Shalender Bhasin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
  2. ncbi request reprint Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, UCLA Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Androl 24:299-311. 2003
  3. ncbi request reprint Testosterone dose-response relationships in healthy young men
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 281:E1172-81. 2001
  4. ncbi request reprint Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine Science, University of California Los Angeles School of Medicine, 90059, USA
    Clin Infect Dis 37:S142-9. 2003
  5. ncbi request reprint Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
  6. ncbi request reprint Testosterone supplementation for aging-associated sarcopenia
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:1002-8. 2003
  7. ncbi request reprint Androgen effects on body composition
    Shalender Bhasin
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Growth Horm IGF Res 13:S63-71. 2003
  8. ncbi request reprint Regulation of body composition by androgens
    S Bhasin
    UCLA School of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol Invest 26:814-22. 2003
  9. pmc Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    JAMA 283:763-70. 2000
  10. ncbi request reprint Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005

Detail Information

Publications85

  1. ncbi request reprint The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
    ..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass...
  2. ncbi request reprint Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, UCLA Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Androl 24:299-311. 2003
  3. ncbi request reprint Testosterone dose-response relationships in healthy young men
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 281:E1172-81. 2001
    ..However, different androgen-dependent processes have different testosterone dose-response relationships...
  4. ncbi request reprint Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine Science, University of California Los Angeles School of Medicine, 90059, USA
    Clin Infect Dis 37:S142-9. 2003
    ..However, the long-term risks and benefits of testosterone administration in human immunodeficiency virus-infected men with fat redistribution syndrome have not been studied in randomized clinical trials...
  5. ncbi request reprint Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  6. ncbi request reprint Testosterone supplementation for aging-associated sarcopenia
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:1002-8. 2003
    ..The long-term risks and benefits of testosterone supplementation in older men are not known...
  7. ncbi request reprint Androgen effects on body composition
    Shalender Bhasin
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Growth Horm IGF Res 13:S63-71. 2003
    ....
  8. ncbi request reprint Regulation of body composition by androgens
    S Bhasin
    UCLA School of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol Invest 26:814-22. 2003
    ....
  9. pmc Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    JAMA 283:763-70. 2000
    ..Previous studies of testosterone supplementation in HIV-infected men failed to demonstrate improvement in muscle strength. The effects of resistance exercise combined with testosterone supplementation in HIV-infected men are unknown...
  10. ncbi request reprint Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005
    ..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength...
  11. ncbi request reprint Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men
    Ravi Jasuja
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:855-63. 2005
    ....
  12. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    ..In conclusion, our data suggest the involvement of AR, beta-catenin, and TCF-4 pathway during androgen action to activate a number of Wnt target genes, including Fst, and cross communication with the Smad signaling pathway...
  13. ncbi request reprint Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  14. pmc Testosterone and growth hormone improve body composition and muscle performance in older men
    Fred R Sattler
    Departments of Medicine, Division of Biokinesiology, Keck School of Medicine, University of Southern California, 1200 North State Street, Room 6442, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:1991-2001. 2009
    ..Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat...
  15. pmc Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study
    Chevon M Rariy
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:989-96. 2011
    ..The physiological importance of endogenous testosterone (T) in older women is poorly understood...
  16. pmc Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action
    Melissa Braga
    Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, United States
    Mol Cell Endocrinol 350:39-52. 2012
    ..We conclude that T stimulation of satellite cell proliferation and myogenic differentiation are associated with up regulation of Fst and inhibition of TGF-β-signaling...
  17. ncbi request reprint Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 283:E154-64. 2002
    ..We conclude that the testosterone induced increase in muscle volume is due to muscle fiber hypertrophy...
  18. pmc Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation
    E Todd Schroeder
    Division of Biokinesiology and PT, University of Southern California, 1540 East Alcazar St CHP 155, Los Angeles, CA 90033, USA
    Eur J Appl Physiol 112:1123-31. 2012
    ..001). Despite sizeable increases in LM measurements at week 8, tests of muscle performance did not show substantive improvements at this time point...
  19. ncbi request reprint A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
    ....
  20. ncbi request reprint Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:718-26. 2004
    ..Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh...
  21. ncbi request reprint Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss
    Karen L Herbst
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    Fertil Steril 85:1794-802. 2006
    ....
  22. ncbi request reprint Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 91:3024-33. 2006
    ..In this study, we determined the effects of graded doses of testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number and replication in older men...
  23. ncbi request reprint Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression
    Kun Ma
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E363-71. 2003
    ..We propose that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression through a glucocorticoid receptor-mediated pathway...
  24. ncbi request reprint Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol 194:63-76. 2007
    ..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation...
  25. ncbi request reprint Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol (1985) 103:1299-310. 2007
    ..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients...
  26. ncbi request reprint Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men
    Peter B Gray
    Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:3838-46. 2005
    ..The relationships between testosterone dose and its effects on sexual function, mood, and visuospatial cognition are poorly understood...
  27. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
    ..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
  28. ncbi request reprint Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 88:1478-85. 2003
    ....
  29. ncbi request reprint Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:5245-55. 2004
    ..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle...
  30. ncbi request reprint Development of models to predict anabolic response to testosterone administration in healthy young men
    Linda J Woodhouse
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 284:E1009-17. 2003
    ..Hence, the anabolic response of healthy, young men to exogenous testosterone administration can largely be predicted by the testosterone dose...
  31. pmc Durability of the effects of testosterone and growth hormone supplementation in older community-dwelling men: the HORMA Trial
    Fred R Sattler
    Department of Medicine, University of Southern CaliforniaDivision of Biokinesiology, University of Southern California, Los Angeles, CASection of Endocrinology, Diabetes, and Nutrition, Boston University, Boston, MADepartment of Preventive Medicine, University of Southern California, Los Angeles, CADepartment of Medicine, Washington University, St Louis, MOJean Mayer USDA Human Nutrition Research Center on Aging of Tufts University, Boston, MADepartment of Urology, University of Southern California, Los Angeles, CA, USA
    Clin Endocrinol (Oxf) 75:103-11. 2011
    ..To determine the durability of anabolic effects and adverse events (AEs) after stopping testosterone and growth hormone supplementation in older men...
  32. pmc Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
    Melissa Braga
    Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, USA
    Obesity (Silver Spring) 21:1180-8. 2013
    ..Although the beneficial effects of Mst inhibition on muscle mass are well known, its role in the regulation of lipid metabolism, and energy expenditure is not very clear...
  33. ncbi request reprint Pharmacokinetics of a testosterone gel in healthy postmenopausal women
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Drew University of California Los Angeles Reproductive Science Research Center, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 91:136-44. 2006
    ..The paucity of pharmacokinetic data on androgen formulations in women has hindered clinical trials of testosterone supplementation in women...
  34. pmc Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4776-84. 2009
    ..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown...
  35. ncbi request reprint Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin
    Suzanne Reisz-Porszasz
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E876-88. 2003
    ..The mechanism of gender specificity remains to be clarified...
  36. pmc The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men
    Kishore M Lakshman
    Division of Endocrinology, Diabetes and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:3955-64. 2010
    ..During testosterone (T) therapy, T is partly converted to 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown...
  37. pmc Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial
    Fred Sattler
    Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    J Gerontol A Biol Sci Med Sci 66:122-9. 2011
    ....
  38. ncbi request reprint Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 285:E197-205. 2003
    ..We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure...
  39. ncbi request reprint Testosterone action on skeletal muscle
    Karen L Herbst
    UCLA School of Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    Curr Opin Clin Nutr Metab Care 7:271-7. 2004
    ..To highlight recent data demonstrating direct anabolic effects of androgens on the mammalian skeletal muscle and review the mechanisms by which testosterone regulates body composition...
  40. ncbi request reprint Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  41. ncbi request reprint Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight
    Wayne E Taylor
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    J Gravit Physiol 9:61-70. 2002
    ..These data indicate that following exposure to microgravity, there is downregulation of genes involved in regulation of muscle satellite cell replication...
  42. ncbi request reprint Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, CA 90509, USA
    Curr Opin Obstet Gynecol 16:405-9. 2004
    ....
  43. ncbi request reprint Determinants of serum total and free testosterone levels in women over the age of 65 years
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Endocrinol Metab 92:509-16. 2007
    ..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age...
  44. ncbi request reprint The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men
    Atam B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 87:136-43. 2002
    ..Long-term studies are needed to determine whether T supplementation of older men with low T levels affects atherosclerosis progression...
  45. ncbi request reprint Role of myostatin in metabolism
    Nestor F Gonzalez-Cadavid
    Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
    Curr Opin Clin Nutr Metab Care 7:451-7. 2004
    ..Myostatin also controls muscle mass in other animals, and appears to affect adipose tissue mass...
  46. ncbi request reprint Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial
    Grace Huang
    From the 1Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 2Department of Biostatistics, Boston University School of Public Health, Boston, MA 3Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA and 4Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, University of California, Los Angeles, CA
    Menopause 21:612-23. 2014
    ..This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy...
  47. ncbi request reprint Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Cell Physiol 190:170-9. 2002
    ..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation...
  48. ncbi request reprint Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  49. ncbi request reprint Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss
    H H Choi
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:1531-41. 2005
    ..Additional studies are needed to fully explore the role of androgens in the regulation of body composition in women...
  50. ncbi request reprint Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats
    R Jasuja
    Division of Endocrinology, Charles R Drew University of Medicine, Los Angeles, California 90059, USA
    Endocrinology 146:4472-8. 2005
    ..This mechanism-based approach should be useful for rapid screening of anabolic/androgenic agents...
  51. pmc Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting
    N F Gonzalez-Cadavid
    Division of Endocrinology, Charles R Drew University, Los Angeles, CA 90059, USA
    Proc Natl Acad Sci U S A 95:14938-43. 1998
    ..These data support the hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and contributes to muscle wasting in HIV-infected men...
  52. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  53. ncbi request reprint Androgen supplementation in older women: too much hype, not enough data
    Maria Clara M Padero
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    J Am Geriatr Soc 50:1131-40. 2002
    ..This article reviews testosterone's effects on sexual function, cognitive function, muscle mass, body composition, and immune function in postmenopausal women...
  54. ncbi request reprint Proof of the effect of testosterone on skeletal muscle
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Endocrinol 170:27-38. 2001
    ..The mechanisms by which testosterone increases muscle mass are not known, but probably involve alterations in the expression of multiple muscle growth regulators...
  55. ncbi request reprint Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells
    W E Taylor
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 E 120th St, Los Angeles, California 90059, USA
    Am J Physiol Endocrinol Metab 280:E221-8. 2001
    ..In conclusion, recombinant myostatin proteins inhibit cell proliferation, DNA synthesis, and protein synthesis in C2C12 muscle cells, suggesting that myostatin may control muscle mass by inhibiting muscle growth or regeneration...
  56. ncbi request reprint Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight
    R Lalani
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
    J Endocrinol 167:417-28. 2000
    ..These data suggest that reciprocal changes in the expression of myostatin and IGF-II may contribute to the multifactorial pathophysiology of muscle atrophy that occurs during spaceflight...
  57. ncbi request reprint Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro
    K Ma
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90509, USA
    Am J Physiol Endocrinol Metab 281:E1128-36. 2001
    ..We speculate that glucocorticoid-associated muscle atrophy might be due in part to the upregulation of myostatin expression...
  58. ncbi request reprint Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene
    K Kastury
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 82:3047-53. 1997
    ..Cloning of the hp28 cDNA and mapping of the intron-exon junctions should now make it possible to test whether a subset of ICS is a consequence of mutations in the human axonemal dynein light chain gene hp28...
  59. ncbi request reprint Neuroendocrine abnormalities associated with HIV infection
    S Bhasin
    Department of Medicine, University of California Los Angeles School of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA
    Endocrinol Metab Clin North Am 30:749-64, viii. 2001
    ..Some of these abnormalities are similar to those seen in other systemic illness, whereas others are unique to HIV infection. The clinical significance of many of these endocrine abnormalities is not well understood...
  60. ncbi request reprint Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men
    A B Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 86:2437-45. 2001
    ..The amount of testosterone cleared by hemodialysis is small, and hemodialysis does not significantly affect serum total and free testosterone concentrations in men treated with the testosterone patch...
  61. ncbi request reprint Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 293:E769-75. 2007
    ..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men...
  62. doi request reprint Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss
    Philip E Knapp
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 294:E1135-43. 2008
    ..Improvements in mood, fatigue, and quality-of-life measures in the testosterone group, although clinically important, need further confirmation...
  63. ncbi request reprint Time for (more research on) testosterone
    Elizabeth Barrett-Connor
    J Clin Endocrinol Metab 89:501-2. 2004
  64. pmc The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways
    Wen Guo
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, USA
    J Biol Chem 283:9136-45. 2008
    ..These effects were mediated, in part, by activation of Smad3 and cross-communication of the TGFbeta/Smad signal to Wnt/beta-catenin/TCF4 pathway, leading to down-regulation of PPARgamma...
  65. ncbi request reprint Testosterone and atherosclerosis progression in men
    Shalender Bhasin
    Diabetes Care 26:1929-31. 2003
  66. ncbi request reprint Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 284:E120-8. 2003
    ..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men...
  67. ncbi request reprint Testosterone, sex hormone-binding globulin, and frailty in older men
    Beth A Mohr
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Am Geriatr Soc 55:548-55. 2007
    ..To determine whether testosterone (T) levels are associated with frailty or its components...
  68. ncbi request reprint Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    Olga M Calof
    Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 60:1451-7. 2005
    ..We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men...
  69. ncbi request reprint Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study
    Carl Grunfeld
    University of California San Francisco, and Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 41:304-14. 2006
    ..To evaluate the efficacy and safety of oxandrolone in promoting body weight and body cell mass (BCM) gain in HIV-associated weight loss...
  70. ncbi request reprint Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone
    Andrea D Coviello
    Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:4669-75. 2006
    ..We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels...
  71. ncbi request reprint Serum androgen levels in black, Hispanic, and white men
    Heather J Litman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:4326-34. 2006
    ..Racial/ethnic differences in androgen levels could account for differences in prostate cancer risk, body composition, and bone loss...
  72. ncbi request reprint The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study
    Beth A Mohr
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    Eur J Endocrinol 155:443-52. 2006
    ..We aimed to determine whether changes in adiposity predict follow-up levels and rates of change in TT, FT and sex hormone-binding globulin (SHBG) in men...
  73. ncbi request reprint Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4445-52. 2006
    ....
  74. pmc Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
    Shalender Bhasin
    Boston University School of Medicine, Boston, MA 02118, USA
    Nat Clin Pract Endocrinol Metab 2:146-59. 2006
    ....
  75. ncbi request reprint Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    Shalender Bhasin
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:1049-57. 2007
    ..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown...
  76. ncbi request reprint Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss
    Monty Montano
    Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:2793-802. 2007
    ..Although androgen treatment increases muscle mass, the cell-intrinsic mechanisms engaged remain poorly understood...
  77. doi request reprint The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports
    Karen Choong
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA
    Asian J Androl 10:351-63. 2008
    ..In spite of effective methods for detecting androgen doping, the policies for screening of athletes are highly variable in different countries and organizations and even existing policies are not uniformly enforced...
  78. pmc Effects of graded doses of testosterone on erythropoiesis in healthy young and older men
    Andrea D Coviello
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 670 Albany Street, 2nd Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:914-9. 2008
    ..Erythrocytosis is a dose-limiting adverse effect of testosterone therapy, especially in older men...
  79. ncbi request reprint An investigation of the relationship between sex-steroid levels and urological symptoms: results from the Boston Area Community Health survey
    Heather J Litman
    New England Research Institutes, Watertown, MA 02472, USA
    BJU Int 100:321-6. 2007
    ..To investigate whether circulating levels of sex hormones are associated with urological symptoms, using data from the Boston Area Community Health (BACH) Survey...
  80. ncbi request reprint Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women
    Elliot Hirshman
    Department of Psychology, George Washington University, Washington, DC 20052, USA
    Horm Behav 45:144-55. 2004
    ....
  81. ncbi request reprint Sexual dysfunction in men and women with endocrine disorders
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, MA 02199, USA
    Lancet 369:597-611. 2007
    ..We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women...
  82. ncbi request reprint Secular decline in male reproductive function: Is manliness threatened?
    Shalender Bhasin
    J Clin Endocrinol Metab 92:44-5. 2007
  83. ncbi request reprint Making a diagnosis of androgen deficiency in adult men: what to do until all the facts are in?
    Shalender Bhasin
    Nat Clin Pract Endocrinol Metab 2:529. 2006
  84. ncbi request reprint Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine S B, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 91:1995-2010. 2006
    ..The objective was to provide guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men...
  85. ncbi request reprint Female androgen deficiency syndrome--an unproven hypothesis
    Shalender Bhasin
    J Clin Endocrinol Metab 90:4970-2. 2005