Affiliation: University of Pittsburgh
- Temporal asymmetry in spike timing-dependent synaptic plasticityGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, E1451 BST, 15213, Pittsburgh, PA, USA
Physiol Behav 77:551-5. 2002..We also discuss our recent studies using a "triplet-spiking" paradigm that reveals nonlinear, temporally asymmetric integration of STDP...
- Coactivation and timing-dependent integration of synaptic potentiation and depressionHuai-Xing Wang
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Nat Neurosci 8:187-93. 2005..The timing dependence of modular interaction provides a quantitative framework for understanding the temporal integration of STDP...
- Timing in synaptic plasticity: from detection to integrationGuo Qiang Bi
Department of Neurobiology and Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Trends Neurosci 28:222-8. 2005..This review is part of the TINS Synaptic Connectivity series...
- Synaptic modification by correlated activity: Hebb's postulate revisitedG Bi
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Annu Rev Neurosci 24:139-66. 2001....
- Recent advances in basic neurosciences and brain disease: from synapses to behaviorGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
Mol Pain 2:38. 2006..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
- Spatiotemporal specificity of synaptic plasticity: cellular rules and mechanismsGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop St E 1452 BST, Pittsburgh, PA 15261, USA
Biol Cybern 87:319-32. 2002..I also highlight several unresolved issues, and suggest future lines of research...
- Calcium time course as a signal for spike-timing-dependent plasticityJonathan E Rubin
Department of Mathematics, University of Pittsburgh, 301 Thackeray Hall, Pittsburgh, PA 15260, USA
J Neurophysiol 93:2600-13. 2005..This may account for the variability of STDP outcomes seen within hippocampal cultures, under repeated application of a single experimental protocol, as well as for that seen in multiple spike experiments across different systems...
- Synaptic mechanisms of persistent reverberatory activity in neuronal networksPak-Ming Lau
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 102:10333-8. 2005..Thus, the oft-overlooked asynchronous phase of synaptic transmission plays a central role in the emergent phenomenon of network reverberation...
- Probing vesicle dynamics in single hippocampal synapsesMatthew Shtrahman
Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260, USA
Biophys J 89:3615-27. 2005..Our measurements suggest that the movement of vesicles to the active zone is the rate-limiting step in this process...
- Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticityRichard C Gerkin
Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
J Neurophysiol 97:2851-62. 2007..Using a simple model, we show that such a modular competition recapitulates our observations...
- Calcium and synaptic dynamics underlying reverberatory activity in neuronal networksVladislav Volman
School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
Phys Biol 4:91-103. 2007..The simplicity of our model enabled a number of predictions that were confirmed by additional analyses of experimental manipulations...
- Synaptic modification in neural circuits: a timely actionBenedikt Berninger
Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
Bioessays 24:212-22. 2002..Ultimately, this synaptic property might also be fundamental for the cognitive process by which we structure our experience through cause and effect relations...
- Spatio-Temporal Specificity of Synaptic PlasticityGUOQIANG BI; Fiscal Year: 2007..Ultimately, these studies will provide insights into and may lead to cures for human diseases in the nervous system, especially those related to learning and memory. ..