Research Topics
Genomes and GenesSpecies | E BierSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Drosophila, the golden bug, emerges as a tool for human geneticsEthan Bier
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92039, USA
Nat Rev Genet 6:9-23. 2005..The general principles by which D. melanogaster can be used to understand human disease, together with several specific examples, are considered in this review...- Drawing lines in the Drosophila wing: initiation of wing vein developmentE Bier
Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
Curr Opin Genet Dev 10:393-8. 2000..As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes... - Localized activation of RTK/MAPK pathways during Drosophila developmentE Bier
Department of Biology, University of California, San Diego, La Jolla 92093 0349, USA
Bioessays 20:189-94. 1998..The ability to visualize the output of RTK signaling also permits detailed establishment of epistatic relationships between signaling components of RTK cascades... - Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programsB Biehs
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
Development 125:4245-57. 1998..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins... - The knirps and knirps-related genes organize development of the second wing vein in DrosophilaK Lunde
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093, USA
Development 125:4145-54. 1998..We propose a model in which the combined activities of kni and knrl organize development of the L2 vein in the appropriate position... - brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signalingA Guichard
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
Dev Biol 226:255-66. 2000..We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium... - rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein developmentA Guichard
Department of Biology, University of California San Diego, La Jolla CA 92093 0349, USA
Development 126:2663-76. 1999..In contrast, spi does not play an essential role in the wing. These data indicate that rho and S act in concert, but independently of spi, to promote vein development through the EGFR/MAPK signaling pathway... - Processing of the Drosophila Sog protein creates a novel BMP inhibitory activityK Yu
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0349, USA
Development 127:2143-54. 2000.... - The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wingM A Sturtevant
Department of Biology, University of California, San Diego, La Jolla 92093 0116, USA
Development 124:21-32. 1997..We discuss how these data provide the final link connecting the formation of a linear adult structure to the establishment of a boundary by the maternal Bicoid morphogen gradient in the blastoderm embryo... - The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein developmentK Yu
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093, USA
Development 122:4033-44. 1996..These data support the view that Sog is a dedicated Dpp antagonist... - Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repressionJ F Emery
Department of Biology, University of California, San Diego, La Jolla 92093, USA
Development 121:3549-60. 1995..We discuss the implications of the striking organizational similarities of the dpn, scrt, and sna pan-neural enhancers... - The Drosophila rhomboid protein is concentrated in patches at the apical cell surfaceM A Sturtevant
Department of Biology, University of California San Diego, La Jolla 92093, USA
Dev Biol 174:298-309. 1996..A limiting cellular component also appears to be required for concentrating Rho in plaques. We discuss clustering of Rho in plasma membrane patches with respect to the proposed role of Rho in promoting EGF-R signaling... - sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryoH Araujo
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA
Development 127:3631-44. 2000..These results broaden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a novel form of crossregulation between the NF(kappa)B and TGF(beta) signaling pathways in pattern formation... - The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectodermB Biehs
Department of Biology, University of California, San Diego, La Jolla 92093, USA
Genes Dev 10:2922-34. 1996.... - The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathwayM A Sturtevant
Department of Biology, University of California, San Diego
Genes Dev 7:961-73. 1993..We discuss models for how localized expression of Rho may amplify signaling mediated by ubiquitously distributed ligand and receptor components... - Anti-neural-inhibition: a conserved mechanism for neural inductionE Bier
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0349, USA
Cell 89:681-4. 1997 - New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracyR Noll
Department of Biology, University of California, San Diego, La Jolla 92093
Development 120:2329-38. 1994..Enhancer piracy may prove to be a general strategy for obtaining dominant alleles of a gene of interest in diverse insects, worms, plants, and potentially in vertebrates such as mice and fish... - Neurogenic expression of snail is controlled by separable CNS and PNS promoter elementsY T Ip
Department of Biology, University of California, San Diego, La Jolla 92093 0322
Development 120:199-207. 1994..The separate control of CNS and PNS sna expression and independence of proneural gene regulation add to a growing body of evidence that current genetic models of neurogenesis are substantially incomplete... 
A systematic analysis of human disease-associated gene sequences in Drosophila melanogasterL T Reiter
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093-0349, USA
Genome Res 11:1114-25. 2001..The Homophila database is available at http://homophila.sdsc.edu...- The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryoY T Ip
Biology Department, University of California, San Diego, La Jolla 92093 0322
Genes Dev 6:1728-39. 1992..This suggests that the dl and bcd morphogens use a similar mechanism to make stripes in the Drosophila embryo... - Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probesJ W O'neill
University of California, San Diego, La Jolla
Biotechniques 17:870, 874-5. 1994.... - Drosophila, an emerging model for cardiac diseaseEthan Bier
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Gene 342:1-11. 2004.... - Formation of the BMP activity gradient in the Drosophila embryoClaudia Mieko Mizutani
Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
Dev Cell 8:915-24. 2005.... - Anthrax lethal factor and edema factor act on conserved targets in DrosophilaAnnabel Guichard
Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093 0349, USA
Proc Natl Acad Sci U S A 103:3244-9. 2006.... - Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligaseLawrence T Reiter
Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093, USA
Hum Mol Genet 15:2825-35. 2006.... - Antioxidants put Parkinson flies back in the PINKEthan Bier
Department of Biology, University of California at San Diego, La Jolla, CA 92093-0349, USA
Proc Natl Acad Sci U S A 103:13269-70. 2006 
Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectodermClaudia Mieko Mizutani
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
PLoS Biol 4:e313. 2006..We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes...- Dynein and Star interact in EGFR signaling and ligand traffickingStanley J P Iyadurai
University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN 55455, USA
J Cell Sci 121:2643-51. 2008..Our direct observations of live S2 cells show that export of Spitz-GFP from the endoplasmic reticulum, as well as the trafficking of Spitz-GFP vesicles, depends on both Star and dynein... - Multiplex detection of RNA expression in Drosophila embryosDave Kosman
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
Science 305:846. 2004.... - Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog proteinKweon Yu
Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
Genetics 166:1323-36. 2004..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities... - Homophila: human disease gene cognates in DrosophilaSamson Chien
San Diego Supercomputer Center and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA
Nucleic Acids Res 30:149-51. 2002..Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu... - Creation of a Sog morphogen gradient in the Drosophila embryoShaila Srinivasan
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Cell 2:91-101. 2002..In addition, we find that Dynamin-dependent retrieval of Sog acts in parallel with degradation by Tld as a dorsal sink for active Sog... - A screen for dominant mutations applied to components in the Drosophila EGF-R pathwayAnnabel Guichard
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Proc Natl Acad Sci U S A 99:3752-7. 2002..The isolation of dominant alleles in several different genes suggests that NOVA mutagenesis should be widely applicable and emerge as an effective tool for generating dominant mutations in genes of unknown function... - Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteinsLawrence T Reiter
University of California, San Diego, Section of Cell and Developmental Biology, La Jolla, California 92093 0349, USA
Expert Opin Ther Targets 6:387-99. 2002.... - Activation of the knirps locus links patterning to morphogenesis of the second wing vein in DrosophilaKaren Lunde
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Development 130:235-48. 2003..These experiments provide a mechanistic basis for understanding how kni and knrl link AP patterning to morphogenesis of the L2 vein by orchestrating the expression of a selective subset of vein-promoting genes in the L2 primordium... - Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in DrosophilaJean Karim Hériché
Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Street, San Francisco, CA 94143 0448, USA
BMC Genet 4:9. 2003..SCF action contributes to cell cycle progression but few of the key targets of its action have been identified... - Integrins modulate Sog activity in the Drosophila wingHelena Araujo
Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, 21941 970, Rio de Janeiro, Brazil
Development 130:3851-64. 2003..We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism... - brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in DrosophilaOrna Cook
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Development 131:2113-24. 2004..The similar mechanisms responsible for the induction of L5 and L2 development reveal how boundaries set by dosage-sensitive responses to a long-range morphogen specify distinct vein fates at precise locations... 
Intriguing extracellular regulation of BMP signalingEthan Bier
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Dev Cell 15:176-7. 2008..In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale...- Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligandsTakatoshi Nakagawa
Department of Cell and Tissue Biology, Program in Cell Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
Dev Dyn 233:1315-31. 2005..The characterization of this protein extends our understanding of the rhomboid family of regulatory proteins...