Philip Bickler

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity
    Philip E Bickler
    University of California, San Francisco, CA, USA
    Anesthesiology 117:280-92. 2012
  2. ncbi Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, CA 94143 0542, USA
    Anesthesiology 103:532-9. 2005
  3. ncbi Hypoxia-induced silencing of NMDA receptors in turtle neurons
    P E Bickler
    Departments of Anesthesia and Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 20:3522-8. 2000
  4. ncbi The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia
    Philip E Bickler
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0542, USA
    Anesth Analg 103:419-29, table of contents. 2006
  5. ncbi Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin
    Philip Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, California, USA
    Anesth Analg 103:1036-7. 2006
  6. ncbi Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability
    Philip E Bickler
    Department of Anesthesia, University of California, San Francisco, California 94143, USA
    Annu Rev Physiol 69:145-70. 2007
  7. pmc Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons
    P E Bickler
    Department of Anesthesia, University of California at San Francisco, 513 Parnassus Avenue, Sciences 255, Box 0542, San Francisco, CA 94143 0542, USA
    Neuroscience 160:51-60. 2009
  8. pmc Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors
    Philip E Bickler
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
    Brain Res 1340:86-95. 2010
  9. doi Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
    J Neurosci Res 88:3520-9. 2010
  10. ncbi Effects of skin pigmentation on pulse oximeter accuracy at low saturation
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Anesthesiology 102:715-9. 2005

Collaborators

Detail Information

Publications32

  1. pmc Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity
    Philip E Bickler
    University of California, San Francisco, CA, USA
    Anesthesiology 117:280-92. 2012
    ..Because neurons are protected from hypoxia-ischemia by anesthetic agents that inhibit N-methyl-D-aspartic acid receptors, we tested whether anesthetics protect neurons from damage caused by PH/RW...
  2. ncbi Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, CA 94143 0542, USA
    Anesthesiology 103:532-9. 2005
    ....
  3. ncbi Hypoxia-induced silencing of NMDA receptors in turtle neurons
    P E Bickler
    Departments of Anesthesia and Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 20:3522-8. 2000
    ..When suppression of NMDARs was prevented with phosphatase inhibitors, tolerance of anoxia was lost. Silencing of NMDARs is thus critical to the remarkable ability of C. picta to tolerate life without oxygen...
  4. ncbi The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia
    Philip E Bickler
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0542, USA
    Anesth Analg 103:419-29, table of contents. 2006
    ..We conclude that isoflurane's protection of hypoxic cortical neurons involves signaling that includes changes in intracellular Ca2+ regulation, several MAP kinase pathways and modulation of apoptosis regulators...
  5. ncbi Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin
    Philip Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, California, USA
    Anesth Analg 103:1036-7. 2006
    ..More data are needed to determine if it is necessary to use the same guidelines for managing peripheral nerve infusion catheters in patients receiving enoxaparin as with epidurals and other types of central nerve catheter infusions...
  6. ncbi Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability
    Philip E Bickler
    Department of Anesthesia, University of California, San Francisco, California 94143, USA
    Annu Rev Physiol 69:145-70. 2007
    ..Tolerance of decreased energy charge and accumulating anaerobic end products as well as enhanced antioxidant defenses and regenerative capacities are also key to hypoxia survival in lower vertebrates...
  7. pmc Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons
    P E Bickler
    Department of Anesthesia, University of California at San Francisco, 513 Parnassus Avenue, Sciences 255, Box 0542, San Francisco, CA 94143 0542, USA
    Neuroscience 160:51-60. 2009
    ..We conclude that the endoplasmic reticulum, acting via redox/NADH-dependent intracellular Ca2+ store release, is an important mediator of the neuroprotective response to hypoxic stress...
  8. pmc Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors
    Philip E Bickler
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
    Brain Res 1340:86-95. 2010
    ..The mechanism involves genes for growth, development, apoptosis regulation and cell survival as well as IP(3) receptors and intracellular Ca(2+)...
  9. doi Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
    J Neurosci Res 88:3520-9. 2010
    ....
  10. ncbi Effects of skin pigmentation on pulse oximeter accuracy at low saturation
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Anesthesiology 102:715-9. 2005
    ..It is uncertain whether skin pigmentation affects pulse oximeter accuracy at low HbO2 saturation...
  11. ncbi Molecular adaptations for survival during anoxia: lessons from lower vertebrates
    Philip E Bickler
    Department of Anesthesia, University of California, San Francisco, USA
    Neuroscientist 8:234-42. 2002
    ..Transcriptional events leading to differential and/or decreased expression of receptors, proteins, and their subunits are probably very important but little studied...
  12. ncbi Adaptive responses of vertebrate neurons to hypoxia
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0542 USA
    J Exp Biol 205:3579-86. 2002
    ..The regulation of organelle and cell fate during long-term hypoxia is almost completely unexplored, and whether programmed cell death and regeneration of lost neurons occur following protracted dormancy is also of considerable interest...
  13. ncbi Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons
    P E Bickler
    Department of Anesthesia, Sciences 257, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Neuroscience 118:25-35. 2003
    ..Modulation of NMDARs by hypoxia may play an important role in the hypoxia tolerance of the mammalian neonate. In addition, oxygen sensing by NMDARs could play a significant role in postnatal brain development...
  14. ncbi Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neurons
    P E Bickler
    Department of Anesthesia, Sciences 261, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Neuroscience 127:673-83. 2004
    ..Thus, a zone of moderately increased [Ca(2+)](i) before a potentially lethal insult promotes cell survival, uncoupling subsequent large increases in [Ca(2+)](i) from initiating cell death processes...
  15. ncbi gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California San Francisco, CA 94143, USA
    Anesth Analg 97:564-71, table of contents. 2003
    ..Based on this and other studies, it is likely that neuroprotection produced by isoflurane is multifactorial and includes actions at both GABA(A) and glutamate receptors and possibly other mechanisms...
  16. ncbi Isoflurane neuroprotection in rat hippocampal slices decreases with aging: changes in intracellular Ca2+ regulation and N-methyl-D-aspartate receptor-mediated Ca2+ influx
    Xinhua Zhan
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, 94143 0542, USA
    Anesthesiology 104:995-1003. 2006
    ..The authors determined whether neuroprotection of hippocampal slices with isoflurane decreases with aging and is due to decreased intracellular Ca regulation and survival protein phosphorylation...
  17. ncbi Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Anesth Analg 100:215-25. 2005
    ..Propofol was not neuroprotective at concentrations that reduce glutamate and NMDA receptor responses in cortical and hippocampal neurons...
  18. pmc Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0542, USA
    Anesthesiology 111:258-66. 2009
    ..The authors hypothesized that the expression of signal transduction genes would be similar after APC and HPC...
  19. ncbi Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2+ and mitogen-activated protein kinases
    Jonathan J Gray
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 94143 0542, USA
    Anesthesiology 102:606-15. 2005
    ....
  20. pmc Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke
    Damjan Osredkar
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Neurobiol Dis 38:259-65. 2010
    ..These findings support the hypothesis that EPO not only prevents ischemia induced cell death but promotes neuronal cell fate commitment in in vitro models of neonatal stroke...
  21. ncbi Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury
    Liel Rubinsky
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Neurosci Res 67:256-9. 2010
    ..The protection observed is believed to be associated with the inhibitory effect of antifreeze protein...
  22. doi Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats
    Greg Stratmann
    Department of Anesthesia, University of California San Francisco, 513 Parnassus Ave, San Francisco, California 94143, USA
    Anesthesiology 112:305-15. 2010
    ..We tested the hypothesis that isoflurane impairs neurogenesis and hippocampal function in aged rats...
  23. ncbi Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia
    Breandan L Sullivan
    Department of Anesthesia, University of California at San Francisco, 94143, USA
    Anesthesiology 96:189-95. 2002
    ....
  24. doi Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 521 Parnassus Ave, San Francisco, CA 94143 0648, USA
    Anesth Analg 111:143-8. 2010
    ..Plymouth, MN) to detect decreases in Sao2...
  25. ncbi Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0648, USA
    Anesth Analg 105:S18-23, tables of contents. 2007
    ..Pulse oximetry may overestimate arterial oxyhemoglobin saturation (Sao2) at low Sao2 levels in individuals with darkly pigmented skin, but other factors, such as gender and oximeter probe type, remain less studied...
  26. ncbi Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organisms
    Philip E Bickler
    Department of Anesthesia, University of California, San Francisco, CA 94143 0542, USA
    J Exp Biol 207:3243-9. 2004
    ..A broad and fundamental understanding of how neurons adapt to hypoxia is likely to help guide efforts to find new treatments for brain hypoxia and ischemia...
  27. doi Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0648, USA
    Anesth Analg 111:1160-7. 2010
    ..In this study we sought to determine whether the manufacturer's modifications have improved the device's ability to detect and accurately measure methemoglobin and deoxyhemoglobin simultaneously...
  28. ncbi Intracellular calcium and survival of tadpole forebrain cells in anoxia
    Michael S Hedrick
    Department of Anesthesia, University of California, San Francisco, CA 94143 0542, USA
    J Exp Biol 208:681-6. 2005
    ..These results indicate that large increases in [Ca2+]i are not necessarily associated with hypoxic cell death in vertebrate brain cells...
  29. ncbi Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress
    Canhui Liu
    Severinghaus Anesthesia Laboratory, Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room s 261, Box 0542, San Francisco, CA 94143 0542, United States
    Brain Res 1031:164-73. 2005
    ..These results confirm a protective physiologic capability of TASK-3 and related 2P K channels, and suggest agents that enhance their activity, such as volatile anesthetics may intensify these protective effects...
  30. ncbi Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia
    Natalie Serkova
    Department of Biology and Chemistry, University of Bremen, Bremen, Germany
    J Cereb Blood Flow Metab 22:342-52. 2002
    ..Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution...
  31. pmc Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK activation despite drastic ATP loss
    Sherri L Christian
    Alaskan Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775 7000, USA
    J Cereb Blood Flow Metab 28:1307-19. 2008
    ..Journal of Cerebral Blood Flow & Metabolism (2008) 28, 1307-1319; doi:10.1038/jcbfm.2008.20; published online 9 April 2008...
  32. ncbi Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere)
    Michael Paige
    Anesth Analg 99:622-3. 2004

Research Grants8

  1. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip Bickler; Fiscal Year: 2007
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  2. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip Bickler; Fiscal Year: 2009
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  3. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip E Bickler; Fiscal Year: 2010
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..