JAMES BIBB

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Cognition enhancement strategies
    James A Bibb
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:14987-92. 2010
  2. ncbi request reprint Role of Cdk5 in neuronal signaling, plasticity, and drug abuse
    James A Bibb
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex 75390 9070, USA
    Neurosignals 12:191-9. 2003
  3. pmc Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart
    Nita Sachan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circ Res 108:437-45. 2011
  4. ncbi request reprint Alternative roles for Cdk5 in learning and synaptic plasticity
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biotechnol J 2:941-8. 2007
  5. pmc Identification of pyruvate kinase as an antigen associated with Tourette syndrome
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Neuroimmunol 181:165-76. 2006
  6. pmc Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    J Neurochem 91:374-84. 2004
  7. ncbi request reprint Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Neurosci 10:880-6. 2007
  8. ncbi request reprint Role of Cdk5 in drug abuse and plasticity
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Ann N Y Acad Sci 1025:335-44. 2004
  9. ncbi request reprint Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12967-76. 2007
  10. pmc Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Brain Res 1129:1-14. 2007

Research Grants

  1. Novel Signal Transduction Mechanisms in Learning and Memory
    James A Bibb; Fiscal Year: 2010
  2. The Regulation of Dopamine Neurotransmission by CDK5
    JAMES BIBB; Fiscal Year: 2009
  3. The Regulation of Dopamine Neurotransmission by CDK5
    James A Bibb; Fiscal Year: 2010
  4. The Role of Cdk5 in Addiction
    JAMES BIBB; Fiscal Year: 2007
  5. The Role of Cdk5 in Addiction
    James A Bibb; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc Cognition enhancement strategies
    James A Bibb
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:14987-92. 2010
    ..Selective targeting of specific effectors in these processes, such as NMDA receptors, may serve as an effective strategy to treat cognitive deficits...
  2. ncbi request reprint Role of Cdk5 in neuronal signaling, plasticity, and drug abuse
    James A Bibb
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex 75390 9070, USA
    Neurosignals 12:191-9. 2003
    ..Studies showing involvement of Cdk5 in reward and motor-based plasticity, which are thought to underlie drug abuse, are discussed...
  3. pmc Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart
    Nita Sachan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circ Res 108:437-45. 2011
    ..Despite overwhelming evidence of the importance of circadian rhythms in cardiovascular health and disease, little is known regarding the circadian regulation of intracellular signaling pathways controlling cardiac function and remodeling...
  4. ncbi request reprint Alternative roles for Cdk5 in learning and synaptic plasticity
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biotechnol J 2:941-8. 2007
    ....
  5. pmc Identification of pyruvate kinase as an antigen associated with Tourette syndrome
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Neuroimmunol 181:165-76. 2006
    ..These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders...
  6. pmc Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    J Neurochem 91:374-84. 2004
    ..These results demonstrate direct and indirect regulation of the phosphorylation state of a Cdk5/ERK1/2 site on TH and suggest a role for these pathways in the neuroadaptive changes associated with chronic cocaine exposure...
  7. ncbi request reprint Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Neurosci 10:880-6. 2007
    ..These findings reveal a previously unknown mechanism by which Cdk5 facilitates calpain-mediated proteolysis of NR2B and may control synaptic plasticity and learning...
  8. ncbi request reprint Role of Cdk5 in drug abuse and plasticity
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Ann N Y Acad Sci 1025:335-44. 2004
    ..These studies and the emerging role of Cdk5 in various forms of neuronal plasticity are reviewed...
  9. ncbi request reprint Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12967-76. 2007
    ..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement...
  10. pmc Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Brain Res 1129:1-14. 2007
    ..Finally, the phosphorylation state of these proteins was further assessed in vivo by systemic administration of caffeine...
  11. pmc Protein kinases talk to lipid phosphatases at the synapse
    Bogachan Sahin
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NC5 410, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:1112-3. 2004
  12. pmc Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e5808. 2009
    ..These findings indicate that Cdk5 regulates synaptic plasticity, controls neuronal and behavioral stimulus-induced excitability and may be a novel pharmacological target for cognitive and anticonvulsant therapies...
  13. pmc Cdk5 is essential for adult hippocampal neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 105:18567-71. 2008
    ..Thus, Cdk5 has an essential role in the survival, but not proliferation, of adult-generated hippocampal neurons through both cell-intrinsic and cell-extrinsic mechanisms...
  14. pmc Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, United States
    Eur J Pharmacol 581:270-5. 2008
    ..These results suggest that PKC exerts its effects on the phosphorylation state of Cdk5 substrates through an indirect mechanism that may involve the regulatory binding partners of Cdk5 other than its neuronal cofactors...
  15. ncbi request reprint Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
    Chan Nguyen
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neurochem 103:1582-93. 2007
    ..Thus, in the striatum the regulation of phosphorylation of Cdk5-dependent sites by NMDA occurs through multiple distinct pathways...
  16. pmc Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology
    Douglas A Meyer
    Departments of Psychiatry and Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 105:18561-6. 2008
    ..Thus, dysregulation of Cdk5 dramatically affects striatal-dependent brain function and may be relevant to non-neurodegenerative disorders involving dopamine neurotransmission...
  17. pmc Cdk5 and the mystery of synaptic vesicle endocytosis
    Chan Nguyen
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    J Cell Biol 163:697-9. 2003
    ..2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports...
  18. ncbi request reprint The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  19. ncbi request reprint Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C
    Bogachan Sahin
    Department of Psychiatry, Protein Chemistry Laboratory, Alliance for Cellular Signaling, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:24322-35. 2006
    ....
  20. ncbi request reprint Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
    Maria Lindskog
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Nature 418:774-8. 2002
    ..Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine...
  21. ncbi request reprint Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Neurochem 81:832-41. 2002
    ..The results provide support for a complex effect of glutamate on dopaminergic signaling through the regulation of dephosphorylation of different sites of DARPP-32 by different protein phosphatases...
  22. ncbi request reprint Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
    Fan Yan Wei
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami Osawa, Hachiohji, Tokyo, Japan
    J Neurochem 93:502-12. 2005
    ..p35(-/-) mice exhibited a lower threshold for induction of long-term potentiation. Thus excitatory glutamatergic neurotransmission regulates Cdk5 activity through p35 degradation, and this pathway may contribute to plasticity...
  23. ncbi request reprint Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, Hirosawa, Wako City, Saitama, Japan
    J Neurochem 94:917-25. 2005
    ..These results demonstrate that p35-dependent Cdk5 activity is important to learning and synaptic plasticity. Deletion of p35 may shift the substrate specificity of Cdk5 due to compensatory expression of p39...
  24. ncbi request reprint Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation
    Taro Saito
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami Osawa, Hachiohji, Tokyo 192 0397, Japan
    J Neurosci 23:1189-97. 2003
    ..These results suggest that the phosphorylation of p35 serves as a protective mechanism that suppresses the generation of p25 in developing brains...
  25. ncbi request reprint Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation
    Hirotsugu Kamei
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachiohji, Tokyo 192 0397, Japan
    J Biol Chem 282:1687-94. 2007
    ....
  26. pmc Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons
    Zhen Yan
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Physiol 540:761-70. 2002
    ....

Research Grants13

  1. Novel Signal Transduction Mechanisms in Learning and Memory
    James A Bibb; Fiscal Year: 2010
    ....
  2. The Regulation of Dopamine Neurotransmission by CDK5
    JAMES BIBB; Fiscal Year: 2009
    ..abstract_text> ..
  3. The Regulation of Dopamine Neurotransmission by CDK5
    James A Bibb; Fiscal Year: 2010
    ..The goal of this research is to delineate new mechanisms by which dopamine neurotransmission is regulated involving the neuronal protein kinase Cdk5 so that new pharmacotherapeutic treatments for these disorders can be developed. ..
  4. The Role of Cdk5 in Addiction
    JAMES BIBB; Fiscal Year: 2007
    ..This information may also serve as the basis for the development of novel treatments for this disorder. ..
  5. The Role of Cdk5 in Addiction
    James A Bibb; Fiscal Year: 2010
    ..By understanding the biology of drug abuse at the biochemical and molecular level, we strive to contribute to the development better treatmems for addiction. (The use of inhibiting drugs will be eliminated.] ..