Research Topics
Species | Philip BicklerSummaryAffiliation: University of California Country: USA Publications
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Publications
Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicityPhilip E Bickler
University of California, San Francisco, CA, USA
Anesthesiology 117:280-92. 2012..Because neurons are protected from hypoxia-ischemia by anesthetic agents that inhibit N-methyl-D-aspartic acid receptors, we tested whether anesthetics protect neurons from damage caused by PH/RW...
Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signalingPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California at San Francisco, CA 94143 0542, USA
Anesthesiology 103:532-9. 2005....- Hypoxia-induced silencing of NMDA receptors in turtle neuronsP E Bickler
Departments of Anesthesia and Neurology, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 20:3522-8. 2000..When suppression of NMDARs was prevented with phosphatase inhibitors, tolerance of anoxia was lost. Silencing of NMDARs is thus critical to the remarkable ability of C. picta to tolerate life without oxygen... - The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxiaPhilip E Bickler
Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0542, USA
Anesth Analg 103:419-29, table of contents. 2006..We conclude that isoflurane's protection of hypoxic cortical neurons involves signaling that includes changes in intracellular Ca2+ regulation, several MAP kinase pathways and modulation of apoptosis regulators... - Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparinPhilip Bickler
Department of Anesthesia and Perioperative Care, University of California at San Francisco, California, USA
Anesth Analg 103:1036-7. 2006..More data are needed to determine if it is necessary to use the same guidelines for managing peripheral nerve infusion catheters in patients receiving enoxaparin as with epidurals and other types of central nerve catheter infusions... - Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availabilityPhilip E Bickler
Department of Anesthesia, University of California, San Francisco, California 94143, USA
Annu Rev Physiol 69:145-70. 2007..Tolerance of decreased energy charge and accumulating anaerobic end products as well as enhanced antioxidant defenses and regenerative capacities are also key to hypoxia survival in lower vertebrates... - Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neuronsP E Bickler
Department of Anesthesia, University of California at San Francisco, 513 Parnassus Avenue, Sciences 255, Box 0542, San Francisco, CA 94143 0542, USA
Neuroscience 160:51-60. 2009..We conclude that the endoplasmic reticulum, acting via redox/NADH-dependent intracellular Ca2+ store release, is an important mediator of the neuroprotective response to hypoxic stress... - Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptorsPhilip E Bickler
Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
Brain Res 1340:86-95. 2010..The mechanism involves genes for growth, development, apoptosis regulation and cell survival as well as IP(3) receptors and intracellular Ca(2+)... 
Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelationPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0542, USA
J Neurosci Res 88:3520-9. 2010....- Effects of skin pigmentation on pulse oximeter accuracy at low saturationPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Anesthesiology 102:715-9. 2005..It is uncertain whether skin pigmentation affects pulse oximeter accuracy at low HbO2 saturation... - Molecular adaptations for survival during anoxia: lessons from lower vertebratesPhilip E Bickler
Department of Anesthesia, University of California, San Francisco, USA
Neuroscientist 8:234-42. 2002..Transcriptional events leading to differential and/or decreased expression of receptors, proteins, and their subunits are probably very important but little studied... - Adaptive responses of vertebrate neurons to hypoxiaPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0542 USA
J Exp Biol 205:3579-86. 2002..The regulation of organelle and cell fate during long-term hypoxia is almost completely unexplored, and whether programmed cell death and regeneration of lost neurons occur following protracted dormancy is also of considerable interest... - Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neuronsP E Bickler
Department of Anesthesia, Sciences 257, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
Neuroscience 118:25-35. 2003..Modulation of NMDARs by hypoxia may play an important role in the hypoxia tolerance of the mammalian neonate. In addition, oxygen sensing by NMDARs could play a significant role in postnatal brain development... - Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neuronsP E Bickler
Department of Anesthesia, Sciences 261, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
Neuroscience 127:673-83. 2004..Thus, a zone of moderately increased [Ca(2+)](i) before a potentially lethal insult promotes cell survival, uncoupling subsequent large increases in [Ca(2+)](i) from initiating cell death processes... - gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal culturesPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California San Francisco, CA 94143, USA
Anesth Analg 97:564-71, table of contents. 2003..In organotypic cultures of rat hippocampus, we show that protection of CA1, CA3, and dentate neurons by 1% isoflurane from death caused by oxygen and glucose deprivation involves GABA(A) receptors... - Isoflurane neuroprotection in rat hippocampal slices decreases with aging: changes in intracellular Ca2+ regulation and N-methyl-D-aspartate receptor-mediated Ca2+ influxXinhua Zhan
Severinghaus-Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, 94143-0542, USA
Anesthesiology 104:995-1003. 2006..A protein kinase C-mediated increase in NMDAR activity may result in increased excitotoxicity and decreased neuroprotection by volatile anesthetics in the aging brain... - Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal culturesJohn R Feiner
Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0542, USA
Anesth Analg 100:215-25. 2005..Propofol was not neuroprotective at concentrations that reduce glutamate and NMDA receptor responses in cortical and hippocampal neurons... - Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice culturesPhilip E Bickler
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0542, USA
Anesthesiology 111:258-66. 2009..The authors hypothesized that the expression of signal transduction genes would be similar after APC and HPC... - Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2+ and mitogen-activated protein kinasesJonathan J Gray
Department of Anesthesia and Perioperative Care, University of California at San Francisco, 94143-0542, USA
Anesthesiology 102:606-15. 2005..Isoflurane neuroprotection thus involves intracellular signaling well known to suppress both excitotoxic and apoptotic/delayed cell death... - Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal strokeDamjan Osredkar
Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
Neurobiol Dis 38:259-65. 2010..These findings support the hypothesis that EPO not only prevents ischemia induced cell death but promotes neuronal cell fate commitment in in vitro models of neonatal stroke... - Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injuryLiel Rubinsky
Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
Neurosci Res 67:256-9. 2010..The protection observed is believed to be associated with the inhibitory effect of antifreeze protein... - Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged ratsGreg Stratmann
Department of Anesthesia, University of California San Francisco, 513 Parnassus Ave, San Francisco, California 94143, USA
Anesthesiology 112:305-15. 2010..We tested the hypothesis that isoflurane impairs neurogenesis and hippocampal function in aged rats... - Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemiaBreandan L Sullivan
Department of Anesthesia, University of California at San Francisco, 94143, USA
Anesthesiology 96:189-95. 2002..CONCLUSIONS: In an in vitro model of simulated ischemia, 1% isoflurane is of similar potency to 10 microm MK-801 in preventing delayed cell death. Modulation of glutamate excitotoxicity may contribute to the protective mechanism... - Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxiaJohn R Feiner
Department of Anesthesia and Perioperative Care, University of California at San Francisco, 521 Parnassus Ave, San Francisco, CA 94143 0648, USA
Anesth Analg 111:143-8. 2010..Plymouth, MN) to detect decreases in Sao2... - Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and genderJohn R Feiner
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0648, USA
Anesth Analg 105:S18-23, tables of contents. 2007..Pulse oximetry may overestimate arterial oxyhemoglobin saturation (Sao2) at low Sao2 levels in individuals with darkly pigmented skin, but other factors, such as gender and oximeter probe type, remain less studied... - Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organismsPhilip E Bickler
Department of Anesthesia, University of California, San Francisco, CA 94143-0542, USA
J Exp Biol 207:3243-9. 2004..A broad and fundamental understanding of how neurons adapt to hypoxia is likely to help guide efforts to find new treatments for brain hypoxia and ischemia... - Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxiaJohn R Feiner
Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143 0648, USA
Anesth Analg 111:1160-7. 2010..In this study we sought to determine whether the manufacturer's modifications have improved the device's ability to detect and accurately measure methemoglobin and deoxyhemoglobin simultaneously... - Intracellular calcium and survival of tadpole forebrain cells in anoxiaMichael S Hedrick
Department of Anesthesia, University of California, San Francisco, CA 94143 0542, USA
J Exp Biol 208:681-6. 2005..These results indicate that large increases in [Ca2+]i are not necessarily associated with hypoxic cell death in vertebrate brain cells... - Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stressCanhui Liu
Severinghaus Anesthesia Laboratory, Department of Anesthesia and Perioperative Care, University of California San Francisco, 513 Parnassus Ave, Room S-261, Box 0542, San Francisco, CA 94143-0542, United States
Brain Res 1031:164-73. 2005..These results confirm a protective physiologic capability of TASK-3 and related 2P K channels, and suggest agents that enhance their activity, such as volatile anesthetics may intensify these protective effects... - Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxiaNatalie Serkova
Department of Biology and Chemistry, University of Bremen, Bremen, Germany
J Cereb Blood Flow Metab 22:342-52. 2002..Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution... - Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK activation despite drastic ATP lossSherri L Christian
Alaskan Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775 7000, USA
J Cereb Blood Flow Metab 28:1307-19. 2008..Journal of Cerebral Blood Flow & Metabolism (2008) 28, 1307-1319; doi:10.1038/jcbfm.2008.20; published online 9 April 2008... - Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere)Michael Paige
Anesth Analg 99:622-3. 2004
Research Grants
- Intracellular signaling in anesthetic and hypoxic preconditioning of neuronsPhilip Bickler; Fiscal Year: 2007..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
- Intracellular signaling in anesthetic and hypoxic preconditioning of neuronsPhilip Bickler; Fiscal Year: 2009..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
- Intracellular signaling in anesthetic and hypoxic preconditioning of neuronsPhilip E Bickler; Fiscal Year: 2010..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..