Jaclyn Biegel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
    Margaret J Dougherty
    The Children s Hospital of Philadelphia, Room 1002 Abramson Research Building, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Neuro Oncol 12:621-30. 2010
  2. ncbi Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
    J A Biegel
    The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA
    Cancer Res 59:74-9. 1999
  3. ncbi Molecular genetics of atypical teratoid/rhabdoid tumor
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Neurosurg Focus 20:E11. 2006
  4. ncbi Molecular analysis of pediatric brain tumors
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 6:445-52. 2004
  5. ncbi Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors
    Jaclyn A Biegel
    Division of Human Genetics and Department of Pathology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 8:3461-7. 2002
  6. ncbi Germline INI1 mutation in a patient with a central nervous system atypical teratoid tumor and renal rhabdoid tumor
    J A Biegel
    Division of Human Genetics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 28:31-7. 2000
  7. ncbi Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system
    J A Biegel
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 6:2759-63. 2000
  8. ncbi Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms
    Alexander R Judkins
    Department of Pathology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:644-50. 2004
  9. pmc Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors
    Katherine W Eaton
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 56:7-15. 2011
  10. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009

Research Grants

  1. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 1999
  2. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2009
  3. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2005
  4. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2004
  5. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2003
  6. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2002
  7. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2001
  8. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn A Biegel; Fiscal Year: 2010

Collaborators

Detail Information

Publications45

  1. pmc Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
    Margaret J Dougherty
    The Children s Hospital of Philadelphia, Room 1002 Abramson Research Building, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Neuro Oncol 12:621-30. 2010
    ..BRAF mutations constitute a major genetic alteration in this histologic group of pediatric brain tumors and may serve as a molecular target for biologically based inhibitors...
  2. ncbi Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
    J A Biegel
    The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA
    Cancer Res 59:74-9. 1999
    ..These studies suggest that INI1 is a tumor suppressor gene involved in rhabdoid tumors of the brain, kidney, and other extrarenal sites...
  3. ncbi Molecular genetics of atypical teratoid/rhabdoid tumor
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Neurosurg Focus 20:E11. 2006
    ..The complex is recruited to promoters of a large variety of genes involved in cell signaling, growth, and differentiation. This review summarizes what is currently known regarding the molecular genetics of RTs...
  4. ncbi Molecular analysis of pediatric brain tumors
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 6:445-52. 2004
    ..Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment...
  5. ncbi Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors
    Jaclyn A Biegel
    Division of Human Genetics and Department of Pathology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 8:3461-7. 2002
    ..The majority of rhabdoid tumors from all sites contained deletions and/or mutations of the INI1 gene. Specific mutations were nonrandomly associated with anatomical site...
  6. ncbi Germline INI1 mutation in a patient with a central nervous system atypical teratoid tumor and renal rhabdoid tumor
    J A Biegel
    Division of Human Genetics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 28:31-7. 2000
    ..We propose that this germline INI1 mutation predisposed the child to the development of both malignancies. These findings lend support to the hypothesis that rhabdoid tumors in all sites have a common genetic etiology...
  7. ncbi Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system
    J A Biegel
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 6:2759-63. 2000
    ..Detection of these mutations suggests that the child has an AT/RT, rather than a MB/PNET, a finding with important prognostic value...
  8. ncbi Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms
    Alexander R Judkins
    Department of Pathology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:644-50. 2004
    ..INI1 immunostaining may have particular utility in the analysis of tumors with indeterminate histologic features or atypical immunophenotypic profiles...
  9. pmc Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors
    Katherine W Eaton
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 56:7-15. 2011
    ..However, these studies were limited by case selection and an inability to detect intragenic deletions and duplications...
  10. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009
    ..Whether these undifferentiated sarcomas represent a clinicopathologic entity distinct from classic malignant rhabdoid tumor requires further investigation...
  11. ncbi High-density single nucleotide polymorphism array analysis in patients with germline deletions of 22q11.2 and malignant rhabdoid tumor
    Eric M Jackson
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hum Genet 122:117-27. 2007
    ..2. These are the first reported cases in which an association has been established between recurrent, interstitial deletions mediated by LCRs in 22q11.2 and a predisposition to cancer...
  12. pmc Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors
    Eric M Jackson
    Department of Neurosurgery and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 15:1923-30. 2009
    ....
  13. ncbi No evidence for hypermethylation of the hSNF5/INI1 promoter in pediatric rhabdoid tumors
    Fan Zhang
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Genes Chromosomes Cancer 34:398-405. 2002
    ..One tumor demonstrated a potential mutation in the promoter region, but further studies are required for determining its functional significance...
  14. ncbi The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors
    Jaclyn A Biegel
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:323-8. 2002
    ..Drs. Malcolm Smith, Jaclyn Biegel, and Roger Packer hosted the meeting. There were 22 participants from 14 institutions...
  15. ncbi Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors
    Andrew C Hoot
    Department of Pathology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:1485-91. 2004
    ....
  16. ncbi INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma
    Alexander R Judkins
    Department of Pathology, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Neuropathol Exp Neurol 64:391-7. 2005
    ..This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone...
  17. pmc Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    Angela J Sievert
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Brain Pathol 19:449-58. 2009
    ..Further studies are required to determine the role of this fusion gene in downstream MAPK signaling and its role in development of pediatric low-grade astrocytomas...
  18. ncbi Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: case report and review of the literature
    Gregory Armstrong
    Division of Hematology and Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Pediatr Blood Cancer 44:400-6. 2005
    ..This case demonstrates the feasibility of detecting ALCL in paucicellular CSF specimens and suggests that even low CSF involvement can herald massive parenchymal disease...
  19. ncbi CLL/SLL diagnosed in an adolescent
    Marlise Luskin
    Division of Hematology Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 61:1107-10. 2014
    ..Management guidelines for CLL/SLL are tailored to older adults making determination of the optimal therapy for this patient a unique challenge...
  20. pmc High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system
    Theodore Nicolaides
    Department of Pediatrics, University of California San Francisco School of Medicine, 505 Parnassus Avenue, M649, Box 0106, San Francisco, CA 94143, USA
    J Neurooncol 98:117-23. 2010
    ..Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach...
  21. ncbi Atypical teratoid/rhabdoid tumor in a patient with Beckwith-Wiedemann syndrome
    Eric M Jackson
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Am J Med Genet A 143:1767-70. 2007
    ..These results suggest that, despite an underlying cancer predisposition, the occurrence of BWS and AT/RT in this patient may be unrelated...
  22. pmc Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6
    Leslie J Raffini
    Division of Oncology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:4568-73. 2002
    ..The sequences in these three cases show additional MLL genomic breakpoint heterogeneity. Each breakpoint junction suggests nonhomologous end joining and is consistent with DNA damage and repair. CDK6-MLL is a new fusion of both genes...
  23. doi ZNF238 is expressed in postmitotic brain cells and inhibits brain tumor growth
    Valerie M Tatard
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Res 70:1236-46. 2010
    ..ZNF238 is thus a novel brain tumor suppressor and its reactivation in tumors could open a novel anticancer strategy...
  24. ncbi Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging
    Robert G Whitmore
    Department of Neurosurgery, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 107:600-9. 2007
    ..The aim of this study was to use perfusion weighted MR imaging to predict tumor grade and cytogenetic profile in oligodendroglial neoplasms...
  25. pmc Surgical treatment of a clival-C2 atypical teratoid/rhabdoid tumor
    Gregory G Heuer
    Department of Neurosurgery, Children s Hospital of Philadelphia, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4399, USA
    J Neurosurg Pediatr 5:75-9. 2010
    ..The conus tumor was resected and found to be consistent with the primary tumor. Several months later the patient presented with disseminated intrathecal disease and ultimately died 42 months after the initial resection...
  26. pmc Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy
    Edward F Attiyeh
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104 4318, USA
    Genome Res 19:276-83. 2009
    ....
  27. ncbi TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms
    Kim E Nichols
    Department of Pediatric Oncology, Children s Hospital of Philadelphia, PA, USA
    J Clin Oncol 21:4505-9. 2003
    ..To clarify whether host genetic factors contribute to secondary tumorigenesis, we performed mutational analyses of the TP53, BRCA1, and BRCA2 tumor suppressor genes in a cohort of 44 HD patients developing one or more SMN...
  28. ncbi Parental heat exposure and risk of childhood brain tumor: a Children's Oncology Group study
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Am J Epidemiol 164:222-31. 2006
    ..4, 95% CI: 1.2, 9.7, and odds ratio = 2.1, 95% CI: 1.1, 4.3, respectively). This new observation regarding paternal exposure to heat just prior to the index pregnancy deserves consideration in future animal and human studies of MB/PNET...
  29. ncbi High-resolution detection and mapping of genomic DNA alterations in neuroblastoma
    Yael P Mosse
    Division of Oncology, Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Genes Chromosomes Cancer 43:390-403. 2005
    ..Taking all of this together indicates that aCGH can accurately measure CNAs in the neuroblastoma genome and facilitate gene discovery efforts by high-throughput refinement of candidate loci...
  30. ncbi Chromophobe renal cell carcinoma in a pediatric living-related kidney transplant recipient
    Andres J Greco
    Department of Surgery, The Children s Hospital of Philadelphia, PA 19104, USA
    Am J Kidney Dis 45:e105-8. 2005
    ..The patient was found to have cat-scratch disease. A renal cell carcinoma should be considered in the differential diagnosis of a pediatric recipient of an adult kidney with an incidental finding of a tumor in the graft...
  31. pmc Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability
    Elizabeth S McKenna
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:6223-33. 2008
    ....
  32. pmc Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation
    Michael S Isakoff
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:17745-50. 2005
    ..Further, conditional mouse models demonstrate that inactivation of p16Ink4a or Rb (retinoblastoma) does not accelerate tumor formation in Snf5 conditional mice, whereas mutation of p53 leads to a dramatic acceleration of tumor formation...
  33. ncbi Atypical teratoid/rhabdoid tumor of the central nervous system: report on workshop
    Roger J Packer
    Department of Neurology, Children s National Medical Center, The George Washington University Medical Center, Washington, DC 20010, USA
    J Pediatr Hematol Oncol 24:337-42. 2002
    ..Therapeutic approached have included surgery, chemotherapy, and radiotherapy. Prospective clinical trials are needed for children with AT/RTs...
  34. ncbi Central nervous system atypical teratoid/rhabdoid tumor: results of therapy in children enrolled in a registry
    Joanne M Hilden
    Department of Pediatric Hematology Oncology, The Children s Hospital, The Cleveland Clinic, 9500 Euclid Avenue, Desk S20, Cleveland, OH 44195, USA
    J Clin Oncol 22:2877-84. 2004
    ..The poor outcome with conventional infant brain tumor therapy has resulted in a lack of clear treatment guidelines. A registry has been established to create an outcomes database and to facilitate biology studies for this tumor...
  35. ncbi INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
    ..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor...
  36. pmc Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium
    Ludvik R Donner
    Department of Pathology, Scott and White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, Texas A and M University Health Science Center College of Medicine, Temple, TX 76508, USA
    Hum Pathol 38:935-9. 2007
    ..Our results demonstrate that deletions and mutations of the INI1 gene can occur also in rare composite rhabdoid tumors of adulthood. Further studies are necessary, however, to determine the prognostic significance of this finding...
  37. ncbi Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review
    Lars M Wagner
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 10:409-15. 2007
    ..Important similarities and differences between hepatoblastoma and rhabdoid tumors are reviewed, and suggestions are offered to help distinguish these 2 tumor types...
  38. ncbi Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults
    Jack Raisanen
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Brain Pathol 15:23-8. 2005
    ..These molecular findings confirm the occurrence of AT/RTs in adults. Although rare, AT/RT should be considered in the differential diagnosis of poorly differentiated intracranial tumors in adults...
  39. ncbi Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma
    Geeta Chacko
    Division of Neuropathology, Department of Neurological Sciences, Christian Medical College, Vellore, India
    J Neurooncol 84:217-22. 2007
    ..We speculate that the PXA was a quiescent tumor and that the secondary genetic alterations, including inactivation of the INI1 gene led to clinical progression...
  40. ncbi Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature
    Elena L Zarovnaya
    Department of Pathology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    J Neurooncol 84:49-55. 2007
    ..An unrestricted autopsy was performed. To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings...
  41. pmc Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study
    Jeffrey C Allen
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neuro Oncol 8:79-82. 2006
    ..This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor...
  42. ncbi Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation
    Kristin Janson
    Department of Radiation Oncology, Tulane University, New Orleans, Los Angeles, USA
    Pediatr Blood Cancer 47:279-84. 2006
    ..Germline mutations of the INI1 gene predispose children to the development of rhabdoid tumors. Reports of familial cases, however, are extremely rare...
  43. ncbi Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
    ..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis...
  44. pmc Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors
    Yushui Wu
    Department of Oncology, University of Calgary, the Tom Baker Cancer Centre, and the Clark H Smith Brain Tumour Research Centre, Calgary, Alberta, Canada
    Clin Cancer Res 14:1218-27. 2008
    ..The purpose of this study was to evaluate the therapeutic potential of two oncolytic viruses, myxoma virus (MV) and an attenuated vesicular stomatitis virus (VSV(DeltaM51)), in experimental models of human rhabdoid tumor...
  45. ncbi Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients
    Edward Pan
    University of California San Francisco, San Francisco, California, USA
    Clin Cancer Res 11:4733-40. 2005
    ..We hypothesized that genetic copy number aberrations (CNA) predict prognosis and would provide improved criteria for predicting outcome...

Research Grants15

  1. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 1999
    ..Identification of the rhabdoid tumor gene will be a major contribution towards the design of sensitive diagnostic assays, and improved treatment protocols. ..
  2. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2009
    ..Understanding the mechanisms by which INI1 is inactivated will be important for treatment stratification, and ultimately designing biologically based therapeutic strategies for patients. ..
  3. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2005
    ....
  4. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2004
    ....
  5. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2003
    ....
  6. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2002
    ....
  7. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn Biegel; Fiscal Year: 2001
    ....
  8. GENETICS OF PEDIATRIC RHABDOID TUMORS
    Jaclyn A Biegel; Fiscal Year: 2010
    ..Understanding the mechanisms by which INI1 is inactivated will be important for treatment stratification, and ultimately designing biologically based therapeutic strategies for patients. ..