S Bhatnagar

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Facilitation of hypothalamic-pituitary-adrenal responses to novel stress following repeated social stress using the resident/intruder paradigm
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Horm Behav 43:158-65. 2003
  2. ncbi Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, Box 1109, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 81:545-55. 2004
  3. ncbi Deletion of the 5-HT3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests
    Seema Bhatnagar
    Department of Psychology, University of Michigan, 525 East University, Box 1109, Ann Arbor, MI 48109 1109, USA
    Behav Brain Res 153:527-35. 2004
  4. ncbi Regulation of chronic stress-induced changes in hypothalamic-pituitary-adrenal activity by the basolateral amygdala
    Seema Bhatnagar
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1032:315-9. 2004
  5. ncbi Prenatal stress differentially affects habituation of corticosterone responses to repeated stress in adult male and female rats
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Horm Behav 47:430-8. 2005
  6. ncbi Chronic stress alters behavior in the conditioned defensive burying test: role of the posterior paraventricular thalamus
    Seema Bhatnagar
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Pharmacol Biochem Behav 76:343-9. 2003
  7. ncbi Pituitary-adrenal activity in acute and chronically stressed male and female mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor 48109 1109, USA
    Stress 7:251-6. 2004
  8. ncbi A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function
    S Bhatnagar
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 20:5564-73. 2000
  9. ncbi The paraventricular nucleus of the thalamus alters rhythms in core temperature and energy balance in a state-dependent manner
    S Bhatnagar
    Department of Physiology, University of California at San Francisco 94143 0444, USA
    Brain Res 851:66-75. 1999
  10. ncbi Interactions among chronic cold, corticosterone and puberty on energy intake and deposition
    S F Akana
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Stress 3:131-46. 1999

Research Grants

  1. Neural Circuitry Underlying Chronic Stress Effects
    Seema Bhatnagar; Fiscal Year: 2005

Detail Information

Publications29

  1. ncbi Facilitation of hypothalamic-pituitary-adrenal responses to novel stress following repeated social stress using the resident/intruder paradigm
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Horm Behav 43:158-65. 2003
    ....
  2. ncbi Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, Box 1109, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 81:545-55. 2004
    ..Together, these data suggest that the 5-HT-3A receptor does not have a unitary role in the regulation of anxiety- and fear-related behaviors but has a potentially substantial role in the regulation of HPA activity...
  3. ncbi Deletion of the 5-HT3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests
    Seema Bhatnagar
    Department of Psychology, University of Michigan, 525 East University, Box 1109, Ann Arbor, MI 48109 1109, USA
    Behav Brain Res 153:527-35. 2004
    ..Whether these effects are due to the interaction of 5-HT3 receptor with gonadal hormones requires further examination...
  4. ncbi Regulation of chronic stress-induced changes in hypothalamic-pituitary-adrenal activity by the basolateral amygdala
    Seema Bhatnagar
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1032:315-9. 2004
    ..Future studies will focus on the neuro-anatomical substrates of BLA's effects on HPA activity including whether inputs from the pPVTh are important...
  5. ncbi Prenatal stress differentially affects habituation of corticosterone responses to repeated stress in adult male and female rats
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Horm Behav 47:430-8. 2005
    ..Together, these results suggest a sex-specific interaction between prenatal stress and adult chronic stress on HPA activity...
  6. ncbi Chronic stress alters behavior in the conditioned defensive burying test: role of the posterior paraventricular thalamus
    Seema Bhatnagar
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Pharmacol Biochem Behav 76:343-9. 2003
    ....
  7. ncbi Pituitary-adrenal activity in acute and chronically stressed male and female mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor 48109 1109, USA
    Stress 7:251-6. 2004
    ..Together, these results indicate that there are sex differences in HPA responses to novel restraint in chronically stressed mice and these differences are partly related to 5-HT-3A receptor function...
  8. ncbi A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function
    S Bhatnagar
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 20:5564-73. 2000
    ..These results demonstrate clearly that chronic stress recruits a new set of pathways that modulate HPA responsiveness to a novel stress...
  9. ncbi The paraventricular nucleus of the thalamus alters rhythms in core temperature and energy balance in a state-dependent manner
    S Bhatnagar
    Department of Physiology, University of California at San Francisco 94143 0444, USA
    Brain Res 851:66-75. 1999
    ....
  10. ncbi Interactions among chronic cold, corticosterone and puberty on energy intake and deposition
    S F Akana
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Stress 3:131-46. 1999
    ..The slope of the relationship between fat depot size and leptin becomes flatter in cold, possibly because of increased sympathetic outflow to these depots...
  11. ncbi Starvation: early signals, sensors, and sequelae
    M F Dallman
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Endocrinology 140:4015-23. 1999
    ....
  12. ncbi Negative feedback functions in chronically stressed rats: role of the posterior paraventricular thalamus
    Azra Jaferi
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 78:365-73. 2003
    ....
  13. ncbi Warning! Nearby construction can profoundly affect your experiments
    M F Dallman
    Department of Physiology, University of California San Francisco, 94143 0444, USA
    Endocrine 11:111-3. 1999
    ..However, we did not anticipate the change and disruption in energy balance that may occur in response to environmental perturbation. We provide two examples of these, below...
  14. ncbi Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations
    J Raber
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 20:2064-71. 2000
    ..These results support a key role for apoE in the tonic inhibition of steroidogenesis and HPA axis activity and have important implications for the behavioral analysis of Apoe(-/-) mice...
  15. ncbi Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint
    S Bhatnagar
    Department of Psychology and the Neuroscience Program, University of Michigan, Ann Arbor 48109 1109, USA
    J Neuroendocrinol 14:403-10. 2002
    ..Thus, the intact pPVTh inhibits HPA activity under conditions of habituation, as well as facilitation, and represents an important regulator of HPA activity under conditions of chronic stress...
  16. ncbi Sucrose ingestion normalizes central expression of corticotropin-releasing-factor messenger ribonucleic acid and energy balance in adrenalectomized rats: a glucocorticoid-metabolic-brain axis?
    K D Laugero
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 142:2796-804. 2001
    ....
  17. ncbi A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress
    Mary F Dallman
    Department of Physiology, University of California San Francisco, Box 0444, San Francisco, CA 94143 0444, USA
    Physiol Behav 79:3-12. 2003
    ..We speculate that the interaction between peripheral and central GC-sensitive signaling systems may be coupled through the inhibitory actions of endogenous opiatergic inputs on corticotropin-releasing factor (CRF) neurons...
  18. ncbi Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress
    Azra Jaferi
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    Endocrinology 147:4917-30. 2006
    ....
  19. pmc Corticotropin-releasing hormone receptors in the medial prefrontal cortex regulate hypothalamic-pituitary-adrenal activity and anxiety-related behavior regardless of prior stress experience
    Azra Jaferi
    Department of Psychology, University of Michigan, MI, USA
    Brain Res 1186:212-23. 2007
    ..Together, these results suggest an excitatory influence of CRH in the mPFC on stress-induced HPA activity and anxiety-related behavior regardless of prior stress experience...
  20. pmc Struggling behavior during restraint is regulated by stress experience
    Nicola Grissom
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Behav Brain Res 191:219-26. 2008
    ..Overall, restraint-induced struggling appears to be regulated in a manner similar to HPA responses to restraint, but is not dictated by adrenal hormones...
  21. ncbi The physical context of previous stress exposure modifies hypothalamic-pituitary-adrenal responses to a subsequent homotypic stress
    Nicola Grissom
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Horm Behav 51:95-103. 2007
    ..These results provide evidence that repeated stress-induced HPA activity depends, in part, on the context in which the stress is experienced...
  22. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  23. ncbi The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection
    S Bhatnagar
    Dept of Physiology, Box 0444, University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Brain Res 797:313-20. 1998
    ..We propose that these modifications are produced by brain regions that are known to regulate cardiovascular function and which are activated by chronic stress...
  24. ncbi Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations
    M F Dallman
    Department of Physiology, University of California San Francisco, 94143 0444, USA
    Int J Obes Relat Metab Disord 24:S40-6. 2000
    ..Thus, chronic mild stress, by overriding the normal mineralocorticoid receptor-mediated corticosteroid feedback regulation of trough CRF and ACTH secretion, facilitates development of the metabolic syndrome...
  25. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  26. pmc Habituation to repeated stress: get used to it
    Nicola Grissom
    Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA
    Neurobiol Learn Mem 92:215-24. 2009
    ....
  27. doi Sex-specific susceptibility to cocaine in rats with a history of prenatal stress
    Mark B Thomas
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Physiol Behav 97:270-7. 2009
    ..Thus, these results suggest that gestational stress is a sex-specific risk factor for different aspects of substance abuse...
  28. pmc The basolateral amygdala regulates adaptation to stress via β-adrenergic receptor-mediated reductions in phosphorylated extracellular signal-regulated kinase
    N M Grissom
    Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA
    Neuroscience 178:108-22. 2011
    ..Individual variations in β-AR activation and intracellular signaling in the BLA may contribute significantly to adaptation to psychological stress and consequent resilience to stress-related psychopathology...
  29. ncbi Effects of maternal separation on behavioural sensitization produced by repeated cocaine administration in adulthood
    Yilin Li
    Department of Psychology and Program in Neuroscience, The University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Brain Res 960:42-7. 2003
    ..Therefore, early maternal separation decreased susceptibility to behavioural sensitization produced by cocaine in adulthood and the specific duration of maternal separation had no effect on this outcome...

Research Grants1

  1. Neural Circuitry Underlying Chronic Stress Effects
    Seema Bhatnagar; Fiscal Year: 2005
    ....