Levi J. Beverly

Summary

Affiliation: University of Louisville
Location: Louisville, USA
Publications:
1. Ascano JM, Beverly LJ, Capobianco AJ. The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem. 2003 Mar 7;278(10):8771-9.
2. Beverly LJ, Capobianco AJ. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell. 2003 Jun;3(6):551-64.
3. Beverly LJ and Capobianco AJ. Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost. Trends Mol Med. 2004 Dec;10(12):591-8.
4. Beverly LJ, Felsher DW and Capobianco AJ. Suppression of p53 by Notch in Lymphomagenesis: Implications for Initiation and Regression. Cancer Res. 2005 Aug;65:(16
5. Carlson TR, Yan Y, Wu X, Lam MT, Tang GT, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, and Wang R. Endothelial Expression of Constitutively Active Notch4 Elicits Reversible Arteriovenous Malformations in Adult Mice. Proc Natl Acad Sci USA. 2005 Jul 12; 102(28):9884-9.
6. Beverly LJ, Ascano JM and Capobianco AJ. Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells. Genes Immun. 2006 Sep; 7(6):476-86.
7. Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ and Kelliher MA. Noth1 contributes to mouse T cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol. 2006 Nov;26(21): 8022-31.
8. Spaulding C, Reschly EJ, Zagort DE, Yashiro-Ohtani Y, Beverly LJ, Capobianco A, Pear WS and Kee BL. Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 2007 Oct 1; 110(7): 2650-8.
9. Podsypanina K, Politi K, Beverly LJ, Varmus HE. Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci US. 2008 Apr 1; 105(13): 5242-7.
10. Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambartzumyan D and Varmus HE. Seeding and propagation of untransformed mouse mammary cells in the lung. Science. 2008 Sep 26;321(5897):1841-4.
11. Beverly LJ and Varmus HE. MYC-induced leukemogenesis is accelerated by all members of the anti-apoptotic BCL family. Oncogene. 2009 Mar 5;28(9):1274-9.
12. Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ, Brafford PA, Xiao M, Himes B, Zabierowski SE, Yashiro-Ohtani Y, Nathanson KL, Bengston A, Pollock PM, Weeraratna AT, Nickoloff BJ, Pear WS, Capobianco AJ, Herlyn M. Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res. 2009 Jul 1;69(13):5312-20.
13. Beverly LJ, Lockwood WW, Erdjument-Bromage H, and Varmus HE. Ubiquitination, localization and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Manuscript in review.
14. Beverly LJ. Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions. In Press, Journal of Cellular Biochemistry.


Publications

  1. ncbi request reprint The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation
    Janice M Ascano
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 278:8771-9. 2003
  2. pmc Active Notch1 confers a transformed phenotype to primary human melanocytes
    Chelsea C Pinnix
    Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Res 69:5312-20. 2009
  3. pmc Seeding and propagation of untransformed mouse mammary cells in the lung
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 321:1841-4. 2008
  4. pmc Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:5242-7. 2008
  5. ncbi request reprint Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas
    Christina Spaulding
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Blood 110:2650-8. 2007
  6. ncbi request reprint Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells
    L J Beverly
    The Wistar Institute, Philadelphia, PA 19104, USA
    Genes Immun 7:476-86. 2006
  7. ncbi request reprint Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression
    Levi J Beverly
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 65:7159-68. 2005
  8. pmc Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
    Timothy R Carlson
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery and Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:9884-9. 2005
  9. ncbi request reprint Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost
    Levi J Beverly
    The Wistar Institute, Molecular and Cellular Oncogenesis Program, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Trends Mol Med 10:591-8. 2004
  10. ncbi request reprint Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis
    Levi J Beverly
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Cancer Cell 3:551-64. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation
    Janice M Ascano
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Ohio 45267 0524, USA
    J Biol Chem 278:8771-9. 2003
    ..Moreover, we conclude that this intrinsic signaling mechanism of JAGGED1 may partly provide a link between aberrant misexpression of JAGGED1 and tumorigenesis...
  2. pmc Active Notch1 confers a transformed phenotype to primary human melanocytes
    Chelsea C Pinnix
    Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Res 69:5312-20. 2009
    ..This new information yields valuable insight into the basic epidemiology of melanoma and launches a realm of possibilities for drug intervention in this deadly disease...
  3. pmc Seeding and propagation of untransformed mouse mammary cells in the lung
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 321:1841-4. 2008
    ..Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors...
  4. pmc Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:5242-7. 2008
    ..These results demonstrate that tumor viability is maintained by each gene in a combination of oncogenes and that targeted approaches will also benefit from combination therapies...
  5. ncbi request reprint Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas
    Christina Spaulding
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Blood 110:2650-8. 2007
    ..Therefore, Notch1 co-opts Lef1 during the process of transformation to maintain survival of T-cell lymphomas...
  6. ncbi request reprint Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells
    L J Beverly
    The Wistar Institute, Philadelphia, PA 19104, USA
    Genes Immun 7:476-86. 2006
    ..We propose that the phenotype of the lck-JAGGED1 transgenic mice is a direct result of specific DSL/Notch interactions and improper cell-to-cell signaling...
  7. ncbi request reprint Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression
    Levi J Beverly
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 65:7159-68. 2005
    ..Furthermore, we propose that suppression of p53 by Notch is a key mechanism underlying the initiation of T-cell lymphoma...
  8. pmc Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
    Timothy R Carlson
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery and Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:9884-9. 2005
    ..Our results provide gain-of-function evidence that Notch signaling in the adult endothelium is sufficient to render arterial characteristics and lead to AVMs...
  9. ncbi request reprint Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost
    Levi J Beverly
    The Wistar Institute, Molecular and Cellular Oncogenesis Program, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Trends Mol Med 10:591-8. 2004
    ..In leukemogenesis, the breakdown of this coordinate regulation underlies one of the pathophysiological mechanisms. Finally, using Notch as a template, potential points of interdiction by designer therapeutics are discussed...
  10. ncbi request reprint Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis
    Levi J Beverly
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Cancer Cell 3:551-64. 2003
    ..We propose that cooperative leukemogenesis occurs in cells that have constitutive N(ic) and altered Ik isoform expression because genes normally repressed by Ik become activated by N(ic)/CSL...
  11. pmc BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
    Levi J Beverly
    Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Biochem J 452:111-9. 2013
    ..Furthermore, we present a feed-forward model by which BAK activation of CerS by chemotherapeutic drugs leads to elevated ceramide levels that result in synergistic channel formation by ceramide (or one of its metabolites) and BAX/BAK...
  12. pmc Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1
    Levi J Beverly
    Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:E119-26. 2012
    ....
  13. doi request reprint Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?
    Levi J Beverly
    Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Cell Biochem 113:3-12. 2012
    ..The focus of this review will be to direct attention to non-canonical regulators of the BCL2-family of proteins, especially our void of understanding of such interactions, and the controversy that surrounds some such interactions...