Anja Katrin Bielinsky
Affiliation: University of Minnesota
Leung W, Baxley R, Moldovan G, Bielinsky A. Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA. Genes (Basel). 2018;10: pubmed publisher
..We will also cover the roles of PCNA PTMs in lagging strand synthesis, meiotic recombination, as well as somatic hypermutation and class switch recombination. ..
Thu Y, Bielinsky A. MCM10: one tool for all-Integrity, maintenance and damage control. Semin Cell Dev Biol. 2014;30:121-30 pubmed publisher
..Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity. ..
Alver R, Zhang T, Josephrajan A, Fultz B, Hendrix C, Das Bradoo S, et al
. The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage. Nucleic Acids Res. 2014;42:8389-404 pubmed publisher
..Since Rad53 phosphorylation in response to UV light appears to be normal in N-terminally truncated mcm10 mutants, we propose that Mcm10 may have a role in replication fork restart or DNA repair. ..
Thu Y, Van Riper S, Higgins L, Zhang T, Becker J, Markowski T, et al
. Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression. Cell Rep. 2016;15:1254-65 pubmed publisher
..Based on these findings, we propose a model in which Slx5/8 allows for passage through mitosis when replication stress is tolerable. ..
Baxley R, Bielinsky A. Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks. Genes (Basel). 2017;8: pubmed publisher
..In this review, we highlight advances in our understanding of when, where and how Mcm10 functions within the replisome to protect against barriers that cause incomplete replication. ..