Sanjoy Bhattacharya

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Age-related reduction in retinal deimination levels in the F344BN rat
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, 1638 NW 10th Avenue, 706, University of Miami, Miami, FL 33136, USA
    Aging Cell 7:441-4. 2008
  2. pmc Increased isolevuglandin-modified proteins in glaucomatous astrocytes
    Bharathi Govindarajan
    Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA
    Mol Vis 15:1079-91. 2009
  3. pmc ETX1 is over-expressed in the glaucomatous trabecular meshwork
    Saradha Iragavarapu
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 15:2061-7. 2009
  4. pmc Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
    PLoS ONE 6:e23070. 2011
  5. pmc Sphingolipids and ceramides in human aqueous humor
    Ayman J Aljohani
    Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Mol Vis 19:1966-84. 2013
  6. pmc Cochlin, intraocular pressure regulation and mechanosensing
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
    PLoS ONE 7:e34309. 2012
  7. pmc Aqueous humor dynamics: a review
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Open Ophthalmol J 4:52-9. 2010
  8. doi request reprint Recent advances in shotgun lipidomics and their implication for vision research and ophthalmology
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Curr Eye Res 38:417-27. 2013
  9. pmc Towards a matrix mechanics framework for dynamic protein network
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Suite 706A, Miami, FL 33136 USA
    Syst Synth Biol 4:139-44. 2010
  10. pmc Network analysis of human glaucomatous optic nerve head astrocytes
    Tatiana Nikolskaya
    Current address Bascom Palmer Eye Institute Department of Ophthalmology, University of Miami Miller School of Medicine 1638 NW 10th Avenue, Miami, FL 33136, USA
    BMC Med Genomics 2:24. 2009

Research Grants

  1. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2006
  2. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2007
  3. Proteomic Analyses of Human Trabecular Meshwork
    Sanjoy Bhattacharya; Fiscal Year: 2007
  4. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2009
  5. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2010
  6. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2009

Collaborators

Detail Information

Publications44

  1. pmc Age-related reduction in retinal deimination levels in the F344BN rat
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, 1638 NW 10th Avenue, 706, University of Miami, Miami, FL 33136, USA
    Aging Cell 7:441-4. 2008
    ..Our findings are important to understand late-onset and progressive diseases such as glaucoma, pseudoexfoliation syndrome, age-related macular degeneration and Oguchi's disease...
  2. pmc Increased isolevuglandin-modified proteins in glaucomatous astrocytes
    Bharathi Govindarajan
    Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA
    Mol Vis 15:1079-91. 2009
    ..In addition, we examined whether the iso[4]LGE(2) protein adducts are altered following exposure of astrocytes to elevated pressure...
  3. pmc ETX1 is over-expressed in the glaucomatous trabecular meshwork
    Saradha Iragavarapu
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 15:2061-7. 2009
    ..To determine whether exon-trapped X chromosome clone 1 (ETX1) is overexpressed in the trabecular meshwork (TM) of glaucomatous human eyes compared to controls...
  4. pmc Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
    PLoS ONE 6:e23070. 2011
    ..Annexin A2 expression and secretion follows cochlin-TREK-1 syn-expression and correlates with cell elongation. Thus cytoskeleton changes in response to fluid shear sensed by cochlin are further mediated by TREK-1 and annexin A2...
  5. pmc Sphingolipids and ceramides in human aqueous humor
    Ayman J Aljohani
    Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Mol Vis 19:1966-84. 2013
    ....
  6. pmc Cochlin, intraocular pressure regulation and mechanosensing
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
    PLoS ONE 7:e34309. 2012
    ..Taken together with previous studies, we show cochlin is involved in regulation of intraocular pressure in DBA/2J potentially through mechanosensing of the shear stress...
  7. pmc Aqueous humor dynamics: a review
    Manik Goel
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Open Ophthalmol J 4:52-9. 2010
    ..The uveoscleral outflow pathway is relatively independent of the intraocular pressure and the proportion of aqueous humor exiting the eye via the uveoscleral pathway decreases with age...
  8. doi request reprint Recent advances in shotgun lipidomics and their implication for vision research and ophthalmology
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Curr Eye Res 38:417-27. 2013
    ..We also provide a brief account of database and bioinformatic tools that have been recently developed toward profiling, identification and quantification of lipids in complex biological mixtures...
  9. pmc Towards a matrix mechanics framework for dynamic protein network
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Suite 706A, Miami, FL 33136 USA
    Syst Synth Biol 4:139-44. 2010
    ....
  10. pmc Network analysis of human glaucomatous optic nerve head astrocytes
    Tatiana Nikolskaya
    Current address Bascom Palmer Eye Institute Department of Ophthalmology, University of Miami Miller School of Medicine 1638 NW 10th Avenue, Miami, FL 33136, USA
    BMC Med Genomics 2:24. 2009
    ..CONCLUSION: Our results suggest several key biological network modules that are involved in regulating neurotoxicity of reactive astrocytes in glaucoma, and comprise potential targets for cell-based therapy...
  11. ncbi request reprint Ocular effects of exposure to industrial chemicals: clinical management and proteomic approaches to damage assessment
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Cutan Ocul Toxicol 26:203-25. 2007
    ..The emerging field of proteomics has been described in relation to its potential role in the assessment of ocular changes following chemical exposures and management of ocular trauma...
  12. doi request reprint Retinal deimination in aging and disease
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    IUBMB Life 61:504-9. 2009
    ..The role of deimination in normal physiology and in late-onset and progressive ocular or retinal degenerative diseases, such as glaucoma and experimental autoimmune encephalomyelitis remains to be elucidated...
  13. ncbi request reprint Modulation of peptidyl arginine deiminase 2 and implication for neurodegeneration
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Curr Eye Res 31:1063-71. 2006
    ..To demonstrate that elevated pressure increases the peptidyl arginine deiminase 2 (PAD2) expression in cultured astrocytes in vitro that can be modulated by pharmacological agents modulating intracellular calcium...
  14. ncbi request reprint Toward failure analyses in systems biology
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, FL, USA
    Wiley Interdiscip Rev Syst Biol Med 2:507-17. 2010
    ..Operation variable identification within each contour level will enhance failure analyses of complex biological systems...
  15. ncbi request reprint Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis
    Sanjoy K Bhattacharya
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 47:2508-14. 2006
    ..Peptidyl arginine deiminase 2 (PAD2), an enzyme that converts protein arginine to citrulline, was found only in POAG optic nerve and was probed further for a mechanistic role in glaucoma...
  16. pmc Cochlin expression in anterior segment organ culture models after TGFbeta2 treatment
    Sanjoy K Bhattacharya
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:551-9. 2009
    ..To determine the effect of transforming growth factor (TGF)-beta2 treatment on intraocular pressure (IOP), outflow facility, and cochlin expression in vitro in monkey and pig organ-cultured anterior segments (MOCAS and POCAS)...
  17. pmc Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork
    Sanjoy K Bhattacharya
    Cole Eye Institute and Lerner Research Institute i31, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Biol Chem 280:6080-4. 2005
    ....
  18. pmc Decreased carbohydrate metabolism enzyme activities in the glaucomatous trabecular meshwork
    Anna K Junk
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
    Mol Vis 16:1286-91. 2010
    ..To determine whether activity of carbohydrate metabolism enzymes (aldolase, pyruvate kinase, isocitrate dehydrogenase, and malate dehydrogenase) are altered in the glaucomatous trabecular meshwork (TM) compared to controls...
  19. pmc Detection of magnetic particles in live DBA/2J mouse eyes using magnetomotive optical coherence tomography
    Jianhua Wang
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA
    Eye Contact Lens 36:346-51. 2010
    ..To demonstrate in vivo molecular imaging of the eye using spectral-domain magnetomotive optical coherence tomography (MMOCT)...
  20. pmc Potential for transcriptional upregulation of cochlin in glaucomatous trabecular meshwork: a combinatorial bioinformatic and biochemical analytical approach
    Renata G Picciani
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:3106-11. 2009
    ..To determine the existence of a relatively higher abundance of potential TFs in glaucomatous trabecular meshwork (TM) that may bind putative promoter regions and affect cochlin protein expression in glaucomatous compared to normal TM...
  21. doi request reprint Recurrent hypoglycemia exacerbates cerebral ischemic damage in streptozotocin-induced diabetic rats
    Kunjan R Dave
    Cerebral Vascular Disease Research Center, Department of Neurology, the Bascom Palmer Eye Institute, 1420 NW 9th Avenue, TSL 204, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 42:1404-11. 2011
    ..We tested the hypothesis that RH exacerbates cerebral ischemic damage in a rodent model of diabetes...
  22. pmc Laser trabeculoplasty induces changes in the trabecular meshwork glycoproteome: a pilot study
    Adriana Amelinckx
    Bascom Palmer Eye Institute, Ophthalmic Biophysics Center, University of Miami Miller School of Medicine, Miami, Forida 33136, USA
    J Proteome Res 8:3727-36. 2009
    ..Further investigation is anticipated to provide insight into how glycosylation changes affect TM proteins and TM regulation of aqueous outflow in response to laser trabeculoplasty...
  23. doi request reprint Proteomic analysis of climatic keratopathy droplets
    Michelle Menegay
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 49:2829-37. 2008
    ..To identify the proteins in the corneal droplets of climatic droplet keratopathy (CDK), a disease that results in the formation of droplets on the cornea. Progressive accumulation of droplets in CDK leads to visual loss...
  24. doi request reprint Strategies to recover proteins from ocular tissues for proteomics
    Nikhil Patel
    Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA
    Proteomics 8:1055-70. 2008
    ..The extraction strategy may affect the final outcome in protein profiling by MS or by other methods...
  25. ncbi request reprint Proteomic analyses of songbird (Zebra finch; Taeniopygia guttata) retina
    Stephanie Sloley
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136, USA
    J Proteome Res 6:1093-100. 2007
    ..Results demonstrate the utility of one-dimensional gel fractionation for mass spectrometry and will be useful for future proteomic comparison of songbird retina and brain tissues in different behavioral and pharmacological studies...
  26. ncbi request reprint Characterization of semenogelin proteins in the human retina
    Vera L Bonilha
    Department of Ophthalmic Research, The Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Exp Eye Res 83:120-7. 2006
    ..Our data support the expression of semenogelin I and II in the human retina in several different compartments. Further studies towards addressing the function of these proteins in the retina are in progress...
  27. pmc Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes
    Mabel E Algeciras
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Curr Eye Res 33:994-1001. 2008
    ..To determine whether the mechanical stretching renders modulation of the peptidyl arginine deiminase 2 (PAD2) expression in cultured astrocytes...
  28. pmc Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork
    Bharathi Govindarajan
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 47:817-25. 2008
    ..These data suggest that interference with proteasomal activity, owing to protein modification by isoLGs, could contribute to glaucoma pathophysiology by decreasing the ability of the TM to modulate outflow resistance...
  29. pmc Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics
    Bharathi Govindarajan
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    CNS Neurol Disord Drug Targets 7:295-304. 2008
    ..Therapeutic neuroprotection strategies using calpain-1 inhibitors will require consideration of such anatomic differences in its activity and biosynthesis...
  30. pmc Cochlin and glaucoma: a mini-review
    Sanjoy K Bhattacharya
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Vis Neurosci 22:605-13. 2005
    ..Here we review these findings and describe how future studies in DBA/2J mice can help resolve whether cochlin plays a causal role in mechanisms of POAG and elevated IOP...
  31. pmc Focus on molecules: cochlin
    Sanjoy K Bhattacharya
    Evelyn F and William L McKnight Vision Research Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33136, USA
    Exp Eye Res 82:355-6. 2006
  32. pmc Cochlin in the eye: functional implications
    Renata Picciani
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Prog Retin Eye Res 26:453-69. 2007
    ..In vitro, cochlin induces aggregation of primary TM cells suggesting a role in cell adhesion, possibly in mechanosensation, and in modulation of the TM filter...
  33. pmc Technical Brief: a novel strategy for enrichment of trabecular meshwork protease proteome
    Renata Picciani
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Mol Vis 14:871-7. 2008
    ..Both serine and cysteine proteases were captured using this strategy with improved coverage compared to our previous identification without affinity enrichment...
  34. pmc Basic fibroblast growth factor impact on retinoblastoma progression and survival
    Colleen M Cebulla
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 49:5215-21. 2008
    ..Since basic fibroblast growth factor (bFGF) is a survival factor for neural precursor cells, bFGF was evaluated as a growth and chemoresistance factor in RB...
  35. pmc Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells
    Oscar Alcazar
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    Mol Cell Proteomics 8:2201-11. 2009
    ..Altogether our findings suggest, for the first time, the potential involvement of RPE blebs in eye disease and shed light on the implication of cell-derived microvesicles in human pathology...
  36. ncbi request reprint Proteomic characterization of isolated retinal pigment epithelium microvilli
    Vera L Bonilha
    The Cole Eye Institute, Department of Ophthalmic Research, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Cell Proteomics 3:1119-27. 2004
    ..The isolation technique used should be amenable for isolating microvilli in other epithelia as well, allowing new insights into additional functions of this important epithelial compartment...
  37. ncbi request reprint Proteomic analyses of zebra finch optic tectum and comparative histochemistry
    Stephanie Sloley
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, 33136, USA
    J Proteome Res 6:2341-50. 2007
    ..As the optic tectum of nonmammals is homologous to the superior colliculus of mammals, the analysis of the tectal and collicular proteome may provide clues about conserved cell and circuit layout, circuit function, and evolution...
  38. ncbi request reprint Uniformly oriented bacterial F0F1-ATPase immobilized on a semi-permeable membrane: a step towards biotechnological energy transduction
    Sumana Bhattacharya
    ABRD Company LLC, 1555 Wood Road, Cleveland, OH 44121, USA
    Biotechnol Appl Biochem 39:293-301. 2004
    ..The re-usability, ratio of amount of enzyme immobilized to enzymic activity conferred on the membranes, ATP synthesized by assembled system and suitability of ATP generated for use in coupled enzymic reactions were determined...
  39. ncbi request reprint CRALBP ligand and protein interactions
    Zhiping Wu
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Adv Exp Med Biol 572:477-83. 2006
  40. pmc The retinal pigment epithelium apical microvilli and retinal function
    Vera L Bonilha
    Cole Eye Institute, Cleveland Clinic Foundation, OH 44195, USA
    Adv Exp Med Biol 572:519-24. 2006
  41. ncbi request reprint Proteomics of the nucleus ovoidalis and field L brain regions of zebra finch
    Alexander Benjamin
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    J Proteome Res 7:2121-32. 2008
    ..The zebra finch brain proteome analyses are poised to provide clues about cell and circuit layout as well as possible circuit function...
  42. ncbi request reprint Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse
    Sanjoy K Bhattacharya
    Exp Eye Res 80:741-4. 2005
    ..Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma...
  43. ncbi request reprint The use of enzyme mixtures for complex biosyntheses
    Sanjoy K Bhattacharya
    Department of Ophthalmic Research, I31 Cleveland Clinic Foundation, Ohio 44195, USA
    Curr Opin Biotechnol 15:449-55. 2004
    ..Increased understanding of the functional interaction of proteins and protein-protein networks is also altering the practice of in vitro biosynthesis...
  44. ncbi request reprint Support for a proposed retinoid-processing protein complex in apical retinal pigment epithelium
    Vera L Bonilha
    Exp Eye Res 79:419-22. 2004
    ..The results support the hypothesis that a visual cycle protein complex may serve in the localization and release of 11-cis-retinoid in the apical RPE...

Research Grants7

  1. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2006
    ..Methods will include intraocular injections, IOP measurements, viral infections, immunohistochemistry as well as other molecular and cell biological techniques. ..
  2. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2007
    ..Methods will include intraocular injections, IOP measurements, viral infections, immunohistochemistry as well as other molecular and cell biological techniques. ..
  3. Proteomic Analyses of Human Trabecular Meshwork
    Sanjoy Bhattacharya; Fiscal Year: 2007
    ..The long-term goal of this proposal is to better understand mechanisms of glaucoma pathogenesis and facilitate the development of effective therapies for limiting disease progression. ..
  4. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2009
    ..Methods will include intraocular injections, IOP measurements, viral infections, immunohistochemistry as well as other molecular and cell biological techniques. ..
  5. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2010
    ..Methods will include intraocular injections, IOP measurements, viral infections, immunohistochemistry as well as other molecular and cell biological techniques. ..
  6. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy Bhattacharya; Fiscal Year: 2009
    ..Methods will include intraocular injections, IOP measurements, viral infections, immunohistochemisty as well as other molecular and cell biological techniques. ..