Neehar Bhatia

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1
    Neehar Bhatia
    Department of Dermatology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Arch Biochem Biophys 508:217-21. 2011
  2. pmc Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin
    Neehar Bhatia
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Arch Biochem Biophys 508:178-84. 2011
  3. pmc MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression
    Tony Z Xiao
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 6:e23747. 2011
  4. pmc MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair
    Neehar Bhatia
    Department of Medicine, University of Wisconsin, Carbone Cancer Center, Madison, Wisconsin 53705, USA
    J Invest Dermatol 133:759-67. 2013
  5. pmc Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells
    Saravanan Thiyagarajan
    Department of Dermatology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Cancer Res 67:10642-6. 2007
  6. ncbi CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling
    Felicite K Noubissi
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Nature 441:898-901. 2006
  7. doi Inhibition of beta-TrCP function potentiates UVB-induced apoptosis in hTERT-immortalized normal human keratinocytes
    Neehar Bhatia
    Department of Dermatology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Photochem Photobiol 84:376-81. 2008
  8. ncbi Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase
    Neehar Bhatia
    Department of Dermatology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 281:19320-6. 2006
  9. pmc Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets
    Jaehyup Kim
    University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Cytotherapy 14:925-35. 2012
  10. pmc MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages
    Ellen Hebron
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Br J Haematol 160:779-84. 2013

Collaborators

Detail Information

Publications10

  1. pmc Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1
    Neehar Bhatia
    Department of Dermatology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Arch Biochem Biophys 508:217-21. 2011
    ..We now report identification of three potential compounds that interfere with MAGE/KAP-1 binding and can be developed as novel chemo-therapeutic agents for treatment of advanced melanoma and other cancers...
  2. pmc Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin
    Neehar Bhatia
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Arch Biochem Biophys 508:178-84. 2011
    ..Our results suggest that β-TrCP may be an essential player in UVB induced responses in skin and can be a potential therapeutic target for skin cancer...
  3. pmc MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression
    Tony Z Xiao
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 6:e23747. 2011
    ..Since KZNFs are required to direct KAP1 to specific genes, these results show that MAGE I proteins can differentially regulate members of the KZNF family and KAP1 mediated gene repression...
  4. pmc MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair
    Neehar Bhatia
    Department of Medicine, University of Wisconsin, Carbone Cancer Center, Madison, Wisconsin 53705, USA
    J Invest Dermatol 133:759-67. 2013
    ....
  5. pmc Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells
    Saravanan Thiyagarajan
    Department of Dermatology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Cancer Res 67:10642-6. 2007
    ..Altogether, our findings suggest that GLI2 plays a critical role in the malignant phenotype of prostate cancer cells, and GLI2 may potentially become an attractive therapeutic target for the treatment of prostate cancer...
  6. ncbi CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling
    Felicite K Noubissi
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Nature 441:898-901. 2006
    ....
  7. doi Inhibition of beta-TrCP function potentiates UVB-induced apoptosis in hTERT-immortalized normal human keratinocytes
    Neehar Bhatia
    Department of Dermatology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Photochem Photobiol 84:376-81. 2008
    ..We also demonstrate that inhibition of beta-TrCP2 function, by induction of dominant negative beta-TrCP2 (beta-TrCP2DeltaN), accentuates UVB induced apoptosis, and this phenomenon is independent of NF-kappaB and p53 pathways...
  8. ncbi Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase
    Neehar Bhatia
    Department of Dermatology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 281:19320-6. 2006
    ..These data identify beta-TrCP2 as a pivotal regulator of Gli2 expression and point to an important role for posttranslational modulation of GLI2 protein levels in Hh pathway-associated human prostate cancer...
  9. pmc Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets
    Jaehyup Kim
    University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Cytotherapy 14:925-35. 2012
    ..In this study, we investigated the biologic and immunomodulatory properties of human pancreatic islet-derived MSC...
  10. pmc MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages
    Ellen Hebron
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Br J Haematol 160:779-84. 2013
    ..Pharmacological MAP3K8 inhibition results in dose-dependent, tumour cell-autonomous apoptosis despite contact with primary stroma. MAP3K8 blockade may disrupt crucial macrophage-tumour cell interactions within myeloma niches...