  38. ncbi request reprint brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila
    Orna Cook
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Development 131:2113-24. 2004
    ..The similar mechanisms responsible for the induction of L5 and L2 development reveal how boundaries set by dosage-sensitive responses to a long-range morphogen specify distinct vein fates at precise locations...
  39. doi request reprint Intriguing extracellular regulation of BMP signaling
    Ethan Bier
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Dev Cell 15:176-7. 2008
    ..In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale...
  40. ncbi request reprint Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands
    Takatoshi Nakagawa
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    Dev Dyn 233:1315-31. 2005
    ..The characterization of this protein extends our understanding of the rhomboid family of regulatory proteins...