John Biaglow

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
  2. ncbi request reprint Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
  3. ncbi request reprint The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Cancer Biol Ther 4:6-13. 2005
  4. ncbi request reprint Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:9929-35. 2002
  5. ncbi request reprint Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication
    Iraimoudi S Ayene
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    J Cell Biochem 103:123-35. 2008
  6. ncbi request reprint Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
    Darren Magda
    Pharmacyclics, Inc, Sunnyvale, California, USA
    Cancer Res 65:3837-45. 2005
  7. ncbi request reprint Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats
    Jun Guan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 162:572-9. 2004
  8. ncbi request reprint Selenomethionine protects against adverse biological effects induced by space radiation
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, USA
    Free Radic Biol Med 36:259-66. 2004
  9. ncbi request reprint Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation
    Kristian Erickson
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:4705-12. 2003
  10. ncbi request reprint Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine
    Randy Burd
    Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Radiat Res 159:328-35. 2003

Research Grants

  1. X-RAY/APOPTOSIS--ROLE OF PENTOSE CYCLE
    John Biaglow; Fiscal Year: 2000
  2. Redox Control of Radiation Response
    John Biaglow; Fiscal Year: 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
    ..The results also show that protein thiol status is a critical factor in cell survival after irradiation...
  2. ncbi request reprint Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
    ..We conclude that radiation sensitivity and cell survival are dependent on vicinal thiol and GSH. In the former and latter cases, the protein thiols are also important...
  3. ncbi request reprint The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Cancer Biol Ther 4:6-13. 2005
    ..These findings suggest that the TRX/TX system may represent an attractive target for development of new cancer therapeutics...
  4. ncbi request reprint Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:9929-35. 2002
    ..In view of the rapidly escalating number of roles ascribed to Ku, these results may have widespread ramifications...
  5. ncbi request reprint Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication
    Iraimoudi S Ayene
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    J Cell Biochem 103:123-35. 2008
    ..The specific role of G6PD in the control of such global protein glutathionylation and Ku function was further demonstrated by reintroducing the G6PD gene into E89 (A1A) cells, which showed a normal phenotype...
  6. ncbi request reprint Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
    Darren Magda
    Pharmacyclics, Inc, Sunnyvale, California, USA
    Cancer Res 65:3837-45. 2005
    ..This class of compounds may provide insight into the development of novel cancer drugs targeting control of intracellular free zinc and the roles that zinc and other metal cations play in biochemical pathways relevant to cancer...
  7. ncbi request reprint Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats
    Jun Guan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 162:572-9. 2004
    ....
  8. ncbi request reprint Selenomethionine protects against adverse biological effects induced by space radiation
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, USA
    Free Radic Biol Med 36:259-66. 2004
    ....
  9. ncbi request reprint Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation
    Kristian Erickson
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:4705-12. 2003
    ..Therefore, the tumor surface is refractory to improvement in pO(2) with this method. Additional refinements may be needed to improve pO(2) of analogous regions in larger tumors; mechanism-driven suggestions are provided...
  10. ncbi request reprint Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine
    Randy Burd
    Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Radiat Res 159:328-35. 2003
    ..Hyperglycemia plus MIBG has the potential to improve response to radiation therapy as well as to hyperthermia and some chemotherapies...
  11. ncbi request reprint Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007
    ..Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia...
  12. ncbi request reprint Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors
    Intae Lee
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 530:177-86. 2003
    ..3 mm Hg to 13.8 mm Hg. We hypothesized that combined treatment with glucose + MIBG significantly enhanced radiation-induced tumoricidal effects on R3230 Ac tumors, mainly due to reduction in QO2 and increase in tumor pO2...
  13. ncbi request reprint Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma
    John E Biaglow
    Departments of Biochemistry and Radiation Oncology, University of Pennsylvania Medical School, Philadelphia, PA, USA
    Adv Exp Med Biol 530:153-64. 2003
    ..LBSO altered the bioreductive capacity of both the R323OAc and A549 cells. These results suggest that the ability of L-BSO to block mitochondrial O2 utilization may be involved in the apoptotic response in R3230Ac cells...

Research Grants12

  1. X-RAY/APOPTOSIS--ROLE OF PENTOSE CYCLE
    John Biaglow; Fiscal Year: 2000
    ..In addition, proteins identified as components of the radiation- sensitive signaling pathway that leads to apoptosis, could be potential targets for new drug development. ..
  2. Redox Control of Radiation Response
    John Biaglow; Fiscal Year: 2006
    ..Ultimately, we hope to develop specific strategies for modifying thiol redox homeostasis in vivo, to make human tumors more sensitive to ionizing radiation. ..