Research Topics
Genomes and Genes | T BiedererSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
CASK and protein 4.1 support F-actin nucleation on neurexinsT Biederer
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 276:47869-76. 2001..Our data suggest that intercellular junctions formed by neurexins, such as junctions initiated by beta-neurexins with neuroligins, are at least partially coupled to the actin cytoskeleton via an interaction with CASK and protein 4.1...- SynCAM, a synaptic adhesion molecule that drives synapse assemblyThomas Biederer
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 297:1525-31. 2002.... - Mints as adaptors. Direct binding to neurexins and recruitment of munc18T Biederer
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 275:39803-6. 2000..Our data support a model whereby one of the functions of Mints is to localize the vesicle fusion protein Munc18 to those sites at the plasma membrane that are defined by neurexins, presumably in the vicinity of points of exocytosis... - SynCAMs organize synapses through heterophilic adhesionAdam I Fogel
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 27:12516-30. 2007..Our results define SynCAM proteins as components of novel heterophilic transsynaptic adhesion complexes that set up asymmetric interactions, with SynCAM proteins contributing to synapse organization and function... - Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion moleculesThomas Biederer
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
Genomics 87:139-50. 2006..These findings aim to facilitate the understanding of SynCAM genes and provide the framework to examine the physiological functions of this family of vertebrate-specific adhesion molecules... - Selective capability of SynCAM and neuroligin for functional synapse assemblyYildirim Sara
Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 25:260-70. 2005..These results suggest that both NL1 and SynCAM act similarly and specifically in artificial synapse induction but that this process does not reflect a shared physiological function of these molecules... - CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding proteinKatsuhiko Tabuchi
The Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 22:4264-73. 2002..Our data suggest that in the vertebrate brain, CASK and Velis form alternative tripartite complexes with either Mint 1 or Caskin 1 that may couple CASK to distinct downstream effectors... 
Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functionsLisa A Thomas
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
J Comp Neurol 510:47-67. 2008..These expression and adhesion profiles of SynCAMs together with their previously reported functions in synapse organization indicate that SynCAM proteins contribute importantly to the synaptic circuitry of the central nervous system...- Cell adhesion molecules in synapse formationPhilip Washbourne
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
J Neurosci 24:9244-9. 2004..This review highlights the molecular mechanisms used by CAMs to regulate presynaptic and postsynaptic differentiation... - A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zonesYun Wang
The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Proc Natl Acad Sci U S A 99:14464-9. 2002.... - Progress from the postsynaptic side: signaling in synaptic differentiationThomas Biederer
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
Sci STKE 2005:pe9. 2005..This Perspective summarizes new insights into early synaptic differentiation signals and discusses underlying principles... - Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoformsThomas Biederer
The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas Texas 75390 9111, USA
J Neurosci 22:7340-51. 2002..In view of their biochemical similarity, the functional differences among Mints are unexpected, suggesting that Mints 1 and 2 have a brain-specific function related to APP that is not executed by the ubiquitous Mint 3... - Cell-cell interactions in synaptogenesisMichael R Akins
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Curr Opin Neurobiol 16:83-9. 2006..Recent progress provides stimulating insights into the role of adhesion and signaling molecules in the formation and function of synaptic specializations... - Hooking up new synapsesThomas Biederer
Nat Neurosci 9:1203-4. 2006 - Mixed-culture assays for analyzing neuronal synapse formationThomas Biederer
Department of Molecular Biophysics and Biochemistry, Yale University, Sterling Hall of Medicine C127, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nat Protoc 2:670-6. 2007..Using this assay, recent studies revealed that single synaptic adhesion complexes can direct a remarkable degree of synaptic differentiation and provided new insights into the cell biological mechanisms of synaptogenesis...