ANN BEYER

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1
    Arindam Dasgupta
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Mol Cell Biol 27:2886-96. 2007
  2. pmc Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes
    Sarah L French
    Department of Microbiology, Box 800734, University of Virginia Health System, Charlottesville, VA 22908 0734, USA
    Mol Cell Biol 31:482-94. 2011
  3. pmc RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase
    Joseph J Sandmeier
    Department of Biochemistry and Molecular Genetics and Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    EMBO J 21:4959-68. 2002
  4. pmc Transcription of multiple yeast ribosomal DNA genes requires targeting of UAF to the promoter by Uaf30
    Robert D Hontz
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:6709-19. 2008
  5. pmc In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes
    Sarah L French
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Mol Cell Biol 23:1558-68. 2003
  6. pmc Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein
    Sarah L French
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Mol Cell Biol 28:4576-87. 2008
  7. ncbi request reprint Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae
    Yvonne N Osheim
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cell 16:943-54. 2004
  8. pmc Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A
    Jeffrey S Johnson
    Department of Microbiology, University of Virginia Health System, P O Box 800734, Charlottesville, VA 22908, USA
    J Virol 78:6459-68. 2004
  9. ncbi request reprint EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3' end cleavage of nascent transcripts
    Yvonne N Osheim
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Chromosoma 111:1-12. 2002
  10. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008

Collaborators

  • JEFFREY SCOTT SMITH
  • DAVID AUBLE
  • D Tollervey
  • Prasad Tongaonkar
  • T R Hughes
  • JOHN REEVE
  • N Proudfoot
  • Yvonne N Osheim
  • Sarah L French
  • Masayasu Nomura
  • Martha L Sikes
  • Robert D Hontz
  • Susan J Baserga
  • David A Schneider
  • Emmanuel Vanrobays
  • Melanie L Oakes
  • Loan Vu
  • Jennifer E G Gallagher
  • François Dragon
  • Yvonne Osheim
  • Asa Segerstolpe
  • Arindam Dasgupta
  • Denis L J Lafontaine
  • Franziska Bleichert
  • Jonathan A Dodd
  • Tran Hoang
  • Sander Granneman
  • Sarah French
  • Jeffrey S Johnson
  • Elizabeth M Prescott
  • Jonathan A Claypool
  • Brianna M Mitchell
  • Joseph J Sandmeier
  • Mitchell M Smith
  • Tashima E Lambert
  • Aziz El Hage
  • Ludivine Wacheul
  • Lars Wieslander
  • Pär Lundkvist
  • Vikram A Misra
  • Laura A Copela
  • Alexis Leplus
  • Sandra L Wolin
  • Cesar F Fernandez
  • Pavel Aprikian
  • Sarah A Juedes
  • Antje Michel
  • Robert Hontz
  • Thomas J Santangelo
  • Shilpa Salgia
  • Rebekka O Sprouse
  • Imran Siddiqi
  • John P Aris
  • Manabu Sato
  • Nevan Krogan
  • Jack Greenblatt
  • Shawna Hiley
  • Wen Tao Peng
  • Krasimir Spasov
  • Claudia M Alen
  • Katsuki Johzuka
  • Judith G Roan
  • Hannah S Jones
  • Erica A Champion
  • Margaux R Emanuel
  • Kristilyn Eliason
  • David A Dunbar
  • Ronald H Reeder
  • Alex Bankovich
  • Kristin M Keck
  • Yuming Xue
  • Daniel A Engel
  • Peter W Lewis
  • Francesco Cioci
  • Donald F Hunt
  • Jeffrey Shabanowitz
  • Kara A Porwancher
  • Steven Wormsley
  • Christopher M Gallo
  • Robert E Settlage
  • Patricia A Compagnone-Post
  • Karen A Wehner
  • Wang L Cheung

Detail Information

Publications21

  1. pmc Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1
    Arindam Dasgupta
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Mol Cell Biol 27:2886-96. 2007
    ....
  2. pmc Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes
    Sarah L French
    Department of Microbiology, Box 800734, University of Virginia Health System, Charlottesville, VA 22908 0734, USA
    Mol Cell Biol 31:482-94. 2011
    ..Positive torsion in front of the polymerase induces supercoiling (writhe) and is largely resolved by Top2. Negative torsion behind the polymerase induces DNA strand separation and is largely resolved by Top1...
  3. pmc RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase
    Joseph J Sandmeier
    Department of Biochemistry and Molecular Genetics and Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    EMBO J 21:4959-68. 2002
    ..However, histone H3 and H4 acetylation was not significantly altered at the rDNA locus in an rpd3Delta mutant. Rpd3 therefore regulates the number of open rDNA repeats...
  4. pmc Transcription of multiple yeast ribosomal DNA genes requires targeting of UAF to the promoter by Uaf30
    Robert D Hontz
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:6709-19. 2008
    ..The results show that Uaf30p is a key targeting factor for the UAF complex that facilitates activation of a large proportion of rDNA genes in the tandem array...
  5. pmc In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes
    Sarah L French
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Mol Cell Biol 23:1558-68. 2003
    ..Results also allow an estimate of elongation rate of approximately 60 nucleotides/s for yeast Pol I and a reinitiation rate of less than 1 s on the most heavily transcribed genes...
  6. pmc Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein
    Sarah L French
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Mol Cell Biol 28:4576-87. 2008
    ....
  7. ncbi request reprint Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae
    Yvonne N Osheim
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cell 16:943-54. 2004
    ..The results show that the approximately 40 components of the SSU processome/90S preribosome can complete their tasks within approximately 85 s in optimal conditions...
  8. pmc Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A
    Jeffrey S Johnson
    Department of Microbiology, University of Virginia Health System, P O Box 800734, Charlottesville, VA 22908, USA
    J Virol 78:6459-68. 2004
    ..These studies define the in vivo functions of protein VII in DNA binding, condensation, and transcriptional repression and indicate a role in E1A-mediated transcriptional activation of viral genes...
  9. ncbi request reprint EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3' end cleavage of nascent transcripts
    Yvonne N Osheim
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Chromosoma 111:1-12. 2002
    ....
  10. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008
    ..Strikingly, DIM2 and RRP12 are both involved in the nucleocytoplasmic translocation of pre-ribosomes, suggesting that this step in the ribosome assembly pathway has been selected as a regulatory target for the TOR pathway...
  11. pmc Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes
    Asa Segerstolpe
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91, Stockholm, Sweden
    Nucleic Acids Res 36:4364-80. 2008
    ..These results show that Mrd1p is required for establishing productive structures within the 90S preribosomal complex...
  12. pmc Transcription elongation by RNA polymerase I is linked to efficient rRNA processing and ribosome assembly
    David A Schneider
    Department of Biological Chemistry, University of California, Irvine, 240 D Medical Sciences I, Irvine, CA 92697 1700, USA
    Mol Cell 26:217-29. 2007
    ....
  13. pmc Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast
    Melanie L Oakes
    Department of Biological Chemistry, University of California Irvine, 240D Medical Sciences I, Irvine, California 92697 1700, USA
    Mol Cell Biol 26:3889-901. 2006
    ....
  14. pmc Histones are required for transcription of yeast rRNA genes by RNA polymerase I
    Prasad Tongaonkar
    Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
    Proc Natl Acad Sci U S A 102:10129-34. 2005
    ..Thus, these results show functional importance of histones associated with actively transcribed rRNA genes...
  15. pmc Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction
    Tran Hoang
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 25:5523-34. 2005
    ..The identification of ABT1 in a large-scale analysis of the human nucleolar proteome indicates that its role may also be conserved in mammals...
  16. pmc RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components
    Jennifer E G Gallagher
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520 8024, USA
    Genes Dev 18:2506-17. 2004
    ..This association may thus represent an early step in the formation of the SSU processome. Our results indicate that rRNA transcription and pre-rRNA processing are coordinated via specific components of the SSU processome...
  17. pmc Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p
    Elizabeth M Prescott
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:6068-73. 2004
    ..The homology of Rpa12p to the small subunit Rpb9p of Pol II and Rpc11p of Pol III, both implicated in transcriptional termination, points to a common termination mechanism for all three classes of RNA polymerase...
  18. pmc Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes
    Jonathan A Claypool
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Biol Cell 15:946-56. 2004
    ....
  19. ncbi request reprint A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis
    François Dragon
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Nature 417:967-70. 2002
    ..We have termed this large RNP the small subunit (SSU) processome...
  20. pmc The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation
    Franziska Bleichert
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9464-9. 2006
    ..Our results suggest that Utp24 might be the elusive endonuclease that cleaves the pre-rRNA at sites A(1) and/or A(2.)...
  21. ncbi request reprint Transcription and translation are coupled in Archaea
    Sarah L French
    Mol Biol Evol 24:893-5. 2007
    ..These complexes are consistent with transcription and translation being coupled in this Archaeon, with translation of transcripts being initiated before the transcript is complete...

Research Grants10

  1. Visualizing Genetic Activity in Normal & Mutant Yeast
    Ann L Beyer; Fiscal Year: 2010
    ..Information gained by a unique approach that involves direct visualization of active genes will reveal regulatory steps that may be promising new targets in cancer therapy. ..
  2. Visualizing Genetic Activity in Normal and Mutant Yeast
    ANN BEYER; Fiscal Year: 2009
    ..abstract_text> ..
  3. Visualizing Genetic Activity in Normal and Mutant Yeast
    ANN BEYER; Fiscal Year: 2007
    ....
  4. Visualizing Genetic Activity in Normal and Mutant Yeast
    ANN BEYER; Fiscal Year: 2004
    ..Furthermore, the recently uncovered role of the nucleolus in aging may be elucidated further by the proposed experiments. ..
  5. Visualizing Genetic Activity in Normal and Mutant Yeast
    Ann L Beyer; Fiscal Year: 2010
    ..abstract_text> ..