- Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anestheticsShannon L Bianchi
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
Neurobiol Aging 29:1002-10. 2008..These findings indicate that inhaled anesthetics influence cognition and amyloidogenesis, but that the mechanistic relationship remains unclear...
- Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse modelJunxia X Tang
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Alzheimers Dement 7:521-531.e1. 2011..Because AD pathology precedes symptoms, we asked ourselves whether anesthetic exposure in the presymptomatic interval accelerated neuropathology and appearance of symptoms...
- Inhaled anesthetic potency in aged Alzheimer miceShannon L Bianchi
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesth Analg 110:427-30. 2010..General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the continuing AD pathogenesis alters anesthetic potency...